2007 Fiscal Year Final Research Report Summary
Molecular evolution of antigen polymoiphism of modem malaria parasite populations
| Project/Area Number |
18390131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Osaka University |
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Principal Investigator |
TANABE Kazuyuki Osaka University, Research Instikne for Itrobial Diseass, SA Professor (40047410)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Tetsuo Tsukuba University, Institute of Biological Sciences, Professor (50208451)
SAWAI Hiromi Osaka University, Research Institute for Microbial Diseases, Designated Researcher (60377124)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Malaria / Antigen / Gene / Infectious disease / Evolution / Plasmodium vivax |
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| Research Abstract |
1. Geographic variation in multiplicity of infection
Multiplicity of infection (MOI) was compared among P falciparum populations from diverse geographic areas. MOI as measured by PCR-based mspl- 5' haplotyping was high in Africa, whereas there was no discernible association between MOI and the intensity of malaria transmission in Melanesia. Results suggest that the acquisition of strain specific protective immunity against malaria is associated with not only the intensity of malaria transmission but also the number of genotypes prevalent in local areas and MOI.
2. Origin of and natural selection in mspl polymorphism of P. vivax
To investigate the evolutionary history of mspl polymorphism in P vivax, phylogenetic trees of mspl from P. vivax and related monkey malaria parasite species was constructed. All P vivax mspl alleles cluster in the P vivax lineage and are not distributed among other species. Similarly, all P cynomolgi mspl alleles cluster in the P cynomolgi lineage. This suggests that the origin of P. vivax mspl polymorphism is relatively recent. We observed positive selection_in the P vivax lineage but not in P cynomolgi. This study shows that the evolutionary history of mspl differs greatly among parasite lineages.
3. Phylogeny of the cytosolic SSUrRNA of Plasmodium spp.
To infer the SSUrRNA phylogeny of the genus Plasmodium, sequences of genes encoding paralogous copies of the cyto-SSUrRNA, A-type-like and S-type-like genes, from eight simian Plasmodium species were obtained. The maximum likelihood analyses of these sequences, together with all cyto-SSUrRNA sequences currently available in the database, clearly demonstrated four independent clades in the unrooted Plasmodium tree: a simian Plasmodium + P vivax clade, a rodent Plasmodium clade (P. berghei/P. yoelii), a large clade including P malariae, P. falciparum, P reichnowi, and avian and reptilian Plasmodium species, and a P ovale clade.
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Research Products
(55 results)
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[Journal Article] Diversity and evolution of the highly diverse rhophl/clag multigene family of Plasmodium falciparum2008
Author(s)
H., Iriko, Kaneko, H., Otsuki, T., Tsuboi, X-Z., Su, K., Tanabe, M., Torii
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Journal Title
Molecular and Biochemical Parasitology 158
Pages: 11-21
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Evolution and phylogeny of the heterogeneous cytosolic SSU rRNA genes in the genus Plasmodium2008
Author(s)
Y., Nishimoto, N., Arisue, S., Kawai, A.A, Escalante, T., Horii, K., Tanabe, T., Hashimoto
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Journal Title
Molecular Phvlogenv and Evolution 47
Pages: 45-53
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia2007
Author(s)
T. Mita, K. Tanabe, N. Takahashi, T. Tsukahara, H. Eto, L. Dysoley, H. Ohmae, K. Kita, S. Krudsood, S. Looareesuwan, A. Kaneko, A. Bjorkman, and T. Kobayakawa.
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Journal Title
Antimicrobial Agents and Chemotherapy 51
Pages: 1071-1077
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp12007
Author(s)
K. Tanabe, N. Sakihama, D. Walliker, H. Babiker, A. A. Abdel-Muhsin, B. Bakote'e, H. Ohmae, N. Arisue, T. Horii, I. Rooth, A. Farnert, A. Bjorkman, and L. Ranford-Cartwright
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Journal Title
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Recent independent evolution of msp1 polymorphism in Plamsodium vivax and related malaria parasites2007
Author(s)
K. Tanabe, A. Escalante, N. Sakihama, M. Honda, N. Arisue, T. Horii, R. Culleton, T. Hayakawa, T. Hashimoto, S. Longacre, S. Pathirana, S. Handunnetti, H. Kishino
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Journal Title
Molecular and Biochemical Parasitology 156
Pages: 74-79
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] A comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P vivax2007
Author(s)
M.A., Pacheco, A.C., Poe, W.E., Collins, A.A., Lal, IC., Tanabe, V., Udhayakumar, A.E., Escalante
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Journal Title
Infection, Genetics and Evolution 7
Pages: 180-187
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia2007
Author(s)
T., Mita, K., Tanabe, N., Takahashi, T., Tsukahara, H., Eto, L., Dysoley, H., Ohmae, K., Kita, S., Krudsood, S., Looareesuwan, A., Kaneko, A., Bjarkrnan, T., Kobayakawa
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Journal Title
Antimicrobial Agents and Chemotherapy 51
Pages: 1071-1077
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines2007
Author(s)
N., Sakihama, M., Nakamura, A.A., Palanca, Jr, R.A., Argubano, E.P., Realon, A.L., Larracas, R.L., Espina, K., Tanabe
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Journal Title
Parasitology Intemational 56
Pages: 185-194
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Production of High-Affinity Human Monoclonal Antibody Fab Fragments to the 19-Kilodalton C-Terminal Merozoite Surface Protein I of Plasmodium falciparum2007
Author(s)
X., Chang, H., Hayasaka, K., Watanabe, Y., Tao, J., Liu, H., Tsukamoto, T., Horii, K., Tanabe, H., Tachibana
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Journal Title
Infection and Immunity 75
Pages: 3614-3620
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum mspl2007
Author(s)
K., Tanabe, N., Sakihama, D., Walliker, H., Babiker, A.A., Abdel-Muhsin, B., Bakote'e, H., Ohmae, N., Arisue, T., Horii, I., Rooth, A., Earned, A., BjOrkman, L., Ranford-Cartwrieht
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Recent independent evolution of mspl polymorphism in Plarnsodium vivax and related malaria parasites2007
Author(s)
K., Tanabe, A., Escalante, N., Sakihama, M., Honda, N., Arisue, T., Horii, R., Culleton, T., Hayakawa, T., Hashimoto, S., Longacre, S., Pathirana, S., Handunnetti, H., Kishino
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Journal Title
Molecular and Biochemical Parasitology 156
Pages: 74-79
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Rapid selection of dhfr mutant allele in P. falcipanint isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guninea.2006
Author(s)
T., Mita, A., Kaneko, I., Hwaihawanje, T., Tsukahara, N., T0akahashi, H., Osawa, K., Tanabe, T., Kobayakawa, A., Hftirkman
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Journal Title
Infection, Genetics and Evolution 6
Pages: 447-452
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections.2006
Author(s)
N.M.Q., Palacpac, B.W.Y., Leung, N., Arisue, K., Tanabe, J., Sattabongkot, T., Tsuboi, M., Torii, R., Udomsangoetch, T., Horii
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Journal Title
Molecular and Biochemical Parasitology 150
Pages: 353-358
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Phylogenetic relationship of malaria parasites inferred from multiple gene data2007
Author(s)
Nobuko Arisue, Tetso Hashimoto, Toshiyuki Hayakawa, Hideya Mitsui, Naoko Sakihama, Mozhi Jia, Nirianne M. Q. Palacpac, Toshihiro Horii, Kazuyuki Tanabe
Organizer
7th Awaji International Forum on Infection and Immunity
Place of Presentation
Awaji, Hyogo, Japan
Year and Date
2007-09-04
Description
「研究成果報告書概要(和文)」より
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[Presentation] Plasmodium vivax in Africa2007
Author(s)
Richard Culletion, Toshihito Mita, Mathieu Ndounga, Holger Onger, Pcdro Cravo, Akira Kaneko, Milijaona, Randrianarivelojosia, Shigeyuki Kano, Takafumi Tsuboi, Anjali Yadava, Anna P. Arez, Virgilio, do Rosario, Francine Ntoumi, Richard Carter, Kazuyuki Tanabe.
Organizer
7th Awaji International Forum on Infection and Immunity
Place of Presentation
Awaji, Hyogo, Japan
Year and Date
2007-09-04
Description
「研究成果報告書概要(和文)」より
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[Presentation] Genetic make-up of Plasmodium vivax populatio in Mae Sot, Thailand2007
Author(s)
Nirianne M. Q. Palacpac, Nobuko Arisue, Tohsihiro Horii, Jetsumon Satabongkt, Takafumi Tsuboi, Motomi Torii, Rachanee Udomsangpetch, Kazuyuki Tanabe
Organizer
7th Awaji International Forum on Infection and Immunity
Place of Presentation
Awaji, Hyogo, Japan
Year and Date
2007-09-04
Description
「研究成果報告書概要(和文)」より
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[Presentation] Recent independent evolution of msp1 polymorphism in Plasmodium vivax and Plasmodium cynomolgi.2007
Author(s)
Kazuyuki Tanabe, Ananias Escalante, Naoko Sakihama, Masanori Honda, Nobuko Arisue, Toshihiro Horii, Richard Culleton, Toshiyuki Hayakawa, Tetsuo Hashimoto, Shirley Longacre, Sisira Pathirana, Shiroma Handunnetti, Hirohisa Kishino.
Organizer
5th European Congress on Tropical Medicien and Internationa Health
Place of Presentation
Amsterdam, Holland
Year and Date
2007-05-26
Description
「研究成果報告書概要(和文)」より
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[Presentation] Recent independent evolution of mspl polymorphism in Plasmodium vivax and Plasmodium cynomolgi.2007
Author(s)
Kazuyuki, Tanabe, Ananias, Escalante, Naoko, Sakihama, Masanori, Honda, Nobuko, Arisue, Toshihiro, Horii, Richard, Culleton, Toshiyuki, Hayakawa, Tetsuo, Hashimoto, Shirley, Longacre, Sisira, Pathirana, Shiroma, Handunnetti, Hirohisa, Kishino
Organizer
5th European Congress on Tropical Medicien and Intemationa Health
Place of Presentation
Amsterdam, Holland
Year and Date
2007-05-26
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Stable antigen polymorphism in modem Plasmodium falciparum populations2007
Author(s)
Kazuyuki, Tanabe, Naoko, Sakihama, Ingegerd, Rooth, Anna, Farnert, Anders, BjOrkman, Marcelo, M., Ferreira, Hiroshi, Ohmae, Kenji, Himyama
Organizer
Asian Research Forum on Emerging and Reemerging Infections-2007
Place of Presentation
Nagasaki, Japan
Year and Date
2007-01-16
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Plasmodium vivax in Africa2006
Author(s)
Richrad Culleton, Matthieu Ndounga, Holger Unger, Richard Carter, Kazuyuki Tanabe
Organizer
第5回分子寄生虫・マラリア研究フォーラム
Place of Presentation
東京
Year and Date
2006-10-28
Description
「研究成果報告書概要(和文)」より
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[Presentation] Evolution of mspl polymorphism after speciation of Plasmodium vivax and Plasmodium cvnomolai2006
Author(s)
Kazuvuki, Tanabe, Naoko, Sakihma, Ananias, Escalante, Sisira, Pathirana, Shiroma, Handunnetti, Masanori, Honda, Hirohisa, Kishino
Organizer
6th Awaji International Forum on Infection and Immunity
Place of Presentation
Awaji, Hyogo,Japan
Year and Date
2006-09-06
Description
「研究成果報告書概要(欧文)」より
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