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2007 Fiscal Year Final Research Report Summary

Clock gene response against skelton type entrainment stimulation in mice

Research Project

Project/Area Number 18390071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionWaseda University

Principal Investigator

SHIBATA Shigenobu  Waseda University, Faculty of Science and Engineering, Professor (10162629)

Co-Investigator(Kenkyū-buntansha) HORIKAWA Kazumasa  Waseda University, Faculty of Human Sciences, Assistant professor (80386664)
KUDO Takashi  Waseda University, Faculty of Science and Engineering, Assistant Professor (10434284)
Project Period (FY) 2006 – 2007
Keywordscircadian / clock gene / food anticipation / liver / light entrainment / nutrition / chrononutrition
Research Abstract

The aim of this experiment is to elucidate the mechanism of skeleton-type photic and non-photic entrainment like food entrainment in mice. First we examined the circadian pattern of clock gene expression in the liver under one-hr light stimulation in the morning and one-hr light stimulation in the evening. This lighting schedule could entrain the locomotor activity rhythm and also liver dock gene expression rhythm. Thus, skeleton lighting schedule can entrain the circadian dock just like usual 12-hr light-dark schedule. Next, we examined the circadian pattern of clock gene expression in the liver under 2-hr feeding in the morning and 2-hr feeding in the evening. This feeding schedule could entrain the liver clock gene expression rhythm, and its pattern was very similar to adlib feeding group. Thus, two feeding times per day with morning and evening could entrain the peripheral circadian rhythm. In the third experiment, we changed the ratio of feeding volume in the morning and evening. If the more feeding volume was applied in the morning, there was little effect on the phase of dock gene expression. However, if the more feeding volume was applied in the evening, phase of dock gene expression rhythm was strongly delayed. Taken together these results suggest that food intake in the morning is important to keep the phase of dock gene expression the peripheral organs.

  • Research Products

    (10 results)

All 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice2008

    • Author(s)
      Iwahana E, Karatsoreos I, Shibata S, Silver R.
    • Journal Title

      Hormone behavior 53

      Pages: 422-430

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet2008

    • Author(s)
      Kudo T, Kawashima M, Tamagawa T, Shibata S.
    • Journal Title

      Am J Physiol Endocrinol Metab 294

      Pages: E120-130

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice.2008

    • Author(s)
      Iwahana E, Karatsoreos I, Shibata S, Silver R.
    • Journal Title

      Hormone and behavior 53

      Pages: 422-430

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.2008

    • Author(s)
      Kudo T, Kawashima M, Tamagawa T, Shibata S.
    • Journal Title

      Am J. Physiol. Endocrinol. Metab. 294

      Pages: E120-130

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Attenuating effect of clock mutation on triglyceride contentd in the ICR mouse liver under a high-fat diet2007

    • Author(s)
      Kudo T, Tamagawa T, Kawashima M, Mito N, Shibata S.
    • Journal Title

      J Biol Rhythms 22

      Pages: 312-323

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Multifactorial rugulation of daily rhythms in expression of the metabolically responsive gene spot14 in the mouse liver2007

    • Author(s)
      Ishihara A, Matsumoto E, Horikawa K, Kudo T, Shibata S, Takiguchi M.
    • Journal Title

      J Biol Rhythms 22

      Pages: 324-334

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders2007

    • Author(s)
      Shirai H, Oishi K, Kudo T, Shibata S, Ishida N.
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 679-682

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet.2007

    • Author(s)
      Kudo T, Tamagawa T, Kawashima M, Mito N, Shibata S.
    • Journal Title

      J Biol. Rhythms. 22

      Pages: 312-323

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene spotl4 in the mouse liver.2007

    • Author(s)
      Ishihara A, Tamura Y, Shibata S, Takiguchi M.
    • Journal Title

      J Biol. Rhythms. 22

      Pages: 324-334

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.2007

    • Author(s)
      Shirai H, Oishi K, Kudo T, Shibata S, Ishida N.
    • Journal Title

      Biochem. Biophys. Res. Commun. 357

      Pages: 679-682

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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