2007 Fiscal Year Final Research Report Summary
Comprehensive study of Buerger's Disease
| Project/Area Number |
18390342
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IWAI Takehisa Tokyo Medical and Dental University, Department of vascular and Applied Surgery, Graduate School, 非常勤講師 (90111591)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Yoshinori Tokyo Medical and Dental University, Graduate School, Department of vascular and Applied Surgery, 講師 (70280964)
UMEDA Makoto Tokyo Medical and Dental University, Graduate School, Department of Hard Tissue Engineering, 助手 (90193937)
YOSHIDA Masayuki Tokyo Medical and Dental University, Graduate School, Department of vascular and Applied Surgery, 特任教授 (80282771)
NAKAMURA Hiroaki Saitama Medical University, Department of Anatomy, 教授 (80073021)
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| Project Period (FY) |
2006 – 2007
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| Keywords | oral bacteria / burger disease / atherosclerosis / porphyromanas gingivalis / platelet aggregation / HAL遺伝子 |
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| Research Abstract |
Weak oral bacteria represented by periodontal bacteria have been demonstrated from the various vascular lesions. Demonstrated regions are various; in the atheroma, thrombus of the occluded artery of Buerger disease, abdominal aortic aneurismal wall, and varicose veins. Serum titer levels are now available to study in each bacteria and have shown a significant relationship with severity and individual differences. It is estimated that lymph vessel openings catch the bacteria on the the pathway from the mouth to the blood stream and then carry them to the vein of the venous angle near the supraclavicular area. As for, periodontal bacteria, a typical one, P. gingivalis, activates the platelet strongly and make the platelets mass including bacteria inside without phagocytosis. At that time, cytokines and serotonin are discharged. Platelet engulfment was clearly demonstrated in the electron microscopy. An animal study using rats showed a small arterial thrombus formation after continuous intravenous infusion of the Pg bacteria for 2-4 weeks.
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