Functional analysis of costimulatory molecules for autoimmune diseases

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18390292
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Juntendo University
• Principal Investigator: OKUMURA Ko Juntendo University, Immunology, Professor (50009700)
• Co-Investigator(Kenkyū-buntansha): YAGITA Hideo Juntendo University, Immunology, Associate professor (30182306) ; AKIBA Hisaya Juntendo University, Immunology, Associate professor (60338316) ; TAKEDA Kazuyoshi Juntendo University, Immunology, Associate professor (80272821) ; NAKANO Himyasu Juntendo University, Immunology, Associate professor (70276476) ; NAKAYAMA Masafumi Juntendo University, Immunology, Assistant professor (20453582)
• Project Period (FY): 2006 – 2007
• Keywords: autoimmune diseases / collagen-induced arthritis / experimental autoimmune uveoretinitis / murine model of asthma / experimental autoimmune encephalomyelitis / costimulatory molecules / CD28-B7 family / TNF-TNFR family

Research Abstract

1.The role of the ICOS/B7RP-1 and OX40/OX40L in murine experimental autoimmune uveoretinitis.
We examined the role of ICOSB7RP-1 and OX40/OX40L pathways in the pathogenesis of mouse experimental autoimmune uveoretinitis (EAU) , an animal model of human autoimmune uveitis. The anti-B7RP-1 monoclonal antibody (mAb)-treated or ICOS-deficient mice showed a substantial reduction of disease scores. Blockade of ICOS/B7RP-1 interaction during the effector phase ameliorated the disease, whereas its blockade during the induction phase exhibited no significant effect. Blockade of OX40/OX40L interaction during the effector phase also ameliorated the disease, whereas its blockade during the induction phase accelerated. These results suggest that ICOS/B7RP-1 and OX40/OX40L interactions play a critical role in the pathogenesis of uveitis. We also indicated that ICOS-mediated costimulation plays differential roles in EAU and experimental autoimmune encephalomyelitis, which is also a Thl disease induced in the same manner as EAU.
2.Amelioration of collagen-induced arthritis (CIA) by anti-RANKL and anti-TWEAK mAbs treatment.
We have investigated the effect of anti-RANKL and anti-TWEAK mAbs on the development of CIA, a well-established murine model of rheumatoid arthritis (RA).Anti-RANKL mAb had no effect on immune responses or inflammation, it ameliorated bone loss at the site of inflammation. Histological analyses revealed that osteoclast formation was impaired at the site of joint inflammation in anti-RANKL-treated CIA mice. These results suggest the utility of anti-RANKL mAb for the prevention of osteoporosis associated with joint inflammation in RA. Administration of anti-TWEAK mAb significantly ameliorated paw swelling, synovial hyperplasia, and infiltration of inflammatory cells. The levels of proinflammatory chemokines in serum and knee joints were reduced. Histological examination revealed that the treatment with anti-TWEAK mAb suppressed the development of small vessels in synovial tissues. These results indicated anti-inflammatory and antiangiogenic effects of the TWEAK blockade in CIA, which may be also beneficial for the treatment of RA.

Research Products

• [Journal Article] Human umbilical cord epithelial cells express Notchl:Implications for its epidermal-like differentiation (2008)
  • Author(s): Ng W
  • Journal Title: OURNAL OF DERMATOLOGICAL SCIENCE 49 Pages: 143-152
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4(+) T cell-mediated colitis (2008)
  • Author(s): Ito Y
  • Journal Title: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 294 Pages: G199-G207
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells (2008)
  • Author(s): Nakajima A
  • Journal Title: ONCOGENE 27 Pages: 76-84
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Runx proteins are involved in regulation of CD 122,Ly49 family and IFN-gamma expression during NK cell differentiation (2008)
  • Author(s): Ohno SI
  • Journal Title: INTERNATIONAL IMMUNOLOGY 20 Pages: 71-79
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes (2008)
  • Author(s): Takagi A
  • Journal Title: JOURNAL OF INVESTIGATIVE DERMATOLOGY 124 Pages: 96-103
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis (2008)
  • Author(s): Jayawardana STM
  • Journal Title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 365 Pages: 137-142
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis (2008)
  • Author(s): Jayawardana, S., T., H. Ushio, F., Niyonsaba, S. P., Gondokaryono, H., Takenaka, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: Biochemical and biophysical research communications 365 Pages: 137-142
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells (2008)
  • Author(s): Nakajima, A., Y., Kojima, M., Nakayama, H., Yagita, K., Okumura, H., Nakano
  • Journal Title: Oncogene 27 Pages: 76-84
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Runx proteins are involved in regulation of CD 122, Ly49 family and IFN-gamma expression during NK cell differentiation (2008)
  • Author(s): Ohno, S., T., Sato, K., Kohu, K., Takeda, K., Okumura, M., Satake, S., Habu
  • Journal Title: International immunology 20 Pages: 71-79
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Watanabe Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis (2008)
  • Author(s): Ito, Y., T., Kanai, T., Totsuka, R., Okamoto, K., Tsuchiya, Y., Nemoto, A., Yoshioka, T., Tomita, T., Nagaishi, N., Sakamoto, T., Sakanishi, K., Okumura, H., Yagita, M
  • Journal Title: American journal of physiology 294 Pages: 199-207
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of Sp 1 in transcription of human ATP2A2 gene in keratinocytes (2008)
  • Author(s): Takagi, A., C. Nishiyama, K., Maeda, T., Tokura, H., Kawada, S., Kanada, Y., Niwa, N., Nakano, N., Mayuzumi, M., Nishiyama, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: The Journal of investigative dermatology 128 Pages: 96-103
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human umbilical cord epithelial cells express Notchl : implications for its epidermal-like differentiation (2008)
  • Author(s): Ng, W., C., Nishiyama, M., Mizoguchi, N., Nakano, Y., Suga, S., Ikeda, S., Itoh, K., Kinoshita, K., Okumura., H., Ogawa
  • Journal Title: Journal of dermatological science 49 Pages: 143-152
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of the OX40 ligand prolongs corneal allograft survival (2007)
  • Author(s): Hattori T
  • Journal Title: EUROPEAN JOURNAL OF IMMUNOLOGY 37 Pages: 3597-3604
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The plasminogen fibrinolytic pathway is required for hematopoietic regeneration (2007)
  • Author(s): Heissig B
  • Journal Title: CELL STEM CELL 1 Pages: 658-670
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils (2007)
  • Author(s): Zheng Y
  • Journal Title: BRITISH JOURNAL OF DERMATOLOGY 157 Pages: 1124-1131
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice (2007)
  • Author(s): Fukushima A
  • Journal Title: IMMUNOLOGY LETTERS 113 Pages: 52-57
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance (2007)
  • Author(s): Ando T
  • Journal Title: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 120 Pages: 916-923
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The extra domain A of fibronectin stimulates murine mast cells via Toll-like receptor 4 (2007)
  • Author(s): Gondokaryono SP
  • Journal Title: JOURNAL OF LEUKOCYTE BIOLOGY 82 Pages: 657-665
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Combination antibody-based cancer immunotherapy (2007)
  • Author(s): Takeda K
  • Journal Title: CANCER SCIENCE 98 Pages: 1297-1302
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase (2007)
  • Author(s): Fukushima A
  • Journal Title: IMMUNOLOGY LETTERS 110 Pages: 133-138
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Roles of programmed death-1(PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3 (2007)
  • Author(s): Seko Y
  • Journal Title: CARDIO VASCULAR RESEARCH 75 Pages: 158-167
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections (2007)
  • Author(s): Nakano N
  • Journal Title: BLOOD 109 Pages: 4846-4855
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Targeting death-inducing receptors in cancer therapy (2007)
  • Author(s): Takeda K
  • Journal Title: ONCOGENE 26 Pages: 3745-3757
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Interleukin-12-and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill (2007)
  • Author(s): Yuminamochi E
  • Journal Title: IMMUNOLOGY 121 Pages: 197-206
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A possible role for TSLP in inflammatory arthritis (2007)
  • Author(s): Koyama K
  • Journal Title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 357 Pages: 99-104
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] TACI regulates IgA production by APRIL in collaboration with HSPG (2007)
  • Author(s): Sakurai D
  • Journal Title: BLOOD 109 Pages: 2961-2967
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of a fermented milk drink containing Lactobacillus casei strain shirota on the human NK-cell activity (2007)
  • Author(s): Takeda K
  • Journal Title: JOURNAL OF NUTRITION 137 Pages: 791S-793S
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration,proliferation and production of proinflammatory cytokines and chemokines (2007)
  • Author(s): Niyonsaba F
  • Journal Title: JOURNAL OF INVESTIGATIVE DERMATOLOGY 127 Pages: 594-604
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Antimicrobial peptides human beta-defensin(hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability (2007)
  • Author(s): Chen XJ
  • Journal Title: EUROPEAN JOURNAL OF IMMUNOLOGY 37 Pages: 434-444
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches (2007)
  • Author(s): Piao JH
  • Journal Title: JOURNAL OF IMMUNOLOGY 178 Pages: 2272-2277
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody (2007)
  • Author(s): Sakuma M
  • Journal Title: INTERNATIONAL IMMUNOLOGY 19 Pages: 117-126
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] TACI attenuates antibody production costimulated by BAFF-R and CD40 (2007)
  • Author(s): Sakurai D
  • Journal Title: EUROPEAN JOURNAL OF IMMUNOLOGY 37 Pages: 110-118
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Antibodies to Tim-1 and Tim-3 suppress the induction and progression of murine allergic conjunctivitis (2007)
  • Author(s): Fukushima A
  • Journal Title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353 Pages: 211-6
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Combination antibody-based cancer immunotherapy (2007)
  • Author(s): Takeda, K., K., Okumura, M. J., Smyth
  • Journal Title: Cancer science 98 Pages: 1297-1302
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4 (2007)
  • Author(s): Gondokaryono, S. P., H., Ushio, F., Niyonsaba, M., Hara, H., Takenaka, S., T., Jayawardana, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: Journal of leukocyte biology 82 Pages: 657-665
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice (2007)
  • Author(s): Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, T., Yamazaki, H., Akiba, K., Okumura, H., Yagita, H., Ueno
  • Journal Title: Immunology letters 113 Pages: 52-57
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance (2007)
  • Author(s): Ando, T., K., Hatsushika, M., Wako, T., Ohba, K., Koyama, Y., Ohnuma, R., Katoh, H., Ogawa, K., Okumura, J., Luo, T., Wyss-Coray, A., Nakao
  • Journal Title: The Journal of allergy and clinical immunology 120 Pages: 916-923
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Targeting death-inducing receptors in cancer therapy (2007)
  • Author(s): Takeda, K., J., Stagg, H., Yagita, K., Okumura, M. J., Smyth
  • Journal Title: Oncogene 26 Pages: 3745-3757
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A possible role for TSLP in inflammatory arthritis (2007)
  • Author(s): Koyama, K., T., Ozawa, K., Hatsushika, T., Ando, S., Takano, M., Wako, F., Suenaga, Y., Ohnuma, T., Ohba, R., Katoh, H., Sugiyama, Y., Hamada, H., Ogawa, K., Okumura, A., Nakao
  • Journal Title: Biochemical and biophysical research communications 357 Pages: 99-104
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK-cell activity (2007)
  • Author(s): Takeda, K., K., Okumura
  • Journal Title: The Journal of nutrition 137 Pages: 791S-793S
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines (2007)
  • Author(s): Niyonsaba, F., H., Ushio, N., Nakano, W., Ng, K., Sayama, K., Hashimoto, I., Nagaoka, K., Okumura, H., Ogawa
  • Journal Title: The Journal of investigative dermatology 127 Pages: 594-604
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] T-cell Ig and mucin domain-containing protein(Tim)-2 regulates murine allergic conjunctivitis during the effector phase (2007)
  • Author(s): Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, K., Okumura, H., Akiba, H., Yagita, H., Ueno
  • Journal Title: Immunology letters 110 Pages: 133-138
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections (2007)
  • Author(s): Nakano, N., C., Nishiyama, S., Kanada, Y., Niwa, N., Shimokawa, H., Ushio, M., Nishiyama, K., Okumura, H., Ogawa
  • Journal Title: Blood 109 Pages: 4846-4855
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill (2007)
  • Author(s): Yuminamochi, E., T., Koike, K., Takeda, I., Horiuchi, K., Okumura
  • Journal Title: Immunology 121 Pages: 197-Z06
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Roles of programmed death-1(PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3 (2007)
  • Author(s): Seko, Y., H., Yagita, K., Okumura, M., Azuma, R., Nagai
  • Journal Title: Cardiovascular research 75 Pages: 158-167
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TACI attenuates antibody production costimulated by BAFF-R and CD40 (2007)
  • Author(s): Sakurai, D., Y., Kanno, H., Hase, H., Kojima, K., Okumura, T., Kobata
  • Journal Title: European journal of immunology 37 Pages: 110-118
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches (2007)
  • Author(s): Piao, J. H., H., Yoshida, W. C., Yeh, T., Doi, X., Xue, H., Yagita, K., Okumura, H., Nakano
  • Journal Title: J lmmunol 178 Pages: 2272-2277
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins(Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis (2007)
  • Author(s): Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, H., Akiba, K., Okumura, H., Yagita, H., Ueno
  • Journal Title: Biochemical and biophysical research communications 353 Pages: 211-216
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antimicrobial peptides human beta-defensin(hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability (2007)
  • Author(s): Chen, X., F., Niyonsaba, H., Ushio, M., Hara, H., Yokoi, K., Matsumoto, H., Saito, I., Nagaoka, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: European journal of immunology 37 Pages: 434-444
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody (2007)
  • Author(s): Sakuma, M., K., Hatsushika, K., Koyama, R., Katoh, T., Ando, Y., Watanabe, M., Wako, M., Kanzaki, S., Takano, H., Sugiyama, Y., Hamada, H., Ogawa, K., Okumura, A., Nakao
  • Journal Title: International immunology 19 Pages: 117-126
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The plasminogen fibrinolytic pathway is required for hematopoietic regeneration (2007)
  • Author(s): Heissig, B., L. R., Lund, H., Akiyama, M., Ohki, Y., Morita, J., Romer, H., Nakauchi, K., Okumura, E., Ogawa, Z., Werb, K., Dano, K., Hattori
  • Journal Title: Cell stem cell 1 Pages: 658-670
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of the OX40ligand prolongs corneal allograft survival (2007)
  • Author(s): Hattori, T., Y., Usui, Y., Okunuki, Y., Sonoda, M., Usui, E., Takada, J., Mizuguchi, H., Yagita, K., Okumura, H., Akiba, M., Takeuchi
  • Journal Title: European journal of immunology 37 Pages: 3597-3604
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils (2007)
  • Author(s): Zheng, Y., F., Niyonsaba, H., Ushio, I., Nagaoka, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: The British journal of dermatology 157 Pages: 1124-1131
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TACI regulates IgA production by APRIL in collaboration with HSPG (2007)
  • Author(s): Sakurai, D., H., Hase, Y., Kanno, H., Kojima, K., Okumura, T., Kobata
  • Journal Title: Blood 109 Pages: 2961-2967
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An antiapoptotic protein,c-FLIPL,directly binds to MKK7 and inhibits the JNK pathway (2006)
  • Author(s): Nakajima A
  • Journal Title: EMBO JOURNAL 25 Pages: 5549-59
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Resistance of infant leukemia with MLL rearrangement to tumor necrosis factor-related apoptosis-inducing ligand:a possible mechanism for poor sensitivity to antitumor immunity (2006)
  • Author(s): Inukai T
  • Journal Title: LEUKEMIA 20 Pages: 2119-29
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis (2006)
  • Author(s): Kamata K
  • Journal Title: JOURNAL OF IMMUNOLOGY 177 Pages: 6433-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts (2006)
  • Author(s): Hori J
  • Journal Title: JOURNAL OF IMMUNOLOGY 177 Pages: 5928-35
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis (2006)
  • Author(s): Usui Y
  • Journal Title: EUROPEAN JOURNAL OF IMMUNOLOGY 36 Pages: 3071-81
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Preferential involvement of Tim-3 in the regulation of hepatic CD8+T cells in murine acute graft-versus-host disease (2006)
  • Author(s): Oikawa T
  • Journal Title: JOURNAL OF IMMUNOLOGY 177 Pages: 4281-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis (2006)
  • Author(s): Kanai T
  • Journal Title: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21 Pages: 1136-42
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody (2006)
  • Author(s): Kamijo S
  • Journal Title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 347 Pages: 124-32
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Eradication of established tumors in mice by a combination antibody-based therapy (2006)
  • Author(s): Uno T
  • Journal Title: NATURE MEDICINE 12 Pages: 693-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of a whole cell vaccine for acute myeloid leukaemia (2006)
  • Author(s): Cheuk A.T
  • Journal Title: Cancer Immunol Immunother 55 Pages: 68-75
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite major allergen Der f 1 (2006)
  • Author(s): Nakamura T
  • Journal Title: JOURNAL OF INVESTIGATIVE DERMATOLOGY 126 Pages: 2719-23
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin (2006)
  • Author(s): Kikuchi Y
  • Journal Title: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 141 Pages: 322-30
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses (2006)
  • Author(s): Kikuchi Y
  • Journal Title: JOURNAL OF IMMUNOLOGY 177 Pages: 1609-17
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prolonged MHC class II expression and CIITA transcription in human keratinocytes (2006)
  • Author(s): Takagi A
  • Journal Title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 347 Pages: 388-93
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation,and phosphorylates MAP kinases p38 and ERK in mast cells (2006)
  • Author(s): Chen XJ
  • Journal Title: JOURNAL OF DERMATOLOGICAL SCIENCE 43 Pages: 63-6
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription:transcriptional mechanism of mast-cell-specific gene expression in mice (2006)
  • Author(s): Maeda K
  • Journal Title: BLOOD 108 Pages: 262-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Glycosylation of recombinant proforms of major house dust mite allergens Der p1 and Der f1 decelerates the speed of maturation (2006)
  • Author(s): Takai T
  • Journal Title: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 139 Pages: 181-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease (2006)
  • Author(s): Oikawa, T., Y., Kamimura, H., Akiba, H., Yagita, K., Okumura, H., Takahashi, M., Zeniya, H., Tajiri, M., Azuma
  • Journal Title: J lmmuno 1177 Pages: 4281-4287
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway (2006)
  • Author(s): Nakajima, A., S., Komazawa-Sakon, M., Takekawa, T., Sasazuki, W. C., Yeh, H., Yagita, K., Okumura, H., Nakano
  • Journal Title: The EMBO journal 25 Pages: 5549-5559
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 2006. B7-Hi-induced apoptosis as a mechanism of immune privilege of corneal allografts (2006)
  • Author(s): Hori, J., M., Wang, M., Miyashita, K., Tanemoto, H., Takahashi, T., Takemori, K., Okumura, H., Yagita, M., Azuma
  • Journal Title: J lmmunol 177 Pages: 5928-5935
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis (2006)
  • Author(s): Kamata, K., S., Kamijo, A., Nakajima, A., Koyanagi, H., Kurosawa, H., Yagita, K., Okumura
  • Journal Title: J lmmunol 177 Pages: 6433-6439
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 2006. Eradication of established tumors in mice by a combination antibody-based therapy (2006)
  • Author(s): Uno, T., K., Takeda, Y., Kojima, H., Yoshizawa, H., Akiba, R. S., Mittler, F., Gejyo, K., Okumura, H., Yagita, M. J., Smyth
  • Journal Title: Nature medicine 12 Pages: 693-698
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FOG-1 represses GATA-1-dependent FcepsilonRl beta-chain transcription : transcriptional mechanism of mast-cell-specific gene expression in mice (2006)
  • Author(s): Maeda, K., C., Nishiyama, T., Tokura, H., Nakano, S., Kanada, M., Nishiyama, K., Okumura, H., Ogawa
  • Journal Title: Blood 108 Pages: 262-269
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells (2006)
  • Author(s): Chen, X., F., Niyonsaba, H., Ushio, I., Nagaoka, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: Journal of dermatological science 43 Pages: 63-66
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 2006. Ameliorating effect of saporin-conjugated anti-CD llb monoclonal antibody in a murine T-cell-mediated chronic colitis (2006)
  • Author(s): Kanai, T., K., Uraushihara, T., Totsuka, Y., Nemoto, R., Fujii, T., Kawamura, S., Makita, D., Sawada, H., Yagita, K., Okumura, M., Watanabe
  • Journal Title: Journal of gastroenterology and hepatology 21 Pages: 1136-1142
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of a whole cell vaccine for acute myeloid leukaemia (2006)
  • Author(s): Cheuk, A., T., L., Chan, B., Czepulkowski, S. A., Berger, H., Yagita, K., Okumura, F., Farzaneh, G. J., Mufti, B. A., Guinn
  • Journal Title: Cancer Immunol Immunother 55 Pages: 68-75
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Resistance of infant leukemia with MLL rearrangement to tumor necrosis factor-related apoptosis-inducing ligand : a possible mechanism for poor sensitivity to antitumor immunity (2006)
  • Author(s): Inukai, T., X., Zhang, M., Goto, K., Hirose, K., Uno, K., Akahane, A., Nemoto, K., Goi, H., Sato, K., Takahashi, H., Honna, K., Kagami, K., Nakamoto, H., Yagita, K., Okumura, T., Koyama-Okazaki, S., Nakazawa, K., Sugita
  • Journal Title: Leukemia 20 Pages: 2119-2129
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite major allergen Der f1 (2006)
  • Author(s): Nakamura, T., Y., Hirasawa, T., Takai, K., Mitsuishi, M., Okuda, T., Kato, K., Okumura, S., Ikeda, H., Ogawa
  • Journal Title: The Journal of investigative dermatology 126 Pages: 2719-2723
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prolonged MHC class II expression and CIITA transcription in human keratinocytes (2006)
  • Author(s): Takagi, A., C., Nishiyama, S., Kanada, Y., Niwa, K., Fukuyama, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: Biochemical and biophysical research communications 347 Pages: 388-393
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody (2006)
  • Author(s): Kamijo, S., A., Nakajima, K., Ikeda, K., Aoki, K., Ohya, H., Akiba, H., Yagita, K., Okumura
  • Journal Title: Biochemical and biophysical research communications 347 Pages: 124-132
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses (2006)
  • Author(s): Kikuchi, Y., T., Takai, T., Kuhara, M., Ota, T., Kato, H., Hatanaka, S., Ichikawa, T., Tokura, H., Akiba, K., Mitsuishi, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: J lmmunol 177 Pages: 1609-1617
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin (2006)
  • Author(s): Kikuchi, Y., T., Takai, M., Ota, T., Kato, K., Takeda, K., Mitsuishi, S., Ikeda, K., Okumura, H., Ogawa
  • Journal Title: International archives of allergy and immunology 141 Pages: 322-330
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation (2006)
  • Author(s): Takai, T., E., Mizuuchi, Y., Kikuchi, T., Nagamune, K., Okumura, H., Ogawa
  • Journal Title: International archives of allergy and immunology 139 Pages: 181-187
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 2006. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis
  • Author(s): Usui, Y., H., Akiba, M., Takeuchi, T., Kezuka, A., Takeuchi, T., Hattori, Y., Okunuki, T., Yamazaki, H., Yagita, M., Usui, K., Okumura
  • Journal Title: European journal of immunology 36 Pages: 3071-3081
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Anti-Delta-like 1 antibody suppressed serum-induced arthritis (2007)
  • Author(s): Sekine Chiyoko
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Spontaneous development of severe inflammatory bowel disease in traf2-/-mice (2007)
  • Author(s): Piao Jianghu
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Paired Ig-like receptors bind to bacteris and shape TLR-mediated cytokine production (2007)
  • Author(s): Nakayama Masafumi
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of c-kit gene expression in mast cells (2007)
  • Author(s): Maeda Keiko
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Role of a transcription factor GATA-1 in commitment between dendritic cells and mast cells (2007)
  • Author(s): Shimokawa Naomi
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pathway analysis of whole transcripts in PU.1 overexpressing bone marrow-derived mast cells (2007)
  • Author(s): Niwa Yusuke
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Notch signaling induces MHC class II expression on mast cell surface (2007)
  • Author(s): Nakano Nobuhiro
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Anti-Delta-like 1 antibody suppressed serum-induced arthritis (2007)
  • Author(s): Sekine, Chiyoko
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Spontaneous development of severe inflammatory bowel disease in traf2-/- mice (2007)
  • Author(s): Piao, Jianghu
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Paired Ig-like receptors bind to bacteris and shape TLR-mediated cytokine production (2007)
  • Author(s): Nakayama, Masafumi
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of c-kit gene expression in mast cells (2007)
  • Author(s): Maeda, Keiko
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Role of a transcription factor GATA-1 in commitment between dendritic cells and mast cells (2007)
  • Author(s): Shimokawa, Naomi
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pathway analysis of whole transcripts in PU.1 overexpressing bone marrow-derived mast cells (2007)
  • Author(s): Niwa, Yusuke
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Notch signaling induces MHC class II expression on mast cell surface (2007)
  • Author(s): Nakano, Nobuhiro
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells (2007)
  • Author(s): Nakajima Akihito
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Combined NKT cell-based immunotherapy eradicates established tumors in mice (2007)
  • Author(s): Takeda Kazuyoshi
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The role of Delta-like 1 expressing macrophages on the development of marginal zone B cells (2007)
  • Author(s): Moriyama Yuko
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] TIM-1 signaling in B cells regulates antibody production (2007)
  • Author(s): Akiba Hisaya
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cytokines production by human keratinocytes stimulated with extracts of allergenic pollens and releasing pattern of proteases and lipids from the pollen grains (2007)
  • Author(s): Gunawan Hendra
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] B7-H3 regulates asthmatic response in a murine model of asthma (2007)
  • Author(s): Nagashima Osamu
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells (2007)
  • Author(s): Nakajima, Akihito
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Combined NKT cell-based immunotherapy eradicates established tumors in mice (2007)
  • Author(s): Takeda, Kazuyoshi
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The role of Delta-like 1 expressing macrophages on the development of marginal zone B cells (2007)
  • Author(s): Moriyama, Yuko
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] TIM-1 signaling in B cells regulates antibody production (2007)
  • Author(s): Akiba, Hisaya
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Cytokines production by human keratinocytes stimulated with extracts of allergenic pollens and releasing pattern of proteases and lipids from the pollen grains (2007)
  • Author(s): Gunawan, Hendra
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] B7-H3 regulates asthmatic response in a murine model of asthma (2007)
  • Author(s): Nagashima, Osamu
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Grand Prince Hotel New Takanawa
  • Year and Date: 2007-11-20
  • Description: 「研究成果報告書概要(欧文)」より