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2007 Fiscal Year Final Research Report Summary

Map of dopamine signaling in the neostriatum under normal and pathophysiological conditions

Research Project

Project/Area Number 18300128
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKurume University

Principal Investigator

NISHI Akinori  Kurume University, Sch of Med, Dept of Pharmacology, Professor (50228144)

Co-Investigator(Kenkyū-buntansha) SOTOGAKU Naoki  Kurume University, Sch of Med, Dept of Pharmacology, Assistant Professor (60368884)
SHUTO Takahide  Kurume University, Sch of Med, Dept of Pharmacology, Research Associate (70412541)
KAWAHARA Yukie  Kurume University, Sch of Med, Dept of Pharmacology, Associate Professor (10279135)
Project Period (FY) 2006 – 2007
Keywordsdopamine / DARPP-32 / neostriatum / phosphorylation / signal transduction
Research Abstract

Dopamine plays a central role in the regulation of psychomotor function in the brain. Many of the actions of dopamine are mediated through DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of M_r 32 kDa). When DARPP-32 is phosphorylated on Thr34, it is converted into a potent inhibitor of protein phosphatase-1 (PP-1), and thereby controls the phosphorylation state and activity of many downstream physiological effectors. It is extremely important to identify signaling cascades activated by dopamine and other neurotransmitters under normal and pathophysiological conditions.
In analysis of dopamine/DARPP-32 signaling under normal conditions, the phosphorylation site of DARPP-32 at Ser97 by CK2 was found to function as nuclear export signal. DARPP-32 at Ser97 is highly phosphorylated by CK2. The phosphorylated form of DARPP-32 enters into and is exported from nucleus. Phospho-Ser97 DARPP-32 is dephosphorylated by the dopamine D1 receptor/PKA/PP2A signaling cascade, and the dephospho-Ser97 DARPP-32 is not exported from nucleus and accumulates in nucleus. Since the dopamine D1 receptor/PKA/PP2A signaling cascade leads to phosphorylate DARPP-32 at Thr34, phospho-Thr34 DARPP-32 inhibits PP-1 and regulates the transcription of genes. In analysis of Mecp^<208/Y> mutant mice (a model mouse of Rett syndrome), we found that dopamine D1 receptor signaling is enhanced in neostriatal neurons after 20 weeks of age. In the study of methamphetamine sensitization, we found that the proportions of dopamine D1^<High> and D2^<High> receptors were increased in the striatum from MAP-sensitized rats, and that repeated administration of R-(+)-SKF38393 reversed the increased proportions of dopamine Dl^<High> and D2^<High> receptors in MAP-sensitized rats.

  • Research Products

    (66 results)

All 2008 2007 2006

All Journal Article (28 results) (of which Peer Reviewed: 12 results) Presentation (38 results)

  • [Journal Article] A phosphatase cascade by which natural rewards and drugs of abuse regulate nucleosomal response in the mouse2008

    • Author(s)
      Stipanovich A
    • Journal Title

      Nature

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1High and D2High receptors in methamphetamine-sensitized rats2008

    • Author(s)
      Shuto T
    • Journal Title

      Eur J Neurosci

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] A phosphatase cascade by which rewarding stimuli control nucleosomal response.2008

    • Author(s)
      Stipanovich A, Valjent E, Matamales M, Nishi A, Ahn J-H, Maroteaux M, Bertran-Gonzalez J, Brami-Cherrier K, Enslen H, Corbille A-G, Filhol O, Nairn AC, Greengard P, Herve D, Girault J-A.
    • Journal Title

      Nature (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1^<High> and D2^<High> receptors in methamphetamine-sensitized rats.2008

    • Author(s)
      Shuto T, Seeman P, Kuroiwa M, Nishi A.
    • Journal Title

      Eur J Neurosci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56δ subunit2007

    • Author(s)
      Ahn J-H
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 2979-2984

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 線条体ドーパミン情報伝達機構:DARPP-32の役割2007

    • Author(s)
      西 昭徳
    • Journal Title

      久留米医学会雑誌 70

      Pages: 8-15

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 52007

    • Author(s)
      Nguyen C
    • Journal Title

      J Biol Chem 282

      Pages: 16511-16520

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The B"/PR72 subunit mediates Ca^<2+>-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A2007

    • Author(s)
      Ahn J-H
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 9876-9881

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization2007

    • Author(s)
      Nguyen C
    • Journal Title

      J Neurochem 103

      Pages: 1582-1593

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergicneurons2007

    • Author(s)
      Sotogaku N
    • Journal Title

      J Neurochem 103

      Pages: 749-760

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum2007

    • Author(s)
      Kitaoka S
    • Journal Title

      J Neurosci 27

      Pages: 12900-12907

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Expression of D1 but not D2 Dopamine Receptors in Striatal Neurons Producing Neurokinin B2007

    • Author(s)
      Sonomura T
    • Journal Title

      Eur J Neurosci 26

      Pages: 3093-3103

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] ドーパミンシグナルの増幅と制御2007

    • Author(s)
      西 昭徳
    • Journal Title

      久留米医学会雑誌 70

      Pages: 165-169

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Protein kinase A activates protein phosphatase 2A by phosphorylation of the B568 subunit.2007

    • Author(s)
      Ahn. J-H, McAvoy T, Rakhilin SV, Nishi A, Greengard P, Nairn AC.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 2979-84

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dopamine signal transduction in the striatum.2007

    • Author(s)
      Nishi A
    • Journal Title

      Kurnme Medical Journal(Japanese) 70

      Pages: 8-15

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.2007

    • Author(s)
      Nguyen C, Nishi A, Kansy JW, Fernandez J, Hayashi K, Gillardon F, Hemmings HC Jr, Nairn AC, Bibb JA.
    • Journal Title

      J Biol Chem 282

      Pages: 16511-16520

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The B/PR72 subunit mediates Ca^<2+>dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.2007

    • Author(s)
      Ahn J-H, Sung JY, McAvoy T, Nishi A, Janssens V, Goris J, Greengard P, Nairn AC.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 9876-9881

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential regulation of the CdkS-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization2007

    • Author(s)
      Nguyen C, Hosokawa T, Kuroiwa M, Ip NY, Nishi A, Hisanaga S, Bibb JA.
    • Journal Title

      J Neurochem 103

      Pages: 1582-1593

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons.2007

    • Author(s)
      Sotogaku N, Tully SE, Gama CI, Higashi H, Tanaka M, Hsieh-Wilson LC, Nishi A.
    • Journal Title

      J Neurochem 103

      Pages: 749-760

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum.2007

    • Author(s)
      Kitaoka S, Furuyashiki T, Nishi A, Shuto T, Koyasu S, Matsuoka T, Miyasaka M, Greengard P, Narumiya S.
    • Journal Title

      J Neurosci 27

      Pages: 12900-12907

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of Dl but not D2 Dopamine Receptors in Striatal Neurons Producing Neurokinin B in rats.2007

    • Author(s)
      Sonomura T, Nakamura K, Furuta T, Hioki H, Nishi A, Yamanaka A, Uemura M, Kaneko T.
    • Journal Title

      Eur J Neurosci 26

      Pages: 3093-3103

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ampification of dopamine signaling2007

    • Author(s)
      Nishi A
    • Journal Title

      Kurume Medical Journal(Japanese) 70

      Pages: 165-169

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist2006

    • Author(s)
      Shuto T
    • Journal Title

      Neuropharmacology 50

      Pages: 991-997

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Role of adenosine A_1 receptors in the modulation of dopamine D_1 and adenosine A_<2A> receptor signaling in the neostriatum2006

    • Author(s)
      Yabuuchi K
    • Journal Title

      Neuroscience 141

      Pages: 19-25

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Sulfation patterns of glycosaminoglycans encode molecular recognition and activity2006

    • Author(s)
      Gama CI
    • Journal Title

      Nat Chem Biol 2

      Pages: 467-473

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist.2006

    • Author(s)
      Shuto T, Kuroiwa M, Hamamura M, Yabuuchi K, Shimazoe T, Watanabe S, Nishi A, Yamamoto T.
    • Journal Title

      Neuropharmacology 50

      Pages: 991-997

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of adenosine Al receptors in the modulation of dopamine DI and adenosine A_<2A> receptor signaling in the neostriatum.2006

    • Author(s)
      Yabuuchi K, Kuroiwa M, Shuto T, Sotogaku N, Snyder GL, Higashi H, Tanaka M, Greengard P, Nishi A.
    • Journal Title

      Neuroscience 141

      Pages: 19-25

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Goddard III WA, Nishi A, Hsieh-Wilson LC. Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.2006

    • Author(s)
      Gama CI, Tully SE, Sotogaku N, Clark PM, Rawat M, Vaidehi N, William A.
    • Journal Title

      Nat Chem Biol 2

      Pages: 467-473

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Long-term administration of citalopram abolished the stress response of monoamines in prefrontal cortex and amygdala of rat2008

    • Author(s)
      Kaneko F
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Reversal of methamphetamine sensitization by repeated administration of dopamine D1 receptor agonism:Effect on the affinity of dopamine D1 and D2 receptor2008

    • Author(s)
      Shuto T
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Neuronal type specific regulation of DARPP-32 phosphorylation in the striatum of D1R/D2R-DARPP-32 mice2008

    • Author(s)
      Kuroiwa M
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Reversal of methamphetamine sensitization by repeated administration of dopamine DI receptor agonism : Effect on the affinity of dopamine Dl and D2 receptor.2008

    • Author(s)
      Shuto T, Seeman P, Nishi A.
    • Organizer
      The 59th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Neuronal type specific regulation of DARPP-32 phosphorylation in the striatum of DIR/D2R-DARPP-32 mice.2008

    • Author(s)
      Kuroiwa M, Bateup HS, Greengard P, Nishi A
    • Organizer
      The 59th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Effect of acute and chronic administration of methamphetamine on locomotor activity in mGluR5 knockout mice2007

    • Author(s)
      Shuto T
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      20070314-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Dopamine D_1-like receptors coupled to adenylyl cyclase,phospholipase C and adenosine A_<2A> receptor signaling regulate DARPP-32 phosphorylation2007

    • Author(s)
      Kuroiwa M
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      20070314-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effect of acute and chronic administration of methamphetamine on locomotor activity in mGluR5 knockout mice.2007

    • Author(s)
      Shuto T, Nishi A.
    • Organizer
      The 59th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      20070314-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Dopamine DI-like receptors coupled to adenylyl cyclase, phospholipase C and adenosine A_<2A> receptor signaling regulate DARPP-32 phosphorylation.2007

    • Author(s)
      Kuroiwa M, Nishi A.
    • Organizer
      The 59th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      20070314-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Neuronal type-specific regulation of DARPP-32 phosphorylation in the striatum of D_1R/D_2R-DARPP-32 mice2007

    • Author(s)
      Kuroiwa M
    • Organizer
      The 5th Neuroscience Workshop in Kyushu
    • Place of Presentation
      福岡
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Neuronal type-specific regulation of DARPP-32 phosphorylation in the striatum of D1R/D2R-DARPP-32 mice.2007

    • Author(s)
      Kuroiwa M, Bateup HS, Greengard P, Nishi A.
    • Organizer
      The 5th Neuroscience Workshop in Kyushu
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Phosphodiesteraseによる線条体リン酸化シグナルの制御:ドーパミン神経終末とmedium spiny neuronの比較2007

    • Author(s)
      西 昭徳
    • Organizer
      第60回日本薬理学会西南部会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] メタンフェタミン逆耐性を消失させるドーパミンD1受容体刺激薬反復投与:線条体ドーパミン受容体親和性への影響2007

    • Author(s)
      首藤 隆秀
    • Organizer
      第60回日本薬理学会西南部会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regulation of the phosphorylation-mediated cascades by phosphodiesterases in the striatum.2007

    • Author(s)
      Nishi A, Kuroiwa M.
    • Organizer
      The 60th Annual Meeting of The Japanese Pharmacological Society in Seinan-Bukai
    • Place of Presentation
      Miyazaki
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Reversal of methamphetamine sensitization by chronic dopamine Dl agonist administration : effect on dopamine receptor affinities in the striatum2007

    • Author(s)
      Shuto T, Nishi A.
    • Organizer
      The 60th Annual Meeting of The Japanese Pharmacological Society in Seinan-Bukai
    • Place of Presentation
      Miyazaki
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Repeated administration of dopamine Dl receptor agonist reverses the increased proportion of high-affinity dopamine Dl and D2 receptors in methamphetamine-sensitized rats.2007

    • Author(s)
      Shuto T, Kuroiwa M, Seeman P, Nishi A
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego in USA
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] DARPP-32 phosphorylation in D1 and D2 cells in response to therapeutic agents and drugs of abuse.2007

    • Author(s)
      Bateup HS, Svenningsson P, Kuroiwa M, Gong S, Heintz N, Nishi A, Greengard P.
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego in USA
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Repeated administration of dopamine D1 receptor agonist reverses the increased proportion of high-affinity dopamine D1 and D2 receptors in methamphetamine-sensitized rats2007

    • Author(s)
      Shuto T
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] DARPP-32 phosphorylation in D1 and D2 cells in response to therapeutic agents and drugs of abuse2007

    • Author(s)
      Bateup HS
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] DARPP-32-dependent regulation of spinophilin Ser94 phosphorylation in neostriatal neurons of direct and indirect pathways2007

    • Author(s)
      Uematsu K
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] DARPP-32-dependent regulation of spinophilin Ser94 phosphorylation in neostriatal neurons of direct and indirect pathways.2007

    • Author(s)
      Uematsu K, Futter M, Higashi H, Maeda H, Nairn AC, Greengard P, Nishi A.
    • Organizer
      The 30th Annual Meeting of The Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] メタンフェタミン逆耐性を消失させるドーパミンD1受容体刺激薬反復投与:線条体ドーパミン受容体親和性および発現数への影響2007

    • Author(s)
      首藤 隆秀
    • Organizer
      第34回日本脳科学会
    • Place of Presentation
      出雲
    • Year and Date
      2007-06-08
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Reversal of methamphetamine sensitization by chronic dopamine DI agonist administration : affinities and binding-sites of dopamine receptors in the striatum2007

    • Author(s)
      Shuto T, Nishi A.
    • Organizer
      The 34th Annual Meeting of The Japan Brain Science Society
    • Place of Presentation
      Izumo
    • Year and Date
      2007-06-08
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Synthetic chondroitin sulfate E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons2006

    • Author(s)
      Sotogaku N
    • Organizer
      The 36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Synthetic chondroitin sulfate E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons.2006

    • Author(s)
      Sotogaku N, Tully SE, Gama GI, Hsieh-Wilson LC, Nishi A.
    • Organizer
      The 36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta in USA
    • Year and Date
      20061014-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] SKF83959 regulates DARPP-32 phosphorylation by activating PLC-dependent and independent cascades2006

    • Author(s)
      Kuroiwa M
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      20060726-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Prostaglandin E2 potentiates dopamine D1 receptor signaling via EP12006

    • Author(s)
      Kitaoka S
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      20060726-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] SKF83959 regulates DARPP-32 phosphorylation by activating PLC-dependent and independent cascades.2006

    • Author(s)
      Kuroiwa M, Nishi A.
    • Organizer
      The 29th Annual Meeting of The Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Year and Date
      20060726-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Prostaglandin E2 potentiates dopamine DI receptor signaling via EPI.2006

    • Author(s)
      Kitaoka S, Koyasu S, Nishi A, Furuyashiki T, Matsuoka T, Narumiya S.
    • Organizer
      The 29th Annual Meeting of The Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Year and Date
      20060726-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] メタンフェタミン逆耐性におけるDARPP-32 in vivoリン酸化の評価2006

    • Author(s)
      首藤 隆秀
    • Organizer
      第8回ブレインサイエンス研究会
    • Place of Presentation
      北九州
    • Year and Date
      20060610-11
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Analysis of DARPP-32 phosphorylation in vivo in methamphetamine-sensitized rats.2006

    • Author(s)
      Shuto T, Nishi A.
    • Organizer
      The 8th Annual Meeting of The Brain Science Kenkyukai
    • Place of Presentation
      Kitakyusyu
    • Year and Date
      20060610-11
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Differential effects of long-term administration of citalopram on the function of α2-adrenoceptors in the amygdala and locus coeruleus2006

    • Author(s)
      Kawahara Y
    • Organizer
      11th International Conference On In Vivo Methods
    • Place of Presentation
      Sardegna,Italy
    • Year and Date
      20060500
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Differential effects of long-term administration of citalopram on the function of α2-adrenoceptors in the amygdala and locus coeruleus.2006

    • Author(s)
      Kawahara Y. Kaneko F, Kawahara H, Nishi A, Tanaka M.
    • Organizer
      The 11th International Conference On In Vivo Methods
    • Place of Presentation
      Sardegna in Italy
    • Year and Date
      20060500
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Role of adenosine A_1 receptors in the modulation of dopamine D_1 and adenosine A_<2A> receptor signaling in the neostriatum2006

    • Author(s)
      Yabuuchi K
    • Organizer
      第59回日本薬理学会西南部会
    • Place of Presentation
      那覇
    • Year and Date
      2006-11-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regulation of DARPP-32 phosphorylation by three distinct dopamine D_1 receptor signaling in the neostriatum2006

    • Author(s)
      Kuroiwa M
    • Organizer
      第59回日本薬理学会西南部会
    • Place of Presentation
      那覇
    • Year and Date
      2006-11-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regulation of DARPP-32 phosphorylation by three distinct dopamine DI receptor signaling in the neostriatum.2006

    • Author(s)
      Yabuuchi K, Kuroiwa M, Nishi A.
    • Organizer
      The 59th Annual Meeting of The Japanese Pharmacological Society in Seinan-Bukai
    • Place of Presentation
      Naha
    • Year and Date
      2006-11-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ドーパミンD1様受容体を介するボスホリパーゼC依存性および非依存性DARPP-32リン酸化調節2006

    • Author(s)
      黒岩 真帆美
    • Organizer
      第33回日本脳科学会
    • Place of Presentation
      旭川
    • Year and Date
      2006-06-01
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regulation of DARPP-32 phosphorylation by dopamine DI receptors : phospholipase C-dependent and-independent mechanisms2006

    • Author(s)
      Kuroiwa M, Tanaka M, Nishi A.
    • Organizer
      The 33th Annual Meeting of The Japan Brain Science Society
    • Place of Presentation
      Asahikawa
    • Year and Date
      2006-06-01
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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