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2008 Fiscal Year Final Research Report

性ホルモンによる心筋イオンチャネル制御の検討-不整脈の性差医療の基礎戦略

Research Project

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Project/Area Number 18390231
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

FURUKAWA Tetsushi  Tokyo Medical and Dental University, 難治疾患研究所, 教授 (80251552)

Co-Investigator(Kenkyū-buntansha) 黒川 洵子  東京医科歯科大学, 難治疾患研究所, 准教授
Co-Investigator(Renkei-kenkyūsha) 中谷 晴昭  千葉大学, 大学院・医学系研究院, 教授
大江 透  岡山大学, 医薬総合研究科, 教授
柳 圭子  佐賀大学, 医学部, 准教授
Project Period (FY) 2006 – 2008
Research Abstract

性ホルモンのテストステロン、エストラジオール、プロゲステロンの心筋イオンチャネルに対する調節メカニズムを明らかにし、これらによる非ゲノム作用による心筋イオンチャネル調節という新たな制御機構を確立することに成功した。得られた基礎データを使って、心筋電気生理の男女差、女性性周期による変動のコンピューターシミュレーションモデルを構築した。

  • Research Products

    (36 results)

All 2009 2008 2007 2006

All Journal Article (15 results) Presentation (21 results)

  • [Journal Article] A receptor-independent effect of estrone sulfate on the HERG channel2009

    • Author(s)
      Kakusaka S, Asayama M, Kaihara A, Sasano T, Suzuki T, Kurokawa J, Furukawa T
    • Journal Title

      J. Pharmacol. Sci 109

      Pages: 152-156.

  • [Journal Article] redox-and calmodulin-dependent s-nitrosylation of the KCNQ1 channel2009

    • Author(s)
      Asada K, Kurokawa J, Furukawa T
    • Journal Title

      J. Biol. Chem 284

      Pages: 6014-6020

  • [Journal Article] A combined approach using patch-clamp study and computer simulation study for understanding long QT syndrome and TdP in women2009

    • Author(s)
      Furukawa T, Kurokawa J, Clancy CE
    • Journal Title

      Curr.Cardiovasc.Rev (in press)

  • [Journal Article] Acute effect of female hormones on cardiac ion channels and cardiac repolarization2009

    • Author(s)
      Kurokawa J, Suzuki T, Furukawa T
    • Journal Title

      J.Pharmacol.Sci. 109

      Pages: 334-340

  • [Journal Article] KCNE variants reveal a critical role of the beta subunit carboxy terminus in PKA-dependent regulation of the Iks potassium channe2009

    • Author(s)
      Kurokawa J, Bankston JR, Kaihara A, Chen L, Furukawa T, Kass RS
    • Journal Title

      Channels 3

      Pages: 16-24

  • [Journal Article] A genetically encoded bioluminescent indicator for the sodium channel activity in living cells2009

    • Author(s)
      Kaihara A, Kurokawa J, Furukawa T
    • Journal Title

      J.Am.Chem.Soc 131

      Pages: 4188-4189

  • [Journal Article] Acute effects of estrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization2008

    • Author(s)
      Kurokawa J, Tamagawa M, Harada N, Honda S, Bai CX, Nakaya H, Furukawa T
    • Journal Title

      J.Physiol 586

      Pages: 2961-2973

  • [Journal Article] non-genomic regulation of cardiac ion channels by sex hormones.2008

    • Author(s)
      Furukawa T, Kurokawa J
    • Journal Title

      Cardiovasc. Hematol. Disord. Drug Targets 8

      Pages: 245-251

  • [Journal Article] Bioluminescent indicators for Ca^<2+> based split Renilla luciferase complementation in living cells2008

    • Author(s)
      Kaihara A, Umezawa Y, Furukawa T
    • Journal Title

      Analyt. Sci 24

      Pages: 1405-1408

  • [Journal Article] Progesterone regulates cardiac repolarization through a nongenomic pathway. An in vitro patch-clamp and computational modeling study2007

    • Author(s)
      Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T
    • Journal Title

      Circulation 116

      Pages: 2913-2922

  • [Journal Article] Anti-KCNH2 antibody-induced long QT syndrome. Novel acquired form of LQT syndrome2007

    • Author(s)
      Nakamura K, Katayama Y, Kusano K, Haraoka K, Tani Y, Nagase S, Morita H, Miura S, Fujimoto Y, Furukawa T, Ueda K, Aizawa Y, Kimura A, Kurachi Y, Ohe T
    • Journal Title

      J.Am.Coll.Cardiol 50

      Pages: 1808-1809

  • [Journal Article] T75M-KCNJ2 mutation causing Andersen-Tawil syndrome enhances inward rectification by changing Mg^<2+>sensitivity2007

    • Author(s)
      Tani Y, Miura D, Kurokawa J, Furukawa T
    • Journal Title

      J.Mol.Cell.Cardiol 43

      Pages: 187-196

  • [Journal Article] Regulation of cardiac ion channels via non-genomic action of sex steroid hormones : Implication for gender-difference in cardiac arrhythmias. Pharmacol2007

    • Author(s)
      Furukawa T, Kurokawa J
    • Journal Title

      Therapeut 115

      Pages: 106-115

  • [Journal Article] Ginsenoside Re, a main phytosterol of panax ginseng, activates cardiac potassium channels via a non-genomic pathway of sex hormones.2006

    • Author(s)
      Furukawa, T, Bai CX, Kaihara A, Ozaki E, Kawano T, Nakaya Y, Awais M, Sato M, Umezawa Y, Kurokawa J
    • Journal Title

      Mol. Pharmacol 70

      Pages: 1916-1924

  • [Journal Article] Potassium channel remodeling in cardiac hypertrophy2006

    • Author(s)
      Furukawa T, Kurokawa J
    • Journal Title

      J.Mol.Cell.Cardiol 41

      Pages: 753-761

  • [Presentation] 性ホルモンによるIKsチャネル調節におけるS-ニトロシル化の関与2008

    • Author(s)
      黒川洵子、浅田健、中村浩章、古川哲史
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20081200
  • [Presentation] Acute effects of female sex hormones on cardiacion channels2008

    • Author(s)
      Kurokawa J, Nakamura H, Furukawa T
    • Organizer
      Gordon Research Conference(Cardiac regulatory mechanism)
    • Place of Presentation
      NH, USA
    • Year and Date
      20080700
  • [Presentation] Site-specific S-nitrosylation acts as a novel regulatory mechanism of the cardiac I_<ks> channel2008

    • Author(s)
      Furukawa T, Kurokawa J
    • Organizer
      Gordon Research Conference(Cardiac regulatory mechanism)
    • Place of Presentation
      NH, USA
    • Year and Date
      20080700
  • [Presentation] Hormonal control of Iks and I_<Kr>. Heart Rhythm 20082008

    • Author(s)
      Furukawa T
    • Organizer
      29th Annual Scientific Session. Symposium "Arrhythmias in women"
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      20080500
  • [Presentation] カベオラを基盤とするホルモン受容体・NOシグナル・イオンチャネルの機能協関制御2008

    • Author(s)
      古川哲史、黒川洵子、白長喜、中村浩章、浅田健
    • Organizer
      第81回日本薬理学会年会シンポジウム「創薬標的としてのイオン制御蛋白分子間機能協関と細胞膜ミクロドメイン集積機構
    • Place of Presentation
      横浜
    • Year and Date
      20080300
  • [Presentation] Receptor-independent regulation of the HERG channel by estrogen2008

    • Author(s)
      角坂祥子、黒川洵子、鈴木岳志、古川哲史
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20080300
  • [Presentation] Receptor-independent effects of estrogen on the HERG channel predispose women to drug-induced arrhythmias2007

    • Author(s)
      Kurokawa J, Furukawa T
    • Organizer
      AHA Scientific Sessions
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      20071103-07
  • [Presentation] 性ホルモン非ゲノム作用による心筋イオンチャネル制御機構2007

    • Author(s)
      古川哲史、黒川洵子、中村浩章、白長喜、浅田健、玉川正次、中谷晴昭、Ronit V, Xu J, Clancy CE, 磯部光章
    • Organizer
      第24回日本心電学会学術集会学術諮問委員指定シンポジウム「不整脈受攻性因子としての性差と加齢」
    • Place of Presentation
      名古屋
    • Year and Date
      20071000
  • [Presentation] Effects of ovarian steroids on cardiac repolarization2007

    • Author(s)
      Kurokawa J, Nakamura H, Bai CX, Furukawa T
    • Organizer
      51st Annual Meeting of the Biophysical Society
    • Place of Presentation
      USA
    • Year and Date
      20070303-07
  • [Presentation] レドックスモチーフに基づく遅延整流性カリウムチャネルのニトロソ化2007

    • Author(s)
      浅田健、黒川洵子、古川哲史
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      20070300
  • [Presentation] 心筋イオンチャネルに対するプロゲステロンの急性作用2006

    • Author(s)
      黒川洵子、中村浩章、大石咲子、白長喜、古川哲史
    • Organizer
      第16回日本循環薬理学会
    • Place of Presentation
      東京
    • Year and Date
      20061200
  • [Presentation] Mechanisms of gender-related differences in susceptibility to torsades de pointes : Reverse effects of estrogen and progesterone on cardiac repolarization2006

    • Author(s)
      Kurokawa J, Nakamura H, Bai CX, Isobe M, Furukawa T
    • Organizer
      AHA Scientific Sessions, Chicago, IL
    • Place of Presentation
      USA, Nov
    • Year and Date
      20061112-15
  • [Presentation] Impact of a non-genomic pathway on QT intervals shortening by testosterone : Mechanism of sex-related difference in fatal arrhythmias2006

    • Author(s)
      Kurokawa J, Bai CX, Furukawa T
    • Organizer
      The 7th International Conference on Systems Biology
    • Place of Presentation
      Yokohama
    • Year and Date
      20061000
  • [Presentation] 非ゲノム経路によるNO産生を介したテストステロンによる心電図QT間隔短縮 : 致死性不整脈における性差のメカニズム2006

    • Author(s)
      黒川洵子、白長喜、古川哲史
    • Organizer
      第6回日本NO学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20060500
  • [Presentation] 植物エストロゲン、ジンセノシド、の心血管作用は一酸化窒素を介する2006

    • Author(s)
      古川哲史、浅田健、黒川洵子
    • Organizer
      第6回日本NO学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20060500
  • [Presentation] エストロゲンによるQT延長のメカニズム2006

    • Author(s)
      黒川洵子、白長喜、角坂祥子、玉川正次、中谷晴昭、古川哲史
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20060300
  • [Presentation] 性ホルモン受容体の作用特異的リガンドとしての薬用人参の主成分ステロールサポニン(ギンセノシド)2006

    • Author(s)
      白長喜、黒川洵子、古川哲史
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20060300
  • [Presentation] NOによる遅延整流性カリウムチャネルへのニトロ化2006

    • Author(s)
      浅田健、黒川洵子、古川哲史
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20060300
  • [Presentation] Effect of progesterone on slow activating delayed rectifier K+ currents2006

    • Author(s)
      中村浩章、白長喜、黒川洵子、古川哲史、磯部光章
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20060300
  • [Presentation] Testosterone shortens ventricular action potential duration via a non-genomic pathway2006

    • Author(s)
      Kurokawa J, Bai CX, Furukawa T
    • Organizer
      50th Annual Meeting of Biophysical Society, Salt Lake City
    • Place of Presentation
      Utah, USA
    • Year and Date
      20060218-22
  • [Presentation] Testosterone regulates cardiac potassium channels via a non-genomic pathway2006

    • Author(s)
      Furukawa T, Kurokawa J
    • Organizer
      Keystone symposium "Cardiac arrhythmias : linking structural biology to gene defects" Tahoe City
    • Place of Presentation
      CA, USA, Jan
    • Year and Date
      2006-02-03

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Published: 2010-06-10   Modified: 2016-04-21  

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