2007 Fiscal Year Final Research Report Summary
Development of molecular medicine using liposomes with imaging function
| Project/Area Number |
18390396
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya University |
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Principal Investigator |
MIZUNO Masaaki Nagoya University, Graduate School of Medicine, Associate Professor (70283439)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Jun Nagoya University, Graduate School of Medicine, Professor (40158449)
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| Project Period (FY) |
2006 – 2007
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| Keywords | bio-molecule / cell / tissue / bio-technology / lipid / liposome / clinical trial / imagine |
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| Research Abstract |
We have been developing novel liposome with imaging function. At first we looked for some target molecules such as X-linked X-linked inhibitor of apoptosis protein (XIAP), Aurora-B, c-Jun N-terminal kinase (JNK), TRAIL and Fas. Thereafter we designed their chemicals using Methods of structure-based drug design or genome-information drug design, confirming their biological activities in cultured human tumor cells. Second, we designed cationic, neutral, anionic liposomes and observed their movement at intracellular region. Furthermore we also encapsulated Gd-DTPA into liposomes and observed their movement at brain using MRI technology. We could get clear imaging on MRI. Thereafter we are responsible for process development, validation, and GMP(Good Manufacturing Practice) production of a broad range of molecular targeting therapies at The Center for Genetic and Regenerative Medicine (CGRM) in our Hospital, which is an institute to put advanced medicine into practice in Nagoya University Hospital.
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Research Products
(34 results)
