2008 Fiscal Year Final Research Report
New therapeutic approach to diabetic nephropathy by modulating mitochondrial function
| Project/Area Number |
18390249
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
MAKINO Hirofumi Okayama University, 大学院・医歯薬学総合研究科, 教授 (50165685)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Jun 岡山大学, 医学部・歯学部附属病院, 講師 (30294408)
SHIKATA Kenichi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00243452)
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| Project Period (FY) |
2006 – 2008
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| Keywords | ミトコンドリア / Tim44 / 活性酸素 / 糖尿病性腎症 / 糖尿病慢性血管合併症 |
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| Research Abstract |
生活習慣の変化により糖尿病患者は増加の一途をたどり、糖尿病性腎症により透析導入となる患者も年々増加している.糖尿病マウスへのtranslocase of inner mitochondrial membrane 44 (Tim44)遺伝子導入によって、糸球体肥大・メサンギウム基質の増加・アルブミン尿の増加が抑制された.Tim44はミトコンドリアへのsuperoxide dismutaseやglutathione dismutaseといった抗酸化酵素をimportしてミトコンドリア由来の活性酸素の産生を抑制することにより治療効果を発揮すると考えられた.
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[Journal Article] Collectrin is involved in the development of salt-sensitive hypertension by facilitating the membrane trafficking of apical membrane proteins via interaction with soluble N-ethylmaleiamide-sensitive factor attachment protein receptor complex2008
Author(s)
Yasuhara A, Wada J, Malakauskas SM, Zhang Y, Eguchi J, Nakatsuka A, Murakami K, Kanzaki M, Teshigawara S, Yamagata K, Le TH, Makino H
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Journal Title
Circulation 118
Pages: 2146-2155
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[Journal Article] Procollagen C-proteinase enhancer-1 (PCPE-1) interacts with ・2-microglobulin (・ 2-m) and may help initiate ・2-m amyloid fibril formation in connective tissues2008
Author(s)
Morimoto H, Wada J, Font B, Mott JD, Hulmes DJ, Ookoshi T, Naiki H, Yasuhara A, Nakatsuka A, Fukuoka K, Takatori Y, Ichikawa H, Akagi S, Nakao K, Makino H
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Journal Title
Matrix Biol 27
Pages: 211-219
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[Journal Article] The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells2007
Author(s)
Zhang Y, Wada J, Yasuhara A, Iseda I, Eguchi J, Fukui K, Yang Q, Yamagata K, Hiesberger T, Igarashi P, Zhang H, Wang H, Akagi S, Kanwar YS, Makino H
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Journal Title
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[Journal Article] Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation2007
Author(s)
Usui HK, Shikata K, Sasaki M, Okada S, Matsuda M, Shikata Y, Ogawa D, Kido Y, Nagase R, Yozai K, Ohga S, Tone A, Wada J, Takeya M, Horiuchi S, Kodama T, Makino H
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Journal Title
Diabetes 56
Pages: 363-372
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[Journal Article] The association of C-reactive protein with an oxidative metabolite of LDL and its implicationin atherosclerosis2007
Author(s)
Tabuchi M, Inoue K, Usui-Kataoka H, Kobayashi K, Teramoto M, Takasugi K, Shikata K, Yamamura M, Ando K, Nishida K, Kasahara J, Kume N, Lopez LR, Mitsudo K, Nobuyoshi M, Yasuda T, Kita T, Makino H, Matsuura E
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Journal Title
J Lipid Res 48
Pages: 768-781
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[Journal Article] 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice2006
Author(s)
Ichinose K, Maeshima Y, Yamamoto Y, Kinomura M, Hirokoshi K, Kitayama H, Takazawa Y, Sugiyama H, Yamasaki Y, Agata N, Makino H
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Journal Title
Diabetes 55
Pages: 1232-1242
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