Development of Reaction Systems using Highly Functionalized Metal Complexes

2008 Fiscal Year Final Research Report

• Project/Area Number: 18350035
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Doshisha University
• Principal Investigator: 小寺 政人 Doshisha University, 理工学部, 教授 (00183806)
• Co-Investigator(Kenkyū-buntansha): MIZUTANI Tadashi 同志社大学, 理工学部, 教授 (40229696) ; FUNABIKI Takuzo 同志社大学, 理工学部, RCAST研究員 (70026061)
• Project Period (FY): 2006 – 2008
• Keywords: 二核金属錯体 / 酸素活性化 / 酸素運搬 / 加水分解反応 / リン酸エステル

Research Abstract

本研究では金属錯体の機能モデル化合物としての高機能性金属錯体を合成し、これを機能中心として用いて、ヘモシアニン機能モデル化合物としての二核銅錯体によるによる酸素分子の可逆的結合反応、メタンモノオキシゲナーゼ機能モデル化合物としての二核鉄錯体による酸素活性化による基質酸素化触媒反応、アルカリホスファターゼ機能モデル化合物としてのリン酸ジエステルの加水分解反応およびDNAと結合できるビスインターカレータ部位を持つ二核銅錯体によるDNAとの特異的結合などの様々な反応システムを開発した。

Research Products

• [Journal Article] Synthesis and Characterization of a Binuclear Iron(III) Complex Bridged by 1 -Aminocyc lopropane-1 -carboxylic Acid EthyleneProduction in the Presence of Hydrogen Peroxide (2009)
  • Author(s): W. Ghattas, Z. Serhan, N. E. Bakkali-Taheri, M. Reglier, M. Kodera, Y. Hitomi, and A. J. Simaan
  • Journal Title: Inorg. Chem. 48 Pages: 3910-3912
• [Journal Article] Molecular Recognition in Anisotropic Media Binding of Alkylpyridines to Amphiphilic Zinc Porphyrins Incorporated in Liposomal Bilayer Membranes (2009)
  • Author(s): Murakami, R. ; Minami, A. ; Mizutani, T.
  • Journal Title: Org. Biomol. Chem. 7,(7) Pages: 1437-1444
• [Journal Article] Selective Adsorption of Biladien-ab-one and Zinc Biladien-ab-one to Mesoporous Silica (2009)
  • Author(s): Akasaka, H. ; Yukutake, H. ; Nagata, Y. ; Funabiki, T. ; Mizutani, T. ; Takagi, H. ; Fukushima, Y. ; Juneja, L. R. ; Kitahata, K
  • Journal Title: Microporous Mesoporous Mater. 120,(3) Pages: 331-338
• [Journal Article] Allosteric Binding of Amino Alcohols and Diamines by Dimeric Zinc Biladienone (2009)
  • Author(s): Shimizu, T. ; Asano, N.; Mizutani, T. ; Chang, H.-C. ; Kitagawa, S.
  • Journal Title: Tetrahedron Letters 50(5) Pages: 536-539
• [Journal Article] Spectroscopic and Computational Studies of (u-oxo)(u-1,2-Peroxo)diiron(III) Complexes of Relevance to Nonheme Diiron Oxygenase Intermediates (2008)
  • Author(s): A. T. Fiedler, X. Shan, M. P. Mehn, J. Kaizer, S. Torelli, J. R. Frisch, M. Kodera, L. Que, Jr.
  • Journal Title: J. Phys Chem. A 112 Pages: 13037-13044
• [Journal Article] One-Phase Synthesis of Small Gold Nanoparticles Coated by a Horizontal Porphyrin Monolayer (2008)
  • Author(s): J. Ohyama, Y. Hitomi, Y. Higuchi,M. Shinagawa, H. Mukai, M. Kodera, K. Teramura, T. Shishido, T. Tanaka
  • Journal Title: Chem. Commun. Pages: 6300-6302
• [Journal Article] Homohelicity-enriched zinc bilinone dimers with chiral aliphatic spacers. Synthesis and application to chiral induction of a nematic liquid crystal (2008)
  • Author(s): Yagi, S. ; Hamakubo, K. ; Ikawa, S. ; Nakazumi, H. ; Mizutani, T.
  • Journal Title: Tetrahedron 64,(46) Pages: 10598-10604
• [Journal Article] Syntheses, structural characterization and photophysical properties of 4-(2-pyridy1)-1,2,3- triazole rhenium (I) complexes (2008)
  • Author(s): M. Obata, A. Kitamura, A. Mori, C. Kameyama, J. A. Czaplewska, R. Tanaka, I. Kinoshita, T. Kusumoto, H. Hashimoto, M. Harada, Y. Mikata, T. Funabiki, S. Yano, J. Chem. Soc
  • Journal Title: Dalton Trans. Pages: 3292-3300
• [Journal Article] Reversible O_2-binding and activation with dicopper and diiron complexes stabilized by various hexapyridine ligands stability, modulation, and flexibility of the dinuclear structure as key aspects for the dimetal/O_2 chemistry (2007)
  • Author(s): M. Kodera, K. Kano
  • Journal Title: Bull. Chem. Soc. Jpn. 80 Pages: 662-76
• [Journal Article] High Utility of Electro- and Cold-Spray Ionization Time-of-Flight Mass Spectra in Development of Functional Metalloenzyme Models : Detection of Labile Metal Complexes and Reactive Intermediates (2007)
  • Author(s): M. Kodera
  • Journal Title: JEOL new 42 Pages: 21-30
• [Journal Article] 金属酵素の機能を再現する高機能性金属錯体の開発とElectro-and Cold-Spray Ionization Time-of-Flight Mass Spectrometerの利用 : 置換活性金属錯体および不安定錯種の検出 (2007)
  • Author(s): M. Kodera
  • Journal Title: JEOL News 39 Pages: 8-18
• [Journal Article] Synthesis of Biladienone and Bilatrienone by Coupled Oxidation of Tetraarylporphyrins (2007)
  • Author(s): Asano, N. ; Uemura, S.; Kinugawa, T. ; Mizutani, T.
  • Journal Title: J Org. Chem Chem. 72,(14) Pages: 5320-5326
• [Journal Article] Thermodynamics of Hydrophobic Interactions : Entropic Recognition of Hydrophobic Moiety by Poly(Ethylene Oxide)-Zinc Porphyrin Conjugates (2007)
  • Author(s): H. ; Mizutani, T. ; Kano, K.
  • Journal Title: Chem. Asian J. 2,(10) Pages: 1267-1275
• [Journal Article] Optical oxygen-sensing properties of porphyrin derivatives anchored on ordered porous aluminium oxide plates (2007)
  • Author(s): N. Araki, Y. Amao, T. Funabiki, M. Kamitakahara, C. Ohtsuki, K. Mitsuo, K. Asai, M. Obata, S. Yano
  • Journal Title: Photochem. Photobiol. Sci. 6 Pages: 794-803
• [Journal Article] Preparation and X-ray structure of a (catecholato)copper(II) complex with a Schonberg adduct (2006)
  • Author(s): B. Tapodi, G. Speier, M. Giorgi, M. Reglier, T. Funabiki, L. Korecz, A
  • Journal Title: Rockenbauer, Inorg. Chem. Comm. 9 Pages: 367-70
• [Journal Article] Structure and Photochemical Properties of (μ-Alkoxo)bis([t -carboxylato)- diruthenium Complexes with Naphthylacetate Ligands (2006)
  • Author(s): R. Tanaka, I. Kinoshita, M. Mikuriya, H. Benten, H. Ohkita, S. Ito, M. Obata, S. Yano
  • Journal Title: Inorg. Chem. 45 Pages: 3048-56
• [Journal Article] Chemical Approach to Catecholdioxygenases based on Homogeneous Catalysis and Bioinorganic Chemistry (2006)
  • Author(s): Y. Hitomi, T. Funabiki
  • Journal Title: Bull. Jpn. Coord. Chem. 48 Pages: 17-32
• [Journal Article] Mechanistic study on regioselective oxygenation reaction of 1,2-quinones with peroxybenzoic acids : Relevant to mechanisms of catechol dioxygenases (2006)
  • Author(s): Y. Hitomi, H. Yoshida, T. Tanaka, T. Funabiki,
  • Journal Title: J. Mol. Catal. A : Chemical 251 Pages: 239-45
• [Journal Article] Non-covalent modification of the heme-pocket of apomyoglobin by a 1,10-phenanthroline derivative (2006)
  • Author(s): Y. Hitomi, H. Mukai, H. Yoshimura, T. Tanaka, T. Funabiki
  • Journal Title: Bioinorg. Med. Chem. Lett. 16 Pages: 8810-21
• [Journal Article] Homohelicity induction of propylene-linked zinc bilinone dimers by complexation with chiral amine and a-amino esters. Preorganization of structurally coupled homohelical subunits (2006)
  • Author(s): Hamakubo, K. ; Yagi, S. ; Nakazumi, H. ; Mizutani, T. ; Kitagawa S.
  • Journal Title: Tetrahedron 62(15) Pages: 3619-3628
• [Journal Article] Thermochromic and solvatochromic zinc biladienones : dynamic equilibria of a metal complex having a flexible framework sensitive to environment (2006)
  • Author(s): K. ; Tokuoka, T. ; Monno, E.; Yagi, S. ; Nakazumi, H. ; Mizutani, T.
  • Journal Title: Tetrahedron Letters 47(10) Pages: 1533-1536
• [Journal Article] A New Molecular Switch Based on Helical Biladienone, Matsui, M. ; Matsuzawa (2006)
  • Author(s): M. ; Matsuzawa, N. N. ; Harnack, O. ; Yamauchi, T. ; Hatazawa, T. ; Yasuda, A. ; Mizutani, T.
  • Journal Title: Adv. Mater. 18(19) Pages: 2523-2528
• [Journal Article] N-Methylporphyrin as a Binding Motif for the Recognition of a Phenolic Hydroxy Group, Kotomari (2006)
  • Author(s): S. ; Yoshikawa, T. ; Mizutani, T .; Takagi, H.
  • Journal Title: Chem. Lett. 35(9) Pages: 1020-1021
• [Journal Article] Peroxodiiron complexes of polypyridine ligands : syntheses, physicochemical properties, and thermal stability markedly enhanced by hexapyridine dinucleating ligand (2006)
  • Author(s): M. Kodera, M. Itoh, K. Kano, T. Funabiki
  • Journal Title: Bull. Chem. Soc. Jpn. 79 Pages: 252-61
• [Journal Article] Redox behavior of a manganese porphyrin complexed with per-O-methylated beta-Cyclodextrin in aqueous solution (2006)
  • Author(s): K. Kano, H. Kitagishi, Y. Sone, N. Nakazawa, M. Kodera, Eur. J.
  • Journal Title: Inorg. Chem. Pages: 4043-53
• [Journal Article] A myoglobin functional model composed of a ferrous porphyrin and a cyclodextrin dimer with an imidazole linker (2006)
  • Author(s): K. Kano, H. Kitagishi, T. Mabuchi, M. Kodera, S. Hirota
  • Journal Title: Chem Asian J. Pages: 358-6
• [Journal Article] Iron porphyrin-cyclodextrin supramolecular complex as a functional model of myoglobin in aqueous solution (2006)
  • Author(s): K. Kano, H. Kitagishi, C. Dagallier, M. Kodera, T. Matsuo, T. Hayashi, Y. Hisaeda, S. Hirota
  • Journal Title: Inorg. Chem. 45 Pages: 4448-60