2009 Fiscal Year Final Research Report
Functional analysis of PAR-1 and search for novel G protein-coupled receptors in cerebral vasospasm
| Project/Area Number |
18209045
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SASAKI Tomio Kyushu University, 大学院・医学研究院, 教授 (10134561)
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| Co-Investigator(Kenkyū-buntansha) |
庄野 禎久 九州大学, 大学院・医学研究院脳神経外科学, 准教授 (00346793)
溝口 昌弘 九州大学, 大学病院脳神経外科学, 講師 (50380621)
宮城 靖 九州大学, デジタルメディシンイニシアティブ, 准教授 (10380403)
前田 善久 九州大学, 大学病院, 助手 (30380455)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 脳血管障害学 / 脳血管攣縮 / くも膜下出血 / 血管平滑筋 |
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| Research Abstract |
The expression of PAR-1 was up-regulated and the contractile response to thrombin was markedly enhanced in the cerebral artery of rabbit subarachnoid hemorrhage (SAH) model. The intrathecal administration of a PAR-1 antagonist prevented the up-regulation of PAR-1 and the enhancement of the contractile responses to thrombin after SAH. Following SAH, thrombin activates PAR-1, thereby up-regulating the expression of PAR-1, which culminates in the increased contractile response to thrombin in the rabbit cerebral artery. The up-regulation of the receptor expression and the enhancement of the agonist-induced contraction were observed in various G protein-coupled receptors and these agonists.
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