2009 Fiscal Year Final Research Report
Molecular mechanism of signal integration between ATP and cAMP in pancreatic -cells
| Project/Area Number |
18390272
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Chiba University (2007-2009)
Kobe University (2006) |
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Principal Investigator |
MIKI Takashi Chiba University, 大学院・医学研究院, 教授 (50302568)
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| Project Period (FY) |
2006 – 2009
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| Keywords | ATP感受性K^+(K_<ATP>)チャネル / ATP / cAMP / インスリン / 分泌 |
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| Research Abstract |
Secretion of insulin, the glucose-lowering hormone, from pancreatic β-cells is regulated by blood glucose and a gut hormone incretin. These stimuli increase intracellular concentrations of ATP and cAMP, respectively, activating intracellular signals to elicit insulin secretion. In this study, mutual interaction between these two signals was elucidated with special emphasis on an ATP-sensor K_<ATP> channel and a cAMP-sensor Epac2.
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Research Products
(44 results)
