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2008 Fiscal Year Final Research Report

Development of auto-IAP-antibody screening array for diagnosing cancer patients

Research Project

  • PDF
Project/Area Number 18390174
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionSapporo Medical University

Principal Investigator

WATANABE Naoki  Sapporo Medical University, 医学部, 教授 (10158644)

Co-Investigator(Kenkyū-buntansha) TSUJI Naoki  札幌医科大学, 医学部, 講師 (00347171)
KOBAYASHI Daisuke  札幌医科大学, 医学部, 講師 (50295359)
Project Period (FY) 2006 – 2008
Keywords臨床検査医学
Research Abstract

分子生物学の進歩に伴い, 癌で発現が亢進あるいは低下し, 浸潤・転移能の増強や治療抵抗性の発現と密接に関与する分子群が, 報告されるようになった。今回我々は, 抗Survivin, LivinおよびXIAP自己抗体に注目し, 各種消化器癌, 肺癌や乳癌患者の血清診断を試みた。癌患者29例中14例(48%)で, いずれかの自己抗体が検出された。なかでも, 抗Survivin自己抗体の陽性率が最も高く, 45%(13/29)であった。

  • Research Products

    (18 results)

All 2009 2008 2007 2006

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (10 results)

  • [Journal Article] Down-regulation of hTERT expression plays an important role in 15-deoxy-Δ ^<12,14>-prostaglandin J_2-iuduced apoptosis in cancer cells2009

    • Author(s)
      Moriai M, Tuji N, Kobayashi D, Kuribayashi K, Watanabe N.
    • Journal Title

      Int J Oncol 34

      Pages: 1363-1372

    • Peer Reviewed
  • [Journal Article] Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression2009

    • Author(s)
      Furuya M, Tsuji N, Kobayashi D, Watanabe N.
    • Journal Title

      Int J Oncol 34

      Pages: 1061-1068

    • Peer Reviewed
  • [Journal Article] Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells2008

    • Author(s)
      Moriai R, Tsuji N, Moriai M, Kobayashi D, Watanabe N.
    • Journal Title

      Breast Cancer Research Treat (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells2007

    • Author(s)
      Kobayashi D, Koshida S, Moriai R, Tsuji N, Watanabe N.
    • Journal Title

      Cancer Sci 98

      Pages: 334-340

    • Peer Reviewed
  • [Journal Article] Specific overepression of OLFM4GW112/hGC-1 mRNA in colon, breast, and lung cancer tissues detected using quantitative analysis2007

    • Author(s)
      Koshida S, Kobayashi D, Moriai R, Tsuji N, Watanabe N.
    • Journal Title

      Cancer Sci 98

      Pages: 315-320

    • Peer Reviewed
  • [Journal Article] Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer2007

    • Author(s)
      Kaneko R, Tsuji N, Asanuma K, Tanabe H, Kobayashi D, Watanabe N.
    • Journal Title

      J Biol Chem 282

      Pages: 19273-19281

    • Peer Reviewed
  • [Journal Article] 15-Deoxy-Delta (12, 14)-prostaglandin J(2) inhibits G(2)-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivn expression2007

    • Author(s)
      Kamagata C, Tsuji N, Moriai M, Kobayashi D, Watanabe N.
    • Journal Title

      Breast Cancer Res Treat 102

      Pages: 263-273

    • Peer Reviewed
  • [Journal Article] Inhibition of estrogen receptor β-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Δ ^<12, 14>-prostaglandin J2-induced apoptosis in cancer cells2007

    • Author(s)
      Kondo K, Tsuji N, Asanuma K, Kobayashi D, Watanabe N
    • Journal Title

      Exp Cell Res 313

      Pages: 3486-3496

    • Peer Reviewed
  • [Presentation] 乳癌および肺癌診断におけるチロシンキナーゼSTYK1解析の意義2008

    • Author(s)
      小林大介, 盛合亮介, 辻直樹, 渡邉直樹
    • Organizer
      第48回日本臨床化学会年次学術集会
    • Place of Presentation
      浜松
    • Year and Date
      20080000
  • [Presentation] ES細胞複製分子Nanogを用いた早期肺癌診断法の開発2008

    • Author(s)
      韮澤慎也, 小林大介, 辻直樹, 渡邉直樹
    • Organizer
      第48回日本臨床化学会年次学術集会
    • Place of Presentation
      浜松
    • Year and Date
      20080000
  • [Presentation] 乳癌組織におけるBmi-1遺伝子の発現量解析2008

    • Author(s)
      佐伯理知, 小林大介, 辻直樹, 渡邉直樹
    • Organizer
      第48回日本臨床化学会年次学術集会
    • Place of Presentation
      浜松
    • Year and Date
      20080000
  • [Presentation] 15d-PFJ2はhTERTの発現抑制を介して癌細胞にアポトーシスを誘導する2007

    • Author(s)
      辻直樹, 小林大介, 渡邉直樹
    • Organizer
      第20回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      札幌
    • Year and Date
      20070000
  • [Presentation] HMG-CoAreductase阻害剤によるSurvivinを標的とした新たな癌治療法2006

    • Author(s)
      辻直樹, 小林大介, 渡邉直樹
    • Organizer
      第19回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      福岡
    • Year and Date
      20060000
  • [Presentation] 新規チロシンキナーゼNOKは乳癌の早期診断に有用である2006

    • Author(s)
      小林大介, 辻直樹, 渡邉直樹
    • Organizer
      第65回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20060000
  • [Presentation] 抗アポトーシス分子SurvivinはhTERTの発現増強を介して癌細胞を不死化する2006

    • Author(s)
      辻直樹, 小林大介, 渡邉直樹
    • Organizer
      第65回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20060000
  • [Presentation] 15-deoxy-Δ ^<12, 14>-prostaglandin J_2はERのリン酸化阻害を介してhTERTの発現を抑制する2006

    • Author(s)
      浅沼康一, 辻直樹, 盛合美加子, 渡邉直樹
    • Organizer
      第46回日本臨床化学年会
    • Place of Presentation
      東京
    • Year and Date
      20060000
  • [Presentation] HMG-CoA reductase阻害剤による癌細胞増殖抑制機序-FFPとGGGPがSurvivinの発現に及ぼす影響2006

    • Author(s)
      辻直樹, 金子礼子, 浅沼康一, 渡邉直樹
    • Organizer
      第46回日本臨床化学年会
    • Place of Presentation
      東京
    • Year and Date
      20060000
  • [Presentation] 抗アポトーシス分子OLFM4は膵癌細胞で抗発現し増殖を促進する2006

    • Author(s)
      小林大介, 辻直樹, 渡邉直樹
    • Organizer
      第37回日本膵臓学会大会
    • Place of Presentation
      横浜
    • Year and Date
      20060000

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Published: 2010-06-10   Modified: 2016-04-21  

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