2007 Fiscal Year Final Research Report Summary
Attempts to develop a novel cell therapy system for chromic viral infections and non-viral tumors.
| Project/Area Number |
18390145
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
YAMAMOTO Naoki National Institute of Infectious Diseases, AIDS Research Center, Director (00094053)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Norio Tokyo Medical and Dental University, Department of Molecular Virology, Assistant Professor (40323703)
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| Project Period (FY) |
2006 – 2007
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| Keywords | cell therapy / persistent infections / cancer / virus / humanized mice / NOG mice |
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| Research Abstract |
Our efforts have been made regarding morphological, genetic and molecular studies on virally-induced diseases (HTLV-I/ATL, HIV-I/AIDS, and EBV/AIDS-associated lymphoma) and non-virally induced cancers using newly developed NOG mice. We initially established a novel animal model for ATL using unconditional NOG mice. We also showed the effect of several newly developed NF-kB inhibitors. We proved efficacy and safety of NK cells in NOG mice as well as in the breast tumor-bearing patients. We also constructed humanized NOG mice by transplanting human cord blood-derived hematopoietic stem cells that eventually developed into human B cells, T cells and other monocytes/macrophages and dendritic cells associated with the generation of lymphoid follicle-like structures in lymphoid tissues. This system allows a long-lasting infection of both HIV-1 and EBV with human immune responses. All these data suggest that NOG mice may have potential as a useful animal model for the development of new regimen against various infectious diseases and cancers of human origin.
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Research Products
(20 results)
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[Journal Article] Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.2008
Author(s)
Saitoh Y, Yamamoto N, Dewan M Z Sugimoto H, Martinez Bruyn V J, Iwasaki Y, Matsubara K, QI X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S.
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Journal Title
Blood 111(10)
Pages: 5118-5129
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses.2007
Author(s)
Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan MZ, YU Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N.
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Journal Title
Blood 109(1)
Pages: 212-218
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Potential role of natural killer cells in contorlling growth and infiltration of AIDS-associated primary effusion lymphoma cells.2006
Author(s)
Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N.
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Journal Title
Cancer Sci 97(12)
Pages: 1381-1387
Description
「研究成果報告書概要(欧文)」より
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