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2008 Fiscal Year Annual Research Report

バングラデシュ胎児コホートを用いた、子供を取り巻く環境保健と疾病予防のための研究

Research Project

Project/Area Number 18256005
Research InstitutionUniversity of Tsukuba

Principal Investigator

我妻 ゆき子  University of Tsukuba, 大学院・人間総合科学研究科, 教授 (40400676)

Co-Investigator(Kenkyū-buntansha) 野口 恵美子  筑波大学, 大学院・人間総合科学研究科, 講師 (40344882)
熊谷 嘉人  筑波大学, 大学院・人間総合科学研究科, 教授 (00250100)
岡田 昌史  筑波大学, 大学院・人間総合科学研究科, 講師 (70375492)
林 泰一  京都大学, 防災研究所, 准教授 (10111981)
寺尾 徹  香川大学, 教育学部, 准教授 (30303910)
Keywords公衆生学 / 環境保健 / 感染症 / 栄養学 / アレルギー・喘息 / 気象学 / 国際研究者交流 / バングラデシュ
Research Abstract

この研究は妊婦の栄養不全・新生児低体重が多い途上国の早期小児期における環境を、とくに栄養・アレルギー・感染症・環境汚染物質・気象にわたり総合的にモニタリングし、それを、胎児期の状況と照らし合わせ、どのような成長発育をしてゆく子供となってゆくのかを観察調査する統合研究である。妊婦一胎児4,500ペアという世界でも最大規模の、胎児期からのフォローアップコホートを使用する科学的にも貴重な研究である。また、京都大学防災研究所が保持するバングラデシュの50年間以上の長期整備済み地上気象データベースを用いて気象変動とその疾病インパクト分析を当該研究に含めた。代表研究者(我妻)はICDDR,Bに2005年3月まで勤務し、ユニセフの低体重児削減介入研究の分担研究者であり、超音波装置による4,500人の胎児成長計測・新生児胸腺計測データは、当人が第一著者として保持している。
平成20年度の主な実績としては、4.5歳児の小児期生命応答プログラミング研究の、データ収集を修了し、4.5歳児フォーローアップデータベースを作成したことである。前年度から引き続き現時点で4.5歳となっているコホートについて、乳幼児期までの特徴を分析し、4.5歳児データとの関連分析に有用な知見を引き出した。妊婦の栄養状態、胎児の発達状況と小児アウトカムに関する成果発表を、招待講演や学会発表により行った。また、砒素の暴露に関しては、胸腺サイズ、免疫指標を変動させ、骨の長さに有意な差を認め、身体サイズや疾病罹患、しいては乳児死亡率とも関連性を認めた

  • Research Products

    (58 results)

All 2009 2008 Other

All Journal Article (31 results) (of which Peer Reviewed: 29 results) Presentation (25 results) Remarks (2 results)

  • [Journal Article] The effect of temperature on mortality in rural Bangladesh-a population-based time-series study.2009

    • Author(s)
      Hashizume M
    • Journal Title

      Int J Epidemiol Jan 30(in press)

    • Peer Reviewed
  • [Journal Article] Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh2009

    • Author(s)
      Raqib R
    • Journal Title

      Toxicol Lett Jan 9(in press)

    • Peer Reviewed
  • [Journal Article] Expression profiling of genes related to asthma exacerbations2009

    • Author(s)
      Aoki.T
    • Journal Title

      Clin Exp Allergy 39

      Pages: 213-221

    • Peer Reviewed
  • [Journal Article] Functional analysis of the thymic stromal lymphopoietin.variants in human bronchial epithelial cells2009

    • Author(s)
      Harada M
    • Journal Title

      Am J Respir Cell Mol Biol 40

      Pages: 368-374

    • Peer Reviewed
  • [Journal Article] Role of aquaporin 9 in cellular accumulation of arsenic and Its cytotoxicity in primary-mouse hepatocytes.2009

    • Author(s)
      Shinkai Y
    • Journal Title

      Toxicology and Appled Pharmacology (in press)

    • Peer Reviewed
  • [Journal Article] The antioxidant defense system Keapl -Nrf2 comprises a multiple sensing mechanism forresponding to a wide range chemical compounds2009

    • Author(s)
      Kobayashi M
    • Journal Title

      Molecular and Cellular Biology 29

      Pages: 493-502

    • Peer Reviewed
  • [Journal Article] ベンガル湾のサイクロン災害2009

    • Author(s)
      林泰一
    • Journal Title

      第20回風工学シンポジウム論文集

      Pages: 217-222

    • Peer Reviewed
  • [Journal Article] Diurnal variation of rainfall.intensity in pre-monsoon and monsoon over Bangladesh and the Northeastern India2009

    • Author(s)
      Terao T
    • Journal Title

      Proceedings of the 2nd International Conference on Water and Flood Management

      Pages: 317-326

    • Peer Reviewed
  • [Journal Article] Characteristics of Cloud System in and around Bangladesh during Monsoon Season2009

    • Author(s)
      Tsushima S
    • Journal Title

      Proceedings of the 2nd International Conference on Water and Flood Management

      Pages: 443-450

    • Peer Reviewed
  • [Journal Article] Factors determining vulnerability to diarrhoea during and after severe floods in Bangladesh2008

    • Author(s)
      Hashizume M
    • Journal Title

      J Water Health 6(3)

      Pages: 323-32.

    • Peer Reviewed
  • [Journal Article] 気侯変動と細鵡魅2008

    • Author(s)
      我妻ゆき子
    • Journal Title

      資源環境聯 44(9)

      Pages: 34-38

    • Peer Reviewed
  • [Journal Article] Detection of malaria parasites in mosquitoes from the malaria-endemic area of Chakaria, Bangladesh.2008

    • Author(s)
      Tanjin A
    • Journal Title

      Biol Pharm Bull 31(4)

      Pages: 703-8

    • Peer Reviewed
  • [Journal Article] The effect of rainfall on the incidence of cholera in Bangladesh.2008

    • Author(s)
      Hashizume M
    • Journal Title

      Epidemiology 19(1)

      Pages: 103-110

    • Peer Reviewed
  • [Journal Article] Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population, family and case-control study2008

    • Author(s)
      Enomoto H
    • Journal Title

      J Hum Genet 57

      Pages: 615-621

    • Peer Reviewed
  • [Journal Article] Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes.2008

    • Author(s)
      Fujimoto M
    • Journal Title

      BMC Med Genet 9

      Pages: 42

    • Peer Reviewed
  • [Journal Article] Genetic polymorphism regulating ORM1 -like 3 (Saccharomyces cerevisiae)expression is associated with childhood atopic asthma in a Japanese population2008

    • Author(s)
      Hirota T
    • Journal Title

      J Allergy Clin Immunol 121

      Pages: 769-770

    • Peer Reviewed
  • [Journal Article] Clinical and genetic analysis of Fabry disease: Report of six cases in cluding three heterozygous females2008

    • Author(s)
      Nagasaki A
    • Journal Title

      J Dermatol Sci 52

      Pages: 61-64

    • Peer Reviewed
  • [Journal Article] Alpha-l-antitrypsin and complement component C7 are involved in asthma exacerbation2008

    • Author(s)
      Nishioka T
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 46-54

    • Peer Reviewed
  • [Journal Article] A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 18 as a key regulator of NGF receptor-initiated,signal transduction.2008

    • Author(s)
      Shibata T
    • Journal Title

      Journal of Neurochemistry 107

      Pages: 1248-1460

    • Peer Reviewed
  • [Journal Article] Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism.2008

    • Author(s)
      Kanda H
    • Journal Title

      Archives of Toxicology 82

      Pages: 803-808

    • Peer Reviewed
  • [Journal Article] Redox cycling of 9,10 -phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide Conjugation in human pulmonary epithelial A549 cells2008

    • Author(s)
      Taguchi K
    • Journal Title

      Free Radical Biology & Medicine 44

      Pages: 1645-1655

    • Peer Reviewed
  • [Journal Article] MatsunagaT . Xylulose reductase is involved in 9,10 -phenanthrenequinone -indiced apoptosis in human T lymphoma cells.2008

    • Author(s)
      MatsunagaT
    • Journal Title

      Free Radical Biology & Medicine 44

      Pages: 1191-1202

    • Peer Reviewed
  • [Journal Article] Downregulation of Arginase II and Renal.Apoptosis by Inorganic Mercury: Overexpression of Arginase II Reduces Its Apoptosis2008

    • Author(s)
      Kanda H
    • Journal Title

      Archives of Toxicology 82

      Pages: 67-93

    • Peer Reviewed
  • [Journal Article] On the interaction between glyceraldehyde -3-phosphate dehydrog enase and airborne particles: Evidence for electrophilic species.2008

    • Author(s)
      Shinyashiki M
    • Journal Title

      Atmospheric Environment 42

      Pages: 517-529

    • Peer Reviewed
  • [Journal Article] T High temporal and spatial resolution observations of meso-scale features of pre- and mature summer monsoon cloud systems over Bangladesh2008

    • Author(s)
      Terao T
    • Journal Title

      Natural Hazards 44(3)

      Pages: 341-351

    • Peer Reviewed
  • [Journal Article] Relationship between atmospheric conditions at Dhaka, Bangladesh and rainfall at Cherrapunjee, India.2008

    • Author(s)
      Murata F
    • Journal Title

      Natural Hazards 44(3)

      Pages: 391-396

    • Peer Reviewed
  • [Journal Article] 2007年11月にバングラデシュを襲ったサイクロ著Sidr」の被害調査報告2008

    • Author(s)
      林泰-
    • Journal Title

      自然災害科学 26(4)

      Pages: 391-396

    • Peer Reviewed
  • [Journal Article] ベンガル湾のサイクロンNargis2008

    • Author(s)
      林泰-
    • Journal Title

      科学 78(7)

      Pages: 698-700

    • Peer Reviewed
  • [Journal Article] Climate Change Impact on Health: Diarrhea Diseases in Bangladesh2008

    • Author(s)
      Wagatsuma Y
    • Journal Title

      Abstracts of papers of the International Workshop ; on Agriculture and Sustainable Development:in Brahmaputra Basin

      Pages: 51-54

    • Peer Reviewed
  • [Journal Article] Rainfall Characteristics in Northeastern Indian Subcontinent during Pre-monsoon and mature Monsoon Seasons, Several.Features and Future Perspective of Weather Condition in the Northeastern Region of the Indian Subcontinent

    • Author(s)
      Terao T
    • Journal Title

      Abstracts of papers of the International Workshopon Agriculture and Sustainable DeVelOpment in Brahmaputra Basin

  • [Journal Article] Several Features and Future Perspective of Weather Condition in the Northeastern Region of the Indian Subcontinent

    • Author(s)
      Hayashi T
    • Journal Title

      Abstracts of papers of the International Workshopon Agriculture and Sustainable DevelopMent in Brahmaputra Basin

  • [Presentation] 一酸化炭素によるメチル水銀の毒性防御機構2009

    • Author(s)
      外山喬士
    • Organizer
      第129年会日本薬学会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
  • [Presentation] 1,2-NQのCys121修飾によるプロテインチロシンボスファターゼ1B(PTPIB)の構造および活性への影響.2009

    • Author(s)
      岩本典子
    • Organizer
      第129年会日本薬学会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
  • [Presentation] Diurnal variation of rainfall intensity in pre-monsoon and monsoon over Bangladesh and the Northeastern India2009

    • Author(s)
      Terao T
    • Organizer
      2nd International Conference on Water_ and Flood Management
    • Place of Presentation
      Dhaka, Bangladesh
    • Year and Date
      2009-03-15
  • [Presentation] バングラデシュの低栄養の母親の母乳とその乳児におけるカルシウム代謝に関2009

    • Author(s)
      土井麻理子
    • Organizer
      第6向日本小児栄養研究会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-14
  • [Presentation] Cyclone Sidi in Bangladesh2009

    • Author(s)
      Hayashi, T
    • Organizer
      Cooperative Actions for Disaster'Risk Reduction, UN University
    • Place of Presentation
      U-Thant International Conference Hall, UN University
    • Year and Date
      2009-03-04
  • [Presentation] Climate change impact on health: diarrhea diseases in Bangladesh2008

    • Author(s)
      Wagatsuma Y
    • Organizer
      International Workshop on Agricultural Ecosystem 200812A19F1 Guwahati, India and Sustainable Development in Brahmaputra Basin
    • Place of Presentation
      Guwahati,India
    • Year and Date
      2008-12-19
  • [Presentation] Several Features and Future. Perspect of Weather Conditionin the Northeastern Region of the Indian Subcontinent2008

    • Author(s)
      Hayashi, T
    • Organizer
      International Workshop on Agriculture and Sustain able Development in Brahmaputra Basin,Assam
    • Place of Presentation
      Guwathati,India
    • Year and Date
      2008-12-19
  • [Presentation] Rainfall characteristics in northeastern Indian subcontinent during pre -monsoon and mature monsoon seasons2008

    • Author(s)
      Terao T
    • Organizer
      Workshop on agricultural ecosystem and sustainable development- in Brahmaputra basin
    • Place of Presentation
      Guwahati, India
    • Year and Date
      2008-12-19
  • [Presentation] 綱羅的遺伝子発現解析による喘息発作関連遺伝子の同定2008

    • Author(s)
      青木健
    • Organizer
      第45回日本小児アレルギー学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-12-13
  • [Presentation] メチル水銀の分子標的としてのソルビトール脱水素酵素2008

    • Author(s)
      外山喬士
    • Organizer
      第1回メタロミクス研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-29
  • [Presentation] スギ花粉症の網羅的遺伝子発現解析2008

    • Author(s)
      松本佑莉
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
  • [Presentation] 全ゲノム連鎖解析によるアトピー性皮膚炎疾患感受性遺伝子の機能解析2008

    • Author(s)
      大塚健太
    • Organizer
      第58回同本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
  • [Presentation] ワークショップ5アレルギー疾患のゲノム解析の最近の話題2008

    • Author(s)
      野口恵美子
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
  • [Presentation] 2007年11月21日バングラデシュ襲ったサイクロン"Sidr"2008

    • Author(s)
      林泰一
    • Organizer
      日本気象学会2008年鰍季大会
    • Place of Presentation
      仙台
    • Year and Date
      2008-11-21
  • [Presentation] インド亜大陸糠部におけるプレモンスーン・モンスーン期の降水醸と降水2008

    • Author(s)
      寺尾徹
    • Organizer
      日本気象会2008年度秋季大会
    • Place of Presentation
      仙台
    • Year and Date
      2008-11-19
  • [Presentation] Fetal growth in Bangladesh2008

    • Author(s)
      Wagatsuma Y
    • Organizer
      International Workshop on Maternal and Infant Nutrition Intervention
    • Place of Presentation
      Uppsala,Sweden
    • Year and Date
      2008-11-03
  • [Presentation] 1,2一ナフトキノンによるプロテインチロシンボスファターゼ1Bの活性阻害におけるCys121の役割2008

    • Author(s)
      岩本典子
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-18
  • [Presentation] 転2一ナフトキノンはCys286を介して転写因子CREBに共有結合しその機能を阻害する2008

    • Author(s)
      遠藤亜希子
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-18
  • [Presentation] 大気中に含まれる未知の親電子性物質とそれにに対する生体応答を評2008

    • Author(s)
      西山彰
    • Organizer
      衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-18
  • [Presentation] Reviews on climate,variability and river wteres, Brahmaputra and Meghna basin in norheastern Indian subcontinent2008

    • Author(s)
      Terao T
    • Organizer
      2nd Kagawa University-Chiang Mai University Acade mic Symposium
    • Place of Presentation
      高松
    • Year and Date
      2008-10-16
  • [Presentation] Bangladesh,Sirajganj付近で発生した大規模な河岸侵食2008

    • Author(s)
      寺尾徹
    • Organizer
      水文・水資源学会2008年度研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-26
  • [Presentation] イソチオシアネートによるレドックス制御を介した神経細胞分化促進2008

    • Author(s)
      柴田貴広
    • Organizer
      第61回日本酸化ストレス学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-19
  • [Presentation] Influence of local and global climatic changes on diarrhea diseases in Bangladesh2008

    • Author(s)
      Wagatsuma Y
    • Organizer
      US-Japan Viral Disease Panel Satellite Symposium
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-26
  • [Presentation] ベンガル湾周辺のサイクロン(1)2008

    • Author(s)
      林泰-
    • Organizer
      日本地球惑星科学連合2008年大会
    • Place of Presentation
      幕張
    • Year and Date
      2008-05-26
  • [Presentation] ベンガル湾商辺のサイクロン(2)2008

    • Author(s)
      林泰一
    • Organizer
      日本地球惑星科学連合2008年大会
    • Place of Presentation
      幕張
    • Year and Date
      2008-05-26
  • [Remarks] The MINIMat Project website

    • URL

      http://www.minimat.org/

  • [Remarks] ホームページ

    • URL

      http://www.rcde.dpri.kyoto-u.ac.jp/

URL: 

Published: 2010-06-11   Modified: 2016-04-21  

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