2009 Fiscal Year Final Research Report
Development of an Artificial Synapse using an Integrated Electrochemical Micropump
| Project/Area Number |
18300154
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Shibaura Institute of Technology |
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Principal Investigator |
YOSHIMI Yasuo Shibaura Institute of Technology, 工学部, 准教授 (30267421)
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| Co-Investigator(Renkei-kenkyūsha) |
KANAMORI Toshiyuki 産業技術総合研究所, 器官発生工学研究ラボ, 主任研究員 (50356797)
YAGI Tohru 東京工業大学, 大学院・情報理工学研究科, 准教授 (90291096)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 電気化学マイクロポンプ / 電気化学マイクロバルブ / ポリジメチルシロキサン / 神経細胞 / 膜電位イメージング / アメフラシ / 神経節 / カリウムイオンチャンネルブロック剤 |
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| Research Abstract |
The final purpose of this project is a development of integrated micropumps working as an interface between electric circuits and neurons or an artificial synapse. We developed a chip of micropump with microvalve using electrodecomposition of water as a driving force. The chip can control the jetting with punctuality to the second. The pump could induce excitatory postsynaptic potential of Aplysia neuron by neurotransmitter administration. We developed also voltage imaging for central nerve system for evaluation of the ability of the interface. It has been difficult to detect the action potential of Aplysia neuron by voltage imaging. We succeeded in the detection of the action potential by prolonging by tetraethylammonium chloride as a potassium channel blocker. The technologies developed in the project will help the development of neuronal interface by neurotransmitter administration.
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