2007 Fiscal Year Final Research Report Summary
NIRS and MEG study on brain mechanisms of social cognitive deficits in schizophrenia and mood disorders
| Project/Area Number |
18390318
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Gunma University |
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Principal Investigator |
FUKUDA Masato Gunma University, Graduate School of Medicine Department of Psychiatry and Human Behavior, Associate Professor (20221533)
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| Co-Investigator(Kenkyū-buntansha) |
MIKUNI Masahiko Gunma University, Graduate School of Medicine, Professor (00125353)
UEHARA Toru Gunma University, Faculty of Medicine, Associate Professor (60303145)
OSHIMA Akihiko Gunma University, Graduate School of Medicine, Assistant Professor (80276526)
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| Project Period (FY) |
2006 – 2007
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| Keywords | near-infrared spectroscopy / magnetoencephalography / schizophrenia / mood disorders / social cognition |
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| Research Abstract |
Objectives: Near-infrared spectroscopy (NIBS) is a recently developed technology that monitors cerebral blood volume changes noninvasively in bedside setting. NIRS has been increasingly employed in psychiatry such as functional neuroimaging studies of personality, aging, and psychiatric disorders. Characteristics of frontal lobe function were investigated using multichannel NIRS machines in schizophrenia, unipolar depression, and bipolar depression.
Methods: Twenty-five patients with schizophrenia, eleven patients with unipolar depression, seventeen patients with bipolar depression, and their age- and sex-matched healthy subjects participated in the study after giving their written informed consents. Changes of oxy-hemoglobin concentration ( [oxy-Hb] ) were monitored every 0.1 s during a word fluency task and a finger-tapping task using two sets of 24-channel NIRS machines (Hitachi Medical Co.) with the probes placed on the subjects' frontal and the bilateral temporal regions.
Results: Three psychiatric groups demonstrated different patterns of [oxy-Hb] changes from those in the control group during the word fluency task although their task performances were equal. The schizophrenic group was characterized by reduced [oxy-Hb] increase during the task period followed by [oxy-Hb] re-increase during the post-task period, the unipolar depression group by smaller [oxy-Hb] increase, and the bipolar depression group by comparable but delayed [oxy-Hb] increase.
Conclusions: The observed differences of [oxy-Hb] changes suggest the characteristics in time courses of reactivity of frontal lobe function: inefficient, reduced, and preserved but delayed activation in schizophrenia, unipolar depression, and bipolar depression, respectively. NIRS has revealed detailed time-courses of frontal lobe activation, and can be employed as a clinical laboratory test for diagnosis and treatment of psychiatric disorders in the near future.
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[Journal Article] HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates alteration of neural activities in prefrontal cortex and limbic/paralimbic regions2007
Author(s)
Aihara M, Ida I, Yuuki N, Oshima A, Kumano H, Takahashi, K, Fukuda M, Oriuchi N, Endo K, Matsuda H, Mikuni M
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Journal Title
Psychiatry Research: Neuroimaging 155
Pages: 245-256
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Comparison between mismatch negativity amplitude and magnetic mismatch field strenght in normal adults2006
Author(s)
Kudo N, Kasai K, Itoh K, Koshida I, Yumoto M, Kato M, Kamio S, Araki T, Nakagome K, Fukuda M, Yamasue H, Yamada H, Abe O, Kato N, Iwanami A
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Journal Title
Biological Psychology 71
Pages: 54-62
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Comparison between mismatch negativity amplitude and magnetic mismatch field strength in normal adults2006
Author(s)
Kudo N, Kasai K, Itoh K, Koshida I, Yumoto M, Kato M, Kamio S, Araki T, Nakagome K, Fukuda M, Yamasue H, Yamada H, Abe O, Kato N, Iwanami A
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Journal Title
Biological Psychology 71
Pages: 54-62
Description
「研究成果報告書概要(欧文)」より
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[Presentation] こころと認知と脳機能2006
Author(s)
福田正人
Organizer
日本特殊教育学会第44回大会
Place of Presentation
前橋
Year and Date
20060916-18
Description
「研究成果報告書概要(和文)」より
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