2009 Fiscal Year Final Research Report
Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury
| Project/Area Number |
18390042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hokuriku University |
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Principal Investigator |
KAJI Toshiyuki Hokuriku University, 薬学部, 教授 (90204388)
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| Co-Investigator(Kenkyū-buntansha) |
山本 千夏 北陸大学, 薬学部, 准教授 (70230571)
藤原 泰之 愛知学院大学, 薬学部, 准教授 (40247482)
周尾 卓也 東京大学, 医科学研究所, 特任研究員 (90399006)
廣岡 孝志 北陸大学, 薬学部, 研究員 (50397519)
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| Project Period (FY) |
2006 – 2009
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| Keywords | メチル水銀 / 血管 / 内皮細胞 / 周皮細胞 / 脳 / 毒性 |
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| Research Abstract |
Methylmercury is an organic metal that is contained in fish at high levels. Proteoglycans are macromolecules that consist of a core protein and glycosaminoglycan side chains. In this study, it was found that biological systems regulated by proteoglycans, including FGF-2 and VEGF systems, are important for the vascular toxicity of methylmercury. In addition, we proposed "Inflammatory hypothesis" as the pathogenesis of cerebellar damage caused by methylmercury.
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Research Products
(23 results)
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[Journal Article] Resistance of human brain microvascular endothelial cells in culture to methylmercury: Cell-density-dependent defense mechanisms.2010
Author(s)
Hirooka, T., Fujiwara, Y., Shinkai, Y., Yamamoto, C., Yasutake,, A., Satoh, M., Eto, K., Kaji, T.
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Journal Title
J. Toxicol. Sci. (in press)
Peer Reviewed
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[Journal Article] Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes.2010
Author(s)
Hirooka, T., Fujiwara, Y., Minami, Y., Ishii, A., Ishigooka, M., Shinkai, Y., Yamamoto, C., Satoh, M., Yasutake, A., Eto, K., Kaji, T.
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Journal Title
Toxicol.In Vitro 24
Pages: 835-841
Peer Reviewed
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[Journal Article] Suppression of fibroblast growth facor-2 expression: Possible mechanism underlying the methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells.2009
Author(s)
Hirooka, T., Fujiwara, Y., Inoue, S., Shinkai, Y., Yamamoto, C., Masahiko, S., Yasutake, A., Eto, K., Kaji, T.
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Journal Title
J. Toxicol. Sci. 34
Pages: 433-439
Peer Reviewed
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[Journal Article] Arsenite but not arsenate Inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells.2008
Author(s)
Fujiwara, Y., Yamamoto, C., Hirooka, T., Terada, N., Satoh, M., Kaji, T.
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Journal Title
J. Toxicol. Sci. 33
Pages: 487-492
Peer Reviewed
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[Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells.2006
Author(s)
Kaji, T., Yamamoto, C., Oh-i, M., Fujiwara, Y., Yamazaki, Y., Morita, T., Plaas, A.H., Wight, T.N.
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Journal Title
Biochim. Biophys. Acta 1760
Pages: 1465-1474
Peer Reviewed
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