Estrogen in human lung cancer-intratumoral hormone production and analysis of intracrine mechanisms-

2008 Fiscal Year Final Research Report

• Project/Area Number: 18390109
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tohoku University
• Principal Investigator: SASANO Hironobu Tohoku University, 大学院・医学系研究科, 教授 (50187142)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Satoshi 東北大学, 病院, 講師 (50344669)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629) ; HAYASHI Shin-ichi 東北大学, 大学院・医学系研究科, 教授 (60144862) ; MIKI Yasuhiro 東北大学, 医学部, 助教 (50451521)
• Project Period (FY): 2006 – 2008
• Keywords: 肺癌 / エストロゲン / アロマタ-ゼ / エストロゲン受容体 / Intracrinology / STS / EST / アンドロゲン

Research Abstract

ヒト肺癌でのE2レベルは腫瘍部位で非腫瘍部位よりも高い濃度で認められ、種々の方法で検討した結果腫瘍細胞でアロマターゼの発現が認められた。次に肺癌培養細胞の検討で肺癌組織内でのE2濃度で有意に細胞増殖を刺激され、種々の受容体拮抗剤でその増殖は抑制された。肺癌における腫瘍内アロマターゼは腫瘍細胞で発現しているERβと有意の相関を示し、特に腺癌ではアロマターゼ及びSTSを中心とした合成酵素により腫瘍局所でエストロゲンが合成され腫瘍細胞核のERβを介して作用している事が考えられた。

Research Products

• [Journal Article] Steroid Sulfatase and Estrogen Sulfotransferase in Colon Carcinoma : Regulators of Intratumoral Estrogen Concentrations and Potent Prognostic Factors (2009)
  • Author(s): Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, Miki Y, Akahira J, Kamogawa Y, Nagasaki S, Yamamoto K, Ii T, Egawa S, Evans DB, Unno M, Sasano H
  • Journal Title: Cancer Res 69 Pages: 914-922
  • Peer Reviewed
• [Journal Article] 17Beta-hydroxysteroid dehydrogenase type 12 in human breast carcinoma : a prognostic factor via potential regulation of fattyacid synthesis (2009)
  • Author(s): Nagasaki S, Suzuki T, Miki Y, Akahira J, Kitada K, Ishida T, Handa H, Ohuchi N, Sasano H
  • Journal Title: Cancer Res 69 Pages: 1392-1399
  • Peer Reviewed
• [Journal Article] New developments in intracrinology of human breast cancer : estrogen sulfatase and sulfotransferase (2009)
  • Author(s): Sasano H, Nagasaki S, Miki Y, Suzuki T
  • Journal Title: Ann N Y Acad Sci 1155 Pages: 76-79
  • Peer Reviewed
• [Journal Article] Intratumoral estrogen and estrogen receptors in human non-small cell lung carcinoma (2008)
  • Author(s): Niikawa H, Suzuki T, Miki Y, Suzuki S, Nagasaki S, Akahira J-I, Honma S, D.B. Evans, Hayashi S-I, Kondo T, Sasano H
  • Journal Title: Clinical Cancer Research 14 Pages: 4417-4426
  • Peer Reviewed
• [Journal Article] Early growth responsive gene 3 in human breast carcinoma : a regulator of estrogen-meditated invasion and a potent prognostic factor (2007)
  • Author(s): Suzuki T, Inoue A, Miki Y, Moriya T, Akahira J, Ishida T, Hirakawa H, Yamaguchi Y, Hayashi S, Sasano H
  • Journal Title: Endocrine- Related Cancer 14 Pages: 279-292
  • Peer Reviewed
• [Journal Article] Hormonal markers in breast cancer : coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study (2007)
  • Author(s): Yang XR, Pfeiffer RM, Garcia-Closas M, Rimm DL, Lissowska J,Brinton LA, Peplonska B, Hewitt SM, Cartun RW, Mandich D, Sasano H, Evans DB, Sutter TR, Sherman ME
  • Journal Title: Cancer Research 67 Pages: 10608-10617
  • Peer Reviewed
• [Journal Article] Aromatase localization in human breast cancer tissues-possible interactions between intratumoral stromal and parenchymal cells (2007)
  • Author(s): Miki Y, Suzuki T, Tazawa C, Yamaguchi Y, Kitada K, Honma S, Moriya T, Hirakawa H, Evans D B, Hayashi S, Ohuchi N, Sasano H
  • Journal Title: Cancer Research 67 Pages: 3945-3954
  • Peer Reviewed
• [Journal Article] 5alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production (2007)
  • Author(s): Suzuki T, Miki Y, Moriya T, Akahira JI, Ishida T, Hirakawa H, Yamaguchi Y, Hayashi SI, Sasano H
  • Journal Title: International Journal of Cancer 120 Pages: 285-291
  • Peer Reviewed
• [Journal Article] Analysis of surrogate markers for target-specific therapy in breast carcinomas using archival materials (2007)
  • Author(s): Sasano H, Suzuki T, Moriya T
  • Journal Title: Biomedicine & Pharmacotherapy 61 Pages: 543-547
  • Peer Reviewed
• [Journal Article] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells : A possible androgenic bone protective effects induced by exemestane (2007)
  • Author(s): Miki Y, Suzuki T, Hatori M, Igarashi K, Aisaki K, Kanno J, Nakamura Y, Uzuki M, Sawai T, Sasano H
  • Journal Title: Bone 40 Pages: 876-887
  • Peer Reviewed
• [Journal Article] Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma (2007)
  • Author(s): Miki Y, Suzuki T, Kitada K, Yabuki N, Shibuya R, Moriya T, Ishida T, Ohuchi N, Blumberg B, Sasano H
  • Journal Title: Cancer Research 66 Pages: 535-542
  • Peer Reviewed
• [Presentation] Aromatase and in situ estrogen production in DCIS(ductal carcinoma in situ)of human breast Ninth International Aromatase (2008)
  • Author(s): H Sasano, Y Miki, R Shibuya,T Suzuki
  • Organizer: Conference
  • Place of Presentation: Shanghai(China)
  • Year and Date: 20081013-17
• [Presentation] Immunolocalization of COUP-TF in human breast carcinoma : a possible prognostic factor (2008)
  • Author(s): S Nagasaki, T Suzuki, Y Miki, J Akahira, H Sasano
  • Organizer: 13^<th> International Congress on Hormonal Steroids and Hormones & Cancer
  • Place of Presentation: Quebec Hilton(Canada)
  • Year and Date: 20080927-30
• [Presentation] Comparative Effects of Raloxifene ,Tamoxifen and Estradiol on Human Osteoblast In Vitro (2008)
  • Author(s): Y Miki, S Nagasaki, S Hata, J-I Akahira, T Suzuki, H Sasano
  • Organizer: The Endocrine Society's 90th Annual Meeting
  • Place of Presentation: San Francisco Convention Center(USA)
  • Year and Date: 20080615-0618
• [Presentation] Intracrinology of Estorogen and Androgens in Human Breast Carcinoma (2008)
  • Author(s): H Sasano, Y Miki, S Nagasaki, T Suzuki
  • Organizer: 13^<th> International Congress on Hormonal Steroids and Hormones & Cancer
  • Place of Presentation: Quebec Hilton(Canada)
  • Year and Date: 2008-09-29
• [Presentation] ヒト組織中ステロイドホルモン測定の臨床的病理的有用性 (2007)
  • Author(s): 鈴木貴、三木康宏、赤平純一、笹野公伸
  • Organizer: 第15回日本ステロイドホルモン学会学術集会
  • Place of Presentation: 艮陵会館(宮城)
  • Year and Date: 2007-11-24