Function of novel intrinsic angiogenesis inhibitor vasohibin on the establishment of vascular architecture

2008 Fiscal Year Final Research Report

• Project/Area Number: 18390226
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: YASUFUMI Sato Tohoku University, 加齢医学研究所, 教授 (50178779)
• Project Period (FY): 2006 – 2008
• Keywords: 血管病態学

Research Abstract

Vasohibin(VASH)ファミリーのうち、VASH-1は主に血管新生が終息する部位の内皮細胞に発現し、血管新生を止めるのに対VASH-2は間質に浸潤する骨髄由来単核球に発現し、VASH-1とは拮抗的は血管新生を促進する。また、内皮細胞に発現すVASH-1は、血管新生を抑制するばかりか、ROSの生成を抑制すると共にSIRT1の産生をも増加させ、内皮細胞のストレス耐性、抗老化に寄与する。

Research Products

• [Journal Article] Vasohibin-1 expressed in endothelium of tumor vessels regulates angiogenesis (2009)
  • Author(s): Hosaka T, Kimura H, Heishi T, Suzuki Y, Miyashita H, Ohta H, Sonoda H, Moriya T, Suzuki S, Kondo T, Sato Y.
  • Journal Title: Am J Pathol (in press)
  • Peer Reviewed
• [Journal Article] Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis (2009)
  • Author(s): Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T, Sato Y.
  • Journal Title: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population (2009)
  • Author(s): Naito H, Kidoya H, Sato Y, Takakura N.
  • Journal Title: J. Biochem(Epub ahead of print
  • Peer Reviewed
• [Journal Article] Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy (2009)
  • Author(s): Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, Ohta H, Sonoda H, Sato Y, Nishida K
  • Journal Title: Diabetologia 52 Pages: 359-361
  • Peer Reviewed
• [Journal Article] Vasohibin-1 in human breast carcinoma : a potential negative feedback regulator of angiogenesis (2009)
  • Author(s): Tamaki K, Moriya T, Sato Y, Ishida T, Maruo Y, Yoshinaga K, Ohuchi N, Sasano H
  • Journal Title: Cancer Sci. 100 Pages: 88-94
  • Peer Reviewed
• [Journal Article] a novel endothelium-derived angiogenesis inhibitor : its expression on endometrial carcinoma in relation to tumor vascularity (2008)
  • Author(s): Yoshinaga, K., Moriya, T., Nagase, S., Takano, T., Niikura, H., Ito, K., Nobuo Yaegashi, N., Sato, Y. Vasohibin
  • Journal Title: Cancer Sci. 99 Pages: 914-919
  • Peer Reviewed
• [Journal Article] Expression of vasohibin, an antiangiogenic factor, in human choroidal neovascular membranes (2008)
  • Author(s): Wakusawa, R., Abe, T., Sato, H., Yoshida, M., Kunitaka, H., Sato, Y., Nishida K.
  • Journal Title: Am.J.Ophthalmol 146 Pages: 235-243
  • Peer Reviewed
• [Journal Article] The vasohibin family : a negative regulatory system of angiogenesis genetically programmed in endothelial cells (2007)
  • Author(s): Sato, Y., and Sonoda, H.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol 27 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Isolation of vasohibin-2 as a sole homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin : a comparative study on their expressions (2007)
  • Author(s): Shibuya, T., Watanabe, K., Yamashita, H., Shimizu, K., Miyashita, H., Abe, M., Moriya, T., Ohta, H., Sonoda, H., Shimosegawa, T., Tabayashi, K., Sato, Y.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. 26 Pages: 1051-1057
  • Peer Reviewed
• [Journal Article] Vasohibin prevents arterial neointimal formation through angiogenesis inhibition. Biochem (2006)
  • Author(s): Yamashita, H., Abe, M., Watanabe, K., Shimizu, K., Moriya, T., Sato, A., Satomi, S., Ohta, H., Sonoda, H., Sato, Y.
  • Journal Title: Biophys. Res. Commun 345 Pages: 919-925
  • Peer Reviewed
• [Journal Article] Campochiaro, PA. Vasohibin is Up-regulated by VEGF in the Retina and Suppresses VEGF receptor 2 and Retinal Neovascularization. (2006)
  • Author(s): Shen, JK., Yang, XR., Sato, Y.
  • Journal Title: FASEB J. 20 Pages: 723-725
  • Peer Reviewed
• [Journal Article] Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin (2006)
  • Author(s): Sonoda, H., Ohta, H., Watanabe, K., Yamashita, H., Kimura H., Sato, Y.
  • Journal Title: Biochem. Biophys. Res. Commun 342 Pages: 640-646
  • Peer Reviewed
• [Presentation] 血管新生阻害剤の分子標的 (2009)
  • Author(s): 佐藤靖史
  • Organizer: 第7回日本臨床腫瘍学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20090321-22
• [Presentation] がんにおける血管新生制御の分子基盤 (2009)
  • Author(s): 佐藤靖史
  • Organizer: 平成20年度がん特定領域研究5領域合同シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20090202-03
• [Presentation] Common molecular basis for the regulation of angiogenesis and vascular aging (2009)
  • Author(s): 佐藤靖史
  • Organizer: 第4回研究所ネットワーク国際シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20090131-0201
• [Presentation] Vasohibin-1 is involved in the mainrenance of vascular endothelial cells (2008)
  • Author(s): 宮下浩輝, 佐藤靖史
  • Organizer: 第16回日本血管生物医学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 20081203-05
• [Presentation] Isolation of a small Vasohibin-binding protein(SVBP)and its impormant role in the secretion of Vasohibin (2008)
  • Author(s): 鈴木康弘, 小林美穂, 宮下浩輝, 太田英樹, 園田光, 佐藤靖史
  • Organizer: 第16回日本血管生物医学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 20081203-05
• [Presentation] 内因性血管新生抑制因子と癌 (2008)
  • Author(s): 佐藤靖史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-30
• [Presentation] Vasohibin結合性低分子量蛋白SVBPの単離とその分泌における役割 (2008)
  • Author(s): 鈴木康弘, 小林美穂, 宮下浩輝, 太田英樹, 園田光, 佐藤靖史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-30
• [Presentation] The Role of Vasohibin in the Regulation of Tumor Angiogenesis (2008)
  • Author(s): Sato, Y
  • Organizer: 9th International Conference Angiogenesis : Basic Science and Clinical Applications
  • Place of Presentation: Patras, Greece
  • Year and Date: 20080622-26
• [Presentation] Vasohibin Suppresses Lymph Node Metastasis via the Inhibition of Lymphangiogenesis in Mice (2008)
  • Author(s): Heishi T, Miyashita H, Takahashi T, Oike Y and Sato Y
  • Organizer: 15th International Vascular Biology Meeting
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20080622-26
• [Presentation] The Role of Vasohibin in the Regulation of Angiogenesis (2008)
  • Author(s): Sato, Y
  • Organizer: 15th International Vascular Biology Meeting
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20080601-05
• [Presentation] 血管内皮細胞におけるVasohibin-1の標的遺伝子の解析 (2008)
  • Author(s): 宮下浩輝, 佐藤靖史
  • Organizer: 第81回日本組織培養学会大会
  • Place of Presentation: つくば
  • Year and Date: 20080519-20
• [Presentation] The role of vasohibin in the regulation of angiogenesis in tumors (2008)
  • Author(s): 佐藤靖史
  • Organizer: The U.S.-Japan Cooperative Cancer Research Program
  • Place of Presentation: 京都
  • Year and Date: 20080319-21
• [Presentation] リンパ管新生の内因性抑制因子に関する研究 (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第15回日本血管生物医学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 20071129-30
• [Presentation] Vasohibin familyの血管新生制御における意義 (2007)
  • Author(s): 木村洋, 宮下浩輝, 佐藤靖史
  • Organizer: 第15回日本血管生物医学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 20071129-30
• [Presentation] Role of vasohibin family in the regulation of angiogenesis (2007)
  • Author(s): Sato, Y
  • Organizer: The Joint Meeting of Vascular Biology Organiz ations in Asia Pacific Region
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 20071021-24
• [Presentation] The role of vasohibin in the regulation of angiogenesis (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-05
• [Presentation] Vasohibin inhibits lymphangiogenesis in mouse cornea and xenograft cancer model (2007)
  • Author(s): 瓶子隆弘, 保坂智子, 木村洋, 宮下浩輝, 高橋隆, 佐藤靖史
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-05
• [Presentation] 転写因子VEZFの標的遺伝子であるメタロチオネインは血管新生制御に関与する (2007)
  • Author(s): 宮下浩輝, 佐藤靖史
  • Organizer: メタロチオネインおよびメタルバイオサイエンス研究会2007
  • Place of Presentation: 徳島
  • Year and Date: 20070928-29
• [Presentation] The role of vasohibin family in the regulation of angiogenesis (2007)
  • Author(s): Sato, Y
  • Organizer: Ang iogenesis & Microcriculation
  • Place of Presentation: Newport, USA
  • Year and Date: 20070819-24
• [Presentation] 血管新生制御におけるvasohibin familyの役割 (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第28回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 20070802-03
• [Presentation] 血管新生制御におけるvasohibin familyの役割 (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第39回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20070713-14
• [Presentation] The role of vasohibin family in the regulation of angiogenesis (2007)
  • Author(s): Sato, Y
  • Organizer: Seventh ESH Euroconference on Angiogenesis
  • Place of Presentation: Albufeira, Portugal
  • Year and Date: 20070511-14
• [Presentation] Significance and therapeutic application of vasohibin to anti-angiogenesis (2006)
  • Author(s): 佐藤靖史
  • Organizer: 第14回日本血管生物医学会
  • Place of Presentation: 東京
  • Year and Date: 20061213-15
• [Presentation] Vasohibinの標的遺伝子の解析 (2006)
  • Author(s): 宮下浩輝、佐藤靖史
  • Organizer: 第14回日本血管生物医学会
  • Place of Presentation: 東京
  • Year and Date: 20061213-15
• [Presentation] Vasohibin inhibits lymphangiogenesis in mouse cornea (2006)
  • Author(s): 瓶子隆弘、保坂智子、木村洋、鈴木康弘、宮下浩輝、佐藤靖史
  • Organizer: 第14回日本血管生物医学会
  • Place of Presentation: 東京
  • Year and Date: 20061213-15
• [Presentation] Significance of Endothelium-derived Angiogenesis Inhibitor Vasohibin in Tumors (2006)
  • Author(s): 佐藤靖史
  • Organizer: The Thirty-seventh International Symposium of The Princess Takamatsu Cancer Research Fund
  • Place of Presentation: 東京
  • Year and Date: 20061114-16
• [Presentation] 内皮由来血管新生抑制因子vasohibinと腫瘍血管の成熟性との関連 (2006)
  • Author(s): 保坂智子、瓶子隆弘、木村洋、宮下浩輝、太田英樹、園田光、森谷卓也、鈴木聡、近藤丘、佐藤靖史
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20060928-30
• [Presentation] Vasohibin, a VEGF-inducible endothelium-derived angiogenesis inhibitor, may act as a terminator of angiogenesis (2006)
  • Author(s): Kimura H, Miyashita H, Ota H, Sonoda H, Shimosegawa T, Sato Y.
  • Organizer: XIVth International Vascular Biology Meeting
  • Place of Presentation: Noordwijkerhout, Netherlands
  • Year and Date: 20060606-10
• [Presentation] Application of vasohibin for prevention of adventitial angiogenesis and arterial neointimal formation (2006)
  • Author(s): Yamashita H, Abe M, Shibuya T, Watanabe K, Shimizu K and Sato Y.
  • Organizer: XIV International Symposium on Atherosclerosis
  • Place of Presentation: Rome, Italy
  • Year and Date: 20060606-10
• [Book] Endogenous inhibitors of angiogenesis. Angiogenesis (2007)
  • Author(s): Sato, Y
  • Total Pages: 1-14
  • Publisher: In けBasic Science and Clinical
• [Patent(Industrial Property Rights)] 特許出願「血管新生促進因子」 (2008)
  • Inventor(s): 佐藤靖史
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 基礎出願2008-21397
  • Filing Date: 2008-01-31
• [Patent(Industrial Property Rights)] 特許出願「バソヒビン1を認識するモノクローナル抗体および該抗体を用いるバソヒビンの免疫測定方法」 (2008)
  • Inventor(s): 佐藤靖史、近藤丘
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 基礎出願2008-218581
  • Filing Date: 2008-06-19
• [Patent(Industrial Property Rights)] 特許出願「バソヒビンからなるリンパ管新生抑制剤」 (2007)
  • Inventor(s): 佐藤靖史
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: WO PCT/JP2007/072838
  • Filing Date: 2007-11-27
  • Overseas
• [Patent(Industrial Property Rights)] 特許出願「バソヒビンからなるリンパ管新生抑制剤」 (2006)
  • Inventor(s): 佐藤靖史
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 基礎出願2006-324773
  • Filing Date: 2006-11-30