2008 Fiscal Year Final Research Report
Study for lymphangiogenesis and tumor immunity by artificial lymphoid tissue construction
| Project/Area Number |
18390062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | National Institute of Biomedical Innovation |
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Principal Investigator |
SUEMATSU Sachiko National Institute of Biomedical Innovation, 基盤的研究部免疫細胞制御プロジェクト, プロジェクトリーダー (50250345)
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| Research Collaborator |
HATTORI Yuki 独立行政法人 医薬基盤研究所, 基盤的研究部免疫細胞制御プロジェクト, 特任研究員
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| Project Period (FY) |
2006 – 2008
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| Keywords | リンパ管 / 血管 / リンパ球ホーミング / 適応免疫 / ストローマ細胞 / 細胞傷害性 / T細胞活性 |
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| Research Abstract |
A tissue-engineered artificial lymphoid tissue (aLT) can be constructed by introducing stromal cells embedded in a collagenous scaffold. In this study, we confirmed functional efferent lymphatic vessel formation in aLTs. It was revealed aLTs had specialized blood vessels distinct from ordinary blood vessels or high endothelial venules. Further, we found that activated lymphocytes were concentrated in aLTs, which enabled aLTs to introduce effective cytotoxic T cell activities in severe-combined immunodeficient mice. Our data suggested that possible therapeutic application of aLTs for adaptive immunity activation against intractable infectious diseases or cancer.
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