Analysis of neural cell adhesion molecule NB-2 involved in the postnatal development of auditory pathways

2008 Fiscal Year Final Research Report

• Project/Area Number: 18300120
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagaoka University of Technology
• Principal Investigator: 渡邉 和忠 Nagaoka University of Technology (70114717)
• Co-Investigator(Kenkyū-buntansha): 霜田 靖
• Project Period (FY): 2006 – 2008

Research Abstract

神経認識分子NB-2はコンタクチン5とも呼ばれ、聴覚系神経回路で特に顕著に発現している。本研究では、先ずNB-2が音の聞こえ始める直前に発現が強くなり、特に高周波数に反応する領域で発現していることを明らかにした。次に、遺伝子欠損型マウスと野生型マウスで聴覚系神経回路の発達と機能を比較し、遺伝子欠損型マウスでは特に興奮性の神経回路のシナプス部位に異常があり、その結果、一部の神経細胞が細胞死を起こしていること、音に対する脳幹の反応に遅れが出ることを明らかにした。

Research Products

• [Journal Article] Contactins : Emerging key roles in the development and function of the nervous system. (2009)
  • Author(s): Shimoda, Y. and Watanabe, K.
  • Journal Title: Cell Adh. Migr. 3(1) Pages: 64-70
• [Journal Article] Preferential localization of neural cell recognition molecule NB-2 in developing glutamatergic neurons in the rat auditory brainstem (2009)
  • Author(s): Toyoshima, M., Sakurai, K., Shimazaki, K., Takeda, Y., Nakamoto, M., Serizawa, S., Shimoda, Y. and Watanabe, K
  • Journal Title: J. Comp. Neurol. 513(4) Pages: 349-362
• [Journal Article] Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the central nervous system. (2009)
  • Author(s): Oiso, S., Takeda, Y., Futagawa, T., Miura, T., Kuchiiwa, S., Nishida, K., Ikeda, R., Kariyazono, H., Watanabe, K. and Yamada, K.
  • Journal Title: J. Neurochem. 109(1) Pages: 158-167
• [Journal Article] Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. (2008)
  • Author(s): Savvaki, M., Panagiotaropoulos, T., Stamatakis, A., Sargiannidou, I., Karatzioula, P., Watanabe, K., Stylianopoulou, F., Karagogeos, D. and Kleopa, K.A.
  • Journal Title: Mol. Cell. Neurosci. 39(3) Pages: 478-490
• [Journal Article] Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve. (2008)
  • Author(s): Chatzopoulou, E., Miguez, A., Savvaki, M., Levasseur, G., Muzerelle, A., Muriel, M.P., Goureau, O., Watanabe, K., Fisher, G., Goutebroze, L., Gaspar, P., Zalc, B., Karagogeos, D. and Thomas, J.L.
  • Journal Title: J. Neurosci. 28(30) Pages: 7624-7636
• [Journal Article] A TAG1-APP signaling pathway through Fe65 negatively modulates neurogenesis. (2008)
  • Author(s): Ma, Q.-H., Yang, W.-I., Futagawa, T., Jiang, X.-D., Takeda, Y., Xu, R.-X., Bagnard, D., Schachner, M., Furley, A.J., Karagogeos, D., Watanabe, K., Dawe, G.S. and Xiao, Z.-C.
  • Journal Title: Nature Cell Biol. 10(3) Pages: 283-294
• [Journal Article] Neural recognition molecule CHL1 and NB-3 regulate apical dendrite orientation in neocortex via PTPα (2008)
  • Author(s): Ye, H., Tan, Y.L.J., Ponniah, S., Takeda, Y., Wang, S.-Q., Schachner, M., Watanabe, K., Pallen, C.J. and Xiao, Z.-C.
  • Journal Title: EMBO J. 27(1) Pages: 188-200
• [Journal Article] Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule Omgp (2006)
  • Author(s): Nie, D.-Y., Ma, Q.-H., Law, J.W.S., Chia, C.-P., Dhingra, N.K., Xu, G., Shimoda, Y., Gong, N., Chen, Q.-W., Hu, Q.-D., Chow, P.K.H., Ng, Y.-K., Ling, E.-A., Watanabe, K., Xu, T.-L., Schachner, M. and Xiao, Z.-C.
  • Journal Title: Neuron Glia Biol. 2 Pages: 151-164
• [Presentation] NB-2欠損マウスにおける聴性脳幹反応(ABR)の変化とグルタミン酸作動性シナプスの形成異常 (2008)
  • Author(s): 豊島学、桜井都衣、武田泰生、島崎久仁子、霜田靖、渡邉和忠
  • Organizer: 第51回日本神経化学会大会
  • Year and Date: 20080000
• [Presentation] 神経認識分子NB-2の欠損がマウス聴覚系に与える影響 (2008)
  • Author(s): 豊島学、桜井都衣、島崎久仁子、霜田靖、渡邉和忠
  • Organizer: 第31回日本神経科学大会
  • Year and Date: 20080000
• [Presentation] Neural recognition molecule NB-2 in the auditory brainstem (2007)
  • Author(s): Toyoshima, M., Okumura, T., Sakurai, K., Shimazaki, K., Shimoda, Y. and Watanabe, K.
  • Organizer: 37th Annual Meeting, Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 20071103-07
• [Presentation] Neural cell recognition molecule NB-3 in the developing mouse cerebellum (2007)
  • Author(s): Sakurai, K., Suzuki, Y., Takeda, Y., Shimoda, Y., Karagogeos, D. and Watanabe, K.
  • Organizer: 37th Annual Meeting, Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 20071103-07
• [Presentation] 聴覚系の上オリーブ核群におけるNB-2の発現 (2007)
  • Author(s): 豊島学、桜井都衣、島崎久仁子、霜田靖、渡邉和忠
  • Organizer: Neuro 2007(第30回日本神経科学大会、第50回日本神経化学会大会、第17回日本神経回路会大会)
  • Year and Date: 20070000
• [Presentation] Expression of NB-2 in GABAergic neurons of the rat auditory system (2006)
  • Author(s): Toyoshima, M., Takagi, M., Takeda, Y., Shimoda, Y. and Watanabe, K
  • Organizer: 36th Annual Meeting, Society for Neuroscience
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20061014-18
• [Presentation] ラット聴覚系のGABA 作動性ニューロンにおけるNB-2の発現 (2006)
  • Author(s): 豊島学、武田泰生、霜田靖、渡邉和忠
  • Organizer: 第29回日本神経科学大会
  • Year and Date: 20060000