Exploration of diagnostic and therapeutic target molecules through integration of 'omics' data based on array technology

2008 Fiscal Year Final Research Report

• Project/Area Number: 18209059
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: AMAGASA Teruo Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (00014332)
• Co-Investigator(Kenkyū-buntansha): INAZAWA Johji 東京医科歯科大学, 難治疾患研究所, 教授 (30193551) ; UZAWA Narikazu 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (30345285) ; IMOTO Issei 東京医科歯科大学, 難治疾患研究所, 准教授 (30258610)
• Project Period (FY): 2006 – 2008
• Keywords: 口腔扁平上皮癌 / 前癌病変 / ゲノム / エピゲノム / アレイCGH / 発現解析 / Omics

Research Abstract

体系的・網羅的に口腔癌の癌化・悪性化の基盤にある遺伝子異常を解明し、「個性診断」や「分子標的治療」に必要十分な癌関連遺伝子を同定することを目的に、ゲノム・エピゲノムレベルから蛋白レベルまでのアレイ技術を中心とする多項目遺伝子異常解析、口腔癌とその前癌病変の臨床検体収集と臨床・病理学的情報のデータベース化と解析、細胞株を駆使した遺伝子の強制発現や発現抑制による、標的遺伝子候補の機能解析を行った。

Research Products

• [Journal Article] Simultaneous assessment of cyclin D1 and epidermal growth factor receptor gene copy number for prognostic factor in oral squamous cell carcinomas (2009)
  • Author(s): Takahashi K, Uzawa N, Amagasa T
  • Journal Title: OSI 6(1)(in press)
  • Peer Reviewed
• [Journal Article] Surgical contribution to recurrence-free survival in patients with macrovascular-invasion-negative hepatocellular carcinoma (2009)
  • Author(s): Tanaka S, Mogushi K, Yasen M, Noguchi N, Kudo A, Kurokawa T, Nakamura N, Inazawa J, Tanaka H, Arii S
  • Journal Title: J Am Coll Surg 208 Pages: 368-74
  • Peer Reviewed
• [Journal Article] ASK1 amd ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis (2009)
  • Author(s): Iriyama T, Takeda K, Nakamura H, Motimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto I, Inazawa J, Chiba K, Kamei Y, Kozuma S, Taketani Y, Matsuzawa A, Ichijo H
  • Journal Title: EMBO J (in press)
  • Peer Reviewed
• [Journal Article] PH domain-only protein PHLDA3 is a p53-regulated repressor of akt (2009)
  • Author(s): Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, Ohta T, Ichikawa H, Aburatani H, Tashiro F, Taya Y
  • Journal Title: Cell 36 Pages: 535-50
  • Peer Reviewed
• [Journal Article] Actinin-4 gene amplification in ovarian cancer : a candidate oncogene associated with poor patient prognosis and tumor chemoresistance (2009)
  • Author(s): Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T, Matsubara O
  • Journal Title: Mod Pathol (in press)
  • Peer Reviewed
• [Journal Article] SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells (2009)
  • Author(s): Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T
  • Journal Title: J Biol Chem 30 Pages: 3334-44
  • Peer Reviewed
• [Journal Article] Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome (2009)
  • Author(s): Arai E, Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
  • Journal Title: Carcinogenesis 30 Pages: 214-21
  • Peer Reviewed
• [Journal Article] Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cellc, Kusa-A1 (2008)
  • Author(s): Katsuki Y, Sakamoto K, Minamizato T, Makino H, Umezawa A, Ikeda M, Perbal B, Amagasa T, Yamaguchi A, Katsube K
  • Journal Title: Biochemical and Biophysical Research Communications 368 Pages: 808-814
  • Peer Reviewed
• [Journal Article] GITR ligand-costimulation actives effector and regulatory functions of CD4+T cells (2008)
  • Author(s): Igarashi H, Cao Y, Iwai H, Piao J, Kamimura Y, Hashiguchi M, Amagasa T, Azuma M
  • Journal Title: Biochemical and Biophysical Research Communications 369 Pages: 1134-1138
  • Peer Reviewed
• [Journal Article] JunD suppresses bone fortmation and contributes to low bone mass induced by estrogen depletion (2008)
  • Author(s): Kawamata A, Izu Y, Yokoyama H, Amagasa T, F.Wagner E, Nakashima K, Ezura Y, Hayata T, and Noda M
  • Journal Title: Journal of Cellular Biochemistry 103 Pages: 1037-1045
  • Peer Reviewed
• [Journal Article] An investigation of magnetic resonance imaging features in 14 patients with synovial chondromatosis of the temporomandibular joint (2008)
  • Author(s): Ida M., Yoshitake H., Okoch K., Tetsumura A., Ohbayashi N., Amagasa T., Omura K., Okada N., Kurabayashi T.
  • Journal Title: Dentomaxillofacial Radiology 37(4) Pages: 213-219
  • Peer Reviewed
• [Journal Article] Hard tissue regeneration capacity of apical pulp derived cells(APDCs)from human tooth with immature apex (2008)
  • Author(s): Abe S., Yamaguchi S., Watanabe A., Hamada K., Amagasa T.
  • Journal Title: Biochemical and Biophysical Research Communications 371 Pages: 90-93
  • Peer Reviewed
• [Journal Article] Synchronous Warthin tumors and lymphoepithelial cyst in tha Ipsilateral parotid gland (2008)
  • Author(s): Takahashi K., Uzawa N., Kosaka S., Yoshino N., Okada N., Amagasa T.
  • Journal Title: Journal of Oral and Maxillofacial Surgery 66(5) Pages: 1053-1056
  • Peer Reviewed
• [Journal Article] ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization (2008)
  • Author(s): Ishihara T, Tsuda H, Hotta A, Kozaki K, Yoshida A, Jaeduk Yoshimura Noh, Ito K, Imoto I, Inazawa J
  • Journal Title: Cancer Sci 99 Pages: 1940-92
  • Peer Reviewed
• [Journal Article] Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization : its association with DNA methylation alteration and patient outcome (2008)
  • Author(s): Arai E, Ushijima S, Tsuda H, Fujimoto H,Hosoda F, Shibata T, Kondo T, Imoto I, Inazawa J, Hirohashi S, Kanai Y
  • Journal Title: Clin Cancer Res 14 Pages: 5531-9
  • Peer Reviewed
• [Journal Article] Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas (2008)
  • Author(s): Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, Ono M, Tsuchida A, Aoki T, Inazawa J,Hirohashi S, Yamada T
  • Journal Title: Clin Cancer Res 14 Pages: 5348-56
  • Peer Reviewed
• [Journal Article] Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes (2008)
  • Author(s): Katsuki Y, Nakada S, Yokoyama T, Imoto I, Inazawa J, Nagasawa M, Mizutani S
  • Journal Title: Cancer Sci 99 Pages: 1539-45
  • Peer Reviewed
• [Journal Article] Activation of B-Myb by E2F1 in hepatocellular carcinoma (2008)
  • Author(s): Nakajima T, Yasui K, Zen K, Inagaki Y, Fujii H, Minami M, Tanaka S, Taniwaki M, Itoh Y, Arii S, Inazawa J, Okanoue T
  • Journal Title: Hepatol Res 38 Pages: 886-95
  • Peer Reviewed
• [Journal Article] Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue (2008)
  • Author(s): Qi S, Mogi S, Tsuda H, Tanaka Y, Kozaki K, Imoto I, Inazawa J, Hasegawa S, Omura K
  • Journal Title: Int J Oral Maxillofac Surg 37 Pages: 1047-53
  • Peer Reviewed
• [Journal Article] Frequent inactivation of a putative conditional tumor-suppressor gene,angiopoietin-like protein 2, in ovarian cancer (2008)
  • Author(s): Kikuchi R, Tsuda H, Kozaki K, Kanai Y, Kasamatsu T, Sengoku K,Hirohashi S, Inazawa J, Imoto I
  • Journal Title: Cancer Res 68 Pages: 5067-75
  • Peer Reviewed
• [Journal Article] Frequent silencing of a putative tumor suppressor gene melatonin receptor 1A(MTNR1A)in oral squamous-cell carcinoma (2008)
  • Author(s): Nakamura E, Kozaki K, Tsuda H, Suzuki, E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I
  • Journal Title: Cancer Sci 99 Pages: 1390-400
  • Peer Reviewed
• [Journal Article] Overexpressed NF-{kappa}B inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells (2008)
  • Author(s): Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez BVJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S
  • Journal Title: Blood 111 Pages: 5118-29
  • Peer Reviewed
• [Journal Article] Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer (2008)
  • Author(s): Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J
  • Journal Title: Cancer Res 68 Pages: 2094-105
  • Peer Reviewed
• [Journal Article] Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization (2008)
  • Author(s): Suzuki A, Shibata T, Murakami Y, Horii A, Shiratori K, Hirohashi S, Inazawa J, Imoto I
  • Journal Title: Cancer Sci 99 Pages: 986-94
  • Peer Reviewed
• [Journal Article] Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy (2008)
  • Author(s): Tanaka S, Arii S, Yasen M, Moqushi K, Su NT, Zhao C, Imoto I, Eishi Y, Inazawa J, Miki Y, Tanaka H
  • Journal Title: Br J Surg 95 Pages: 611-9
  • Peer Reviewed
• [Journal Article] POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17 (2008)
  • Author(s): Zhao C, Inoue J, Imoto I, Otsuki T, Iida S, Ueda R, Inazawa J
  • Journal Title: Oncogene 27 Pages: 63-75
  • Peer Reviewed
• [Journal Article] Fluorescence in situ hybridization for detecting genomic alterations of Cyclin D1 and p16 in oral squamous cell carcinomas (2007)
  • Author(s): Uzawa N, Sonoda I, Myo K, Takahashi K, Miyamoto R, Amagasa T
  • Journal Title: Cancer 110 Pages: 2230-2239
  • Peer Reviewed
• [Journal Article] Muktilineage Cells from Apical Pulp of Human Tooth with Immature Apex (2007)
  • Author(s): Abe S.,Yamaguchi Y.,Amagasa T.
  • Journal Title: Oral Science International 4(1) Pages: 45-58
  • Peer Reviewed
• [Journal Article] Serum osteopontin,an enhancer of tumor metastasis to bone,promotes B16 melanoma cell migration (2007)
  • Author(s): Hayashi C., Rittling S., Hayata T., Amagasa T. Denhardt D., Ezura Y., Nakashima K., and Noda M.
  • Journal Title: Journal of Cellular Biochemistry 101 Pages: 979-986
  • Peer Reviewed
• [Journal Article] Noninvasive quantitative assessment of oral tongue cancer by intraoral ultrasonography (2007)
  • Author(s): Yamane M., Ishii J., Izumo T., Nagasawa T., Amagasa T.
  • Journal Title: Head&Neck 29(4) Pages: 307-314
  • Peer Reviewed
• [Journal Article] Genetically distinct and clinically relevant classification of hepatocellular carcinoma : putative therapeutic targets (2007)
  • Author(s): Katoh H, Ojima H, Kokubu A, Saito S, Kondo T, Kosuge T, Hosoda F, Imoto I, Inazawa J, Hirohashi S, Shibata T
  • Journal Title: Gastroenterology 133 Pages: 1475-86
  • Peer Reviewed
• [Journal Article] Actinin-4 expression in ovarian cancer : a novel prognostic indicator independent of clinical stage and histological type (2007)
  • Author(s): Yamamoto S, Tsuda H, Honda K, Kita T, Takano M, Tamai S, Inazawa J, Yamada T, Matsubara O
  • Journal Title: Mod Pathol 20 Pages: 1278-85
  • Peer Reviewed
• [Journal Article] Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomas (2007)
  • Author(s): Mitsui F, Dobashi Y, Imoto I, Inazawa J, Kono K, Fujii H, Ooi A
  • Journal Title: Mod Pathol 20 Pages: 622-31
  • Peer Reviewed
• [Journal Article] Analysis of Sentinel Node involvement in gastric cancer (2007)
  • Author(s): Morita D, Tsuda H, Ichikura T, Kimura M, Aida S, Kosuda S, Inazawa J, Mochizuki H, Matsubara O
  • Journal Title: Clin Gastroenterol Hepatol 5 Pages: 1046-52
  • Peer Reviewed
• [Journal Article] Clinicopathological significance of WT1 expression in ovarian cancer : a possible accelerator of tumor progression in serous adenocarcinoma (2007)
  • Author(s): Yamamoto S, Tsuda H, Kita T, Maekawa K, Fujii K, Kudoh K, Furuya K, Tamai S, Inazawa J, Matsubara O
  • Journal Title: Virchows Arch 451 Pages: 27-35
  • Peer Reviewed
• [Journal Article] Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation (2007)
  • Author(s): Kawanishi H, Takahashi T, Ito M, Matsui Y, Watanabe J, Ito N, Kamoto T, Kadowaki T, Tsujimoto G, Imoto I, Inazawa J, Nishiyama H, Ogawa O
  • Journal Title: Br J Cancer 97 Pages: 260-6
  • Peer Reviewed
• [Journal Article] Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer (2007)
  • Author(s): Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I
  • Journal Title: Cancer Res 67 Pages: 7095-105
  • Peer Reviewed
• [Journal Article] PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation (2007)
  • Author(s): Suzuki E, Imoto I, Pimkhaokham A, Nakagawa T, Kamata N, Kozaki K,Amagasa T, Inazawa J
  • Journal Title: Oncogene 26 Pages: 7921-32
  • Peer Reviewed
• [Journal Article] Epigenetic silencing of prostaglandin E receptor 2(PTGER2)is associated with progression of neuroblastomas (2007)
  • Author(s): Sugino Y, Misawa A, Inoue J, KitagawaM, Hosoi H, Sugimoto T, Imoto I, Inazawa J
  • Journal Title: Oncogene 26 Pages: 7401-13
  • Peer Reviewed
• [Journal Article] Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma (2007)
  • Author(s): Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, Aiko S, Yoshizumi Y, Iwai T, Kawano T, Inazawa J
  • Journal Title: Oncogene 26 Pages: 6456-68
  • Peer Reviewed
• [Journal Article] Association of KLK5-overexpression with invasiveness of urinary bladder carcinoma cells (2007)
  • Author(s): Shinoda Y, Kozaki K, Imoto I, Obara W, Tsuda H, Mizutani Y, Shuin T, Fujioka T, Miki T, Inazawa J
  • Journal Title: Cancer Sci 98 Pages: 1078-86
  • Peer Reviewed
• [Journal Article] BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line (2007)
  • Author(s): Kawasaki T, Yokoi S, Tsuda H, Izumi H, Kozaki k, Aida S, Ozeki Y, Yoshizawa Y, Imoto I, Inazawa J
  • Journal Title: Cancer Sci 98 Pages: 1070-7
  • Peer Reviewed
• [Journal Article] The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma (2007)
  • Author(s): Tanaka E, Hashimoto Y, Ito T, Kondo K, Higashiyama M, Tsunoda S, Ortiz C, Sakai Y, Inazawa J, Shimada Y
  • Journal Title: Clin Cancer Res 13 Pages: 1331-40
  • Peer Reviewed
• [Journal Article] Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma : identification of genetic indicators that predict patient outcome (2007)
  • Author(s): Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S
  • Journal Title: Cancer Sci 98 Pages: 392-400
  • Peer Reviewed
• [Journal Article] Reduced levels of ATF-2 predispose mice to mammary tumors (2007)
  • Author(s): Maekawa T, Shinagawa T, Sano Y, Sakuma T, Nomura S, Nagasaki K, Miki Y, Saito-Ohara F, Inazawa J, Kohno T, Yokota J, Ishii S
  • Journal Title: Mol Cell Biol 27 Pages: 1730-44
  • Peer Reviewed
• [Journal Article] RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest (2007)
  • Author(s): Saigusa K, Imoto I, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J
  • Journal Title: Oncogene 26 Pages: 1110-21
  • Peer Reviewed
• [Journal Article] Oral Leukoplakia related to malignant transformation (2006)
  • Author(s): Amagasa T, Yamasshiro M, Ishikawa H
  • Journal Title: Oral Science International 3(2) Pages: 45-55
  • Peer Reviewed
• [Journal Article] A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity (2006)
  • Author(s): Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J
  • Journal Title: Oncogene 26 Pages: 1178-87
  • Peer Reviewed
• [Journal Article] PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma (2006)
  • Author(s): Kozaki K, Imoto I, Pimkhaokham A, Hasegawa S, Tsuda H, Omura K, Inazawa J
  • Journal Title: Cancer Sci 97 Pages: 1351-8
  • Peer Reviewed
• [Journal Article] Genomic loss and epigenetic silencing of very low density lipoprotein receptor involved in gastric carcinogenesis (2006)
  • Author(s): Takada H, Imoto I, Tsuda H, Nakanishi Y, Sakakura C, Mitsufuji S, Hirohashi S, Inazawa J
  • Journal Title: Oncogene 25 Pages: 6554-62
  • Peer Reviewed
• [Journal Article] Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma (2006)
  • Author(s): Nakagawa T, Pimkhaokham A, Suzuki E, Omura K, Inazawa J, Imoto I
  • Journal Title: Cancer Sci 97 Pages: 1070-4
  • Peer Reviewed
• [Journal Article] Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers (2006)
  • Author(s): Imoto I, Izumi H, Yokoi S, Hosoda H, Shibata T, Hosoda F, Ohki M, Hirohashi S, Inazawa J
  • Journal Title: Cancer Res 66 Pages: 4617-26
  • Peer Reviewed
• [Presentation] ゲノムアレイプラットフォームで展開するがんのゲノム・エピゲノム解析 (2008)
  • Author(s): 稲澤譲治
  • Organizer: 第31回日本分子生物学会年会・第81回日本生科学会大会・合同大会
  • Place of Presentation: 神戸ポートアイランド.兵庫
  • Year and Date: 2008-12-11
• [Presentation] ヒト癌におけるゲノム一次構造異常領域から同定された増幅標的癌遺伝子候補としてのdual specificity phosphatase (2008)
  • Author(s): 井本逸勢、稲澤譲治
  • Organizer: 第31回日本分子生物学会年会・第81 回日本生科学会大会・合同大会
  • Place of Presentation: 神戸ポートアイランド.兵庫
  • Year and Date: 2008-12-11
• [Presentation] 舌扁平上皮癌同一固体内における癌・上皮異形成の網羅的解析 (2008)
  • Author(s): 佐藤博章, 鵜澤成一, 高橋謙一郎, 道川千絵子, 園田格, 茂櫛薫, 岡田憲彦, 天笠光雄
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋国際会議場.愛知
  • Year and Date: 2008-10-31
• [Presentation] 統合的ゲノム・エピゲノム解析から見出された癌のバイオマーカーと治療標的分子 (2008)
  • Author(s): 稲澤譲治
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場.愛知
  • Year and Date: 2008-10-28
• [Presentation] 舌癌後発頸部転移症例の検討 (2008)
  • Author(s): 赤津千絵, 鵜澤成一, 山根正之, 大山厳雄, 鈴木美保, 道泰之, 石井純一, 岩城博, 天笠光雄
  • Organizer: 第53回日本口腔外科学会総会
  • Place of Presentation: アスティとくしま. 徳島
  • Year and Date: 2008-10-21
• [Presentation] 口腔扁平上皮癌の偽陰性リンパ節転移に関する検討 (2008)
  • Author(s): 佐藤博章, 鵜澤成一, 山根正之, 大山厳雄, 鈴木美保, 中久木康一, 道泰之, 石井純一, 岩城博, 天笠光雄
  • Organizer: 第53回日本口腔外科学会総会
  • Place of Presentation: アスティとくしま. 徳島
  • Year and Date: 2008-10-21
• [Presentation] Global assessment of chromosomal changes in cancer (2008)
  • Author(s): 稲澤譲治
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 国立京都国際会館.京都
  • Year and Date: 2008-10-11
• [Presentation] ゲノム構造解析による食道扁平上皮癌の標的遺伝子探索 (2008)
  • Author(s): 井本逸勢、稲澤譲治
  • Organizer: 第17回日本アポトーシス研究会学術集会-細胞死研究の楽しさを考える-
  • Place of Presentation: メルパルク京都.京都
  • Year and Date: 2008-08-02
• [Presentation] 口腔扁平上皮癌における第7, 9, 11染色体の異数性に関する検討 (2008)
  • Author(s): 鵜澤成一, 高橋謙一郎, 佐藤博章, 名生邦彦, 天笠光雄
  • Organizer: 第32回日本頭頸部癌学会
  • Place of Presentation: ハイアットリジェンシー東京. 東京
  • Year and Date: 2008-06-12
• [Presentation] 口腔扁平上皮癌におけるSNP Microarraysを用いた全ゲノム領域に対する遺伝子数的変異の解析 (2008)
  • Author(s): 高橋謙一郎, 鵜澤成一, 宮口健, 水島洋, 田中博, 天笠光雄
  • Organizer: 第62回日本口腔科学会
  • Place of Presentation: 福岡国際会議場. 福岡
  • Year and Date: 2008-04-17
• [Presentation] Whole-Genome analysis of copy number variations in oral cancer using high-density SNP microarrays (2007)
  • Author(s): Miyaguchi K, Mogushi K, Imamura T, Mizushima H, Takahashi K, Uzawa N, Amagasa T, Tanaka H
  • Organizer: GIW(Genome Informatics Workshop)2007
  • Place of Presentation: Singapore
  • Year and Date: 20071203-05
• [Presentation] 口腔扁平上皮癌におけるCyclin D1, EGFR 遺伝子数的異常の予後予測因子としての検討 (2007)
  • Author(s): 高橋謙一郎、鵜澤成一、名生邦彦、宮本亮三、天笠光雄
  • Organizer: 第45回日本癌治療学会総会優秀演題講演
  • Place of Presentation: 京都国際会議場. 京都
  • Year and Date: 20071024-26
• [Presentation] がんのトランスレーショナルゲノミクス-Copy number variation(CNV)と疾患- (2007)
  • Author(s): 稲澤譲治
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 国立京都国際会館.京都
  • Year and Date: 2007-10-25
• [Presentation] Cancer genomic and epigenomic analyses on BAC-array platform (2007)
  • Author(s): 井本逸勢、小崎健一、稲澤譲治
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-05
• [Presentation] Identification of novel amplification-taeget genes in oral squamous cell carcinoma using array-CGH-assisted strategy (2007)
  • Author(s): Begum Asma、鈴木江美奈、中村恵理奈、井本逸勢、小崎健一、津田均、天笠光雄、稲澤譲治
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-04
• [Presentation] Epigenetic silencing of TSOC25 by hypermethylation of the CpG island in oral cancer (2007)
  • Author(s): 中村恵理奈、鈴木江美奈、中川貴之、津田均、山本剛、入江太朗、小崎健一、井本逸勢、立川哲彦、天笠光雄、稲澤譲治
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-03
• [Presentation] 口腔扁平上皮癌原発巣およびリンパ節におけるcyclin D1遺伝子数的異常に関する検討 (2007)
  • Author(s): 鵜澤成一、高橋謙一郎、名生邦彦、宮本亮三、天笠光雄
  • Organizer: 第31回日本頭頸部癌学会総会
  • Place of Presentation: パシフィコ横浜. 横浜
  • Year and Date: 2007-06-15
• [Presentation] FNA-FISH法による口腔扁平上皮癌における遺伝的解析とその臨床応用 (2007)
  • Author(s): 鵜澤成一
  • Organizer: 第61回日本口腔科学会 シンポジウム
  • Place of Presentation: 神戸国際会議場. 神戸
  • Year and Date: 2007-04-20
• [Presentation] RGC32, a novel p53-inducible tumor-suppressor gene, is located on centrosomes during mitosis and results in G2/M arrest (2007)
  • Author(s): Imoto I, Saigusa K, Tanikawa C, Aoyagi M, Ohno K, Nakamura Y, Inazawa J
  • Organizer: 98th annual meeting of American Association for Cancer Research 2007
  • Place of Presentation: LosAngeles, USA
  • Year and Date: 2007-04-16
• [Presentation] Cancer genomic and epigenomic analyses on a BAC-array pratform (2007)
  • Author(s): Inazawa J
  • Organizer: 7th AACR/JCA Joint International Conference
  • Place of Presentation: Hawaii,USA
  • Year and Date: 2007-01-22
• [Presentation] Cyclin D1 gene numerical aberration is a predictive marker for occult cervical lymph node metastasis in stage I and II squamous cell carcinoma of the oral cavity (2006)
  • Author(s): Uzawa N, Myo K, Takahashi K, Miyamoto R, Amagasa T
  • Organizer: 7th Asian Congress on Oral and Maxillofacial Surgery. Hong Kong Convention and Exhibition Centre
  • Place of Presentation: Hong Kong. China
  • Year and Date: 20061105-09
• [Presentation] Genomic alteration patterns of the cyclin D1 and EGFR gene in oral squamous cell carcinomas (2006)
  • Author(s): Takahashi K, Uzawa N, Myo K, Miyamoto R, Amagasa T.
  • Organizer: 7th Asian Congress on Oral and Maxillofacial Surgery. Hong Kong Convention and Exhibition Centre
  • Place of Presentation: Hong Kong. China
  • Year and Date: 20061105-09
• [Presentation] Evaluation of Masticatory function in tongue cancer patients (2006)
  • Author(s): Yamashiro M, Uzawa N, Michi Y, Aikou K, Amagasa T
  • Organizer: The 7th Asian Congress on Oral and Maxillofacial Surgery
  • Place of Presentation: Hong Kong Convention and Exhibition Centre. Hong Kong. China
  • Year and Date: 20061105-09
• [Presentation] In-house BACアレイを用いたゲノム一次構造解析によるがんと遺伝疾患の個別医療実現へのアプローチ (2006)
  • Author(s): 井本逸勢
  • Organizer: 日本人類遺伝学会第51回大会
  • Place of Presentation: 米子コンベンションホール.鳥取
  • Year and Date: 2006-10-20
• [Presentation] DNAメチル化により発現制御をうける新規口腔癌関連遺伝子候補TSOC10の解析 (2006)
  • Author(s): 鈴木江美奈、井本逸勢、井上純、中川貴之、Atiphan Pimkhaokham、細田文恵、大木操、天笠光雄、稲澤譲治
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜.横浜
  • Year and Date: 2006-09-30
• [Presentation] 口腔癌のアレイCGH解析により検出した新規ホモ欠失領域の標的癌関連遺伝子候補の解析 (2006)
  • Author(s): 中村恵理奈、鈴木江美奈、中川貴之、山本剛、入江太郎、小崎健一、井本逸勢、立川哲彦、天笠光雄、稲澤譲治
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜.横浜
  • Year and Date: 2006-09-30
• [Presentation] In-house BACアレイを用いた癌のゲノム構造・機能異常解析からの分子標的探索 (2006)
  • Author(s): 井本逸勢、稲澤譲治
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜.横浜
  • Year and Date: 2006-09-30
• [Presentation] 口腔扁平上皮癌におけるp16遺伝子異常のパターンの解析 (2006)
  • Author(s): 名生邦彦, 鵜澤成一, 宮本亮三, 天笠光雄
  • Organizer: 第30回日本頭頸部癌学会
  • Place of Presentation: 大阪国際会議場. 大阪
  • Year and Date: 2006-06-15
• [Book] 造血器腫瘍アトラス-形態、免疫、染色体と遺伝子-改訂第4版 (2009)
  • Author(s): 阿部達生、稲澤譲治、井本逸勢、井上純(分担)
  • Total Pages: 574
  • Publisher: 日本医事新報社(東京)
• [Book] 講義録腫瘍学 (2009)
  • Author(s): 稲澤譲治(分担)
  • Total Pages: 4
  • Publisher: メジカルビュー社(東京)
• [Book] 口腔癌の早期診断アトラス (2008)
  • Author(s): 天笠光雄、岡田憲彦、作田正義、立川哲彦、道健一(分担)
  • Total Pages: 163
  • Publisher: 医歯薬出版株式会社(東京)
• [Book] がんの分子標的治療(鶴尾隆編) (2008)
  • Author(s): 稲澤譲治(分担)
  • Total Pages: 441
  • Publisher: 南山堂(東京)
• [Book] 染色体・ゲノム異常 (2006)
  • Author(s): 稲澤譲治(分担)
  • Total Pages: 809
  • Publisher: 新臨床腫瘍学. 南江堂(東京)
• [Remarks] 東京医科歯科大学・難治疾患研究所・分子細胞遺伝CGHデータベース
  • URL: http://www.cghtmd.jp/CGHDatabase/index_j.jsp
• [Patent(Industrial Property Rights)] 口腔扁平上皮癌の検出方法 (2008)
  • Inventor(s): 稲澤譲治・井本逸勢・中村恵理奈・津田均
  • Industrial Property Rights Holder: 稲澤譲治, 国立大学法人東京医科歯科大学, 富士フィルム株式会社
  • Industrial Property Number: 特許,特願2008-205138
  • Filing Date: 2008-08-08
• [Patent(Industrial Property Rights)] 癌の検出方法および癌抑制剤 (2008)
  • Inventor(s): 稲澤譲治・小崎健一・井本逸勢
  • Industrial Property Rights Holder: 稲澤譲治, 国立大学法人東京医科歯科大学, 富士フィルム株式会社
  • Industrial Property Number: 特許,特願2008-012256
  • Filing Date: 2008-01-23
• [Patent(Industrial Property Rights)] 口腔扁平上皮癌の検出方法、及び抑制方法 (2007)
  • Inventor(s): 稲澤譲治・井本逸勢・鈴木江美奈
  • Industrial Property Rights Holder: 稲澤譲治, 国立大学法人東京医科歯科大学, 富士フィルム株式会社
  • Industrial Property Number: 特許,特願2007-143110
  • Filing Date: 2007-05-30
• [Patent(Industrial Property Rights)] 食道癌の判別方法 (2007)
  • Inventor(s): 稲澤譲治・井本逸勢・田中浩司
  • Industrial Property Rights Holder: 稲澤譲治, 国立大学法人東京医科歯科大学, 株式会社ビー・エム・エル
  • Industrial Property Number: 特願2007-111033
  • Filing Date: 2007-04-19
• [Patent(Industrial Property Rights)] 食道癌の検出方法 (2006)
  • Inventor(s): 稲澤譲治・井本逸勢・田中浩司・津田均
  • Industrial Property Rights Holder: 稲澤譲治, 国立大学法人東京医科歯科大学, 株式会社ビー・エム・エル
  • Industrial Property Number: 特許,特願2006-303331
  • Filing Date: 2006-07-27