2009 Fiscal Year Final Research Report
Stress-surveillance and signal network originated from dendrite of various cells
| Project/Area Number |
18209026
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
TANAKA Yoshiya University of Occupational and Environmental Health, Japan, 医学部, 教授 (30248562)
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| Co-Investigator(Kenkyū-buntansha) |
UETA Youiti 産業医科大学, 医学部, 教授 (10232745)
KOUNO Kimitoshi 産業医科大学, 医学部, 教授 (00153479)
TOKURA Yoshiki 産業医科大学, 医学部, 教授 (00172156)
NAKAMURA Toshitaka 産業医科大学, 医学部, 教授 (50082235)
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| Project Period (FY) |
2006 – 2009
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| Keywords | ストレス科学 |
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| Research Abstract |
"Dendrite" is expressed on various cells including neuron in CNS and periphery, dendritic cells in immune system, Langerhans cells in skin, osteocyte in bone and so on. The dendrite receives multiple stresses and functions as stress-surveillance sensors. The cells possessing the dendrite receive stress-stimulation, transform it to multiple intracellular signals through nucleic transcription and transduce the signals to various defensive cellular functions in central nerve, immune, skin, metabolic systems in human body. Thus, we postulate that the dendrite plays a pivotal role in the self-defense system through initiating multiple stress-stimulation as a central sensor.
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Research Products
(17 results)
