2007 Fiscal Year Final Research Report Summary
Isolation and characterization of candidate myeloid tumor-suppressor genes on the long arm of chromosome7.
| Project/Area Number |
18390284
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hiroshima University |
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Principal Investigator |
INABA Toshiya Hiroshima University, Res. Inst. for Radiat. Biol. and Med., Professor (60281292)
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| Co-Investigator(Kenkyū-buntansha) |
ASOU Hiroya Hiroshima University, Res. Inst. for Radiat. Biol. and Med., Associate Prof (60243614)
MATSUI Hirotaka Hiroshima University, Res. Inst. for Radiat. Biol. and Med., Associate Prof (60379849)
AKI Daisuke Hiroshima University, Res. Inst. for Radiat. Biol. and Med., Associate Prof (50420500)
HONDA Hiroaki Hiroshima University, Res. Inst. for Radiat. Biol. and Med., Prof (40245064)
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| Project Period (FY) |
2006 – 2007
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| Keywords | 7 / 7q / mvelodysolastic syndrome / chromosome instability / centrosome / mitotic abnormiality / nuclear morphology |
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| Research Abstract |
Monosomy 7 is a common nonrandom chromosomal abnormality found frequently in myelodysplastic syndrome (MDS) and related acute myeloid leukemia (AML). A previously uncharacterized genes, Miki, Titan Kasumi, were isolated from the site of a common microdeletion cluster in the 7q21 band. Mild protein localizes to the Golgi apparatus, centrosomes and mitotic spindles. Downregulation of Mild disturbs the maturation and positioning of centrosomes, resulting in unorganized spindles. Cells undergo pre-anaphase arrest and exit mitosis in the absence of chromosome segregation or terminate mitosis by cell death. In addition, chromosome instability is found in the progeny. The binding of Mild to spindles depends on the poly (ADP-ribose) polymerase activity of tankyrase-1. Titan-deficient mice looked normal. However, AML developed at very high frequency by infection of retrovirus and common integration sites were now establishing from these mice. These findings suggests that the three genes are promising candidates for long-sought responsible genes for -7/7q- in MDS and AML.
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Research Products
(40 results)
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[Presentation] (^<*1>Tokyo Univ.) A novel golgi-resident protein, Mild, is required for maintenance of golgi structure and endosome-to-golgi transport2007
Author(s)
Aki, D., Takemura, Y.^<*1>, Asou, H., Matsui, H., Nagamachi, A., Ozaki, Y., Inaba, T
Organizer
The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th of Annual Meeting of the Japanese Biochemical Society
Place of Presentation
Yokohama
Year and Date
20071211-15
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Div. Of Oncology, Institute for Medical Science, Tokyo University) Downregulation of a Candidate Myeloid Tumor Suppressor Gene Isolated from 7q21 Induces Abnormal Mitosis Due to Insufficient Centrosome Maturation2007
Author(s)
Asou, H., Matsui, H., Ozaki, Y., Nagamachi, A., Aki, D., Ohsugi, M.^<*1>, Inaba, T
Organizer
The 49th Annual Meeting of the American Society of Hematology
Place of Presentation
Atlanta, Georgia
Year and Date
20071208-11
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Pediatrics, University of Yamanashi, Faculty of Medicine, ^<*2>Pediatrics, Dokkyo Medical University, ^<*3>Pediatrics, Yokohama City University, Faculty of Medicine, ^<*4>Pediatrics, Iwate Medical University Faculty of Medicine, ^<*5>Immunology, Juntendo University School of Medicine, ^<*6>Pediatrics, Oncology, Dana-Farber Cancer Institute) Induction of Death Receptors for TRAIL, a Cytotoxic Factor for GVL Effect, by Oncogenic Fusion E2A-HLF Derived from t(17 ; 19)-Positive Acute Lymphoblastic Leukemia2007
Author(s)
Zhang, X.^<*1>, Inukai, T.^<*1>, Akahane, K.^<*1>, Hirose, K.^<*1>, Kuroda, I.^<*1>, Honna, H.^<*1>, Goi, Kagami, K.^<*1>, Inaba, T., Kurosawa, H.,^<*2>, Goto, H.^<*3>, Endo, M.^<*4>, Yagita, H.^<*5>, Look, A.T.^<*6>, Sugita, K.^<*1>
Organizer
The 4962 Annual Meeting of the American Society of Hematology
Place of Presentation
Atlanta, Georgia
Year and Date
20071208-11
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept, of Pediatrics, Nagoya University Graduate School of Medicine) Analysis of the mutation and the large deletion of Mal gene in the children with aplastic anemia2007
Author(s)
Wang, Y.^<*1>, Tanigasaki, H.^<*1>Hama, A.^<*1>, Nishio, N.^<*1>, Takahashi,Y.^<*1>, Asou, H., Inaba, T., Kojima, S.^<*1>
Organizer
The 69th Annual Meeting of Japanese Society of Hematology and The 49th Annual Meeting of Japanese Society of Clinical Hematology
Place of Presentation
Yokohama
Year and Date
20071011-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept Dev. Oncol.) Candidate responsible genes isolated from 7q possibly involvement in ds-DNA break repair2007
Author(s)
Matsui, H., Asou, H., Honda, H.^<*1>", Nagamachi, A., Ozaki, Y, Aid, D., Fujioka, K., Inaba, T
Organizer
The 69th Annual Meeting of Japanese Society of Hematology and The 49th Annual Meeting of Japanese Society of Clinical Hematology
Place of Presentation
Yokohama
Year and Date
20071011-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>The Institute of Medical Science, The University of Tokyo, ^<*2>Mie University School of Medicine ^<*3>Dept of Hematology/Oncology, ^<*4>Dept. of Hematology/Oncology, The University of Tokyo, ^<*5>Mesenchymal stem cell project, The Institute of Medical Science, The University of Tokyo)RasGRP4 collaborates with AML1 point mutation to induce T cell leukemia in a mouse BMT model2007
Author(s)
Watanabe-Okochi, N.^<*1>", Oki, T.^<*1>", Ono, R.^<*2>, Harada, H.^<*3>, Yuji, K.^<*4>, Tojyo, A.^<*4>, Nakajima, H.^<*5>, Nosaka,T.^<*2>, Inaba, T., Kitaura, J.^<*1>, Kitamura, T.^<*1>
Organizer
The 69th Annual Meeting of Japanese Society of Hematology and The 49th Annual Meeting of Japanese Society of Clinical Hematology
Place of Presentation
Yokohama
Year and Date
20071011-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept of Pediatrics, University of Yamanashi, Faculty of Medicine,^<*2>Jichi Medical University, ^<*3>Dept. of Pediatrics, Dokkyo Medical University,^<*4>Dept of Pediatrics, Iwate Medical University, ^<*5>Dept of Pediatrics, Yokohama City University, Faculty of Medicine) Anti-apoptotic activity of LMO2 overexpressed in t(17 : 19)-ALL2007
Author(s)
Hirose, K.^<*1>, Inukai, T.^<*1>, Kikuchi, J.^<*2>, Kuroda, I.^<*1>, Zang, X.^<*1>, Honna, H.^<*1>, Goi, K.^<*1>, Kagami, K.^<*1>, Inaba,T.,Kurosawa, H.^<*3>, Endo, M.^<*4>, Gotou, H.^<*5>, Furukawa, Y., Nakazawa, S.^<*1>, Sugita,K.^<*1>
Organizer
The 69th Annual Meeting of Japanese Society of Hematology and The 49th Annual Meeting of Japanese Society of Clinical Hematology
Place of Presentation
Yokohama
Year and Date
20071011-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept of Pediatrics, Dokkyo Medical University,^<*2>Dept.of Pediatrics, University of Yamanashi, Faculty of Medicine,^<*3>Dept. of Pediatrics, Iwate Medical University,^<*4>, Dept of Pediatrics, Yokohama City University Faculty of Medicine) Hypercalcemia in t(17 ; 19)+ALL by E2A-HLF inducing PTHrP overexpression2007
Author(s)
Kurosawa, H.^<*1>, Matsunaga, T. ^<*1>, Okutani, M.^<*1>, Fukushima, K.<*1>, Sugita, Inukai, T.^<*2>, Inaba, T., Endo, M.^<*3>, Gotou, H.^<*4>, Arisaka, O. ^<*1>
Organizer
The 69th Annual Meeting of Japanese Society of Hematology and The 49th Annual Meeting of Japanese Society of Clinical Hematology
Place of Presentation
Yokohama
Year and Date
20071011-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept. of Dev. Oncol. E2A/FLF cooperates with Gfil, Ikaros, or Evi3 transcription factor to induce leukemia2007
Author(s)
Tazaki, S.^<*1>, Miyazaki, K.^<*1>, Oda, H.^<*2>, Inaba, T., Honda, H.^<*1>
Organizer
The 69th Annual Meeting of Japanese Society of Hematology and The 49th Annual Meeting of Japanese Society of Clinical Hematology
Place of Presentation
Yokohama
Year and Date
20071011-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept Dev. Oncol.,^<*3> Dept. Stem Cell Biol.,^<*3> Div. Oncol. Inst. Med. Sci. Tokyo Univ.) Haploinsufficiency of Mild on 7q encoding a PARsylated protein induces mitotic disturbance characteristic to MDS/AML2007
Author(s)
Asou, H., Matsui, H., Honda,Ozaki,Y., Nagamachi, A., Aki, D., Yasunaga,S.^<*1>, Takihara, Y.^<*2>, Ohsugi, M.^<*3>, Inaba, T
Organizer
Proceedings 66th Annual Meeting of the Japanese Cancer Association
Place of Presentation
Yokohama
Year and Date
20071003-05
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept. Dev. Oncol.) Involvement of novel myeloid tumor suppressor candidate genes on 7q in the DNA repair system2007
Author(s)
Matsui, H., Asou, H., Honda, H.^<*1>, Nagamachi, A., Ozaki, Y., Aki, D., Fujioka, K., Inaba, T
Organizer
Proceedings 66th Annual Meeting of the Japanese Cancer Association
Place of Presentation
Yokohama
Year and Date
20071003-05
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept. Dev. Oncol.) Miki, a putative responsible gene for radiation induced leukemia, plays an important role in cellular mitotic process. The 48th Annual Meeting of Late Effects of Atomic Bomb2007
Author(s)
Asou, H., Ozaki, Y., Matsui, R, Aid, D., Nagamachi, A., Honda, H^<*1>., Inaba, T
Organizer
The 48th Annual Meeting of Late Effects of Atomic Bomb
Place of Presentation
Hiroshima
Year and Date
2007-06-03
Description
「研究成果報告書概要(欧文)」より
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[Presentation] (^<*1>Dept Dev. Oncol.) Kasumi/Titan, putative responsible genes for radiation induced leukemia, function in gene repair system induced by Mitomycin C2007
Author(s)
Asou, H., Nagamachi, A., Honda, H^<*1>., Ozald, Y., Matsui, H., Aki, D., Fujioka, K., Inaba, T
Organizer
The 48th Annual Meeting of Late Effects of Atomic Bomb
Place of Presentation
Hiroshima
Year and Date
2007-06-03
Description
「研究成果報告書概要(欧文)」より
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