Study on the therapy for dural arteriovenous fistula by anti-angiogenic factor

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18390402
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Nara Medical University
• Principal Investigator: SAKAKI Toshisuke Nara Medical University, 附属病院, 病院長 (20118029)
• Project Period (FY): 2006 – 2009
• Keywords: 脳血管障害学

Research Abstract

これまで、慢性脳静脈圧亢進モデルから実験的に硬膜動静脈奇形を発生させ、静脈洞内圧亢進状態が慢性的に持続することにより硬膜動静脈瘻が形成されることを血管撮影で形態学的に評価し, 同部位での血管新生因子であるVascular Endothelial Growth Factor (VEGF)の発現を確認した。VEGFが病的な血管新生を促進し, 硬膜動静脈瘻の発生に関わるものと推察された。血管新生因子が脳静脈性虚血にどのように影響しているかを検討する。

Research Products

• [Journal Article] Reactive astrocytes produce adrenomedullin in the ischemic brain subjected to delayed cerebral vasospasm due to aneurysmal subarachnoid hemorrhage (2008)
  • Author(s): Fujioka M., Nishio K., Maeda Y., Ueda S., Mishima K., Okuchi K., Sakaki T., Siesjo B.K.
  • Journal Title: Stroke 39 Pages: 728
• [Journal Article] Basic study on the pathogenesis of dural arteriovenous (2006)
  • Author(s): Nakase H., Shin Y., Tamura K., Tamaki R., Miyake H., Takeshima Y., Inui T., Nakamura M., Shimada K., Konishi N., Sakaki T.
  • Journal Title: Neurotrauma Research 18 Pages: 4-7
• [Journal Article] Anti-edema effect of selective myosin light chain kinase inhibitor ML-7 in rat 2-vein occlusion model (2006)
  • Author(s): Tamaki R., Nakase H., Tamura K., Inui T., Takeshima Y., Miyake H., Horiuchi K., Sakaki T.
  • Journal Title: Neurotrauma Research 18 Pages: 16-19
• [Presentation] 後頭蓋窩AVMに対する治療成績 (2009)
  • Author(s): 松田良介, 中瀬裕之, 本山靖, 弘中康雄, 西村文彦, 田村健太郎, 三島秀明, 朴永銖, 平林秀裕, 榊寿右
  • Organizer: Stroke2009
  • Place of Presentation: 松江
  • Year and Date: 20090000
• [Presentation] Surgical resection of the unruptured left hemisphere AVMs (2008)
  • Author(s): Sakaki T., Nakase H., Motoyama Y.
  • Organizer: The 9th Japanese and Korean friendship conference on surgery for cerebral stroke
  • Place of Presentation: Daegu
  • Year and Date: 20080000
• [Presentation] Prevention of venous problems associated with the neurosurgery (2008)
  • Author(s): Nakase H., Tamura K., Tamaki R. , Park Y-S , Hirabayashi H., Sakaki T.
  • Organizer: The 9th Japanese and Korean friendship conference on surgery for cerebral stroke
  • Place of Presentation: Daegu
  • Year and Date: 20080000
• [Book] Kanno T. (Editor in Chief), Kato Y. (Ed.):Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology, Springer-Verlag,Tokyo (2006)
  • Author(s): Nakase H. , Kimura R. , Nishioka T., Tamaki R. , Miyake H. , Takeshima Y. , Sakaki T.
  • Total Pages: 181-185
  • Publisher: Neuroprotective approaches in experimental model of cerebral venous infarct
• [Book] VI. 脳血管奇形 脳動静脈奇形 脳動静脈奇形の発見とその対策 (分担執筆) (2006)
  • Author(s): 川口正一郎, 榊寿右
  • Total Pages: 657-662
  • Publisher: 日本臨牀 インターベンション時代の脳卒中学(改訂第2版)<下> -超急性期から再発予防まで-,(株)日本臨牀社,大阪