2009 Fiscal Year Final Research Report
Radiation sensitization though regulation of transcriptional factor Sp1
| Project/Area Number |
18390330
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Niigata University (2008-2009)
The University of Tokyo (2006-2007) |
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Principal Investigator |
HOSOI Yoshio Niigata University, 原爆放射線医科学研究所, 教授 (50238747)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Yoshihisa 東京工業大学, 原子炉工学研究所, 助教授 (20302672)
ENOMOTO Atsushi 東京大学, 大学院・医学系研究科, 助手 (20323602)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 放射線 / Sp1 / ATM / DNA-PK |
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| Research Abstract |
The protein and mRNA levels of Sp1, Ku70, Ku80, DNA-PKcs, XRCC4, NBS1, MRE11 and MDC1 were down regulated by the Sp1-siRNA treatment. The DSBs-repair after 80 Gy irradiation and DNA-PK activity were suppressed by the Spl-siRNA treatment. The surviving fraction after irradiation was also suppressed by the Spl-siRNA treatment.
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Research Products
(61 results)
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[Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.2010
Author(s)
Sasano N, Enomoto A, 細井義夫, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
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Journal Title
Cancer Letters 293
Pages: 52-57
Peer Reviewed
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[Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis.2010
Author(s)
Morita Q, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, 細井義夫, Ikekita M
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Journal Title
Cancer Research 70
Pages: 257-265
Peer Reviewed
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[Journal Article] Relation between acute & late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head and neck cancer.2006
Author(s)
Yamashita H, Nakamura N, Abe K, Asakage T, Ohmoto M, Okada S, Matsumoto I, 細井義夫, Sasano N, Yamakawa S, Ohtomo K, Nakagawa K
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Journal Title
International Journal of Radiation Oncology Biology Physics 66
Pages: 1422-1429
Peer Reviewed
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[Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.2006
Author(s)
Tonotsuka N, 細井義夫, Miyazaki S, Miyata G, Sugawara K, Mori T, Ouchi N, Satomi S, Matsumoto Y, Nakagawa K, Miyagawa K, Ono T
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Journal Title
International Journal of Molecular Medicine 18
Pages: 441-447
Peer Reviewed
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[Journal Article] Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation : a report of two successful cases.2006
Author(s)
Nakagawa K, Kanda Y, Yamashita H, 細井義夫, Oshima K, Ohtomo I, Ban N, Yamakawa, S, Nakagawa S, Chiba S
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Journal Title
Bone Marrow Transplantation 37
Pages: 583-587
Peer Reviewed
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