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2008 Fiscal Year Final Research Report

Analysis of the system for osmosensation, drinking, and body fluid regulation at the cellular, molecular and whole-body levels

Research Project

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Project/Area Number 18380175
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionTottori University

Principal Investigator

SHIBUYA Izumi  Tottori University, 農学部, 教授 (50162649)

Co-Investigator(Renkei-kenkyūsha) KITAMURA Naoki  鳥取大学, 農学部, 准教授 (80301951)
YAMANO Yoshiaki  鳥取大学, 農学部, 教授 (00182593)
ASANO Atsushi  鳥取大学, 農学部, 准教授 (90312404)
Project Period (FY) 2006 – 2008
Keywords浸透圧受容 / 視索上核 / 脳弓下器官 / 背根神経節 / バゾプレシン / カプサイシン / TRP / NGF
Research Abstract

動物の体液浸透圧・体液量の維持機構において、中心的な役割を果たす「浸透圧受容器」ならびに、「浸透圧受容ニューロン」の性質について分子生物学的、細胞生理学的な解析を行い、(1) 浸透圧受容器として想定されているTRPV1受容体がバゾプレシンニューロンの細胞体が存在する視索上核(SON)に局在すること(2) SONニューロンの細胞体には神経終末に比し遙かに多様なCa^(2+)クリアランス機構が存在すること(3) SFOニューロンがGABA、ANP、Galaninの3種の抑制性伝達物質により直接抑制されること(4) NGF投与がTRPV1受容体の選択的アゴニストであるカプサイシン感受性の背根神経節(DRG)ニューロンに自発性Ca^(2+)振動を引き起こすことが明らかとなった。

  • Research Products

    (29 results)

All 2009 2008 2007 2006

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (13 results)

  • [Journal Article] Hypoalgesic behaviors of P/Q-type voltage-gated Ca^<2+> channel mutant mouse rolling mouse Nagoya2009

    • Author(s)
      Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I
    • Journal Title

      Neuroscience 160

      Pages: 165-73

    • Peer Reviewed
  • [Journal Article] NGF-induced hyperexcitability causes spontaneous fluctuations of intracellular Ca^<2+> in rat nociceptive dorsal root ganglion neurons2008

    • Author(s)
      Ozaki Y, Kitamura N, Tsutsumi A, Dayanithi G, Shibuya I
    • Journal Title

      Cell Calcium 45

      Pages: 209-15

    • Peer Reviewed
  • [Journal Article] The role of calcium in the action andrelease of vasopressin and oxytocin fromthe CNS neurons/terminals to the heart2008

    • Author(s)
      Dayanithi G, Viero C, Shibuya I
    • Journal Title

      J Physiol Pharmacol 59 Suppl 8

      Pages: 7-26

    • Peer Reviewed
  • [Journal Article] Overexpression of a new rice vacuolar antiporter regulating protein OsARP improves salt tolerance in tobacco2008

    • Author(s)
      Uddin MI, Qi Y, Yamada S, Shibuya I, Deng XP, Kwak SS, Kaminaka H, Tanaka K
    • Journal Title

      Plant Cell Physiol 49

      Pages: 880-90

    • Peer Reviewed
  • [Journal Article] Chick spinal accessory lobes contain functional neurons expressing voltage-gated sodium channels generating action potentialsChick spinal accessory lobes contain functional neurons expressing voltage-gated sodium channels generating action potentials2008

    • Author(s)
      Yamanaka Y, Kitamura N, Shibuya I
    • Journal Title

      Biomed Res 29

      Pages: 205-211

    • Peer Reviewed
  • [Journal Article] Cloning and expression of a gene encoding gallerimycin, a cysteine-rich antifungal peptide, from eri-silkworm, Samia cynthia ricini2008

    • Author(s)
      Hashimoto K, Yamano Y, Morishima I
    • Journal Title

      Comp, Biochem, Physiol, B Biochem, Mol, Biol 150

      Pages: 229-232

    • Peer Reviewed
  • [Journal Article] Characterization and epitope mapping of monoclonal antibodies to the nucleocapsid protein of severe acute respiratory syndrome coronavirus2008

    • Author(s)
      Kariwa H, Noda H, Nakauchi M, Ishizuka M, Hashiguchi K, Hashimoto S, Yoshii K, Asano A, Agui T, Kogaki H, Kurano Y, Uchida Y, Fujii N, Okada M, Takashima I
    • Journal Title

      Jpn. J. Vet. Res. 55

      Pages: 115-127

    • Peer Reviewed
  • [Journal Article] Expression of Ha-ras suppressor family member 5 gene in the maturing rat testis2008

    • Author(s)
      Yamano Y, Asano A, Ohyama K, Ohta M, Nishio R, Morishima I
    • Journal Title

      Biosci. Biotech. Biochem 72

      Pages: 1360-1363

    • Peer Reviewed
  • [Journal Article] Three peptidoglycan recognition protein (PGRP) genes encoding potential amidase from eri-silkworm, Samia cynthia ricin2007

    • Author(s)
      K. Hashimoto K, Mega Y, Matsumoto Y, Bao Y, Yamano Y, Morishima I
    • Journal Title

      Comp, Biochem, Physiol, B Biochem, Mol, Biol. 148

      Pages: 322-328

    • Peer Reviewed
  • [Journal Article] Peptidoglycan recognition protein (PGRP) from eri-silkworm, Samia cynthia ricini ; protein purification and induction of the gene expression2007

    • Author(s)
      Onoe H, Matsumoto A, Hashimoto K, Yamano Y, Morishima I
    • Journal Title

      Comp. Biochem. Physiol. B Biochem. Mol. Biol. 147

      Pages: 512-519

    • Peer Reviewed
  • [Journal Article] A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism2007

    • Author(s)
      Sasaki N, Hosoda Y, Nagata A, Ding M, Cheng J-M, Miyamoto T, Okano S, Asano A, Miyoshi I, Agui T
    • Journal Title

      Mol. Endocrinol 21

      Pages: 1713-1721

    • Peer Reviewed
  • [Journal Article] A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat2007

    • Author(s)
      Asano A, Tsubomatsu K, Jung C-G, Sasaki N, Agui T
    • Journal Title

      Mammal.Genome 18

      Pages: 779-786

    • Peer Reviewed
  • [Journal Article] Maternal exposure of low dose of TCDD modulates the expression of estrogen receptor subunits of male gonads in offspring2007

    • Author(s)
      Ohyama K, Ohta M, Sano T, Sato K, Nakagomi T, Shimura Y, Yamano Y
    • Journal Title

      J.Vet.Med.Sci. 69

      Pages: 619-625

    • Peer Reviewed
  • [Journal Article] β-1, 3-glucan inducible expression of prophenoloxidase-activating proteinase from eri-silkworm, Samia cynthia ricini2007

    • Author(s)
      Bao Y, Yamano Y, Morishima I
    • Journal Title

      Comp. Biochem. Physiol. B Biochem. Mol. Biol. 147

      Pages: 45-48

    • Peer Reviewed
  • [Journal Article] Pfaff DW. Acute estradiol application increases inward and decreases outward whole-cell currents of neurons in rat hypothalamic ventromedial nucleus2006

    • Author(s)
      Kow L-M, Devidze N, Pataky S, Shibuya I
    • Journal Title

      Brain Res 1116

      Pages: 1-11

    • Peer Reviewed
  • [Journal Article] Deficiency of the tensin2 gene in the ICGN mouse, an animal model for congenital nephrotic syndrome2006

    • Author(s)
      Cho A-R, Uchio-Yamada K, Torigai T, Miyamoto T, Miyoshi I, Matsuda J, Kurosawa T, Kon Y, Asano A, Sasaki N, Agui T
    • Journal Title

      Mamm.Genome 17

      Pages: 407-416

    • Peer Reviewed
  • [Presentation] 鳥類特有の平衡感覚器官に存在するニューロンの細胞生理学的機能の解明2009

    • Author(s)
      北村直樹, 山中祐子, 篠原光, 澁谷泉
    • Organizer
      第19回日本病態生理学会
    • Year and Date
      2009-01-24
  • [Presentation] 精子形成期ラット精巣における精子鞭毛関連遺伝子の発現2008

    • Author(s)
      山野好章、大山建司、太田正法、利谷明繁
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
  • [Presentation] Host-cell-intrinsic antiviral defense induced by type I interferons2008

    • Author(s)
      Asano, A
    • Organizer
      The 5th International Symposium of Aguricultural Science between Japan and Korea
    • Place of Presentation
      Chungnam National University, Korea
    • Year and Date
      2008-11-13
  • [Presentation] ラット精巣におけるNYD-SP14遺伝子発現調節機構に関する検討2008

    • Author(s)
      太田正法、佐野友昭、小林基章、矢ヶ崎英晃、田辺良子、山野好章、大山建司
    • Organizer
      第42回日本小児内分泌学会
    • Place of Presentation
      米子
    • Year and Date
      2008-10-02
  • [Presentation] 鶏脊髄accessory lobeニューロンに発現する新規陽イオンチャネルの同定2008

    • Author(s)
      篠原光、山中祐子、北村直樹、澁谷泉
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎
    • Year and Date
      2008-09-25
  • [Presentation] 運動失調変異マウスRollingNagoyaで見られる侵害刺激感受性の低下2008

    • Author(s)
      小浜陽子、福本奈央、北村直樹、高橋英機、澁谷泉
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎
    • Year and Date
      2008-09-25
  • [Presentation] 精子形成ラット精巣に発現する癌抗原遺伝子の解析2008

    • Author(s)
      神尾高志、浅野淳、大山建司、山野好章
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎
    • Year and Date
      2008-09-24
  • [Presentation] 組換えニワトリインターフェロンλタンパク質の精製2008

    • Author(s)
      増田康充、浅野淳、神尾高志、北村直樹、澁谷泉、山野好章
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎
    • Year and Date
      2008-09-24
  • [Presentation] Mycoplasma pulmonis感染の高感度血清学的モニタリングのための組換えP46-like lipoproteinを用いたELISA法の開発2008

    • Author(s)
      浅野淳、鳥越大輔、高倉彰、佐々木宣哉、安居院高志
    • Organizer
      第55回日本実験動物学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-16
  • [Presentation] ニワトリ脊髄accessory lobeニューロンの機能解明2008

    • Author(s)
      北村直樹、山中祐子、澁谷泉
    • Organizer
      第145回日本獣医学会
    • Place of Presentation
      相模原
    • Year and Date
      2008-03-30
  • [Presentation] ラット背根神経節ニューロンのNGFによる自発性細胞内カルシウム濃度変動2007

    • Author(s)
      尾崎結、北村直樹、澁谷泉
    • Organizer
      第144回日本獣医学会
    • Place of Presentation
      江別
    • Year and Date
      2007-09-04
  • [Presentation] ニワトリ脊髄Accessory Lobe内に存在するニューロンの機能的研究2007

    • Author(s)
      山中祐子、北村直樹、澁谷泉
    • Organizer
      第144回日本獣医学会
    • Place of Presentation
      江別
    • Year and Date
      2007-09-04
  • [Presentation] LECラットのヘルパーT 細胞欠損変異(thid)の原因はPtprk 遺伝子の欠失である2007

    • Author(s)
      浅野淳、坪松耕太、Cha-Gyun Jung、佐々木宣哉、安居院高志
    • Organizer
      第144回日本獣医学会
    • Place of Presentation
      江別
    • Year and Date
      2007-09-04

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Published: 2010-06-10   Modified: 2016-04-21  

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