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2008 Fiscal Year Final Research Report

Studies for regulation mechanism of meiotic crossover formation through the protein-chromosome structure

Research Project

  • PDF
Project/Area Number 18370003
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Genetics/Genome dynamics
Research InstitutionOsaka University

Principal Investigator

SHINOHARA Miki  Osaka University, 蛋白質研究所, 准教授 (80335687)

Project Period (FY) 2006 – 2008
Keywords減数分裂期 / 相同組換え / シナプトネマ複合体
Research Abstract

減数分裂期に発現するSpo16 タンパク質が、シナプトネマ複合体と呼ばれる減数分裂期に形成される染色体高次構造体の新規構成因子であることを明らかにした。配偶子を作るとき、染色体数を半数にするために、キアズマを染色体上で正しく配置する仕組み(干渉)と全ての染色体にキアズマを必ず作る仕組み(保証)がある。シナプトネマ複合体が干渉と保証の両方を制御するがそれぞれに異なるユニットを用いることを明らかにした。

  • Research Products

    (26 results)

All 2009 2008 2007 2006

All Journal Article (9 results) Presentation (17 results)

  • [Journal Article] 減数分裂期組換え制御の分子メカニズム2009

    • Author(s)
      篠原美紀、篠原彰
    • Journal Title

      蛋白質核酸酵素 54

      Pages: 466-471

  • [Journal Article] Csm4-dependent telomere movement onnuclear envelope promotes meiotic recombination2008

    • Author(s)
      Kosaka, Hiromichi, Miki Shinohara and Akira Shinohara
    • Journal Title

      PLoS Genet. 4 : e1000196

  • [Journal Article] Rapid telomere movement in meioticprophase is promoted by NDJ1, MPS3 andCSM4 and is modulated by recombination2008

    • Author(s)
      Conrad, Michael, Chih-Ying Lee, GeneChao, Miki Shinohara, Hiromichi Kosaka, Akira Shinohara, J.A.Conchello, and Michel E.Dresser
    • Journal Title

      Cell 133

      Pages: 1175-87

  • [Journal Article] FHA domain of yeast Xrs2, a homologue ofhuman Nbs1, promotes non-homologousend joining through the interaction with aligase IV partner protein, Lif12008

    • Author(s)
      Matsuzaki, Kenichiro, Akira Shinohara andMiki Shinohara
    • Journal Title

      Genetics 179

      Pages: 213-25

  • [Journal Article] Rad52 promotes postinvasion steps ofmeiotic double-strand-break repair2008

    • Author(s)
      Lao, Jeccica P, Steve D.Oh, Miki Shinohara, Akira Shinohara, Neil Hunter
    • Journal Title

      Mol.Cell 29

      Pages: 517-524

  • [Journal Article] Crossover assurance and crossoverinterference are distinctly regulated by theZMM/SIC proteins during meiosis2008

    • Author(s)
      Shinohara, Miki, Steve D. Oh, Neil Hunterand Akira Shinohara
    • Journal Title

      Nature Genet 40

      Pages: 299-309

  • [Journal Article] タンパク質リン酸化を介したDNA 二重鎖切断修復制御のメカニズム2008

    • Author(s)
      篠原美紀
    • Journal Title

      生化学 80

      Pages: 1029-1033

  • [Journal Article] Meiotic recombination-related DNAsynthesis and its implications for cross-overand non-cross-over recombinant formation2007

    • Author(s)
      Terasawa, Masahiro, Hideyuki Ogawa, Yasumasa Tsukamoto, Miki Shinohara, Katsuhiko Shirahige, Nancy Kleckner andTomoko Ogawa
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104 : (14)

      Pages: 5965-5970

  • [Journal Article] Distinct functions of the twospecificity-determinants in replicationinitiation of the plasmids ColE2-P9 andColE3-CA382007

    • Author(s)
      Aoki, Kazuaki, Miki Shinohara and Tateo Itoh
    • Journal Title

      J Bacteriol 19

      Pages: 2392-2400

  • [Presentation] 日本分子生物学会年会2008

    • Author(s)
      篠原美紀
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      20081209-12
  • [Presentation] 日本放射線影響学会2008

    • Author(s)
      篠原美紀
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      20081119-21
  • [Presentation] 3R Symposium2008

    • Author(s)
      Miki Shinohara
    • Place of Presentation
      静岡県つま恋
    • Year and Date
      20081027-30
  • [Presentation] 酵母遺伝学フォーラム2008

    • Author(s)
      篠原美紀
    • Place of Presentation
      北海道大学
    • Year and Date
      20080910-12
  • [Presentation] XX International Congress of Genetics2008

    • Author(s)
      Miki Shinohara
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      20080712-17
  • [Presentation] EMBO Workshop2008

    • Author(s)
      Miki Shinohara
    • Place of Presentation
      Il Ciocco, Italy
    • Year and Date
      20080516-23
  • [Presentation] 染色体ワークショップ2008

    • Author(s)
      篠原美紀
    • Place of Presentation
      ウエルサンピア姫路
    • Year and Date
      20080126-28
  • [Presentation] 第23回染色体ワークショップ2007

    • Author(s)
      小坂宏道、唐津
    • Year and Date
      20070131-22
  • [Presentation] 日本分子生物学会第30回年会2007

    • Author(s)
      篠原美紀
    • Place of Presentation
      横浜国際会議場
    • Year and Date
      2007-12-13
  • [Presentation] InternationalSymposium on "Chromosome andGenome Stability & Instability"2007

    • Author(s)
      Miki Shinohara
    • Place of Presentation
      Osaka
    • Year and Date
      2007-11-08
  • [Presentation] 日本遺伝学会第79回大会2007

    • Author(s)
      篠原美紀
    • Place of Presentation
      岡山大学
    • Year and Date
      2007-09-13
  • [Presentation] The 8th European Meiosis Meeting2007

    • Author(s)
      Miki Shinohara
    • Place of Presentation
      Kanagawa
    • Year and Date
      2007-09-13
  • [Presentation] 酵母遺伝学フォーラム2007

    • Author(s)
      篠原美紀
    • Place of Presentation
      大阪大学
    • Year and Date
      2007-09-11
  • [Presentation] 組換えワークショップ2006

    • Author(s)
      篠原美紀
    • Place of Presentation
      淡路島夢舞台国際会議場
    • Year and Date
      20061127-29
  • [Presentation] 日本遺伝学会第78回大会2006

    • Author(s)
      篠原美紀, つくば
    • Year and Date
      20060925-27
  • [Presentation] 酵母遺伝学フォーラム第39回大会2006

    • Author(s)
      篠原美紀、三島
    • Year and Date
      20060715-17
  • [Presentation] The 20^<th> IUBMB International Congress ofBiochemistry and MolecularBiology2006

    • Author(s)
      Miki Shinohara, Kyoto
    • Year and Date
      2006-07-22

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Published: 2010-06-10   Modified: 2016-04-21  

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