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2007 Fiscal Year Final Research Report Summary

Study of the mucosal immunomoduLation by intestinal commensal bacteria

Research Project

Project/Area Number 18380084
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionNihon University

Principal Investigator

KAMINOGAWA Shuichi  Nihon University, College of Bioresource Sciences, Professor (50011945)

Co-Investigator(Kenkyū-buntansha) HOSONO Akira  Nihon University, College of Bioresource Sciences, Associate Professor (70328706)
Project Period (FY) 2006 – 2007
Keywordsallergy / intestinal microbacteria / immunology / gene
Research Abstract

Intestinal commensal bacteria play important roles in the regulation of intestinal immune responses such as anti-allergic reaction and anti-infection. It has been shown that intestinal commensal bacteria greatly affect the development of gut-associated lymphoid tissues and mucosal immune responses, such as IgA production, in the gut. Given the large numbers of intestinal microbiota, particularly in the large intestine, it is believed that immunocytes in the large intestine are modulated by microbacteria. While IgA production by immunocytes in the small intestine has been previously studied, IgA production in the large intestine is, however, poorly understood. In this study, we show that IgA production by lymphocytes is induced by microbacteria present in the large intestine.
Lamina propria lymphocytes from the large intestine (L-LP) were isolated from germ-free (GF) and conventional (CV) mice. Flow cytometric analysis of L-LP lymphocytes was used to assess the frequency of IgM+B220+ cel … More ls, IgA+B220+ cells, and IgA+Syndecan-l+B220- cells. In addition, to determine whether stimulation by commensal bacteria influences differentiation of IgM+ cells into IgA-plasma cells, IgM+ cells separated from L-LP lymphocytes of GF mice were co-cultured with Bacteroides acidofaciens isolated from intestinal commensal bacteria of CV mice.
The frequency of IgA+Syndecan-1+B220- cells and IgA+B220+ cells in L-LP of GF were all lower than that of CV mice, but there was no difference in the frequency of IgM+13220+ cells in L-LP between GF and CV mice. IgA production by IgM+ cells stimulated by B. acidofaciens was higher than in those without bacterial stimulation.
These results indicate that direct stimulation by B. acidofaciens induces differentiation of IgM+ cells into IgA-producing plasma cells from the large intestine. These also suggest that IgA production in the large intestine might be induced by intestinal commensal bacteria, thus intestinal microbacteria promote the class switching from IgM to IgA in the large intestine. Less

  • Research Products

    (90 results)

All 2008 2007 2006

All Journal Article (28 results) (of which Peer Reviewed: 14 results) Presentation (60 results) Book (2 results)

  • [Journal Article] Prior stimulation of antigen-presenting cells with Lactobacillus regulates excessive antigen-specific cytokine responses in vitro when compared with Bacteroides2007

    • Author(s)
      Tsuda M, Hosono A, Yanagibashi T, Hachimura S, Hirayama K, Itoh K, Takahashi K, Kaminogawa S.
    • Journal Title

      cytotechnol 55

      Pages: 89-101

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Bifidobacterium components have immunomodulatory characteristics dependant on the method of preparation2007

    • Author(s)
      Hiramatsu Y, Hosono A, Takahashi K, Kaminogawa S.
    • Journal Title

      Cytotechnol 55

      Pages: 79-87

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Isolated lymphoid follicles are not IgA inductive sites for recombinant Salmonella2007

    • Author(s)
      Hashizume T, Momoi F, Kurita-Ochiai T, Kaminogawa S, Hosono A, Kataoka K, Shinozaki-Kuwahara N, Kweon MN, Yamamoto M.
    • Journal Title

      Biochem Biophys Res Commun 360

      Pages: 288-293

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Identification of marker genes for intestinal immunomodulating effect of afructooligosaccharide by DNA microarray analysis2007

    • Author(s)
      Fukasawa T, Murashima K, Matsumoto I, Hosono A, OharaH, Nojiri C, Koga J, Kubota H, Kanegae M, Kaminogawa S, Abe K, Kono T.
    • Journal Title

      J Agric Food Chem 55

      Pages: 3174-3179

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Cytokine responses of intestinal epithelial-like Caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric acid2007

    • Author(s)
      Saegusa S, Totsuka M., Kaminogawa S, Hosoi T
    • Journal Title

      Biosci.Biotechnol.Biochem 71

      Pages: 2428-2434

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Dietary melibiose regulates Th cell response and enhances the induction of Oral tolerance2007

    • Author(s)
      Tomita K, Nagura T, Okuhara Y, Nakajima-Adachi H, Shigematsu N, Aritsuka T, Kaminogawa S, Hachimura S
    • Journal Title

      Biosci.Biotechnol.Biochem 71

      Pages: 2774-2780

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 食品とアレルギー2007

    • Author(s)
      上野川 修一
    • Journal Title

      日本家政学会誌 58

      Pages: 45-46

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Prior stimulation of antigen-presenting cells with Lactobacillus regulates excessive antigen-specific cytokine responses in vitro when compared with Bacteroides2007

    • Author(s)
      Tsuda, M., et. al.
    • Journal Title

      Cytotechnol 55

      Pages: 89-101

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bifidobacterium components have immunomodulatory characteristics dependant on the method of preparation2007

    • Author(s)
      Hiramatsu, Y., et. al.
    • Journal Title

      Cytotechnol 55

      Pages: 79-87

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Isolated lymphoid follicles are not IgA inductive sites for recombinant Salmonella2007

    • Author(s)
      Hashizume, T., et. al.
    • Journal Title

      Biochem Biophys Res Commun 360

      Pages: 288-293

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] dentification of marker genes for intestinal immunomodulating effect of a fructooligosaccharide by DNA microarray analysis2007

    • Author(s)
      Fukasawa, T., et. al.
    • Journal Title

      J Agric Food Chem 55

      Pages: 3174-3179

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cytokine responses of intestinal epithelial-like Caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric acid2007

    • Author(s)
      Saegusa, S., et. al.
    • Journal Title

      Biosci. Biotechnol. Biochem 71

      Pages: 2428-2434

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dietary melibiose regulates Th cell response and enhances the induction of oral tolerance2007

    • Author(s)
      Tomita, K., et. al.
    • Journal Title

      Biosci, Biotechnol, Biochem 71

      Pages: 2774-2780

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Food and allergy2007

    • Author(s)
      Kaminogawa, S
    • Journal Title

      Nippon Kasei Gakkaishi 58

      Pages: 45-46

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Food antigen causes TH2-dependent enteropathy followed by tissue repairin T-cell receptor transgenic mice2006

    • Author(s)
      Nakajima-Adachi H, Ebihara A, Kikuchi A, Ishida T, Sasaki K, Hirano K, Watanabe H, Asai K, Takahashi Y, Kanamori Y, Shimojo N, Matsuda H, Kohno Y, Hachimura S, Kaminogawa S
    • Journal Title

      J. Allergy Clin.Immunol 117

      Pages: 1125-1132

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms for transcriptional regulation of human high-affinity IgE receptor β-chain gene induced by GM-CSF2006

    • Author(s)
      Takahashi K, Hayashi N, Kaminogawa S, Ra C
    • Journal Title

      J.Immunol. 177

      Pages: 4605-4611

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Increase in terminal fragments of 16S rRNA genes derived from Bacteroidetes after administration of short-chain fructooligosaccharides2006

    • Author(s)
      Nakanishi Y, Murashima K, Ohara H, Suzuki T, Hayashi H, Sakamoto M, Fukasawa T, Kubota H, Hosono A, Kono T, Kaminogawa S, Benno Y
    • Journal Title

      Appl.Environ.Microbiol 72

      Pages: 6271-6276

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The role of Bifidobacterium in the development of gut immune systems:analysis using gnotobiotic TCR-transgenic mice2006

    • Author(s)
      Tsuda M, Hosono A, Fujioka M, Hachimura S, Nakamura R, Hirayama K, Itoh K, Kaminoawa S
    • Journal Title

      Animal Cell Technology:Basic&Applied Aspects 14

      Pages: 93-99

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The role of CD4^+T cells in IgA production in murine Peyer's patches followin oral feeding of Bifidobacterium components2006

    • Author(s)
      Nakanishi Y, Hosono A, Kimura T, Kaminogawa S
    • Journal Title

      Animal Cell Technology:Basic&Applied Aspects 14

      Pages: 101-106

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Modulation of cytokine and immunoglobulin A release bybeta-(1,3-1,6)-glucan from Aureobasidium ullulans strain IA 12006

    • Author(s)
      Suzuki T, Hosono A, Hachimura S, Suzuki T, Kaminogawa S
    • Journal Title

      Animal Cell Technology:Basic&Applied Aspects 14

      Pages: 369-375

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] In vivo immunopotentiating effects of cellular components from Lactococcus lactis ssp lactis2006

    • Author(s)
      Kim JY, Lee S, Jeong DW, Hachimura S, Kaminogawa S, Lee HJ
    • Journal Title

      J.Microbiol.Biotechnol 16

      Pages: 786-790

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Food antigen causes TH2-dependent enteropathy followed by tissue repair in T-cell receptor transgenic mice2006

    • Author(s)
      Nakajima-Adachi, H., et. al.
    • Journal Title

      J. Allergy Clin. Immunol 117

      Pages: 1125-1132

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular mechanisms for transcriptional regulation of human high-affinity IgE receptor β-chain gene induced by GM-CSF2006

    • Author(s)
      Takahashi, K., et. al.
    • Journal Title

      J. Immunol 177

      Pages: 4605-4611

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Increase in terminal fragments of 16S rRNA genes derived from Bacteroidetes after administration of short-chain fructooligosaccharides2006

    • Author(s)
      Nakanishi, Y., et. al.
    • Journal Title

      Appl. Environ. Microbiol 72

      Pages: 6271-6276

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The role of Bifidobacterium in the development of gut immune systems : analysis using gnotobiotic TCR-transgenic mice2006

    • Author(s)
      Tsuda, M., et. al.
    • Journal Title

      Animal Cell Technology : Basic & Applied Aspects 14

      Pages: 93-99

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The role of CD4+ T cells in IgA production in murine Peyer's patches following oral feeding of Bifidobacterium components2006

    • Author(s)
      Nakanishi, Y., et. al.
    • Journal Title

      Animal Cell Technology : Basic & Applied Aspects 14

      Pages: 101-106

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Modulation of cytokine and immunoglobtilin A release by beta-(1,3-1,6)-glucan from Aureobasidium pullulans strain 1A12006

    • Author(s)
      Suzuki, T., et. al.
    • Journal Title

      Animal Cell Technology : Basic & Applied Aspects 14

      Pages: 369-375

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] In vivo immunopotentiating effects of cellular components from Lactococcus lactis ssp lactis2006

    • Author(s)
      Kim, JY., et. al.
    • Journal Title

      J. Microbiol. Biotechnol 16

      Pages: 786-790

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 腸内細菌は小腸におけるIgA産生より大腸におけるそれを強く誘導する2008

    • Author(s)
      柳橋 努・細野 朗・津田 真人・八村 敏志・高橋 宜聖・平山 和宏・伊藤 喜久治・高橋 恭子・上野川 修一
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      20080326-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 腸内細菌はバイエル板細胞の経口抗原に対するサイトカイン産生の抑制と制御性T細胞の発現を誘導する2008

    • Author(s)
      津田 真人、細野 朗、柳橋 努、八村 敏志、平山 和宏、伊藤 喜久治、高橋 恭子、上野川 修一
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      20080326-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] ITLR2を介したマスト細胞のアレルギー応答の抑制とその機序2008

    • Author(s)
      笠倉 和巳, 高橋 恭子, 細野 朗, 上野川 修一
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      20080326-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 腸管上皮細月包におけるTollip遺伝子の発現制御機構2008

    • Author(s)
      杉由 高, 高橋 恭子, 細野 朗, 上野川 修一
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      20080326-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 小腸CD3-IL-2R^+細胞はpoly I:C刺激とインフルエンザウイルス感染に応答してIL-5を高発現する2008

    • Author(s)
      梅田 幸子、高橋 宜聖、小川 晋平、馬渕 信行、山田 潔、細野 朗、辻 典子、戸塚 護、上野川 修一、佐藤 隆一郎、八村 敏志
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      20080326-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 経口免疫寛容において誘導されるCD62L^<high/int>CD44^<int>およびCD62L^<low>CD44^<high>制御性T細胞の免疫抑制機能解析2008

    • Author(s)
      田辺 康祐、浜口 修一、塩河 亜弥、若月 芳雄、上野川 修一、伊勢 渉、佐藤 隆一郎、八村 敏志
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      20080326-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] プロバイオティクス・腸内共生菌とアレルギー2007

    • Author(s)
      上野川 修一
    • Organizer
      第44回日本小児アレルギー学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20071208-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regulation of TLR gene expression in intestinal epithelial cells2007

    • Author(s)
      Takahashi K, Hosono A, Kaminogawa S
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071120-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Directly effects of Lactobacillus GG and L. gasseri TMC0356 on mast cells2007

    • Author(s)
      Harata G, Takahashi K, He F, Kubota A, Hosono A, Kaminogawa S
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071120-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Expression pattem of CD62L/CD44 and regulatoly function of T cells induced by oral administration of antigen2007

    • Author(s)
      Tanabe K, Hamaguchi S, Wakatsuki Y, Kaminogawa S, Ise W, Sato R, Hachimura S
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071120-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Intestinal CD3-IL-2R^+cells respond to poly I:C stimuli and influenza virusinfection2007

    • Author(s)
      Umeda Y, Kuraoka M, Takahashi Y, Yamada K, Tsuji N, Kouro T, Totsuka M, Takatsu K, Kaminogawa S, Sato R, Hachimura S
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071120-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regulation of TLR gene expression in intestinal epithelial cells2007

    • Author(s)
      Takahashi, K., et. al.
    • Organizer
      The 37th Annual Meeting ofJapanese Society for Immunology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20071120-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Directly effects of Lactobacillus GG and L. gasseri TMCO356 on mast cells2007

    • Author(s)
      Harata, G., et. al.
    • Organizer
      The 37th Annual Meeting of Japanese Society for Immunology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20071120-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Expression pattern of CD62L/CD44 and regulatory function of T cells induced by oral administration of antigen2007

    • Author(s)
      Tanabe, K., et. al.
    • Organizer
      The 37th Annual Meeting of Japanese Society for Immunology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20071120-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Intestinal CD3IL-2R+ cells respond to poly I : C stimuli and influenza virus infection2007

    • Author(s)
      Umeda, Y., et. al.
    • Organizer
      The 37th Annual Meeting of Japanese Society for Immunology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20071120-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Differentiated implication of Lactobacillus GG and L. gasseri TMC0356 on gut-associated immune lymphoid tissues2007

    • Author(s)
      Harata G, He F, Kawase M, Kubota A, Hiramitsu M, Hosono A, Takahashi K, Kaminogawa S
    • Organizer
      The 4th Asian Congress on Lactic Acid Bacteria
    • Place of Presentation
      Shanghai,China
    • Year and Date
      20071014-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] On the horizon of food immunology2007

    • Author(s)
      Kaminogawa S
    • Organizer
      13th International Congress of Mucosal Immunology(ICMI 2007)
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Modulation of T cell and antibody responses by food2007

    • Author(s)
      Hachimura S, Kaminogawa S
    • Organizer
      13th International Congress of Mucosal Immunology(ICMI 2007)
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Murine intestinal commensal Lactobacillus modulates antigen-specific cytokine production via antigen-presenting cells differently to Bacteroides2007

    • Author(s)
      Tsuda M, Hosono A, Yanagibashi T, Hachimura S, Hirayama K, Itoh K, Takahashi K, Kaminogawa S
    • Organizer
      13th International Congress of Mucosal Immunology(ICMI 2007)
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Bacteroides acidofaciens induces differentiation of IgM^+ cells into IgA-plasma cells from the large intestine2007

    • Author(s)
      Yanagibashi T, Hosono A, Tsuda M, Hachimura S, Hirayama K, Itoh K, Takahashi K, Kaminogawa S
    • Organizer
      13th International Congress of Mucosal Immunology(ICMI 2007)
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Expression pattern of CD62L/CD44 and regulatory function of T cells induced by oral administration of antigen2007

    • Author(s)
      Tanabe K, Hamaguchi S, Fujimoto K, Wakatsuki Y, Kaminogawa S, Sato R, Ise W, Hachimura S
    • Organizer
      13th International Congress of Mucosal Immunology(ICMI 2007)
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] CD3-IL-2R^+ Peyer's patch cells respond to TLR Stimuli,secrete IL-5,and induce IgA production2007

    • Author(s)
      Umeda Y, Kuraoka M, Yamada K, Kouro T, Takahashi Y, Tsuji NM, Totsuka M, Takatsu K, Kaminogawa S, Sato R, Hachimura S
    • Organizer
      13th International Congress of Mucosal Immunology(ICMI 2007)
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] On the horizon of food immunology2007

    • Author(s)
      Katninoaawa, S
    • Organizer
      13th International Congress of Mucosal Immunology (ICMI 2007)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Modulation of T cell and antibody responses by food2007

    • Author(s)
      Hachimura, S., Kaminouawa, S
    • Organizer
      13th International Congress of Mucosal Immunology (ICMI 2007)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Murine intestinal commensal Lactobacillus modulates antigen-specific cytokine production via antigen-presenting cells differently to Bacteroides2007

    • Author(s)
      Tsuda, M., et. al.
    • Organizer
      13th International Congress of Mucosal Immunology (ICMI 2007)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Bacteroides acidofaciens induces differentiation of IgM+ cells into IgA-plasma cells from the large intestine2007

    • Author(s)
      Yanagibashi, T., et. al.
    • Organizer
      13th International Congress of Mucosal Immunology (ICMI 2007)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Expression pattern of CD62L/CD44 and regulatory function of T cells induced by oral administration of antigen2007

    • Author(s)
      Tanabe, K., et. al.
    • Organizer
      13th International Congress of Mucosal Immunology (ICMI 2007)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] CD3IL-2R+ Peyer's patch cells respond to TLR Stimuli, secrete IL-5, and induce IgA production2007

    • Author(s)
      Umeda, Y., et. al.
    • Organizer
      13th International Congress of Mucosal Immunology (ICMI 2007)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Differentiated implication of Lactobacillus GG and L. gasseri TMCO356 on gut-associated immune lymphoid tissues2007

    • Author(s)
      Harata, G., et. al.
    • Organizer
      13th International Congress of Mucosal Immunology (ICMI 2007)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 食物とアレルギー2007

    • Author(s)
      上野川 修一
    • Organizer
      日本動物細胞工学会2007年度大会(JAACT2007)
    • Place of Presentation
      高崎
    • Year and Date
      20070703-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 処理条件の異なるBifidobacterium菌体調製物とその免疫修飾作用の相関について2007

    • Author(s)
      平松 靖浩、細野 朗、高橋 恭子、上野川 修一
    • Organizer
      日本動物細胞工学会2007年度大会(JAACT2007)
    • Place of Presentation
      高崎
    • Year and Date
      20070703-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 腸内細菌由来菌体成分によるマスト細胞のアレルギー応答の調節2007

    • Author(s)
      相澤 奉文、高橋 恭子、笠倉 和巳、細野 朗、上野川 修一
    • Organizer
      日本動物細胞工学会2007年度大会(JAACT2007)
    • Place of Presentation
      高崎
    • Year and Date
      20070703-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 調製法の異なるBifidobacterium菌体成分が修飾する免疫応答の特2007

    • Author(s)
      平松 靖浩、細野 朗、高橋 恭子、上野川 修一
    • Organizer
      第11回腸内細菌学会
    • Place of Presentation
      東京
    • Year and Date
      20070614-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 無菌マウスにおける食品抗原特異的な免疫応答の特徴:腸管免疫系と全身免疫系のサイトカイン産生の違い2007

    • Author(s)
      津田 真人・細野 朗・柳橋 努・八村 敏志・平山 和宏・伊藤 喜久治・高橋 恭子・上野川 修一
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      20070324-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 腸管上皮細胞におけるTLR4遺伝子の発現制御機構2007

    • Author(s)
      高橋 恭子・細野 朗・上野川 修一
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      20070324-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] ビフィズス菌菌体破砕物のアレルギー反応抑制効果2007

    • Author(s)
      相澤 奉文・高橋 恭子・細野 朗・石嶋 慶太・城内 健太・中村 亜矢・西村 和大・上野川 修一
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      20070324-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] TLR-2を介したマスト細胞のアレルギー応答の調節2007

    • Author(s)
      笠倉 和巳・高橋 恭子・青山 円佳・石田 里沙・大澤 香織・細野 朗・上野川 修一
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      20070324-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Lactobacillus rhamnosus GGとLactobacillus gasseri TMC0356による腸管免疫応答に与える影響2007

    • Author(s)
      原田 岳・何方・川瀬 学・細野 朗・高橋 恭子・上野川 修一
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      20070324-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 経口免疫寛容において誘導されるCD62L^<high/Int>CD44^<Int>およびCD62L^<low>CD44^<high>制御性T細胞の機能解析2007

    • Author(s)
      田辺 康祐・浜口 修一・伊勢 渉・上野川 修一・佐藤 隆一郎・八村 敏志
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      20070324-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 経口免疫寛容を誘導されたT細胞に高発現する遺伝子zfhxlbの機能解析2007

    • Author(s)
      谷貝 英紀・後藤 浩文・後藤 貴康・野中 敦子・伊勢 渉・山田 潔・戸塚 護・高橋 宜聖・北村 俊雄・上野川 修一・佐藤 隆一郎・八村 敏志
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      20070324-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Comparison of the immunomodulatory effects of murine commensal Lactobacillus and Bacteroides on antigen-specific immune responses by intestinal immune cells derived from germ-free ovalbumin TCR-transgenicmlce2006

    • Author(s)
      Tsuda M, Hosono A, Hachimura S, Takahashi K, Kaminogawa S
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20061211-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Synergistic activation of Fc receptor γ-chain gene expression by Sp-1 and GAB in mast cells2006

    • Author(s)
      Takahashi K, Hayashi N, Shimokawa T, Kaminogawa S, Ra C
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20061211-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] CD3IL-2R^+ Peyer's patch cells respond to poly I:C stimuli and secrete IL-52006

    • Author(s)
      Umeda Y, Akema Y, Kuraoka M, Yamada K, Hashiguchi M, Ise W, Kouro T, Takahashi Y, Totsuka M, Takatsu K, Kaminogawa S, Sato R, Hachimura S
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20061211-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Comparison of the immunomodulatory effects of inurine commensal Lactobacillus and Bacteroides on antigen-specific immune responses by intestinal immune cells derived from germ-free ovalbumin TCR-transgenic mic2006

    • Author(s)
      Tsuda, M., et. al.
    • Organizer
      The 36th Annual Meeting of Japanese Society for Immunology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20061211-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Synergistic activation of Fc receptor y-chain gene expression by Sp-1 and GABP in mast cells2006

    • Author(s)
      Takahashi, K., et. al.
    • Organizer
      The 36th Annual Meeting of Japanese Society for Immunology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20061211-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] CD3IL-2R+ Peyer's patch cells respond to poly I : C stimuli and secrete IL-52006

    • Author(s)
      Umeda, Y., et. al.
    • Organizer
      The 36th Annual Meeting of Japanese Society for Immunology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20061211-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 無菌・コンベンショナルマウスの比較による大腸部位におけるIgA産生に腸内細菌が与える影響について2006

    • Author(s)
      柳橋 努・細野 朗・津田 真人・八村 敏志・高橋 宜聖・平山 和宏・伊藤 喜久治・高橋 恭子・上野川 修一
    • Organizer
      日本食品免疫学会第2回学術大会
    • Place of Presentation
      東京
    • Year and Date
      20061023-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] フラクトオリゴ糖を構成する異なる糖鎖構造のオリゴ糖によって誘導される腸管粘膜IgA産生について2006

    • Author(s)
      細野 朗・柳橋 努・中西 祐輔・村島 弘一郎・深澤 朝幸・高橋 恭子・上野川 修一
    • Organizer
      日本食品免疫学会第2回学術大会
    • Place of Presentation
      東京
    • Year and Date
      20061023-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 無菌マウス由来腸管免疫細胞の培養系においてマウス腸内共生細菌の刺激が抗原特異的なサイトカイン応答を調節する2006

    • Author(s)
      津田 真人・細野 朗・柳橋 努・八村 敏志・平山 和宏・伊藤 喜久治・高橋 恭子・上野川 修一
    • Organizer
      日本食品免疫学会第2回学術大会
    • Place of Presentation
      東京
    • Year and Date
      20061023-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 経口投与したBifidobacterium菌体は腸管免疫組織に取り込まれることで、免疫修飾作用を直接的に誘導する2006

    • Author(s)
      平松 靖浩・細野 朗・武藤 正達・佐藤 隆一郎・高橋 恭子・八村 敏志・上野川 修一
    • Organizer
      日本食品免疫学会第2回学術大会
    • Place of Presentation
      東京
    • Year and Date
      20061023-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 非病原性酵母Candida albicansに対する好中球様HL60細胞のサイトカイン応答2006

    • Author(s)
      三枝 静江・戸塚 護・上野川 修一・細井 知弘
    • Organizer
      日本食品免疫学会第2回学術大会
    • Place of Presentation
      東京
    • Year and Date
      20061023-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 経口免疫寛容において誘導されるT細胞のCD62L/CD44発現パターンと免疫抑制機能.免疫寛容を誘導されたT細胞に特異的に発現する遺伝子の解析2006

    • Author(s)
      田辺 康祐・浜口 修一・伊勢 渉・上野川 修一・佐藤 隆一郎・八村 敏志
    • Organizer
      日本食品免疫学会第2回学術大会
    • Place of Presentation
      東京
    • Year and Date
      20061023-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 難消化性オリゴ糖ラフィノースおよびメリビオースの抗アレルギー免疫調節作用2006

    • Author(s)
      名倉 泰三・富田 響子・八村 敏志・上野川 修一
    • Organizer
      日本食品免疫学会第2回学術大会
    • Place of Presentation
      東京
    • Year and Date
      20061023-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Murine intestinal bacteria modulate antigen-specific cytokine production by intestinal immune cells derived from germ-free TCR-transgenic mice2006

    • Author(s)
      Tsuda M, Hosono A, Yanagibashi T, Hachimura S, Hirayama K, Umesaki Y, Itoh K, Takahashi K, Kaminogawa S.
    • Organizer
      The 19th Annual and International Meeting of Japanese Association for Animal Cell Technology(JAACT2006)
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      20060925-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Oral injection of Bifidobacterium induces immunomodulation directly following the uptake of bacterial components into the intestinal lymphoid tissues2006

    • Author(s)
      Hiramatsu Y, Hosono A, Nakanishi Y, Muto M, Hachimura S, Sato R, Takahashi K, Kaminogawa S.
    • Organizer
      The 19th Annual and International Meeting of Japanese Association for Animal Cell Technology(JAACT2006)
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      20060925-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] In vitro observation of the effect of intestinal bacteria on IgA production by immunocytes in the large intestine:comparison between germ-free and conventional mice2006

    • Author(s)
      Yanagibashi T, Hosono A, Tstuda M, Hachimura S, Hirayama K, Itoh K, Takahashi K, Kaminogawa S.
    • Organizer
      The 19th Annual and International Meeting of Japanese Association for Animal Cell Technology(JAACT2006)
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      20060925-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Murine intestinal bacteria modulate antigen-specific cytokine production by intestinal immune cells derived from germ-free TCR-transgenic mice2006

    • Author(s)
      Tsuda, M., et. al.
    • Organizer
      The 19th Annual and International Meeting of Japanese Association for Animal Cell Technology (JAACT2006) Sep
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20060925-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Oral injection of Bifidobacterium induces immunomodulation directly following the uptake of bacterial components into the intestinal lymphoid tissues2006

    • Author(s)
      Hiramatsu, Y., et. al.
    • Organizer
      The 19th Annual and International Meeting of Japanese Association for Animal Cell Technology (JAACT2006) Sep
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20060925-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vitro observation of the effect of intestinal bacteria on IgA production by immunocytes in the large intestine : comparison between germ-free and conventional mice2006

    • Author(s)
      Yanagibashi, T., et. al.
    • Organizer
      The 19th Annual and International Meeting of Japanese Association for Animal Cell Technology (JAACT2006) Sep
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20060925-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 無菌マウス由来腸管免疫系細胞の抗原特異的なサイトカイン応答に対するマウス常在細菌刺激の影響。2006

    • Author(s)
      津田 真人・細野 朗・柳橋 努・八村 敏志・平山 和宏・梅崎 良則・伊藤 喜久治・上野川 修一
    • Organizer
      第10回腸内細菌学会
    • Place of Presentation
      東京
    • Year and Date
      20060601-02
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 第2章プロバイオティクス乳酸菌と免疫.上野川修一濫修・乳酸菌の保健機能と応用2007

    • Author(s)
      柳橋 努・細野 朗・上野川 修一
    • Total Pages
      15-23(321)
    • Publisher
      シーエムシー出版(東京)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 第2編機能性食品・素材, 第6章免疫アレルギーから見た機能性食品.吉川敏一・大澤俊彦監修:アンチエイジングと機能性食品-今なぜバイオマーカーか2006

    • Author(s)
      細野 朗・上野川 修一
    • Total Pages
      191-205(234)
    • Publisher
      シーエムシー出版(東京)
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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