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2007 Fiscal Year Final Research Report Summary

Functional analysis of glycosaminoglycans as a potential drug target and the decoding of carbohydrate signaling of the functional domains

Research Project

Project/Area Number 18390030
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

SUGAHARA Kazuyuki  Hokkaido University, Faculty of Advanced Life Science, Professor (60154449)

Co-Investigator(Kenkyū-buntansha) KITAGAWA Hiroshi  KOBE Pharmaceutical University, Faculty of Pharmacy, Professor (40221915)
YAMADA Shuhei  HOKKAIDO University, Faculty of Advanced Life Science, Associate Professor (70240017)
MIKAMI Tadahisa  KOBE Pharmaceutical University, Faculty of Pharmacy, Lecturer (20330425)
Project Period (FY) 2006 – 2007
Keywordsdermatan sulfate / iduronic acid / neurite outgrowth / hydra / carbohydrate chain / hepatocyte growth factor / pleiotrophin / chondroitin sulfate
Research Abstract

We isolated for the first time non-sulfated chondroitn, which is a potential drug target, from Hydra. However, it was also found that hyaluronan was not synthesized in Hydra as reported for nematode (C. elegans). Previously, we reported that chondroitin plays critical roles in cytokinesis and cell division in C. elegans (Mizuguchi et al., Nature 2003). Here we identified a chondroitin hydrolase in C. elegans (filed for patent). These results may lead to a discovery of a novel function of chondroitin in Hydra, which has a nervous system. In addition, non-sulfated chondroitin was demonstrated in bird's nest, which has also a potential therapeutic application.
On the other hand, hepatocyte growth factor (HGF) was identified as a regulatory molecule involved in the neurite outgrowth promoting activity of chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains derived from pig brain. Furthermore, it was demonstrated that the molecular mechanisms of such activity involve the signal transduction of HGF and pleiotrophin. In addition, CS/DS hybrid chains, which showed the neurite outgrowth promoting activity, were also found in shark liver but also in king crab cartilage. A novel, sensitive, and non-destructive 1D ^1H-NMR-based method was developed to determine the proportion of iduronic acid and glucuronic acid residues in CS/DS hybrid chains.
The sugar sequences of the CS epitopes drecognized by several antibodies, powerful tools of the functional analysis of CS, were determinded. Furthermore, the molecular shape and the distribution of the electrostatic potential were demonstrated to be critical in the sugar recognition by the antibodies. A part of these results was recently reviewed (Sugahara K., and Mikami T., Curr. Opin. Struct. Biol., 2007).

  • Research Products

    (107 results)

All 2008 2007 2006

All Journal Article (27 results) (of which Peer Reviewed: 12 results) Presentation (76 results) Book (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Determination of Iduronic Acid and Glucuronic Acid in Sulfated Chondroitin/Dermatan Hybrid Chahls by 1H-Nuclear Magnetic Resonance Spectroscopy.2008

    • Author(s)
      Li, F.
    • Journal Title

      Glycocojugate J. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Determination of Iduronic Acid and Glucuronic Acid in Sulfated Chondroitin/Dermatan Hybrid Chains by 1H-Nuclear Magnetic Resonance Spectroscopy.2008

    • Author(s)
      Li, F., Yamada, S., Basappa, Shetty, A. K., Sugiura, M., and Sugahara, K.
    • Journal Title

      Glycoconjugate J. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.2008

    • Author(s)
      Kaneiwa, T., Yamada, S., Mizumoto, S., Montano, A. M., Mitani, S., and Sugahara, K.
    • Journal Title

      J Biol. Chem. 283(22)

      Pages: 15047-15055.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2-O-phosphorylation of xylose and 6-O-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region's synthesis.2008

    • Author(s)
      Tone, Y., Pedersen, L. C., Yamamoto, T., Izumikawa, T., Kitagawa, H., Nishihara, J., Tamura, J., Negishi, M., and Sugahara, K.
    • Journal Title

      J. Biol. Chem. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird's nest).2007

    • Author(s)
      Nakagawa, H.
    • Journal Title

      Glycobiology 17

      Pages: 157-164

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver: Involvement of the pleiotrophin and hepatocyte growth factor sienaline pathways.2007

    • Author(s)
      Li, F.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 2956-2966

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Novel sulfated octa- and decasaccharides from squid cartilage chondroitinsulfate-E: Sequencing and their application for detemination of the epitope structure of monoclonal antibody MO-225.2007

    • Author(s)
      Deepa, S. S.
    • Journal Title

      Biochemistry 46

      Pages: 2453-2465

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Structural Determination of Novel Sulfated Octasaccharides Isolated from Chondroitin Sulfate of Shark Cartilage and Their Application for Characterizing Monoclonal Antibody Epitopes.2007

    • Author(s)
      Deepa, S. S.
    • Journal Title

      Glycobiology 17

      Pages: 631-645

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Glycosaminoglycans in Hydra magnipapillata (Hydrozoa, Cnidaria): demonstration of chondroitin in the developing nematocyst, sting organelle, and structural characterization of glycosaminoglycans.2007

    • Author(s)
      Yamada, S.
    • Journal Title

      Glycobiology 17

      Pages: 886-894

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Functions of Chondroitin Sulfate/Dermatan Sulfate Chains in Brain Development: Critical Roles of E and iE Disaccharide Units Recognized by a Single Chain Antibody GD3G7.2007

    • Author(s)
      Purushothaman, A.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 19442-19452

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Chondroitin/dermatan sulfate in the central nervous system.2007

    • Author(s)
      Sugahara, K.
    • Journal Title

      Curr. Opin. Struct. Biol. 17

      Pages: 536-545

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Chondroitinase-mediated degradation of rare 3-O-sulfated glucuronic acid in functional oversulfated chondroitin sulfate K andE.2007

    • Author(s)
      Fongmoon, D.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 36895-36904

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird's nest).2007

    • Author(s)
      Nakagawa, H., Hama, Y., Sumi, T., Li, S. C., Maskos, K., Kalayanamitra, K., Mizumoto, S., Sugahara, K., and Li, Y. T.
    • Journal Title

      Glycobiology 17(2)

      Pages: 157-164

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver: Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways.2007

    • Author(s)
      Li, F., Shetty, A. K., and Sugahara, K.
    • Journal Title

      J. Biol. Chem. 282(5)

      Pages: 2956-2966

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel sulfated octa- and decasaccharides from squid cartilage chondroitin sulfate-E: Sequencing and their application for determination of the epitope structure of monoclonal antibody MO-2252007

    • Author(s)
      Deepa, S. S., Kalayanamitra, K, Ito, Y., Kongtawelert, P, Fukui, S., Yamada, S., Mikami, T., and Sugahara, K.
    • Journal Title

      Biochemistry 46(9)

      Pages: 2453-2465

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Structural Determination of Novel Sulfated Octasaccharides Isolated from Chondroitin Sulfate of Shark Cartilage and Their Application for Characterizing Monoclonal Antibody Epitopes.2007

    • Author(s)
      Deepa, S. S., Yamada, S., Fukui, S., and Sugahara, K.
    • Journal Title

      Glycobiology 17(6)

      Pages: 631-645

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Glycosaminoglycans in Hydra magnipapillata (Hydrozoa, Cnidaria): demonstration of chondroitin in the developing nematocyst, sting organelle, and structural characterization of glycosaminoglycans.2007

    • Author(s)
      Yamada, S., Morimoto, H., Fujisawa, T., and Sugahara, K.
    • Journal Title

      Glycobiology 17(8)

      Pages: 886-894

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Functions of Chondroitin Sulfate/Dermatan Sulfate Chains in Brain Development: Critical Roles of E and iE Disaccharide Units Recognized by a Single Chain Antibody GD3G7.2007

    • Author(s)
      Purushothaman, A., Fukuda, J., Mizumoto, S., ten Dam, G. B., van Kuppevelt, T. H., Kitagawa, H., Mikami, T., and Sugahara K.
    • Journal Title

      J. Biol. Chem. 282(27)

      Pages: 19442-19452

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chondroitin/dermatan sulfate in the central nervous system.2007

    • Author(s)
      Sugahara, K., and Mikami, T.
    • Journal Title

      Curr. Opin. Struct. Biol. 17

      Pages: 536-545

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Two related but distinct chondroitin sulfate mimetope octasaccharide sequences recognized by monoclonal antibody WF6.2007

    • Author(s)
      Pothacharoen, P., Kalayanamitra, K., Deepa, S. S., Fukui, S., Hattori, T., Fukushima, N., Hardingham, T., Kongtawelert, P., and Sugahara, K.
    • Journal Title

      J. Biol. Chem. 282(48)

      Pages: 35232-35246

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chondroitinase-mediated degradation of rare 3-O-sulfated glucuronic acid in functional oversulfated chondroitin sulfate K and E.2007

    • Author(s)
      Fongmoon, D., Shetty, A. K., Basappa, Yamada, S., Sugiura, M., Kongtawelert, P., and Sugahara, K.
    • Journal Title

      J. Biol. Chem. 282(51)

      Pages: 36895-36904

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Composition of perieuronal net extracellular matrix in rat brain: A diff6rent disaccharide composition for the net-associated proteoglycans.2006

    • Author(s)
      Deepa, S. S.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 17789-17800

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum: Spatiotemporal regulation of the expression of critical disulfateddisaccharides by specific sulfotransferases.2006

    • Author(s)
      Mitsunaga, C.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 18942-18952

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Chondroitin 4-O-sulfotransferase-1 regulates "E" disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity.2006

    • Author(s)
      Uyama, T.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 38668-38674

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Composition of perineuronal net extracellular matrix in rat brain: A different disaccharide composition for the net-associated proteoglycans.2006

    • Author(s)
      Deepa, S. S. Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., and Fawcett, J. W.
    • Journal Title

      J. Biol. Chem. 281(26)

      Pages: 17789-17800

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum: Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases.2006

    • Author(s)
      Mitsunaga, C., Mikami, T., Mizumoto, S., Fukuda, J., and Sugahara, K.
    • Journal Title

      J. Biol. Chem. 281(26)

      Pages: 18942-18952

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chondroitin 4-O-sulfotransferase-1 regulates "E" disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity.2006

    • Author(s)
      Uyama, T., Ishida, M., Izumikawa, T., Trybala, E., Tufaro, F., Bergstrom, T., Sugahara, K., and Kitagawa, H.
    • Journal Title

      J. Biol. Chem. 281(50)

      Pages: 38668-38674

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 線虫Caenorhabditis elegansにおける新規のコンドロイチン加水分解酵素の同定2008

    • Author(s)
      山田 修平
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 線虫Caenorhabditis elegansにおける新規のコンドロイチン加水分解酵素の同定2008

    • Author(s)
      金岩 知之
    • Organizer
      第42回高分子学会北海道支部研究発表会
    • Place of Presentation
      札幌
    • Year and Date
      2008-01-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Two Related but Distinct Chondroitin Sulfate Mimetope Octasaccharide Sequences of Monoclonal Antibody WF6, Which Recognizes a Human Ovarian Tumor Marker.2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 27th Sapporo Cancer Seminar International Symposium
    • Place of Presentation
      札幌
    • Year and Date
      20070712-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Two Related but Distinct Chondroitin Sulfate Mimetope Octasaccharide Sequences of Monoclonal Antibody WF6, Which Recognizes a Human Ovarian Tumor Marker.2007

    • Author(s)
      Peraphan Pothacharoen, Kittiwan Kalayanamitra, Sarama S. Deepa, Shigeyuki Fukui, Tomohide Hattori, Nobuhiro Fukushima, Timothy Hardingham, Prachya Kongtawelert, and Kazuyuki Sugahara
    • Organizer
      The 27^<th> Sapproro Cancer Seminar International Symposium
    • Place of Presentation
      Sapporo
    • Year and Date
      20070712-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Proteoglycan Signaling in Brain Development.2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会)
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] コンドロイチン硫酸(CS)/デルマタン硫酸(DS)中のグルクロン酸(GlcA)とイズロン酸(IdoA)の1H NMR解析による定量2007

    • Author(s)
      山田 修平
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会)
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Chondroitinase-Mediated Degradation of Rare 3-O-Sulfated Glucuronic Acid in Functional Oversulfated Chondroitin Sulfate Chain.2007

    • Author(s)
      Ajaya K Shetty
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会)
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Determination of iduronic acid and glucuronic acid in sulfated chondroitin/dermatan hybrid chains by 1H-nuclear magnetic resonance spectroscopy2007

    • Author(s)
      Fuchuan Li & Shuhei Yamada & Makiko Sugiura & Kazuyuki Sugahara
    • Organizer
      BMB2007
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Chondroitinase-Mediated Degradation of Rare 3-O-Sulfated Glucuronic Acid in Functional Oversulfated Chondroitin Sulfate Chains2007

    • Author(s)
      Ajaya K Shetty, Duriya Fongmoon, Basappa, Shuhei Yamada, Makiko Sugiura, Prachya Kongtawelert and Kazuyuki Sugahara
    • Organizer
      BMB2007
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 「研究成果報告書概要(欧文)」より2007

    • Author(s)
      Kazuyuki Sugahara, Fuchuan Li, Ajaya Shetty, Shuji Mizumoto, Anurag Purushothaman, Junko Fukuda, Chie Mitsunaga, Tadahisa Mikami, Hiroshi Kitagawa, Gerdy B. ten Dam, and Toin H. van Kuppevelt
    • Organizer
      BMB2007
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-12-12
  • [Presentation] Glycobiology of Proteoglycan Signaling in Brain Development.2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      Pierre Fabre Meeting "Proteoglycans and Glycosaminoglycans as Therapeutic Targets and Tools"
    • Place of Presentation
      Soreze, France
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Glycobiology of Proteoglycan Signaling in Brain Development2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      Pierre Fabre Meeting "Proteoglycans and Glycosaminoglycans as Therapeutic Targets and Tools"
    • Place of Presentation
      Soreze, France
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Glycosaminoglycan Research for 30 Years: Structure, Biosynthesis, and Functions.2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      5^<th> International Conference on Proteoglycans
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2007-09-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] サメ軟骨コンドロイチン硫酸由来の八糖の構造解析と抗体のエピトープ解析への応用2007

    • Author(s)
      山田 修平
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] アナツバメ唾液腺(ツバメの巣)由来コンドロイチンプロテオグリカンの同定2007

    • Author(s)
      水本 秀二
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 単クローン抗体MO-225が認識するコンドロイチン硫酸E由来のオリゴ糖の構造解析2007

    • Author(s)
      山田 修平
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 抗コンドロイチン硫酸抗体のエピトープ構造2007

    • Author(s)
      菅原 一幸
    • Organizer
      第27回日本糖質学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2007-08-01
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The epitope structure recognized by anti-chondroitin sulfate antibodies2007

    • Author(s)
      Kazuyuki Sugahara, Sarama S. Deepa, Kittiwan Kalayanamitra, Peraphan Pothacharoen, Prachya Kongtawelert, Yumi Ito, Tadahisa M Ikami, Basappa, Shuhei Yamada, Shigeyuki Fukui, Tim Hardingham, Veronique Blanchard, Franck Chevalier, Anne Imberty, Bas R. Leeflang, Johannis P. Kamerling, Tomohide Hattori, Nobuhiro Hukushima
    • Organizer
      The 27^<th> Japanease Carbohydrate Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-08-01
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structural determination of novel sulfated octasaccharides isolated from chondroitin sulfate of shark cartilage and their application for characterizing monoclonal antibody epitopes2007

    • Author(s)
      Sarama S. Deepa, Shuhei Yamada, Shigeyuki Fukui, Kazuyuki Sugahara
    • Organizer
      The 27^<th> Japanease Carbohydrate Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-08-01
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird's nest)2007

    • Author(s)
      Hiroki Nakagawa, Yoichiro Hama, Toshihisa Sumi, Su-Chen Li, Karol Maskos, Kittiwan Kalayanamitra, Shuji Mizumoto, Kazuyuki Sugahara, Yu-The Li
    • Organizer
      The 27^<th> Japanease Carbohydrate Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-08-01
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Novel Sulfated Octa- and Decasaccharides from Squid Cartilage Chondroitin Sulfate E: Sequencing and Application for Determination of the Epitope Structure of the Monoclonal Antibody MO-2252007

    • Author(s)
      Sarama Sathyaseelan Deepa, Kittiwan Kalayanamitra, Yumi Ito, Prachya Kongtawelert, Shigeyuki Fukui, Shuhei Yamada, Tadahisa Mikami, Kazuyuki Sugahara
    • Organizer
      The 27^<th> Japanease Carbohydrate Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-08-01
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Two Related but Distinct Chondroitin Sulfate Mimetope Octasaccharide Sequences Recognized by Monoclonal Antibody WF6.2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      Glyco 19 (XIX International Symposium on Glycoconjugates)
    • Place of Presentation
      Cairns
    • Year and Date
      2007-07-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Two Related but Distinct Chondroitin Sulfate Mimetope Octasaccharide Sequences Recognized by Monoclonal Antibody WF6.2007

    • Author(s)
      K. Sugahara, P. Pothacharoen, K. Kalayanamitra, S.S. Deepa, S. Fukui, T. Hattori, N. Fukushima, T. Hardingham, and P. Kongtawelert
    • Organizer
      Glycol9 (XLX International Symposium on Glycoconjugates)
    • Place of Presentation
      Cairns
    • Year and Date
      2007-07-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Chondroitinase-Mediated Degradation of Rare 3-O-Sulfated Glucuronicacid in Functional Oversulfated Chondroitin Sulfate Chainsfate Chains.2007

    • Author(s)
      Duriya Fongmoon
    • Organizer
      Glyco 19 (XIX International Symposium on Glycoconjugates)
    • Place of Presentation
      Cairns
    • Year and Date
      2007-07-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Chondroitinase-Mediated Degradation of Rare 3-O-Sulfated Glucuronic acid in Functional Oversulfated Chondroitin Sulfate Chains.2007

    • Author(s)
      D. Fongmoon, A.K. Shetty, B. Basappa, S. Yamada, M. Sugiura, P. Kongtawelert, and K. Sugahara
    • Organizer
      Glycol9 (XIX International Symposium on Glycoconjugates)
    • Place of Presentation
      Cairns
    • Year and Date
      2007-07-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird's nest)2007

    • Author(s)
      水本 秀二
    • Organizer
      第44回 日本生化学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 抗コンドロイチン硫酸D(CS-D)抗体MO-225が認識するCS-E由来のオリゴ糖の構造解析2007

    • Author(s)
      山田 修平
    • Organizer
      第44回 日本生化学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Conformational Studies on Five Chondroitin Sulfate Octasaccharidesusing NMR and Molecular Modeling.2007

    • Author(s)
      Basappa
    • Organizer
      第44回 日本生化学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Neuritogenic Activity And Mechanism of BRAIN Chondroitin/Dermatan Sulfate Hybrid Chains.2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      Benzon Symposium No. 54, "Glycosylation: Opportunities in Drug Development"
    • Place of Presentation
      Copenhagen
    • Year and Date
      2007-06-14
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Neuritogenic Activity And Mechanism of BRAIN Chondroitin/Dermatan Sulfate Hybrid Chains2007

    • Author(s)
      Sugahara K, Li F, & Shetty AK
    • Organizer
      Benzon Symposium No.54, "Glycosylation: Opportunities in Drug Development"
    • Place of Presentation
      Copenhagen
    • Year and Date
      2007-06-14
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Glycobiology of Proteoglycan Signaling in Brain Development.2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      FEBS Advanced Lecture Course, "Matrix Pathobiology, Signaling and Molecular Targets"
    • Place of Presentation
      Patras, Greece
    • Year and Date
      2007-05-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Glycobiology of proteoglycan signaling in brain development.2007

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      FEBS advanced lecture course
    • Place of Presentation
      Patras, Greece
    • Year and Date
      2007-05-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Glycobiology of Proteoglycan Signaling in Brain Development2007

    • Author(s)
      Sugahara K
    • Organizer
      FEBS Advanced Lecture Course, "Matrix Pathobiology, Signaling and Molecular Targets"
    • Place of Presentation
      Patras, Greece
    • Year and Date
      2007-05-23
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] コンドロイチン硫酸(CS)/デルマタン硫酸(DS)中のイズロン酸(IdoA)とグルクロン酸(GlcA)の1H NMR解析による定量2007

    • Author(s)
      山田 修平
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] ブタ胎仔脳とサメ肝臓由来のコンドロイチン/デルマタン硫酸ハイブリッド鎖の神経突起伸長促進活性:プレイオトロフィンンとHGFシグナル伝達経路の関与2007

    • Author(s)
      菅原 一幸
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird's nest).2007

    • Author(s)
      水本 秀二
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Fate and Detection of Rare 3-O-Sulfated Glucuronic Acid-containing Disaccharides in Various Chondroitin Sulfate Preparations.eparations.2007

    • Author(s)
      Ajaya K Shetty
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Fate and Detection of Rare 3-O-Sulfated Glucuronic Acid-containing Disaccharides in Various Chondroitin Sulfate Preparations2007

    • Author(s)
      Ajaya Kumar Shetty, Duriya Fongmoon, Basappa, Shuhei Yamada, Kazuyuki Sugahara
    • Organizer
      The 127th Japanease Pharmaceutical Symposium
    • Place of Presentation
      Toyama
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Determination of iduronic acid and glucuronic acid in sulfated chondroitin/dermatan hybrid chains by 1H-nuclear magnetic resonance spectroscopy2007

    • Author(s)
      Fuchuan Li & Shuhei Yamada & Makiko Sugiura & Kazuyuki Sugahara
    • Organizer
      The 127th Japanease Pharmaceutical Symposium
    • Place of Presentation
      Toyama
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Occurrence of a non-sulfated chondroitin proteoglycan in the dried saliva of collocalia swiftlets (edible bird's nest)2007

    • Author(s)
      Hiroki Nakagawa, Yoichiro Hama, Toshihisa Sumi, Su-Chen Li, Karol Maskos, Kittiwan Kalayanamitra, Shuji Mizumoto, Kazuyuki Sugahara, Yu-The Li
    • Organizer
      The 127th Japanease Pharmaceutical Symposium
    • Place of Presentation
      Toyama
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Functions of chondroitin sulfate/dermatan sulfate in the brain development: Critical roles of"E"and/or"iE"disaccharide units recognized by a single chain antibody GD3G7.2007

    • Author(s)
      菅原 一幸
    • Organizer
      Glycobiology and Sphingobiology 2007 (GS2007)-Hakomori Commemorative Forum-.
    • Place of Presentation
      徳島
    • Year and Date
      2007-02-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Functions of chondroitin sulfate/dermatan sulfate in the brain development: Critical roles of "E" and/or "iE" disaccharide units recognized by a single chain antibody GD3G72007

    • Author(s)
      A. Purushothaman, Junko Fukuda, Shuji Mizumoto, GB. ten Dam, T. H. van Kuppevelt, Hiroshi Kitagawa, Tadahisa Mikami, Kazuyuki Sugahara
    • Organizer
      Glycobiology and Sphingobiology 2007 (GS2007)-Hakomori Commemorative Forum-
    • Place of Presentation
      Tokushima
    • Year and Date
      2007-02-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] CHONDROITIN 4-ο-SULFOTRANSFERASB-1 RFGULATES "E" DISACCHARIDE EXPRESSION OF CHONDROITIN SULFATE REQUIRED FOR HERPES SIMPLEX VIRUS INFECTIVITY.2006

    • Author(s)
      石田 美穂
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      20061206-08
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 小脳の発達に関与するコンドロイチン硫酸/デルマタン硫酸ハイブリッド糖鎖2006

    • Author(s)
      水本 秀二
    • Organizer
      第127回日本薬学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Novel Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Shark Liver, Which Exhibit Potent Neuritogenic Activities Mediaiated by HGF and Pleiotrophin.2006

    • Author(s)
      Li, F.
    • Organizer
      第127回日本薬学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Chondroitin/dermatan sulfate hybrid chain involved in cerebellar development2006

    • Author(s)
      Shuji Mizumoto, Chie Mitsunaga, Junko Fukuda, Tadahisa Mikami, Kazuyuki Sugahara
    • Organizer
      The 127<th> Japanease Pharmaceutical Symposium (Hokkaido branch)
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Novel Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Shark Liver, Which Exhibit Potent Neuritogenic Activities Mediated by HGF and Pleiotrophin2006

    • Author(s)
      Fuchuan Li, Ajaya Kumar Shetty, Kazuyuki Sugahara
    • Organizer
      The 127<th> Japanease Pharmaceutical Symposium (Hokkaido branch)
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Development of Analytical Method to Detect Rare 3-ο-Sulfated Glucuronic Acid-containing Disaccharides in Various Chondroitin Sulfate Preparations.2006

    • Author(s)
      Duriya Fongmoon
    • Organizer
      第43回日本生化学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2006-11-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] コンドロイチン硫酸Eは単純ヘルペスウィルスのglycoprotein Cに直接結合し、抗ウィルス活性を発揮する2006

    • Author(s)
      山田 修平
    • Organizer
      第43回日本生化学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2006-11-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Development of Analytical Method to Detect Rare 3-O-Sulfated Glucuronic Acid-containing Disaccharides in Various Chondroitin Sulfate Preparations2006

    • Author(s)
      Duriya Fongmoon, Ajaya Kumar Shetty, Basappa, Shuhei Yamada, Kazuyuki Sugahara
    • Organizer
      The 43th Japanease Biochemistry Symposium (Hokkaido Branch)
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-11-03
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Development of Analytical Method to Detect Rare 3-ο-Sulfated Glucuronic Acid-containing Disaccharides in Various Chondroitin Sulfate Preparations.2006

    • Author(s)
      Duriya Fongmoon
    • Organizer
      第26回日本糖質学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-08-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 脳の発達におけるコンドロイチン/デルマタン硫酸ハイブリッド鎖の機能2006

    • Author(s)
      菅原 一幸
    • Organizer
      第26回日本糖質学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 単純ヘルペスウィルスの感染に関わるコンドロイチン硫酸E2006

    • Author(s)
      山田 修平
    • Organizer
      第26回日本糖質学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 脳の発達段階におけるE/iEユニット含有コンドロイチン硫酸/デルマタン硫酸鎖の発現2006

    • Author(s)
      福田 純子
    • Organizer
      第26回日本糖質学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 小脳の発達に関与するコンドロイチン硫酸/デルマタン硫酸ハイブリッド糖鎖2006

    • Author(s)
      水本 秀二
    • Organizer
      第26回日本糖質学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Novel Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Shark Liver, Which Exhibit Specific Growth Factor-binding and Potent Neuritogenic Activities.2006

    • Author(s)
      Li, F.
    • Organizer
      第26回日本糖質学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] A Novel Pleotrophin-Binding Hexasaccharide Sequence Isolated from Shark Skin Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains.2006

    • Author(s)
      Li, F.
    • Organizer
      第26回日本糖質学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Novel Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Shark Liver, Which Exhibit Specific Growth Factor-binding and Potent Neuritogenic Activities2006

    • Author(s)
      Fuchuan Li, Ajaya Kumar Shetty, Kazuyuki Sugahara
    • Organizer
      XXVIth Japanease Carbohydrate Symposium
    • Place of Presentation
      Sendai
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] A Novel Pleotrophin-Binding Hexasaccharide Sequence Isolated from Shark Skin Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains2006

    • Author(s)
      Fuchuan Li, Chilkunda D. Nandini, Xingfeng Bao, Takashi Muramatsu, Kazuyuki Sugahara
    • Organizer
      XXVIth Japanease Carbohydrate Symposium.
    • Place of Presentation
      Sendai
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Development of Analytical Method to Detect Rare 3-O-Sulfated Glucuronic Acid-containing Disaccharides in Various Chondroitin Sulfate Preparations2006

    • Author(s)
      Duriya Fongmoon, Ajaya Kumar Shetty, Basappa, Shuhei Yamada, Kazuyuki Sugahara
    • Organizer
      XXVIth Japanease Carbohydrate Symposium.
    • Place of Presentation
      Sendai
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Functions and structural motifs of chondroitin sulfate/dermatan sulfate.2006

    • Author(s)
      菅原 一幸
    • Organizer
      The 12th Gordon Research Conference on Proteoglycans.
    • Place of Presentation
      Andover, USA
    • Year and Date
      2006-07-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Functions and structural motifs of chondroitin sulfate/dermatan sulfate2006

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 12<th> Gordon Research Conference on Proteoglycans
    • Place of Presentation
      Andover, USA
    • Year and Date
      2006-07-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum: spatiotemporal regulation of the expression of critical disulfated disaccharide by specific sulfotransferases.2006

    • Author(s)
      菅原 一幸
    • Organizer
      5th International Symposium on Glycosyltransferases.(GlycoT 2006)
    • Place of Presentation
      つくば
    • Year and Date
      2006-06-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum: spatiotemporal regulation of the expression of critical disulfated disaccharide by specific sulfotransferases2006

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      5<th> International Symposium on Glycosyltransferases (GlycoT 2006)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2006-06-27
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Chondroitin Sulfate E Directly Interacts with Herpes Simplex Virus Attachment Glycoprotein C and Exhibits Potent Antiviral Activity.2006

    • Author(s)
      内藤 聡美
    • Organizer
      第20回国際生化学・分子生物学会議
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Chondroitin Sulfate E Directly Interacts with Herpes Simplex Virus Attachment Glycoprotein C and Exhibits Potent Antiviral Activity2006

    • Author(s)
      Satomi Naito, Shuhei Yamada, Kicki Bergefall, Edward Trybala, Maria Johansson, Torn Uyama, Hiroshi Kitagawa, Kazuyuki Sugahara, Tomas Bergstrom
    • Organizer
      20^<th> IUBMB International Congress of Biochemistry and Molecular Biology and 11<th> FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Functions of chondroitin sulfate/dermatan sulfate in the brain development:Critical roles of E and/or iE disaccharide units recognized by a specific antibody.2006

    • Author(s)
      菅原 一幸
    • Organizer
      Extracellular Glycomatrix in Health and Disease.
    • Place of Presentation
      淡路島
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Chondroitinase ACI-resistant hexasaccharides isolated from shark cartilage chondroitin sulfate: Structures and binding activities toward signaling molecules and antibody.2006

    • Author(s)
      Kittiwan Kalayanamitra
    • Organizer
      Extracellular Glycomatrix in Health and Disease.
    • Place of Presentation
      淡路島
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structural determination of a sulfated octasaccharide isolated from shark cartilage chondroitin sulfate.2006

    • Author(s)
      Kittiwan Kalayanamitra
    • Organizer
      Extracellular Glycomatrix in Health and Disease.
    • Place of Presentation
      淡路島
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Glycosaminoglycans in Hydra magnipapillata.2006

    • Author(s)
      山田 修平
    • Organizer
      Extracellular Glycomatrix in Health and Disease.
    • Place of Presentation
      淡路島
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Functions of chondroitin sulfate/dermatan sulfate in the brain development: Critical roles of E and/or iE disaccharide units recognized by a specific antibody2006

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      Extracellular Glycomatrix in Health and Disease
    • Place of Presentation
      Awaji
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Chondroitinase ACI-resistant hexasaccharides isolated from shark cartilage chondroitin sulfate: Structures and binding activities toward signaling molecules and antibody2006

    • Author(s)
      Kittiwan Kalayanamitra, Shuji Mizumoto, Sarama Sathyaseelan Deepa, Prachya Kongtawelert, Shigeyuki Fukui, Kazuyuki Sugahara
    • Organizer
      Extracellular Glycomatrix in Health and Disease
    • Place of Presentation
      Awaji
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structural determination of a sulfated octasaccharide isolated from shark cartilage chondroitin sulfate2006

    • Author(s)
      Peraphan Pothacharoen, Kittiwan Kalayanamitra, Sarama Sathyaseelan Deepa, Timothy Hardingham, Kazuyuki Sugahara, P rachya Kongtawelert
    • Organizer
      Extracellular Glycomatrix in Health and Disease
    • Place of Presentation
      Awaji
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Glycosaminoglycans in Hydra magnipapillata2006

    • Author(s)
      Shuhei Yamada, Hideto Morimoto, Toshitaka Fujisawa, Kazuyuki Sugahara
    • Organizer
      Extracellular Glycomatrix in Health and Disease
    • Place of Presentation
      Awaji
    • Year and Date
      2006-06-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 小脳の発達に関与するコンドロイテン硫酸/デルマタン硫酸ハイブリッド糖鎖:コンドロイチン硫酸/デルマタン硫酸に特異的な硫酸基転移酵素による空間時間特異的な硫酸化糖鎖の発現調節2006

    • Author(s)
      水本 秀二
    • Organizer
      北海道大学先端生命科学研究院付属次世代ポストゲノム研究センター発足記念シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2006-05-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Novel Chondroitin sulfate/Dermatan Sulfate Hybrid Chains from Shark Liver, Which Exhibit Specific Growth Factor-binding and Potent Neuritogenic Activities.2006

    • Author(s)
      Li, F.
    • Organizer
      北海道大学先端生命科学研究院付属次世代ポストゲノム研究センター発足記念シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2006-05-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Comprehensive Glycoscience (Kamerling J.P., ed.) vol.32007

    • Author(s)
      Uyama, T.
    • Total Pages
      79-104
    • Publisher
      Elsevier (Amsterdam)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] グリコサミノグリカン糖鎖の構造解析法2006

    • Author(s)
      山田 修平
    • Total Pages
      89-97
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] コンドロイチン硫酸/デルマタン硫酸による神経突起形成の調節2006

    • Author(s)
      水本 秀二
    • Total Pages
      84-91
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] ムコ多糖分解促進剤2007

    • Inventor(s)
      菅原一幸, 山田修平, 水本秀二
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      特願2007-291424
    • Filing Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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