2007 Fiscal Year Final Research Report Summary
Studies on Regenerative Medicine for Diabetes Mellitus by Cell Biology
| Project/Area Number |
18390364
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SUMI Shoiciro Kyoto University, Institute For Regenerative Medicine, Associate Professor (80252906)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Naoya Okayama University, Hospital, Lecturer (10325102)
HIURA Akihito Kyoto University, Institute for Regenerative Medicine, Lecturer (20378904)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Reeenerative medicine / Diabetes Mellitus / Rio-artificial Pancreas / Islet Encapusulation / Induction of Neo-vascularization / Cell Fusion / Islet Transplantation / Poly Vinyl Alcohol |
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| Research Abstract |
The number of patients suffering from diabetes mellitus is apparently increasing all aver the world with the growing incidence of severe complications such as nephropathy and retinopathy. Pancreas and islet transplantation by which severe diabetes can be effectively treated retain inevitable problems of donor shortage and immuno-suppression-related issues. Bio-artificial pancreas is a therapeutic modality by which allo- and even xeno-geneic islets can be used without immuno-suppression. In several kinds of bio-artificial pancreas, macro-encapsulation of the islets is the most promising device for clinical use : We developed a novel method of islet macro-encapsulation with poly vinyl alcohol (PVA) hydro-gel and studied several improvements of procession and its usefulness. We also studied fibrin and other agents in novel methods of neo-vascularization at the subcutaneous site where macro-encapsulated islets (MEI) can be transplanted. We further studied cell fusion between islet cells and mesenchymal stem cells to search new cell source for diabetes therapy.
PVA-MEI was processed y freezing and thawing the sheet-shape-molded PVA solution containing rat islets. The device was transplanted to diabetic mice or rats.
Transplantation of PVA-MEI significantly improved hyperglycemia and metabolic disaster of diabetic mice with better survival rate and protected kidney from diabetic renal dysfunction. PVA-MEI was transplanted to diabetic rats in iso- and allo-geneic situations. The transplantation decreased the hyperglycemia for several weeks without any remarkable difference between the situations. These results, together with other findings, indicate that macro-encapsulation effectively protect islets from allo- and xeno-geneic immune regection and that further improvement in processing and other methods are needed to elongate the efficacy of the transplantation.
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[Journal Article] Hyperglycemia and diabetic renal change in a model of PVA bio-artificial pancreas transplantation2007
Author(s)
Sakata, N., Sumi, S., Gu, Y., Qi, M., Yamamoto, C., Sunamura, M., Egawa, S., Unno, M., Matsuno, S., Inoue, K
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Journal Title
Pancreas 34
Pages: 458-465
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The effect of fibrin on the survival of ischemic skin flap in rats2007
Author(s)
Qi, Z., Gu, Y., Kim, D., Hiura, A., Sumi, S., Inoue, K
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Journal Title
Plastic and Reconstructive Surgery 120
Pages: 1148-1155
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cold preservation of islets in UW solution -with special reference to apoptosis2006
Author(s)
Shirouzu, Y., Gu, Y., Koga, M., Sakurai, T., Qi, M., Hiura, A., Sumi, S., Inoue, K
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Journal Title
J Surg Res 133
Pages: 167-175
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effect of rat-to-mouse bio-artificial pancreas xenotransplantation on diabetic renal damage and survival2006
Author(s)
Sakata, N., Gu, Y., Qi, M., Yamamoto, C., Hiura, A., Sumi, S., Sunamura, M., Matsuno, S., Inoue, K
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Journal Title
Pancreas 32
Pages: 249-257
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Oral administration of nicorandil enhances the survival of ischemic skin flap in rats2006
Author(s)
Qi, Z., Hiura, A., Nakagawa, N., Koga, M., Yanai, G., Sumi, S., Inoue, K
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Journal Title
Eur J Pharmacol 550
Pages: 127-133
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Studies on polyvinyl alcohol(PVA)macro-encapsulated islets.2007
Author(s)
Sumi S, Qi Z, Yanai G, Qi M, Gu Y-J, Sakata N, Yamamoto C, Hiura A, Inoue K
Organizer
2007 Joint Conference(Cell Transplantation Society, International Pancreas and Islet Transplantation Association and International Xenotransplantation Association
Place of Presentation
Minneapolis, MN, USA
Year and Date
20070915-20
Description
「研究成果報告書概要(和文)」より
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[Presentation] Analysis of macro-encapsulated islets using polyvinyl alcohol (PVA)2007
Author(s)
Qi, Z., Qi, M., Sakata, N., Yamamoto, C., Yanai, G., Hiura, A., Sumi, S
Organizer
International Symposium on Regenerative Medical Therapy
Place of Presentation
Kyoto
Year and Date
20070219-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Studies on electro-fusion of mesenchymal stem cells and pancreatic islet-cells2007
Author(s)
Yanai, G., Hayashi, T., Qi, Z., Hiura, A., Sumi, S., Shimabukuro, T., Inoue, K
Organizer
International Symposium on Regenerative Medical Therapy
Place of Presentation
Kyoto
Year and Date
20070219-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Studies on polyvinyl alcohol (PVA) macro-encapsulated islets2007
Author(s)
Sumi, S., Qi, Z., Yanai, G., Qi, M., Gu, Y., J., Sakata, N., Yamamoto, C., Hiura, A., Inoue, K
Organizer
2007 Joint Conference (Cell Transplantation Society, International Pancreas and Islet Transplantation Association and International Xenotransplantation Association)
Place of Presentation
Minneapolis, MN, USA
Year and Date
20070215-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Processing and usefulness of polyvinyl alcohol macro-encapsulated islets by freezing method2007
Author(s)
Qi, Z., Sumi, S., Qi, M., Sakata, N., Yamamoto, C., Yanai, G., Hiura, A., Inoue, K
Organizer
38th Annual Meeting of Japan Pancreas Society
Place of Presentation
Fukuoka
Year and Date
2007-06-28
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Studies on polyvinyl alcohol (PVA) bio-artificial pancreas freezing method2007
Author(s)
Qi, Z., Sumi, S., Qi, M., Sakata, N., Yamamoto, C., Yanai, G., Hiura, A., Inoue, K
Organizer
24th Meeting of Japan Society for by Bilio-Pancreatic Physiology
Place of Presentation
Kanazawa
Year and Date
2007-06-23
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Polyvinyl alcohol (PVA) macro-encapsulated islets by freezing method2007
Author(s)
Qi, Z., Sumi, S., Qi, M., Sakata, N., Yamamoto, C., Yanai, G., Hiura, A., Inoue, K
Organizer
19th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
Place of Presentation
Yokohama
Year and Date
2007-06-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Polyvinyl alcohol (PVA) macroencapsulation for the bioartificial pancreas (BAP)2007
Author(s)
Qi, Z., Qi, M., Sakata, N., Yamamoto, C., Yanai, G., Hiura, A., Sumi, S., Inoue, K
Organizer
The First Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association
Place of Presentation
Fukuoka
Year and Date
2007-03-22
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Studies on polyvinyl alcohol (PVA) bio-artificial pancreas by freezing method2007
Author(s)
Qi, Z., Qi, M., Sakata N., Yamamoto, C., Yanai, G., Hiura, A., Sumi, S., Inoue, K
Organizer
6th Annual Meeting of the Japanese Society for Regenerative Medicine
Place of Presentation
Yokohama
Year and Date
2007-03-14
Description
「研究成果報告書概要(欧文)」より
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[Presentation] バイオ人工膵の開発2006
Author(s)
角 昭一郎、漆 智、柳井 伍一、Shakibur Rahman、日裏 彰人.
Organizer
IFMS, IMEG, CDBジョイントフォーラム
Place of Presentation
京都市
Year and Date
20061010-11
Description
「研究成果報告書概要(和文)」より
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[Presentation] Development of bio-Artificial pancreas2006
Author(s)
Sumi, S., Qi, Z., Yanai, G., Rahman, S., Hiura, A
Organizer
Joint Forum of IFMS, IMEG and CDB
Place of Presentation
Kyoto
Year and Date
20061010-11
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Studies on parameters of blood sugar regulation model with portal vein compartment2006
Author(s)
Shindo, M., Furutani, E., Satake, A., Sumi, S., Inoue, K
Organizer
50th Lecture Meeting of the Institute of Systems, Control and Information Engineering
Place of Presentation
Kyoto
Year and Date
20060510-12
Description
「研究成果報告書概要(欧文)」より
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