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2007 Fiscal Year Final Research Report Summary

Mechanism of porphyrin ring cleavage in the heme oxygenase catalysis

Research Project

Project/Area Number 18370052
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionTohoku University

Principal Investigator

SAITO Masao  Tohoku University, Tohoku University, Institute of Multidisciplinary Research for Advanced Materials, Professor (70302239)

Co-Investigator(Kenkyū-buntansha) MATSUI Toshitaka  Tohoku University, Institute of Multidisciplinary Research for Advanced Materials, Senior Assistant Professor (90323120)
UNNO Masaki  Tohoku University, Institute of Multidisciplinary Research for Advanced Materials, Assistant Professor (10359549)
Project Period (FY) 2006 – 2007
Keywordsheme / oxygen activation / X-ray crystallography / heme oxygenase / reaction mechanism / verdoheme
Research Abstract

Heme oxygenase (HO) degrades heme to biliverdin through three successive oxygenations. While the third oxygenation, ring opening of verdoheme, is considered as the rate-determining step to regulate HO enzyme activity in vivo, this step has been the least understood in the Ho catalysis. Specific aim of this research project is to delineate the third oxygenation by HO through detailed reaction analysis, crystallographic and spectroscopic characterization. We also have examined a new HO reaction that affords a novel heme catabolite under physiologically relevant condition.
In the classical HO reaction, we have found that HO degrades verdoheme through a dual pathway using either O_2 or H_2O_2. Together with inhibitory and mutational studies, we have proposed a mechanism involving an Fe-OOH verdoheme as a reactive intermediate. This proposal is strongly supported by the fact that the macrocycle cleavage with small alkyl hydroperoxides (MeOOH and EtOOH) incorporated the alkyl group into one end of linear tetrapyrroles produced.
The reactive peroxy species is crystallographically characterized for the first time in myoglobin, a model protein of heme enzymes. Crystals of the peroxy myoglobin have been successfully generated by radiolytic reduction of the oxy myoglobin crystals at 100 K by irradiation with 1.0 A synchrotron radiation. Diffraction data is collected by 0.6 A synchrotron radiation without further reaction of the peroxy species.
The new heme catabolite, S-biliverdin, has been chemically synthesized and identified by LC-MS and NMR analysis. The verdoheme cleavage in the new HO reaction proceeds through an O2-independent manner and the product ratio of S-biliverdin over biliverdin largely depends on the O2 concentration. These mechanistic changes are expected to affect on the physiological functions, namely an O2 sensing property of HO.

  • Research Products

    (74 results)

All 2008 2007 2006

All Journal Article (18 results) (of which Peer Reviewed: 9 results) Presentation (56 results)

  • [Journal Article] Alkyl peroxides reveal the ring opening mechanism of verdoheme catalyzed by heme oxygenase2008

    • Author(s)
      Matsui , et. al.
    • Journal Title

      Journal of the American Chemical Society 130

      Pages: 4220-4221

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Ligand design for the improvement of stability of metal complex・protein hybrids2008

    • Author(s)
      Yokoi , et. al.
    • Journal Title

      Chemical Communications

      Pages: 229-231

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Alkyl peroxides reveal the ring opening mechanism of verdoheme catalyzed by heme oxygenase2008

    • Author(s)
      Matsui et. al.
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 4220-4221

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ligand design for the improvement of stability of metal complex protein hybrids2008

    • Author(s)
      Yokoi et. al.
    • Journal Title

      Chem. Commun.

      Pages: 229-231

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Structural Characterization of the Fleeting Ferric Peroxo Species in Myoglobin: Experiment and Theory2007

    • Author(s)
      Unno , et. al.
    • Journal Title

      Journal of the American Chemical Society 129

      Pages: 13394-13395

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Distinct reaction pathways followed upon reduction of oxy-heme oxygenase and oxy-myoglobin as characterized by Mossbauer spectroscopy2007

    • Author(s)
      Garcia-Serres , et. al.
    • Journal Title

      Journal of the American Chemical Society 129

      Pages: 1402-1412

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Bach1, a heme-dependent transcription factor, reveals presence of multiple heme binding sites with distinct coordination structure2007

    • Author(s)
      Hira , et. al.
    • Journal Title

      IUBMB Life 59

      Pages: 541-551

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Structure and catalytic mechanism of heme oxygenase2007

    • Author(s)
      Unno , et. al.
    • Journal Title

      Natural Products Reports 24

      Pages: 553-570

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Structural characterization of the fleeting ferric peroxo species in myoglobin: Experiment and theory2007

    • Author(s)
      Unno et. al.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 13394-13395

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Distinct reaction pathways followed upon reduction of oxy-heme oxygenase and oxy-myoglobin as characterized by Mossbauer spectroscopy2007

    • Author(s)
      Garcia-Serres et. al.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 1402-1412

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bachl, a heme-dependent transcription factor, reveals presence of multiple heme binding sites with distinct coordination structure2007

    • Author(s)
      Hira et. al.
    • Journal Title

      IUBMB Life 59

      Pages: 542-551

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Structure and catalytic mechanism of heme oxygenase2007

    • Author(s)
      Unno et. al.
    • Journal Title

      Nat. Prod. Rep 24

      Pages: 553-570

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Compound I of heme oxygenase cannot hydroxylate its heme meso-carbon2006

    • Author(s)
      Matsui , et. al.
    • Journal Title

      Journal of the American Chemical Society 128

      Pages: 1090-1091

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Time-resolved small-angle X-ray scattering investigation of the folding dynamics of heme oxygenase2006

    • Author(s)
      Uzawa , et. al.
    • Journal Title

      Journal of Molecular Biology 357

      Pages: 997-1008

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Design of metal cofactors activated by a protein-protein electron transfer system2006

    • Author(s)
      Ueno , et. al.
    • Journal Title

      Proceedings of the National Academy of Sciences 103

      Pages: 9416-9421

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Compound I of heme oxygenase cannot hydroxylate its heme meso-carbon2006

    • Author(s)
      Matsui et. al.
    • Journal Title

      J. Am. Chem. Soc. 128

      Pages: 1090-1091

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Time-resolved small-angle X-ray scattering investigation of the folding dynamics of heme oxygenase: Implication of the scaling relationship for the submillisecond intermediates of protein folding2006

    • Author(s)
      Uzawa et. al.
    • Journal Title

      J. Mol. Biol. 357

      Pages: 997-1008

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Design of metal cofactors activated by a protein-protein electron transfer system2006

    • Author(s)
      Ueno et. al.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A. 103

      Pages: 9416-9421

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Ring Opening Mechanism of Verdoheme Catalyzed by Heme Oxygenase2008

    • Author(s)
      T. Matsui
    • Organizer
      Global COE in Chemistry, Nagoya Special Symposium
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Intermediates structures of heme oxygenase catalysis2008

    • Author(s)
      M. Unno
    • Organizer
      Global COE in Chemistry, Nagoya Special Symposium
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Ring Opening Mechanism of Verdoheme Catalyzed by Heme Oxygenase2008

    • Author(s)
      T. Matsui
    • Organizer
      Global COE in Chemistry, Nagoya Special Symposium
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2008-03-20
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Intermediates structures of heme oxygenase catalysis2008

    • Author(s)
      M. Unno
    • Organizer
      Global COE in Chemistry, Nagoya Special Symposium
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2008-03-20
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structures of peroxo and hydroperoxo intermediates of heme proteins2008

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      Gordon Research Conference, Metals in Biology
    • Place of Presentation
      Ventura (USA)
    • Year and Date
      2008-01-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structures of peroxo and hydroperoxo intermediates of heme proteins2008

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      Gordon Research Conference, Metals in Biology
    • Place of Presentation
      Ventura, USA
    • Year and Date
      2008-01-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Crystal structures of the hydroperoxo-heme-and alpha-meso-hydroxyheme intermediates in heme oxygenase catalysis2007

    • Author(s)
      M. Unno
    • Organizer
      13th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      Wien (Austria)
    • Year and Date
      20070715-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Ring opening mechanism of verdoheme catalyzed by heme oxygenase2007

    • Author(s)
      T. Matsui
    • Organizer
      13th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      Wien (Austria)
    • Year and Date
      20070715-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Crystal structures of the hydroperoxo-heme- and alpha-meso-hydroxyheme intermediates in heme oxygenase catalysis2007

    • Author(s)
      M. Unno
    • Organizer
      13 th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      Wien, Austria
    • Year and Date
      20070715-20
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Ring opening mechanism of verdoheme catalyzed by heme oxygenase2007

    • Author(s)
      T. Matsui
    • Organizer
      13th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      Wien, Austria
    • Year and Date
      20070715-20
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Crystal Structures of Heme Oxygenase Catalytic Intermediates2007

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      Gordon Research Conference : Metals in Biology
    • Place of Presentation
      Ventura (USA)
    • Year and Date
      20070128-0202
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Crystal Structures of Heme Oxygenase Catalytic Intermediates2007

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      Gordon Research Conference: Metals in Biology
    • Place of Presentation
      Ventura, USA
    • Year and Date
      20070128-0202
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] イオンチャンネル型グルタミン酸受容体GluR5と天然物由来アゴニストの結合様式2007

    • Author(s)
      海野昌喜
    • Organizer
      第45回日本生物物理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Binding Mechanism of the Agonists for the Ionotropic Glutamate Receptor, GluR52007

    • Author(s)
      M. Unno
    • Organizer
      45th Annual Meeting of the Biophysical Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-12-23
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structural characterization of catalytic intermediates of heme oxygenase2007

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      The 67th Okazaki Conference "Molecular Science and Chemical Biology of Biomolecular Function
    • Place of Presentation
      岡崎
    • Year and Date
      2007-11-11
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structural characterization of catalytic intermediates of heme oxygenase2007

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      The 67th Okazaki Conference "Molecular Science and Chemical Biology of Biomolecular Function
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2007-11-11
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structural Characterization of Peroxo Species in Myoglobin2007

    • Author(s)
      M. Unno
    • Organizer
      The 67th Okazaki Conference "Molecular Science and Chemical Biology of Biomolecular Function
    • Place of Presentation
      岡崎
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Ring Opening Mechanism of Verdoheme Catalyzed by Heme Oxygenase2007

    • Author(s)
      T. Matsui
    • Organizer
      The 67th Okazaki Conference "Molecular Science and Chemical Biology of Biomolecular Function
    • Place of Presentation
      岡崎
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structural Characterization of Peroxo Species in Myoglobin2007

    • Author(s)
      M. Unno
    • Organizer
      The 67th Okazaki Conference "Molecular Science and Chemical Biology of Biomolecular Function
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Ring Opening Mechanism of Verdoheme Catalyzed by Heme Oxygenase2007

    • Author(s)
      T. Matsui
    • Organizer
      The 67th Okazaki Conference "Molecular Science and Chemical Biology of Biomolecular Function
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ヘムオキシゲナーゼによるベルドヘム開環の分子機構2007

    • Author(s)
      松井敏高
    • Organizer
      第22回生体機能関連化学シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-09-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Molecular Mechanism of Verdoheme Ring-Opening Catalyzed by Heme Oxygenase2007

    • Author(s)
      T. Matsui
    • Organizer
      The 22th Symposium on Biofunctional Chemistyr
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2007-09-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 低温下X線照射によるパーオキソ型ミオグロビン捕捉および結晶構造解析2007

    • Author(s)
      海野昌喜
    • Organizer
      第57回錯体化学討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-26
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structural Characterization of the Fleeting Ferric Peroxo Species in Myoglobin by Cryogenic X-ray-induced photo-reduction2007

    • Author(s)
      M. Unno
    • Organizer
      The 57th Japan Society of Coordination Chemistry
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2007-09-26
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structure and catalytic mechanism of heme oxygenase2007

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      The 5th International Congress Heme Oxygenases
    • Place of Presentation
      Krakow (Poland)
    • Year and Date
      2007-09-05
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structure and catalytic mechanism of heme oxygenase2007

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      The 5th International Congress Heme Oxygenases
    • Place of Presentation
      Krakow, Poland
    • Year and Date
      2007-09-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] タンパク質内水分子による酵素反応制御:ヘムオキシゲナーゼの場合2007

    • Author(s)
      齋藤正男
    • Organizer
      第7回日本蛋白質科学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] ヘムオキシゲナーゼ反応中間体の構造解析2007

    • Author(s)
      海野昌喜
    • Organizer
      第7回日本蛋白質科学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Reaction Control by Water Molecules in Protein Active Site: A Case Study on Heme Oxygenase2007

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      The 7th Annual Meeting of Protein Science Society of Japan
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2007-05-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Intermediates structures of heme oxygenase catalysis2007

    • Author(s)
      M. Unno
    • Organizer
      The 7th Annual Meeting of Protein Science Society of Japan
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2007-05-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 原子レベル分解能でヘム分解反応を見る2007

    • Author(s)
      海野昌喜
    • Organizer
      分子研研究会「ヘム代謝に関わる酵素の分子科学」
    • Place of Presentation
      岡崎
    • Year and Date
      2007-03-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] ヘムオキシゲナーゼにおけるベルドヘムの反応2007

    • Author(s)
      松井敏高
    • Organizer
      分子研研究会「ヘム代謝に関わる酵素の分子科学」
    • Place of Presentation
      岡崎
    • Year and Date
      2007-03-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Watch the Heme Degradation Reaction at Atomic Resolution2007

    • Author(s)
      M. Unno
    • Organizer
      IMS Symposium "Molecular Science of Enzymes in Heme Catabolism"
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2007-03-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Verdoheme Reactions in Heme Oxygenase Catalysis2007

    • Author(s)
      T. Matsui
    • Organizer
      IMS Symposium "Molecular Science of Enzymes in Heme Catabolism"
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2007-03-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Cryo-trapped intermediates of the heme oxygenase catalysis by X-ray-induced photo reduction2006

    • Author(s)
      M. Unno
    • Organizer
      Gordon research Conference, Diffraction methods in structural biology
    • Place of Presentation
      Lewiston (USA)
    • Year and Date
      20060716-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Cryo-trapped intermediates of the heme oxygenase catalysis by X-ray-induced photo reduction2006

    • Author(s)
      M. Unno
    • Organizer
      Gordon research Conference, Diffraction methods in structural biology
    • Place of Presentation
      Lewiston, USA
    • Year and Date
      20060716-21
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Crystal structure of the heme oxygenase complexed with α-meso hydroxyheme, a high reactive intermediate2006

    • Author(s)
      M. Unno
    • Organizer
      Joint Conference of the Asian Crystallographic Association and the Crystallographic Society of Japan
    • Place of Presentation
      Tsukuba (Japan)
    • Year and Date
      2006-11-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Crystal structure of the heme oxygenase complexed with α-meso hydroxyheme, a high reactive intermediate2006

    • Author(s)
      M. Unno
    • Organizer
      Joint Conference of the Asian Crystallographic Association and the Crystallographic Society of Japan
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2006-11-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Crystal structure of the heme oxygenase complexed with α-meso hydroxyheme, a high reactive intermediate2006

    • Author(s)
      M. Unno
    • Organizer
      Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan
    • Place of Presentation
      Naha (Japan)
    • Year and Date
      2006-11-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Crystal structure of the heme oxygenase complexed with a-meso hydroxyheme, a high reactive intermediate2006

    • Author(s)
      M. Unno
    • Organizer
      Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan
    • Place of Presentation
      Naha, Japan
    • Year and Date
      2006-11-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Catalytic Mechanism of Heme Oxygenase2006

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      3rd Asian Biological Inorganic Chemistry Conference
    • Place of Presentation
      Nanjing(China)
    • Year and Date
      2006-11-01
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Catalytic Mechanism of Heme Oxygenase2006

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      3rd Asian Biological Inorganic Chemistry Conference
    • Place of Presentation
      Nanjing, China
    • Year and Date
      2006-11-01
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ヘム分解酵素の分子機構:反応メカニズムから見えてくるもの2006

    • Author(s)
      松井敏高
    • Organizer
      第28回有機化学コロキウム
    • Place of Presentation
      秋田
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Molecular Mechanism of Heme Oxygenase Catalysis2006

    • Author(s)
      T. Matsui
    • Organizer
      The 28th Colloquium on Organic Chemistry
    • Place of Presentation
      Akita, Japan
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structure of unstable intermediates of heme oxygenase2006

    • Author(s)
      M. Unno
    • Organizer
      Center for Structural Biology Seminar
    • Place of Presentation
      Winston-Salem (USA)
    • Year and Date
      2006-07-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structure of unstable intermediates of heme oxygenase2006

    • Author(s)
      M. Unno
    • Organizer
      Center for Structural Biology Seminar
    • Place of Presentation
      Winston-Salem, USA
    • Year and Date
      2006-07-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] チオール化合物によるヘムオキシゲナーゼのアイソザイム選択的阻害2006

    • Author(s)
      松井敏高
    • Organizer
      第33回生体分子科学討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Isozyme-selective inhibition of heme oxygenase by thiol compounds2006

    • Author(s)
      T. Matsui
    • Organizer
      The 33th Conference on Molecular Science of Biological Molecules
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Reaction Mechanism of Heme Oxygenase2006

    • Author(s)
      T. Matsui
    • Organizer
      International Symposium on Gas Biology
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2006-06-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Reaction Mechanism of Heme Oxygenase2006

    • Author(s)
      T. Matsui
    • Organizer
      International Symposium on Gas Biology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-06-27
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Reaction Mechanism of Heme Oxygenase2006

    • Author(s)
      T. Matsui
    • Organizer
      Biochemistry and Molecular Biology of Sensor Enzymes and Proteins
    • Place of Presentation
      Sendai (Japan)
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Reaction Mechanism of Heme Oxygenase2006

    • Author(s)
      T. Matsui
    • Organizer
      Biochemistry and Molecular Biology of Sensor Enzymes and Proteins
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Heme Oxygenase Catalysis2006

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      Post Hayaishi Symposium "Chemical Biology of Redox Metalloenzymes"
    • Place of Presentation
      Harima (Japan)
    • Year and Date
      2006-04-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Heme Oxygenase Catalysis2006

    • Author(s)
      M. Ikeda-Saito
    • Organizer
      Post Hayaishi Symposium "Chemical Biology ofRedox Metalloenzymes"
    • Place of Presentation
      Harima, Japan
    • Year and Date
      2006-04-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] The Final Step of Heme Degradation Catalyzed by Heme Oxygenase2006

    • Author(s)
      T. Matsui
    • Organizer
      Post Hayaishi Symposium "Chemical Biology of Redox Metalloenzymes"
    • Place of Presentation
      Harima (Japan)
    • Year and Date
      2006-04-14
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The Final Step of Heme Degradation Catalyzed by Heme Oxygenase2006

    • Author(s)
      T. Matsui
    • Organizer
      Post Hayaishi Symposium "Chemical Biology ofRedox Metalloenzymes"
    • Place of Presentation
      Harima, Japan
    • Year and Date
      2006-04-14
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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