Molecular mechanisms of cell-to-cell signaling in bacteria, and its manipulation for novel therapeutic strategies

2009 Fiscal Year Final Research Report

• Project/Area Number: 18390294
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Toho University
• Principal Investigator: TATEDA Kazuhiro Toho University, 医学部, 准教授 (20236558)
• Co-Investigator(Kenkyū-buntansha): ISHII Yoshikazu 東邦大学, 医学部, 助教 (90246695) ; KIMURA Soichiro 東邦大学, 医学部, 助教 (60408870) ; MIYAIRI Shinichi 日本大学, 薬学部, 教授 (50209855) ; HORIKAWA Manabu サントリー生物有機科学研究所, 研究員 (70270569) ; FUKUSHIMA Jun 秋田県立大学, 生物資源科学部, 准教授 (00181256) ; GOTO Naomasa 京都薬科大学, 薬学部, 教授 (30121560)
• Project Period (FY): 2006 – 2009
• Keywords: 感染症 / 病原因子 / 治療法 / 細菌間情報伝達

Research Abstract

We performed the project "Molecular mechanisms of cell-to-cell signaling in bacteria, and its manipulation for novel therapeutic strategies" for 4 years and the significant insight and progress were obtained for further development of this research and clinical application. Especially, the new data regarding interspecies communication observed by pseudomonas autoinducer molecules may be promising.

Research Products

• [Journal Article] Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers. (2010)
  • Author(s): Ueda C, Tateda K, Horikawa M, Kimura S, Ishii Y, Nomura K, Yamada K, Suematsu T, Inoue Y, Ishiguro M, Miyairi S, Yamaguchi K.
  • Journal Title: Antimicrob Agents Chemother 54 Pages: 683-8
  • Peer Reviewed
• [Journal Article] Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia. (2009)
  • Author(s): Kikuchi Y, Tateda K, Fuse ET, Matsumoto T, Gotoh N, Fukushima J, Takizawa H, Nagase T, Standiford TJ, Yamaguchi K.
  • Journal Title: Pulm Pharmacol Ther 22 Pages: 333-9
  • Peer Reviewed
• [Journal Article] Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa. (2009)
  • Author(s): Aoki N, Tateda K, Kikuchi Y, Kimura S, Miyazaki C, Ishii Y, Tanabe Y, Gejyo F, Yamaguchi K.
  • Journal Title: J Antimicrob Chemother 63 Pages: 534-42
  • Peer Reviewed
• [Journal Article] Pseudomonas aeruginosa Las quorum sensing autoinducer suppress growth and biofilm production in Legionella species. (2009)
  • Author(s): Kimura S, Tateda K, Ishii Y, Horikawa M, Miyairi S, Gotoh N, Ishiguro M, Yamaguchi K.
  • Journal Title: Microbiology 155 Pages: 1934-9
  • Peer Reviewed
• [Journal Article] A low concentration of azithromycin inhibits the mRNA expression of N-acyl homoserine lactone synthesis enzymes, upstream of lasI or rhlI, in Pseudomonas aeruginosa. (2009)
  • Author(s): Kai T, Tateda K, Kimura S, Ishii Y, Ito H, Yoshida H, Kimura T, Yamaguchi K.
  • Journal Title: Pulmonary Pharmacology & Therapeutics 22 Pages: 483-6
  • Peer Reviewed
• [Journal Article] Role of Toll-like receptor 2 in recognition of Legionella pneumophila in a murine pneumonia model. (2007)
  • Author(s): Fuse ET, Tateda K, Kikuchi Y, Matsumoto T, Gondaira F, Azuma A, Kudoh S, Standiford TJ, Yamaguchi K.
  • Journal Title: J Med Microbiol 56 Pages: 305-12
  • Peer Reviewed
• [Journal Article] Predictive analysis of ceftazidime hydrolysis in CTX-M-type beta-lactamase family members with a mutational substitution at position 167. (2007)
  • Author(s): Kimura S, Ishii Y, Tateda K, Yamaguchi K.
  • Journal Title: Int J Antimicrob Agents 29 Pages: 326-331
  • Peer Reviewed
• [Journal Article] Suppression of Pseudomonas aeruginosa quorum-sensing systems by macrolides: a promising strategy or an oriental mystery (2007)
  • Author(s): Tateda K, Ishii Y, Kimura S, Horikawa M, Miyairi S, Yamaguchi K.
  • Journal Title: J Infect Chemother 13 Pages: 357-367
  • Peer Reviewed
• [Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages. (2006)
  • Author(s): Horikawa M, Tateda K, Tuzuki E, Ishii Y, Ueda C, Takabatake T, Miyairi S, Yamaguchi K, Ishiguro M.
  • Journal Title: Bioorg Med Chem Lett 16 Pages: 2130-3
  • Peer Reviewed
• [Journal Article] Semi-quantitative analysis of Streptococcus pneumoniae urinary antigen: Kinetics of antigen titers and severity of diseases. (2006)
  • Author(s): Tateda K, Kusano E, Matsumoto T, Kimura K, Uchida K, Nakata K, Yamaguchi K.
  • Journal Title: Scand J Infect Dis 38 Pages: 166-71
  • Peer Reviewed
• [Journal Article] Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection. (2006)
  • Author(s): Miyairi S, Tateda K, Fuse ET, Ueda C, Saito H, Takabatake T, Ishii Y, Horikawa M, Ishiguro M, Standiford TJ, Yamaguchi K.
  • Journal Title: J Med Microbiol 55 Pages: 1381-7
  • Peer Reviewed
• [Presentation] Macrolides modulate virulence factors through an intracellular signaling in Pseudomonas aeruginosa. (2009)
  • Author(s): Kimura S, Tateda K, Mori N, Ishii Y, Yamaguchi K.
  • Organizer: 49th ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2009-09-23
• [Presentation] New evidence of intravenous immunoglobulin as a critical supportive therapy against Clostridium difficile toxin-mediated lethality in mice. (2009)
  • Author(s): Saito T, Tateda K, Hosono N, Kimura S, Sumiyama Y, Kusachi S, Nagao J, Yamaguchi K.
  • Organizer: 49th ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2009-09-23
• [Presentation] Re-evaluation of diagnosis and host responses of Legionella pneumophila pneumonia in a mouse model. (2009)
  • Author(s): Chen Y, Tateda K, Kimura S, Ishii Y, Yamaguchi K.
  • Organizer: 49th ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2009-09-23
• [Presentation] Virulence-Suppressing Effects of Linezolid on MRSA: Possible Contribution to Early Defervescence. (2008)
  • Author(s): Yoshizawa S, Tateda K, Yamaguchi K.
  • Organizer: 48rd ICAAC
  • Place of Presentation: Washington DC
  • Year and Date: 2008-10-15
• [Presentation] Antibacterial Potential of Tetramic Acid Derived from Pseudomonas Quorum-Sensing Autoinducer against Clostridium difficile and Clostridium perfringens. (2008)
  • Author(s): Ueda C, Tateda K, Kimura S, Ishii Y, Horikawa M, Yamaguchi K.
  • Organizer: 48rd ICAAC
  • Place of Presentation: Washington DC
  • Year and Date: 2008-10-15
• [Presentation] In Vivo Efficacy of Tomopenem (formerly CS-023) Human-simulated Exposure against Pseudomonas aeruginosa and MRSA. (2008)
  • Author(s): Tateda K, Sugihara K, Yamamura N, Koga T, Sugihara C, Yamaguchi K.
  • Organizer: 48rd ICAAC
  • Place of Presentation: Washington DC
  • Year and Date: 2008-10-15
• [Presentation] A novel aspect of interspecies communication in Candida and Pseudomonas: Co-existence of Candida modulates dissemination of and lethality in Pseudomonas aeruginosa pulmonary infection. (2008)
  • Author(s): Fujita K, Tateda K, Kimura S, Saga T, Ishii Y, Yamaguchi K.
  • Organizer: 48rd ICAAC
  • Place of Presentation: Washington DC
  • Year and Date: 2008-10-15
• [Presentation] Roles of Pseudomonas aeruginosa autoinducers and their degradation products, tetramic acids, in bacterial survival and behavior in ecological niches. (2007)
  • Author(s): Hosono N, Tateda K, Ueda C, Horikawa M, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] Antibacterial potential of Pseudomonas aeruginosa quorum-sensing autoinducers and their degradation products, tetramic acids, against Clostridium difficile. (2007)
  • Author(s): Ueda C, Tateda K, Horikawa M, Kimura S, Ishii Y, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] Efficacy of colistin combination therapy in a mouse model of pneumonia by multiple drug-resistant Pseudomonas aeruginosa. (2007)
  • Author(s): Aoki N, Tateda K, Kimura S, Ishii Y, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] Carbapenemase stability of CS-023 (RO4908463) and other carbapenems. (2007)
  • Author(s): Sugihara K, Ishii Y, Tateda K, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] In vitro activity of CS-023 (RO4908463) against variousβ-lactamase producing pathogens. (2007)
  • Author(s): Sugihara K, Ishii Y, Tateda K, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] In vitro activity of S-013420, a novel bicyclolide against clinical isolates in Japan including acrolide-resistant gram-positive cocci. (2007)
  • Author(s): Sato T, Tateda K, Ishii Y, Kimura S, Ohno A, Miyazaki S, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] Bactericida activity and persistent effect of S-013420, a novel bicyclolide against Legionella pneumophila in epithelial cells and macrophages. (2007)
  • Author(s): Sato T, Tateda K, Ishii Y, Kimura S, Ohno A, Miyazaki S, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] Bactericida activity and persistent effect of S-013420, a novel bicyclolide against Haemophilus influenzae in epithelial cell layers. (2007)
  • Author(s): Sato T, Tateda K, Ishii Y, Kimura S, Ohno A, Miyazaki S, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] In vitro synesgistic effects of combination of CP3242, as a novel metallo-b-lactamase inhibitor, and carbapenems against carbapenemae producing organisms. (2007)
  • Author(s): Ishii Y, Sugihara K, Tateda K, Yamaguchi K
  • Organizer: 47rd ICAAC
  • Place of Presentation: Chicago
  • Year and Date: 2007-09-17
• [Presentation] An evidence for sensing of quorum-sensing autoinducer molecules by intracellular organism Legionella. (2006)
  • Author(s): Kimura S, Tateda K, Ishii Y, Fuse E, Yamaguchi K
  • Organizer: 46rd ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2006-09-19
• [Presentation] Different impact of steroid hormone on pulmonary growth of Legionella pneumophila and host responses in A/J and other strains of mice. (2006)
  • Author(s): Sato T, Tateda K, Yamaguchi K
  • Organizer: 46rd ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2006-09-19
• [Presentation] Paradoxiacally high survival of NKT cell-deficient mice in Legionella pneumophila pneumonia. (2006)
  • Author(s): Hayakawa K, Tateda K, Fuse ET, Matsumoto T, Yamaguchi K
  • Organizer: 46rd ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2006-09-19
• [Presentation] Prevalence of metallo-b-lactamase in Pseudomonas aeruginosa and other gram-negative bacilli: results of the Japanese nationwide survey (2004). (2006)
  • Author(s): Ishii Y, Kimura S, Tateda K, Yamaguchi K
  • Organizer: 46rd ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2006-09-19
• [Presentation] Anti-Legionella activity of S-013420, a first-in-class bridged bicyclic macrolide. (2006)
  • Author(s): Sato T, Tateda K, Ishii Y, Kimura S, Ohno A, Miyazaki S, Yamaguchi K
  • Organizer: 46rd ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2006-09-19
• [Presentation] Multi-center study to evaluate blood stream infection with Helicobacter cinaedi in Japan. (2006)
  • Author(s): Matsumoto T, Goto M, Murakami H, Tanaka T, Nishiyama H, Ono E, Okada C, Sawabe E, Yagoshi M, Yoneyama A, Okuzumi K, Tateda K, Misawa N, Yamaguchi K
  • Organizer: 46rd ICAAC
  • Place of Presentation: San Francisco
  • Year and Date: 2006-09-19