Modulation mechanism of adult neurogenesis specific for primates

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18390392
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kanazawa University
• Principal Investigator: YAMASHIMA TETsumori Kanazawa University, 医学系, 准教授 (60135077)
• Project Period (FY): 2006 – 2009
• Keywords: 霊長類 / 海馬 / ニューロン新生 / GPR40 / 多価不飽和脂肪酸

Research Abstract

ドコサヘキサエン酸(DHA)やアラキドン酸などの多価不飽和脂肪酸(polyunsaturatedfatty acid : PUFA)は、脳の発達や機能維持のために重要な役割を果たしている。しかも、近年、学習や記憶などの生理機能のみならず、うつ病など精神疾患の症状改善効果も報告されていが、その作用機序は十分に解明されてはいない。PUFA には細胞膜のリニューアル以外にも何らかの機能があるに相違ないと考え、膵臓におけるインスリン分泌と2 型糖尿病の発症に関わるオーファン受容体の一つであるGPR40 に着目し、成体脳のニューロン新生におけるGPR40 の役割を明らかにするために解析を行った。

Research Products

• [Journal Article] A putative link of PUFA, GPR40 and adult-born hippocampal neurons for memory (2008)
  • Author(s): Yamashima T.
  • Journal Title: Prog Neurobiol 84(2) Pages: 105-15
  • Peer Reviewed
• [Journal Article] Expression of free fatty acid receptor GPR40 in the neurogenic niche of adult monkey hippocampus (2008)
  • Author(s): Ma D, Lu L, Boneva NB, Warashina S, Kaplamadzhiev DB, Mori Y, Nakaya MA, Kikuchi M, Tonchev AB, Okano H, Yamashima T.
  • Journal Title: Hippocampus 18(3) Pages: 326-33
  • Peer Reviewed
• [Journal Article] Expression of free fatty acid receptor GPR40 in the CNS of adult monkeys (2007)
  • Author(s): Ma D, Tao B, Warashina S, Kotani S, Lu L, Kaplamadzhiev DB, Mori Y, Tonchev AB, Yamashima T.
  • Journal Title: Neurosci Res 58(4) Pages: 394-401
  • Peer Reviewed
• [Journal Article] Implication of "Down syndrome cell adhesion molecule" in the hippocampal neurogenesis of ischemic monkeys (2006)
  • Author(s): Yamashima T, Popivanova BK, Guo J, Kotani S, Wakayama T, Iseki S, Sawamoto K, Okano H, Fujii C, Mukaida N, Tonchev AB
  • Journal Title: Hippocampus 16(11) Pages: 924-35
  • Peer Reviewed
• [Journal Article] Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction (2006)
  • Author(s): Kotani S, Sakaguchi E, Warashina S, Matsukawa N, Ishikura Y, Kiso Y, Sakakibara M, Yoshimoto T,Guo J, Yamashima T
  • Journal Title: Neurosci Res 56(2) Pages: 159-64
  • Peer Reviewed
• [Presentation] Role of PUFA and GPR40 for adult neurogenesis in primates (2008)
  • Author(s): Yamashima, T
  • Organizer: 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-11
• [Remarks]
  • URL: http://web.kanazawa-u.ac.jp/%7Emed66/