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2008 Fiscal Year Final Research Report

Biopharmaceutical Study on Organic Ions Transporters Which Act as Central Nervous System Modulators

Research Project

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Project/Area Number 18390054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionRitsumeikan University (2007-2008)
Kyoto Pharmaceutical University (2006)

Principal Investigator

FUJITA Takuya  Ritsumeikan University, 薬学部, 教授 (00247785)

Project Period (FY) 2006 – 2008
Keywords中枢神経系 / トランスポーター / 神経化学 / 受容体 / 薬物輸送 / 遺伝子発現
Research Abstract

本研究では、グリア細胞自身が神経伝達物質の回収に関与するトランスポーターのみならず、情報伝達物質に対する様々な受容体、チャネルをも発現している知見をもとに、中枢神経系に発現する生体有機イオンに対する様々なトランスポーターがイオンチャネルや受容体の機能発現の調節を担っている可能性も見出した。 さらに、中枢における生体物質輸送にかかわる様々な有機イオントランスポーターの発現と機能解析を精力的に行い、これらトランスポーターの分子的実体について明らかにした。

  • Research Products

    (24 results)

All 2009 2008 2007 2006

All Journal Article (13 results) Presentation (10 results) Book (1 results)

  • [Journal Article] Functional characterization and cloning of amino acid transporter B^<0,+> (ATB^<0,+>) in primary cultured rat pneumocytes2008

    • Author(s)
      T. Uchiyama, T. Fujita, H. J. Gukasyan, K. -J. Kim, Z. Borok, E. D. Crandall and V. H. L. Lee
    • Journal Title

      J. Cell. Physiol 214

      Pages: 645-654

  • [Journal Article] P-glycoprotein restricts the penetration of Oseltamivir across the blood-brain barrier2008

    • Author(s)
      A. Ose, H. Kusuhara, K. Yamatsugu, M. Kanai, M. Shibasaki, T. Fujita, A. Yamamoto and Y. Sugiyama
    • Journal Title

      Drug Metab. Dispos 36

      Pages: 427-434

  • [Journal Article] Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein2008

    • Author(s)
      K. Morimoto, M. Nakakariya, Y. Shirasaka, C. Kakinuma, T. Fujita I. Tamai and T. Ogihara
    • Journal Title

      Drug Metab. Dispos 36

      Pages: 6-9

  • [Journal Article] Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers towards effective intestinal absorption2007

    • Author(s)
      Y. Hayashi, K. Takayama, Y. Suehisa, T. Fujita, J.-T. Nguyen, S. Futaki, A. Yamamoto and Y. Kiso
    • Journal Title

      Bioorg. Med. Chem Lett 17

      Pages: 5129-5132

  • [Journal Article] Identity of the high-affinity sodium/carboxylate cotransporter NaC3 as the N-acetyl-L-aspartate transporter2006

    • Author(s)
      V. Ganapathy and T. Fujita
    • Journal Title

      Adv ExpMed Biol 576

      Pages: 67-76

  • [Journal Article] What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine2006

    • Author(s)
      T. Ogihara, M. Kamiya, M. Ozawa, T. Fujita, A. Yamamoto, S. Yamashita, S. Ohnishi and Y. Isomura
    • Journal Title

      Drug Metab. Pharmacokinet 21

      Pages: 238-244

  • [Journal Article] Functional expression of taurine transporter and its up-regulation in developing neurons from mouse cerebral cortex2006

    • Author(s)
      T. Fujita, A. Shimada, M. Wada, S. Miyakawa and A. Yamamoto
    • Journal Title

      Pharm. Res 23

      Pages: 689-696

  • [Journal Article] Functional characterization of Na^+-coupled citrate transporter NaC2/NaCT expressed in primary cultures of neurons from mouse cerebral cortex2006

    • Author(s)
      M. Wada, A. Shimada and T. Fujita
    • Journal Title

      Brain Res 1081

      Pages: 92-100

  • [Journal Article] Functional and molecular identification of sodium-coupled dicarboxylate transporters in primary cultured cerebrocortical astrocytes and neurons2006

    • Author(s)
      E. Yodoya, M. Wada, A. Shimada, H. E. Yodoya, M. Wada, A. Shimada, H. Katsukawa, N. Okada, A. Yamamoto, V. Ganapathy and T. Fujita
    • Journal Title

      J. Neurochem 97

      Pages: 162-173

  • [Journal Article] Functional characterization of Zn^<2+>-sensitive GABA transporter expressed in primary cultures of astrocytes from rat astrocytes2006

    • Author(s)
      Q. Wu, M. Wada, A. Shimada, N. Okada, A. Yamamoto and T. Fujita
    • Journal Title

      Brain Res 1075

      Pages: 99-108

  • [Journal Article] Functional expression of metabotropic γ-aminobutyric acid GABA_B receptor in primary culture of astrocytes from rat cerebral cortex. Biochem. Biophys2006

    • Author(s)
      M. Oka, M. Wada, Q. Wu, A. Yamamto and T. Fujita
    • Journal Title

      Res. Commun 341

      Pages: 874-881

  • [Journal Article] Functional characterization of Na^<+>-independent choline transport in primary cultures of neurons from mouse cerebral cortex2006

    • Author(s)
      T. Fujita, A. Shimada, N. Okada and A. Yamamoto
    • Journal Title

      Neurosci. Lett 393

      Pages: 216-221

  • [Journal Article] Functional characteristics of H^+-dependent nicotinic acid transport in primary cultures of astrocytes from rat cerebral cortex2006

    • Author(s)
      A. Shimada, Y. Nakagawa, H. Morishige, A. Yamamoto and T. Fujita
    • Journal Title

      Neurosci. Lett 392

      Pages: 207-212

  • [Presentation] 脳脊髄液中薬物濃度が脳中遊離型薬物濃度の指標となるための条件解析2009

    • Author(s)
      小平浩史, et.al.
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡県コンベンションセンター(静岡)
    • Year and Date
      2009-05-23
  • [Presentation] ラットアストロサイトにおけるH^+依存症ニコチン酸の輸送特性2008

    • Author(s)
      松元靖浩, et.al.
    • Organizer
      第2回創剤フォーラム若手研究発表討論会
    • Place of Presentation
      京都薬科大学(京都)
    • Year and Date
      20081000
  • [Presentation] Can drug concentration in the cerebrospinal fluid be a surrogate for the unbound concentration of CNS drugs in the brain?2008

    • Author(s)
      H. Kodaira, et.al.
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館(熊本)
    • Year and Date
      2008-10-30
  • [Presentation] Functional characterization of Na^+-independent choline transport in primary cultures of neurons from mouse cerebral cortex. Pharmaceutical2007

    • Author(s)
      S. Fujiwara, et.al.
    • Organizer
      Sciences World Congress
    • Place of Presentation
      Amsterdam (Netherlands)
    • Year and Date
      20070400
  • [Presentation] Analysis of distribution mechanism of oseltamivir in the brain2007

    • Author(s)
      A. Ose, et.al.
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2007-11-27
  • [Presentation] Transport characteristics of N-acetyl-L-aspartate mediated Na^+-coupled dicarboxylate transporter NaC3 and its functional linkage with organic anion transporter OAT32007

    • Author(s)
      S. Fujiwara, et.al.
    • Organizer
      8th International ISSX meeting
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2007-10-12
  • [Presentation] Na^+/Cl^-依存性GABAトランスポーターGAT1の関与2006

    • Author(s)
      藤原史織, et.al.
    • Organizer
      第21回日本薬物動態学会年会
    • Place of Presentation
      江戸川区民センター(東京)
    • Year and Date
      20061100
  • [Presentation] ラット初代培養アストロサイトにおけるH^+依存症ニコチン酸輸送機能特性2006

    • Author(s)
      松元靖浩, et.al.
    • Organizer
      第21回日本薬物動態学会年会
    • Place of Presentation
      江戸川区民センター(東京)
    • Year and Date
      20061100
  • [Presentation] マウス大脳皮質ニューロンにおけるカルニチンの輸送機構 : Na+/Cl-依存性GABAトランスポーターGAT1の関与2006

    • Author(s)
      藤原史織, et.al.
    • Organizer
      第2回創剤フォーラム若手研究発表討論会
    • Place of Presentation
      京都薬科大学(京都)
    • Year and Date
      20061000
  • [Presentation] Functional characterization of organic solute transporters in central nervous system2006

    • Author(s)
      Takuya Fujita
    • Organizer
      The 3^<rd> Korea-Japan Joint Symposium on Drug Delivery and Therapy
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      20060400
  • [Book] Identity of thehigh-affinity sodium/carboxylate cotransporter NaC3 as the N-acetyl-L-aspartate transporter2006

    • Author(s)
      V. Ganapathy and T. Fujita
    • Total Pages
      576, 67-76
    • Publisher
      Adv ExpMed Biol

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Published: 2010-06-10   Modified: 2016-04-21  

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