2009 Fiscal Year Final Research Report
LET and Ion-species dependent bystander effects induced by microbeams
| Project/Area Number |
18310042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
SUZUKI Masao National Institute of Radiological Sciences, 重粒子医科学センター, 主任研究員 (70281673)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 粒子放射線 / マイクロビーム / バイスタンダー効果 / 細胞間情報伝達機構 / ギャップジャンクション |
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| Research Abstract |
We have investigated bystander chromosomal damage in primary normal human bronchial epithelial cells irradiated with low-energy He-ion beams. When the unirradiated cells were kept with He-ion irradiated cells on the dishes, bystander chromosomal effect was observed in the unirradiated bystander cells. Chromatid-type fragments, such as chromatid break, acentric fragment, isochromatid deletion and interchromatin exchange, were observed in the direct hit cells. On the other hand, only chromatid breaks and acentric fragments were observed in the bystander cells. There is evidence that simple chromosomal damage occur in bystander chromosomal effect.
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Research Products
(26 results)
