2007 Fiscal Year Final Research Report Summary
Biological role of genes at genetic alteration regions for proliferation and differentiation in hem
| Project/Area Number |
18390286
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
SETO Masao Aichi Cancer Center Research Institute, Molecular Medicine, Chief (80154665)
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| Project Period (FY) |
2006 – 2007
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| Keywords | ATLL / T / NK lymphoma / PTCL-U |
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| Research Abstract |
1. Adult T-cell leukemia/lymphoma : Array CGH analysis revealed that genome profiles of acute and lymphoma types are distinct, and suggested that ATLL genetic alterations after HTLV1 infection may play a role for oncogenesis of the two clinmically distinct disease subtypes. Further characterization of genomic regions and identification of responsible genes from these regions are warranted. This will reveal functional significance of these genes in cell profilferation and differentiations.
2. T/NK leukemia/lymphoma : extranodal T/NK and Aggressive NK lymphomas were found to have distinct genetic alteration patterns although clinical manifestations and EBV involvement are similar.
3. Peripheral T-cell lymphoma-unspecified(PTCL-U) : PTCL-U with multiple genomic alterations were found in about half of the cases and the pattern of genomic alterations are similar to that of ATLL lymphoma type. Histology also showed similarity in that they have peomorphic nuclear shape and CCR4 expression.
4. B-cell lymphoma : We have identified BIM gene loss in mantle cell lymphoma(MCL) . BIM gene is known to regulate BCL2 function. We therefore examined significance of apoptotic gene family by expression profiling analysis and suggested that a poor prognosis group in the MCL exist. This needs to further confirmation.
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Research Products
(71 results)
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[Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in cular. Adnexal marginal zone B cell lymphoma.2008
Author(s)
Honma, K., Tsuzuki, S., Nakagawa, M, Karnan, S., Aizawa, Y., Kim, WS., Kim, YD., Ko, YH., Seto, M.
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Journal Title
Genes Chrom. Cancer 47
Pages: 39821
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Clinical features and prognosis of gastric MALT lymphoma with special reference to responsiveness to H. pylori eradication and API2-MALT1 status.2008
Author(s)
Nakamura, T., Seto., M, Tajima, M., Kawai, H., Yokoi, T., Yatabe, Y., Nakamura, S.
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Journal Title
Am J Gastroenterol 103
Pages: 62-70
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genetic abnormalities involved in t(12 ; 21) TEL-AML1 acute lymphoblastic leukemia : Analysis by means of array-based comparative genomic hybridization.2007
Author(s)
Tsuzuki, S., Karnan, S., Horibe, K., Matsumoto, K., Kato, K., Inukai, T., Goi, K., Sugita, K., Nakazawa, S., Kasugai, Y., Ueda, R., Seto., M.
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Journal Title
Cancer Sci. 98
Pages: 698-706
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.2007
Author(s)
Taniguchi, T., Karnan, S, Fukui, T., Yokoyama, T., Tagawa, H., Yokoi, K, Ueda, Y., Mitsudomi, T., Horio, Y, Hida, T., Yatabe, Y., Seto., M., Sekido, Y.
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Journal Title
Cancer Sci. 98
Pages: 438-46
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1.2007
Author(s)
Tsuzuki, S., Hong, D., Gupta, E., Matsuo, K., Seto., M., Enver, T.
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11; 18)(q21; q21) negative gastric malt lymphomas.2007
Author(s)
Fukuhara, N., Nakamura, T., Nakagawa, M, Tagawa, H., Takeuchi, I, Yatabe, Y., Morishima, Y, Nakamura, S., Seto., M.
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Journal Title
Genes Chromosomes and Cancer 46
Pages: 784-790
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genome-wide array-based comparative genomic hybridization of ocular marginal zone b cell lymphoma : comparison with pulmonary and nodal marginal zone b cell lymphoma.2007
Author(s)
Kim, W-S., Honma, K., Karnan, S., Tagawa, H., Kim, Y-D., Oh, Y-L., Seto, M., Ko, Y-H.
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Journal Title
Genes Chromosomes and Cancer 46
Pages: 776-783
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] API2-MALT1 chimeric transcript-positive gastroduodenal MALT lymphoma with subsequent development of adenocarcinoma as a collision tumour over a clinical course of 7 years.2007
Author(s)
Isaka, T., Nakamura, T., Tajika, M., Kawai, H., Imaoka, H., Okamoto, Y, Aoki, M., Inoue, H., Takahashi, K., Mizuno, N., Sawaki, A., Yamao, K., Seto., M, Yokoi, T., Yatabe, Y., Nakamura, S.
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Journal Title
Histopathology 51
Pages: 119-123
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Trisomy 3 is a specific genomic aberration of t(14 ; 18) negative follicular lymphoma.2007
Author(s)
Tagawa, H., Karube, K., Guo, Y., Takeshita, M., Kikuchi, M., Morishima, Y., Nakamura, S., Ohshima, K., Seto M.
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Journal Title
Leukemia 21
Pages: 2549-2551
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma.2007
Author(s)
Yoshimoto, T., Matsuura, K., Karnan, S., Tagawa, H., Nakada, C., Tanigawa, M., Tsukamoto, Y., Uchida, T., Kashima, K., Akizuki, S., Takeuchi, I., Sato, F., Mimata, H., Seto., M., Moriyama, M.
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Journal Title
J Pathol. 213
Pages: 392-401
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia.2006
Author(s)
Karnan, S., Tsuzuki, S., Kiyoi, H., Tagawa, H., Ueda, R., Seto, M., Naoe, T.
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Journal Title
Genes Chrom. Cancer 45
Pages: 420-425
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma.2006
Author(s)
Oshiro, A., Tagawa, H., Ohshima, K, Karube, K, Uike, N., Tashiro, Y., Utsunomiya, A., Masuda, M., Takasu, N., Nakanura, S., Morishima, Y., Seto, M.
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Journal Title
Blood 107
Pages: 4500-4507
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Characterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma.2006
Author(s)
Fukuhara, N, Tagawa, H., Kameoka, Y., Kasugai, Y., Karnan, S., Kameoka, J., Sasaki, T., Morishima, Y., Nakamura, S, Seto., M.
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Journal Title
Cancer Sci. 97
Pages: 499-504
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression profiling analysis of the CD5(+) diffuse large B-cell lymphoma subgroup : Development of a CDS signature.2006
Author(s)
Suguro, M., Tagawa, H., Kagami, Y., Okamoto, M., Ohshima, K., Shiku, H., Morishima, Y., Nakamura, S., Seto, M.
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Journal Title
Cancer Sci. 97
Pages: 868-874
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] CD10(-) MUM1(+) follicular lymphoma lacks BCL2 translocation and shows characteristic biological and clinical features.2006
Author(s)
Karube, K., Guo, Y., Suzumiya, J., Sugita, Y., Nomura, Y., Yamamoto, K., Shimizu, K., Yoshida, S., Komatani, H., Takeshita, M., Kikuchi, M., Nakamura, N., Takasu, O., Arakawa, F., Tagawa, H., Seto, M., Ohshima, K.
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Journal Title
Blood 109
Pages: 3076-3079
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Analysis of advanced gastric carcinoma with array-based comparative genomic hybridization.2007
Author(s)
Uchida, T., Karnan, S., Tsukamoto, Y., Noguchi, T., Tagawa H., Hijiya, N., Matsuura, K., Seto, M., Moriyama, M.
Organizer
66th Annual Meeting of the Japanese Cancer Association
Place of Presentation
Yokohama
Year and Date
20071002-05
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Array CGH analysis of peripheral T-cell lymphoma-unspecified revealed common genomic alterations with adult T-cell leukemia/lymphoma.2007
Author(s)
Nakagawa M., Nakagawa-Oshiro A., Tagawa H., Karnan, S., Tsuzuki S, Ohshima, K., Nakamura, S., Seto, M.
Organizer
An AACR special conference in cancer research ; oncogenomis 2007
Place of Presentation
USA
Year and Date
20070131-0203
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Array CGH analysis for PTCL-U revealed two genetically distinct subgroups.2006
Author(s)
Nakagawa, M., Oshiro, A., Tagawa, H., Karnan S., Tsuzuki, S., Ohshima, K., Nakamura, S., Seto, M.
Organizer
48th American society of hematology Annual meeting and enposition
Place of Presentation
USA
Year and Date
20061208-12
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Genomic imbalances are associated with outcome of helicobacter pylori eradication in t(11; 18)(q21; q21) -negative gastric MALT lymphomas.2006
Author(s)
Fukuhara, N., Tagawa, H., Nakamura, T., Inagaki, H., Morishima, Y., Nakamura, S., Seto M.
Organizer
48th American society of hematology Annual meeting and enposition
Place of Presentation
USA
Year and Date
20061208-12
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Genomic alterations in aggressive adult T-cell leukemia/lymphoma and PTCL-U.2006
Author(s)
Oshiro, A., Tagawa, H., Nakagawa M., Oshima, K., Utsunomiya A., Nakamura, S., Morishima, Y., Seto, M.
Organizer
The 9th Korean-Japanese Lymphoreticular Workshop
Place of Presentation
South Korea
Year and Date
20060908-11
Description
「研究成果報告書概要(欧文)」より
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