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2007 Fiscal Year Final Research Report Summary

Aphysiological role and the controlmeellanism ofa phosphate senser

Research Project

Project/Area Number 18390250
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

MIYAMOTO Ken-ichi  The University of Tokushima, Institute of health biosciences graduate school, Professor (70174208)

Co-Investigator(Kenkyū-buntansha) KUWAHATA Masashi  The University of Tokushima, Institute of health biosciences graduate school, Lecturer (30304512)
SEGAWA Hiroko  The University of Tokushima, Institute of health biosciences graduate school, Assistant professor (70325257)
TATSUMI Sawako  The University of Tokushima, Institute of health biosciences graduate school, COE Fellow researchm (80420545)
Project Period (FY) 2006 – 2007
Keywordskidney / phosphate / HHRH / hypophosphatemia / mineralization / rickets
Research Abstract

Phosphate (Pi) has long been recognized to play an important role in bone mineralization.
The homeostatic maintenance of extracellular phosphate is achieved primarily by re-absorption of phosphate in the proximal kidney tubule through the hormone- and phosphate sensitive sensor protein (type II Na/Pi cotrnsporter. Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a rare inherited disorder in an autosomal recessive fashion, characterized by hypophosphatemia, short stature, rickets and/or osteomalacia and secondary absorptive hypercalciuria. More recently, linkage analysis of HHRH demonstrated that the candidate gene is the phosphate sensor (type IIc Na/Pi (NaPi-IIc) cotransporter). In the present study, we demonstrated that lack of functional NaPi-IIc protein with HHRH results in severe renal Pi-wasting, leading to hypophosphatemia (10). These observations suggest that the NaPi-IIc cotransporter has an important role in renal Pi reabsorption and bone mineralization, and may be a key determinant of plasma Pi concentrations in human (11). However, it is not clear why loss of function of the less abundant and energetically less favorable electroneutral NaPi-Iic transporter causes rickets and osteomalacia in humans whereas mutations in the more abundant electrogenic NaPi-Iia transporter elicits a mild skeletal phenotype that lacks the typical features of rickets and osteomalacia in mice. To understand the role of NaPi-Iia and NaPi-Iic transporters in the overall maintenance of Pi homeostasis and bone mineralization, we have disrupted the murine NaPi-Iia/NaPi-Iic gene and analyzed phenotypes of each mutant. The present studies suggest that NaPi-Iic may be a more important regulator of Pi homeostasis in humans than in mice.

  • Research Products

    (74 results)

All 2008 2007 2006

All Journal Article (36 results) (of which Peer Reviewed: 13 results) Presentation (34 results) Book (4 results)

  • [Journal Article] Polypyrimidine tract-binding protein is involved in regulation of albumin synthesis in response to food intake.2008

    • Author(s)
      Kuwahata M.
    • Journal Title

      J Nutr Svi Vitaminol. 54(2)(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] カルシウム・リン代謝の基本と最近の話題2008

    • Author(s)
      宮本賢一
    • Journal Title

      medicina 45(3)

      Pages: 413-416

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Correlation between hyperphosphatemia and type II Na/Pi cotransporter a ctivity in klotho mice.2007

    • Author(s)
      Segawa H.
    • Journal Title

      Am J Physiol Renal Physiol. 292(2)

      Pages: F769-779

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure.2007

    • Author(s)
      Kuwahata M.
    • Journal Title

      Biochim Biophys Acta. 1772(1)

      Pages: 60-65

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter.2007

    • Author(s)
      Segawa H.
    • Journal Title

      Am J Physiol Renal Physiol. 292(1)

      Pages: F395-403

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cells.2007

    • Author(s)
      Ito M.
    • Journal Title

      Am J Physiol Cell Physiol. 292(1)

      Pages: C526-534

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Anxiolytic effect of music depends on ovarian steroid in female mice.2007

    • Author(s)
      Chikahisa S.
    • Journal Title

      Behav Brain Res. 179(1)

      Pages: 50-59

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice.2007

    • Author(s)
      Kitaoka K.
    • Journal Title

      Brain Res. May 30(1150)

      Pages: 121-130

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts.2007

    • Author(s)
      Sawada N.
    • Journal Title

      Bone. 41(1)

      Pages: 52-58

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Control of phosphate appetite in young rats.2007

    • Author(s)
      Ohnishi R.
    • Journal Title

      J Med Invest. 53(3-4)

      Pages: 366-369

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Localization of polypyrimidine-tract-binding protein is involved in the regulation of albumin synthesis by branched-chain amino acids in HepG2 cells.2007

    • Author(s)
      Kuwahata M.
    • Journal Title

      J Nutr Biochem. Aug 16(Epub ahead of print)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter.2007

    • Author(s)
      Miyamoto K.
    • Journal Title

      Am J Nephrol. 27(5)

      Pages: 503-515

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Life-long caloric restriction reveals biphasic and dimorphic effects on bone metabolism in rodents.2007

    • Author(s)
      Tatsumi S.
    • Journal Title

      Endocrinology. Nov 8(Epub ahead of print)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.2007

    • Author(s)
      Tatsumi S.
    • Journal Title

      Cell Metab. 5(6)

      Pages: 464-475

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Ca/P/Mg輸送調節の新展開-基礎と臨床2007

    • Author(s)
      宮本賢一
    • Journal Title

      腎と骨代謝 20(1)

      Pages: 7-11

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] リン輸送異常とKlotho/FGF232007

    • Author(s)
      瀬川 博子
    • Journal Title

      腎と骨代謝 20(1)

      Pages: 39-44

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] α Klothoとリン代謝2007

    • Author(s)
      宮本賢一
    • Journal Title

      CLINICAL CALCIUM 17(5)

      Pages: 54-59

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 腎臓とミネラル代謝ホルモン2007

    • Author(s)
      宮本賢一
    • Journal Title

      日本腎臓学会誌 49(4)

      Pages: 406-411

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] リン酸の新しい代謝調節作用2007

    • Author(s)
      宮本賢一
    • Journal Title

      CLINICAL CALCIUM 17(10)

      Pages: 13-20

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] リン摂取量と食品に含まれるリン2007

    • Author(s)
      桑波田雅士
    • Journal Title

      腎と骨代謝 20(4)

      Pages: 305-312

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] リン代謝とその異常2007

    • Author(s)
      宮本賢一
    • Journal Title

      日本医事新報 4364

      Pages: 67-71

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Pの役割とその異常2007

    • Author(s)
      宮本賢一
    • Journal Title

      腎と透析 63

      Pages: 96-100

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 栄養不良の定義2007

    • Author(s)
      伊藤美紀子
    • Journal Title

      臨牀透析 24(2)

      Pages: 127-133

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Correlation between hyperphosphatemia and type II Na/Pi cotransporter activity in klotho mice2007

    • Author(s)
      Segawa, H
    • Journal Title

      Am J Physiol Renal Physiol 292(2)

      Pages: 769-79

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure2007

    • Author(s)
      Kuwahata, M
    • Journal Title

      Biochim Biophys Acta 1772(1)

      Pages: 60-5

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Parathyroid hormone-dependent endocytosis of renal type Ilc Na-Pi cotransporter2007

    • Author(s)
      Segawa, H
    • Journal Title

      Am J Physiol Renal Physiol 292(1)

      Pages: 395-403

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cells2007

    • Author(s)
      Ito, M
    • Journal Title

      Am J Physiol Cell Physiol 292(1)

      Pages: 526-34

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Anxiolytic effect of music depends on ovarian steroid in female mice2007

    • Author(s)
      Chikahisa, S
    • Journal Title

      Behav Brain Res 179(1)

      Pages: 50-59

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice2007

    • Author(s)
      Kitaolca, K
    • Journal Title

      Brain Res. May 30(1150)

      Pages: 121-30

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts2007

    • Author(s)
      Sawada, N
    • Journal Title

      Bone 41(1)

      Pages: 52-8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Control of phosphate appetite in young rats2007

    • Author(s)
      Ohnishi, R
    • Journal Title

      J Med Invest 54(3-4)

      Pages: 366-9

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Localization of polypyrimidine-tract-binding protein is involved in the regulation of albumin synthesis by branched-chain amino acids in HepG2 cells2007

    • Author(s)
      Kuwahata, M
    • Journal Title

      J Nutr Biochem. 2007 Aug 16 ; [Epub ahead of print]

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] New aspect of renal phosphate reabsorption : the type Ik sodium-dependent phosphate transporter2007

    • Author(s)
      Miyamoto, K
    • Journal Title

      Am J Nephrol 27(5)

      Pages: 503-15

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Life-long caloric restriction reveals biphasic and dimorphic effects on bone metabolism in rodents2007

    • Author(s)
      Tatsumi, S
    • Journal Title

      Endocrinology. 2007 Nov 8 ; [Epub ahead of print]

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction2007

    • Author(s)
      Tatsumi, S
    • Journal Title

      Cell Metab 5(6)

      Pages: 464-75

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Polypyrimidine tract-binding protein is involved in regulation of albumin synthesis in response to food intake2007

    • Author(s)
      Kuwahata, M
    • Journal Title

      J Nutr Svi Vitaminol 54(2)(in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 生体内リン代謝調節機構の解明〜リン酸トランスポーターの調節機構を中心として〜2008

    • Author(s)
      上畑 陽子
    • Organizer
      第11回日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 慢性腎不全における腸管ペプチド吸収機構と甲状腺ホルモンの関与2008

    • Author(s)
      古谷 順也
    • Organizer
      第11回日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 栄養素による代謝調節機構:ミネラル代謝の基礎と臨床2008

    • Author(s)
      宮本 賢一
    • Organizer
      第11回日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 慢性腎不全時における 腸管ペプチド及び、アミノ酸輸送機構の解析2007

    • Author(s)
      古谷 順也
    • Organizer
      第1回日本アミノ酸学会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 遺伝性低リン血症性くる病(HHRH)原因遺伝子の生理機能解明2007

    • Author(s)
      上畑 陽子
    • Organizer
      第40回日本栄養・食糧学会中四国支部大会
    • Place of Presentation
      広島
    • Year and Date
      2007-11-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 腎臓と骨を結ぶリン代謝系の探索:NaPi-IIc遺伝子プロモーターの検討2007

    • Author(s)
      島村 仁子
    • Organizer
      第40回日本栄養・食糧学会中四国支部大会
    • Place of Presentation
      広島
    • Year and Date
      2007-11-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Thyroid Hormones Regulate the Phosphate Homeostasis through the Tran scriptional Control of the Renal Type IIa Sodium-Dependent Phosphate Cotransporter (NaPi-IIa)Gene.2007

    • Author(s)
      Yamamoto H.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Role of Ezrin in the Regulation of Membrane Localization of Type IIa Sodium-Dependent Phosphate Transporter(NaPi-IIa).2007

    • Author(s)
      Taketani Y.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Localization of Sodiuln-Phosphate Cotmllsporters NaPi-IIa and-IIc in Human Renal Proximal and Distal Tubules.2007

    • Author(s)
      Ohkido I..
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Thyroid Hormones Regulate the Phosphate Homeostasis through the Transcriptional Control of the Renal Type Ha Sodium-Dependent Phosphate Cotransporter(NaPHIa) Gene2007

    • Author(s)
      Yamamoto, H
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Role of Ezrin in the Regulation of Membrane Localization of Type Ha Sodium-Dependent Phosphate Transporter(NaPi-Ha)2007

    • Author(s)
      Taketani, Y
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Localization of Sodium-Phosphate Cotransporters NaPi-IIa and -IIc in Human Renal Proximal and Distal Tubules2007

    • Author(s)
      Ohkido, I
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] The Molecular Mechanisms for the Alteration of PepT1 Expression in 3/4 Nephrectomized Rats.2007

    • Author(s)
      Furutani J.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2007-11-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Npt2a and Npt2c in Mice Play Distinct and Synergistic Roles in Inorganic Phosphate Metabolism and Skeletal Development.2007

    • Author(s)
      Segawa H.
    • Organizer
      The American Society of Nephrology.
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2007-11-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The Molecular Mechanisms for the Alteration of PepT1 Expression in 3/4 Nephrectomized Rats2007

    • Author(s)
      Furutani, J
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-03
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Npt2a and Npt2c in Mice Play Distinct and Synergistic Roles in Inorganic Phosphate Metabolism and Skeletal Development2007

    • Author(s)
      Sezawa, H
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-03
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 食品に含まれる抗うつ成分評価系の開発2007

    • Author(s)
      宮本 賢一
    • Organizer
      第54回日本栄養改善学会
    • Place of Presentation
      長崎
    • Year and Date
      2007-09-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The role of the type IIc sodium-dependent phosphate transporter (NPt2c), which is involved in hereditary hypophosphatemic rickets with hypercalc iuria (HHRH).2007

    • Author(s)
      Segawa H.
    • Organizer
      The American Society for Bone and Mineral Research.
    • Place of Presentation
      San Honolulu, USA.
    • Year and Date
      2007-09-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Role of Npt2c in renal Pi reabsorption in Npt2a KO mice.2007

    • Author(s)
      Tomoe Y.
    • Organizer
      The American Society for Bone and Mineral Research.
    • Place of Presentation
      San Honolulu, USA.
    • Year and Date
      2007-09-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The role of the type IIc sodium-dependent phosphate transporter(Npt2c), which is involved in hereditary hypophosphatemic rickets with hypercalciuria(HHRH)2007

    • Author(s)
      Segawa, H
    • Organizer
      The American Society for Bone and Mineral Research
    • Place of Presentation
      San Honolulu, USA
    • Year and Date
      2007-09-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Role of Npt2c in renal Pi reabsorption in Npt2a KO mice2007

    • Author(s)
      Tomoe, Y
    • Organizer
      The American Society for Bone and Mineral Research
    • Place of Presentation
      San Honolulu
    • Year and Date
      2007-09-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 新しいリン代謝調節因子の理解に向けて2007

    • Author(s)
      瀬川 博子
    • Organizer
      第52回日本透析医学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] リン代謝調節機構におけるNpt2aとNpt2cの役割2007

    • Author(s)
      瀬川 博子
    • Organizer
      第50回日本腎臓学会
    • Place of Presentation
      静岡
    • Year and Date
      2007-05-26
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 無機リン酸代謝異常症の解析;リントランスポートソームの構成蛋白の膜移行シグナル2007

    • Author(s)
      櫻井 文
    • Organizer
      第61回日本栄養・食糧学会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 遺伝性低リン血症性くる病に関与するリントランスポーターNpt2cスプライシングバリアントの同定と機能解析2007

    • Author(s)
      本田 尚子
    • Organizer
      第61回日本栄養・食糧学会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] ヒト肝癌細胞におけるmTOR依存症アルブミン合成調節機構2007

    • Author(s)
      桑波 田雅士
    • Organizer
      第61回日本栄養・食糧学会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Roles of Type IIc Na/Pi Cotransporters in Body Pi Homeostasis2006

    • Author(s)
      Segawa, H
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2006-11-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] The Last Intracellular Loop of Nan-11c Contains the Apical Localization Signal for Renal Epithelial Cells2006

    • Author(s)
      Ito, M
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2006-11-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] NaPi IIc Is Present in Cholesterol, Sphingomyelin, and Ceramide Enriched Membrane Microdomains of the Renal Proximal Tubular Brush Border Membranes2006

    • Author(s)
      Takahashi, H
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2006-11-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Alteration of Intestinal Peptide and Amino Acid Transporter Levels in Renal Insufficiency Rat2006

    • Author(s)
      Furutani, J
    • Organizer
      The American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2006-11-17
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Regulation of Npt2c in Npt2a null mice2006

    • Author(s)
      Segawa, H
    • Organizer
      ISN The Bone and the Kidney
    • Place of Presentation
      Denmark
    • Year and Date
      2006-10-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Type He Na/Pi mutation in Japanese patients with hereditary hypophosphatemic rickets with hypercalciuria2006

    • Author(s)
      Aranami, F
    • Organizer
      ISN The Bone and the Kidney
    • Place of Presentation
      Denmark
    • Year and Date
      2006-10-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Role of ezrin in the localization and hormonal regulation of sodium-dependent phosphate transporter2006

    • Author(s)
      Taketani, Y
    • Organizer
      ISN The Bone and the Kidney
    • Place of Presentation
      Denmark
    • Year and Date
      2006-10-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Abnormal regulation of the type II sodium dependent phosphate cotransporters in klotho mice2006

    • Author(s)
      Segawa, H
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB CONGRESS
    • Place of Presentation
      Kyoto Japan
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Annual Review腎臓20082008

    • Author(s)
      宮本 賢一
    • Total Pages
      43-48
    • Publisher
      FGF23/klothoシグナルによるリン代謝調節
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] からだの科学2008

    • Author(s)
      伊藤 美紀子
    • Total Pages
      86-90
    • Publisher
      分子栄養学的アプローチによるテーラーメイド予防
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 日本医師会雑誌特別号2007

    • Author(s)
      宮本 賢一
    • Total Pages
      S104-S105
    • Publisher
      Caの異常[成人]
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 日本医師会雑誌特別号2007

    • Author(s)
      宮本 賢一
    • Total Pages
      S108-S109
    • Publisher
      Pの異常[成人]
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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