2008 Fiscal Year Final Research Report
Functional analysis of chondroitin sulfate E expressed in glioma
Project/Area Number |
18390113
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Shinshu University |
Principal Investigator |
NAKAYAMA Jun Shinshu University, 大学院・医学系研究科, 教授 (10221459)
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Project Period (FY) |
2006 – 2008
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Keywords | 分子病理 / 脳腫瘍 / 糖鎖遺伝子 / グリコサミノグリカン鎖 / ヘパリン結合性増殖因子 / RNA干渉 / in situ hybridization / 免疫組織化学 |
Research Abstract |
高度に硫酸化されたグリコサミノグリカン鎖であるコンドロイチン硫酸E(CS-E)と、その生合成に係わるバアセチルガラクトサミン4硫酸6-0-硫酸転移酵素(Ga1NAc4S-6ST)のmRNAはヒト星細胞腫で高頻度に発現し、特に後者は予後不良因子であった。膠芽腫U251細胞においてGa1NAc4S-6STsiRNAの導入により、プレイオトロピンやミッドカインへの走触能が低下した。以上の結果より、CS-Eは星細胞腫の浸潤能と係わっていることが示唆された。
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[Journal Article] Identification of mRNA splicing factor as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells2009
Author(s)
Hatakeyama S, Sugihara K, Nakayama j, Akama TO, Wong SA, Kawashima H, Zhang J, Smith DF, Ohyama C, Fukuda M, Fukuda MN
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 3095-3100
Peer Reviewed
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[Journal Article] Role of ASC in the mouse model of Helicobacter pylori infection2009
Author(s)
Benoit BN, Kobayashi M, Kawakubo M, Takeoka M, Sane K, Zou J, Itano N, Tsutsui H, Neda T, Fukuda M, Nakayama J, Taniguchi S
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Journal Title
J Histochem Cytochem 57
Pages: 327-338
Peer Reviewed
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[Journal Article] Critical role of bone marrow ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice2008
Author(s)
Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, Sagara J, Nakayama J, Taniguchi S, Ikeda U
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Journal Title
Circulation 117
Pages: 3079-3087
Peer Reviewed
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[Journal Article] The role of trophinin, an abhesion molecule unique to human trophoblasts, in progression of colorectal cancer2007
Author(s)
Harada O, Suga T, Suzuki T, Nakamoto K, Kobayashi M, Nomiyama T, Nadano D, Ohyama C, Fukuda MN, Nakayama J
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Journal Title
Int J Cancer 121
Pages: 1072-1078
Peer Reviewed
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[Journal Article] Trophoblast cell activation by trophinin ligation : Possible role in human embryo implantation2007
Author(s)
Sugihara K, Sugiyama D, Byrne J, Wolf DP, Lowitz KP, Kobayashi Y, Kabir-Salmani M, Nadano D, Aoki D, Nozawa S, Nakayama J, Mustelin T, Ruoslahti E, Yamaguchi N, Fukuda MN
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Journal Title
Proc Natl Acad Sci USA 104
Pages: 3799-3804
Peer Reviewed
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[Journal Article] Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-0 sulfotransferase2006
Author(s)
Hayashida Y, Akama TO, Beecher N, Lewis P, Young RD, Meek KM, Kerr B, Hughes CE, Caterson B, Tanigami A, Nakayama J, Fukada MN, Tano Y, Nishida K, Quantock AJ
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Journal Title
Proc Natl Acad Sci USA 103
Pages: 13333-13338
Peer Reviewed
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