2008 Fiscal Year Final Research Report
Development of new diagnostic markers and drug based on comprehensive search of gene and protein in hepatocellular carcinoma
| Project/Area Number |
18390366
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
OKA Masaaki Yamaguchi University, 大学院・医学系研究科, 教授 (70144946)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA KAZUYUKI 山口大学, 医学系研究科, 教授 (90107748)
IIZUKA NORIO 山口大学, 医学系研究科, 准教授 (80332807)
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| Project Period (FY) |
2006 – 2008
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| Keywords | 肝癌 / ゲノム / マイクロアレイ / プロテオーム / バイオテクノロジー |
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| Research Abstract |
肝癌の新規診断と創薬の研究を行った。新規診断では、カスタムチップおよび定量的PCR による肝切除後早期再発予測システムを開発した。タンパク診断では、肝癌の新たなマーカーとして3 種類(HSP70、PRX、Mn-SOD)の自己抗体を検出できた。創薬としては、ID2 遺伝子およびENO1 タンパクが標的になること、さらにはID2 発現がHDAC 阻害剤の分子マーカーとなることを発見した。
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[Journal Article] Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma2008
Author(s)
Hamaguchi T, Iizuka N, Tsunedomi R, Hamamoto Y, Miyamoto T, Iida M, Tokuhisa Y, Sakamoto K, Takashima M, Tamesa T, Oka M.
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Journal Title
Int J Oncol 33
Pages: 725-731
Peer Reviewed
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[Journal Article] A three-gene predictor for earlyintrahepatic recurrence ofhepatocellular carcinoma after curativehepatectomy2008
Author(s)
Somura H, Iizuka N, Tamesa T, Sakamoto K, Hamaguchi T, Tsunedomi R, Yamada-Okabe H, Sawanura M, Eramoto M, Miyamoto T, Hamamoto Y, Oka M.
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Journal Title
Oncology Rep 19
Pages: 489-495
Peer Reviewed
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[Journal Article] ID2 Expression is Associated with a Risk of Hepatocellular Carcinoma Progression2008
Author(s)
Tsunedomi R, Iizuka N, Yamada-Okabe H, Tamasa T, Okada T, Sakamoto K, Takashima M, Hamaguchi T. Miyamato T, Uchimura S, Hamamoto Y, Oka M.
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Journal Title
Clin Cancer Res 14
Pages: 1025-1031
Peer Reviewed
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[Journal Article] Identification of ID2 associated with invasion of hepatitis C virus-relatedhepatocellular carcinoma by geneexpression profile2006
Author(s)
Tsunedomi R, Iizuka N, Yamada-Okabe H, Tamesa T, Okada T, Sakamoto K, Takashima M, Hamaguchi T, Miyamoto T, Uchimura S, Hamamoto Y, Yamada M, Oka M.
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Journal Title
Int J Oncol 29
Pages: 1445-1451
Peer Reviewed
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