2007 Fiscal Year Final Research Report Summary
Individually optimum therapy based on less invasive bio-imaging in brain yumors
| Project/Area Number |
18390401
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MINEURA Katsuyoshi Kyoto Prefectural University of Medicine, Department of Neurosurgery, Professor (70134103)
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| Co-Investigator(Kenkyū-buntansha) |
SASAJIMA Hiroyasu Kyoto Prefectural University of Medicine, Department of Neurosurgery, Associate Professor (80196188)
OHWASDA Kei Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor (80332948)
KAWABE Takuya Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor (10360033)
KURIOKA Hiroki Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor (30405295)
MIYAMOTO Junichi Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor (10453094)
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| Project Period (FY) |
2006 – 2007
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| Keywords | brain tumors / PET / F-18 fluorodeoxvglucose / specific diagnosis / blood flow / metabolism / tumor localization / bio-imaging |
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| Research Abstract |
The therapeutic results of brain tumors remain dismal and unsatisfactory in spite of recent development in therapeutic modalities. Less invasive bio-imaging using positron emission tomography (PET) is expected to be more sensitive than anatomic imaging in detecting early abnormalities of the central nervous system (CNS) lesions .The investigators have extensively applied PET with various tracers on brain tumors and non-tumor CNS diseases.
Oxygen metabolism remained low in most non-tumor CNS diseases, whereas it increased in CNS infections such as sarcoidosis or brain abscess. The 11C-methyl-L-methionine PET images illustrate the existence of tumor cells as a hot lesion, characterized by marked accumulation, even in a narrow lesion of tumor.
^<18>F-Fluorodeoxyglucose (FDG) is not a specific tracer to brain tumors but a physiologic tracer as an indicator of glucose metabolism. FDG incorporates in normal tissue such as brain and muscles. Malignant brain tumors located in the gray matter do not always illustrate "hot" image differently from the surrounding tissue. Modified methods (using metabolic shift) of FDG depression in the brain have some advantage that visualizes the tumors "hot" more differently from the surrounding brain tissue.
^<18>F-Fluorodopa (DOPA) PET reflects a topographic localization of dopaminergic cells and reveals the contour of basal ganglia. Dispersion of DOPA uptake pattern implies diffusely infiltrating growth of tumor into the basal ganglia, thus limiting surgical resection, whereas distortion implies expansive growth of the tumor against the basal ganglia of and surrounding tissue.
Multidisciplinary bio-imaging studies may allow us to establish tumor-specificity, and to hemodynamically and metabolically characterize individual brain tumors; accordingly, tailor-made treatment modalities are more feasible.
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[Journal Article] Multitensor tractography enables better depiction of motor pathways. Initial clinical experience using diffusion-weighted MR imaging with standard b-value2007
Author(s)
Yamada, K, Sakai, K, Hoogenraad, FGC, Holthuizen, R, Akazawa, K, Ito, H, Oouchi, H, Matsushima, S, Kubota, T, Sasajima, H, Nishimura, T
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Surgery for lesions at/adjacent to pyramidal and optic pathways using tractography2006
Author(s)
Tatsuzawa, K, Sasajima, H, Ohwada, K, Inoue, Y, Mineura, K, Yamada, K
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Journal Title
in Tabuchi K (ed): Brain Tumor Surgery. Medica Publisher, Suita, Osaka in Japanese
Pages: 64-68
Description
「研究成果報告書概要(欧文)」より
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[Presentation] PET imaging for surgical indication and approach in brain tumors2007
Author(s)
Mineura, K, Furuno, Y, Kawabe, T, Miyamoto, J, Sasajima, H
Organizer
World Federation of Neurosurgical Societies, 13th Interim Meeting/12th Asian Australasian Congress of Neurological Surgeons
Place of Presentation
Nagoya
Year and Date
20071118-22
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Cerebral oxygen metabolism in patients with idiopathic normal pressure hydrocephalus (i-NPH)2007
Author(s)
Miyamoto, J, Tatsuzawa, K, Owada, K, Kawabe, T, Kurioka, H, Furuno, Y, Sasajima, H, Mineura, K
Organizer
World Federation of Neurosurgical Societies, 13th Interim Meeting/12th Asian Australasian Congress of Neurological Surgeons
Place of Presentation
Nagoya
Year and Date
20071118-22
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effectiveness of combined surgery and radiosurgery in the treatment of metastatic brain tumors2007
Author(s)
Kawabe, T, Furuno, Y, Kurioka, H, Miyamoto, J, Owada, K, Tatsuzawa, K, Kimura, S, Sasajima, H, Mineura, K
Organizer
World Federation of Neurosurgical Societies, 13th Interim Meeting/12th Asian Australasian Congress of Neurological Surgeons
Place of Presentation
Nagoya
Year and Date
20071118-22
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Therapeutic strategy based on molecular imaging in brain tumors2007
Author(s)
Mineura, K, Ohwada, K, Tatsuzawa, K, Kimura, S, Sasajima, H
Organizer
5th Asian Society for Neuro-Oncology
Place of Presentation
Istanbul, Turkey
Year and Date
20071102-04
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Clinical role of positron emission tomography in pediatric brain tumors2007
Author(s)
Mineura, K, Furuno, Y, Kawabe, T, Miyamoto, J, Sasajima, H
Organizer
35th International Syposium of Pediatric Neurosurgery (ISPN)
Place of Presentation
Liverpool, UK
Year and Date
20070909-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Suprasellar cyst causing bobble-head doll syndrome. F-18 dopa PET study2007
Author(s)
Furuno, Y, Sasajima, H, Tatsuzawa, K, Ohwada, K, Mineura, K
Organizer
35th International Syposium of Pediatric Neurosurgery (ISPN)
Place of Presentation
Liverpool, UK
Year and Date
20070909-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Clinical application of molecular imaging on the management of brain tumors2006
Author(s)
Mineura, K, Fujita, T, Kurioka, H, Miyamoto, J, Kawabe, T, Inoue, Y, Ohwada, K, Tatsuzawa, K, Kimura, S, Sasajima, H
Organizer
11th World Congress on Advances in Oncology and 9th International Symposium on Molecular Medicine
Place of Presentation
Crete, Greece
Year and Date
20061012-14
Description
「研究成果報告書概要(欧文)」より
