2009 Fiscal Year Final Research Report
Determination of phosphorylation sites of the ceramide transport protein CERT, and a role of the phosphorylation
| Project/Area Number |
18370049
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
HANADA Kentaro National Institute of Infectious Diseases, 細胞化学部, 部長 (30192701)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMAGAI Keigo , 感染研・細胞化学部, 研究員 (40443105)
TOMISHIGE Nario , 感染研・細胞化学部, 協力研究員 (10435711)
KAWANO Miyuki , 感染研・細胞化学部, 協力研究員 (10454498)
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| Project Period (FY) |
2006 – 2009
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| Keywords | セラミド / スフィンゴミエリン / 脂質輸送 / 小胞体 / ゴルジ体 |
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| Research Abstract |
The ceramide transport protein CERT has a PH domain recognizing phosphatidylinositol 4-monophosphate and a START domain catalyzing intermembrane transfer of ceramide. We showed that multiple phosphorylations of CERT induce an auto-inhibitory interaction between the PH and START domains, thereby down-regulating the function of CERT, and that casein kinase Iγ2 is relevant to the phosphorylation.
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