Molecular mechanisms of cell-to-cell signaling in bacteria, and its manipulation for novel therapeutic strategies

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18390294
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Toho University
• Principal Investigator: TATEDA Kazuhiro Toho University, 医学部, 准教授 (20236558)
• Project Period (FY): 2006 – 2009
• Keywords: 感染症 / 病原因子 / 治療法 / 細菌間情報伝達

Research Abstract

近年、細菌の産生するホルモン様物質autoinducerを介したQuorum-sensing機構が注目されている。グラム陰性菌から陽性菌まで臨床的に重要な多くの病原体が本機構を使って病原因子の発現・biofilm形成等を制御していることが明らかとなっている。さらに最近では、このautoinducer分子が生体細胞に対しても多彩な影響を及ぼしていることが報告され、菌側・生体側の両面から感染症の病態形成に関与するシステムとして注目されている。本研究では、緑膿菌のQuorum-sensing機構に焦点をあて、(1) Quorum-sensing機構による病原因子発現制御の分子メカニズムの解明、(2) 感染病態形成におけるQuorum-sensing機構の役割と重要性、(3) Quorum-sensing機構の制御による新しい感染症治療の可能性、について検討する。

Research Products

• [Journal Article] Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia (2009)
  • Author(s): Kikuchi Y, Tateda K, Fuse ET, Matsumoto T, Gotoh N, Fukushima J, Takizawa H, Nagase T, Standiford TJ, Yamaguchi K.
  • Journal Title: Pulm Pharmacol Ther (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa (2009)
  • Author(s): Aoki N, Tateda K, Kikuchi Y, Kimura S, Miyazaki C, Ishii Y, Tanabe Y, Gejyo F, Yamaguchi K.
  • Journal Title: J Antimicrob Chemother 63 Pages: 534-42
  • Peer Reviewed
• [Journal Article] Paradoxically high resistance of natural killer T(NKT)cell-deficient mice to Legionella pneumophila : another aspect of NKT cells for modulation of host responses (2008)
  • Author(s): Hayakawa K, Tateda K, Fuse ET, Matsumoto T, Akasaka Y, Ishii T, Nakayama T, Taniguchi M, Kaku M, Standiford TJ, Yamaguchi K.
  • Journal Title: J Med Microbiol 57 Pages: 1340-8
  • Peer Reviewed
• [Journal Article] Clinical and radiological features of Pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and Pneumocystis pneumonia in acquired immunodeficiency syndrome : a multicenter study (2008)
  • Author(s): Tokuda H, Sakai F, Yamada H, Johkoh T, Imamura A, Dohi M, Hirakata M, Yamada T, Kamatani N, Kikuchi Y, Sugii S, Takeuchi T, Kamatani N, Kikuchi Y, Sugii S, Takeuchi T,Kamatani N, Kikuchi Y, Sugii S, Takeuchi T, Tateda K, Goto H.
  • Journal Title: Intern Med. 47 Pages: 915-23
  • Peer Reviewed
• [Presentation] Virulence-Suppressing Effects of Linezolid Virulence-Suppressing Effects of Linezolid Defervescence (2008)
  • Author(s): Yoshizawa S, Tateda K, Yamaguchi K.
  • Organizer: 48^<rd> ICAAC
  • Place of Presentation: Washington DC
  • Year and Date: 20081000
• [Presentation] Antibacterial Potential of Tetramic Acid Derived from Pseudomonas Quorum-Sensing Autoinducer against Clostridium difficile and Clostridium perfringens (2008)
  • Author(s): Ueda C, Tateda K, Kimura S, Ishii Y, Horikawa M, Yamaguchi K.
  • Organizer: 48^<rd> ICAAC
  • Place of Presentation: Washington DC
  • Year and Date: 20081000
• [Presentation] In Vivo Efficacy of Tomopenem(formerly CS-023)Human-simulated Exposure against Pseudomonas aeruginosa and MRSA (2008)
  • Author(s): Tateda K, Sugihara K, Yamamura N, Koga T, Sugihara C, Yamaguchi K.
  • Organizer: 48^<rd> ICAAC
  • Place of Presentation: Washington DC
  • Year and Date: 20081000
• [Presentation] A novel aspect of interspecies communication in Candida and Pseudomonas : Co-existence of Candida modulates dissemination of and lethality in Pseudomonas aeruginosa pulmonary infection (2008)
  • Author(s): Fujita K, Tateda K, Kimura S, Saga T, Ishii Y, Yamaguchi K.
  • Organizer: 48^<rd> ICAAC
  • Place of Presentation: Washington DC
  • Year and Date: 20081000