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2008 Fiscal Year Final Research Report

Multidisciplinary study on the regulation of the remodeling of the patellar tendon matrix in response to mechanical environment

Research Project

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Project/Area Number 18390406
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

TOHYAMA Harukazu  Hokkaido University, 大学病院, 准教授 (60301884)

Co-Investigator(Kenkyū-buntansha) YASUDA Kazurori  北海道大学, 大学院・医学研究科, 教授 (20166507)
ONODERA Shin  北海道大学, 大学院・医学研究科, 特任講師 (00359481)
KONDO Eiji  北海道大学, 創成科学研究機構, 特任准教授 (60374724)
Project Period (FY) 2006 – 2008
Keywords腱・靱帯 / バイオメカ二クス / サイトカイン / 炎症 / 力学的負荷 / 廃用
Research Abstract

廃用がもたらす除負荷は腱組織の力学特性を低下させることが知られているが、この機序や制御に関しては不明であった。本研究ではin vivo動物モデルを用い、除負荷が膝蓋腱細胞におけるIL-1β発現を亢進させ、IL-1抑止は除負荷膝蓋腱の力学特性を改善させることを明らかにし、廃用による腱組織の力学的劣化には炎症性サイトカインが重要な役割を担い、本サイトカイン制御により廃用がもたらす腱の力学的劣化を抑止する可能性を示した。

  • Research Products

    (34 results)

All 2008 2007 2006

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (4 results) Book (8 results)

  • [Journal Article] Active immunization against macrophage migration inhibitory factor using a novel DNA vaccine prevents ovariectomy-induced2008

    • Author(s)
      Onodera S, Oshima S, Nishihira J, Yasuda K, Tohyama H, Irie K, Koyama Y.
    • Journal Title

      bone loss in mice. Vaccine 26(6)

      Pages: 829-36

    • Peer Reviewed
  • [Journal Article] Local administration of interleukin-1 receptor antagonist inhibits deterioration of mechanical properties of the stress-shielded patellar tendon2008

    • Author(s)
      Miyatake S, Tohyama H, Kondo E, Katsura T, Onodera S, Yasuda K
    • Journal Title

      J Biomech 41(4)

      Pages: 884-9

    • Peer Reviewed
  • [Journal Article] Ex vivo supplementation of TGF-beta1 enhances the fibrous tissue regeneration effect of synovium-derived fibroblast transplantation in a tendon defect a biomechanical study2008

    • Author(s)
      Okamoto S, Tohyama H, Kondo E, Anaguchi Y, Onodera S, Hayashi K, Yasuda K.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 16(3)

      Pages: 333-9

    • Peer Reviewed
  • [Journal Article] Simultaneous anterior and posterior cruciate ligament reconstruction in chronic knee instabilities surgical concepts and clinical outcome.2008

    • Author(s)
      Hayashi R, Kitamura N, Kondo E, Anaguchi Y, Tohyama H, Yasuda K.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 16(8)

      Pages: 763-9

    • Peer Reviewed
  • [Journal Article] A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sepsis2008

    • Author(s)
      Tohyama S, Onodera S, Tohyama H, Yasuda K, Nishihira J, Mizue Y, Hamasaka A, Abe R, Koyama Y.
    • Journal Title

      Gene Ther 15(23)

      Pages: 1513-22

    • Peer Reviewed
  • [Journal Article] In vivo local administration of osteogenic protein-1 increases structural properties of the overstretched anterior cruciate ligament with partial midsubstance laceration a biomechanical study in rabbits2008

    • Author(s)
      Hayashi R, Kondo E, Tohyama H, Saito T, Yasuda K.
    • Journal Title

      J Bone Joint Surg Br. 90(10)

      Pages: 1392-400

    • Peer Reviewed
  • [Journal Article] Ex vivo infiltration of fibroblasts into the tendon deteriorates the mechanical properties of tendon fascicles but not those of tendon bundles2007

    • Author(s)
      Ikema Y, Tohyama H, Yamamoto E, Kanaya F, Yasuda K.
    • Journal Title

      Clin Biomech (Bristol, Avon) 22(1)

      Pages: 120-6

    • Peer Reviewed
  • [Journal Article] The tensile properties of collagen fascicles harvested from regenerated and residual tissues in the patellar tendon after removal of the central third2007

    • Author(s)
      Maeda E, Noguchi H, Tohyama H, Yasuda K, Hayashi K.
    • Journal Title

      Biomed Mater Eng 17(2)

      Pages: 77-85

    • Peer Reviewed
  • [Journal Article] A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis2007

    • Author(s)
      Onodera S, Ohshima S, Tohyama H, Yasuda K, Nishihira J, Iwakura Y, Matsuda I, Minami A, Koyama Y.
    • Journal Title

      Arthritis Rheum 56(2)

      Pages: 521-30

    • Peer Reviewed
  • [Journal Article] Antibody neutralization of TGF-beta enhances the deterioration of collagen fascicles in a tissue-cultured tendon matrix with ex vivo fibroblast infiltration2007

    • Author(s)
      Azuma C, Tohyama H, Nakamura H, Kanaya F, Yasuda K.
    • Journal Title

      J Biomech 40(10)

      Pages: 2184-90

    • Peer Reviewed
  • [Journal Article] Radiologic evaluation of femoral and tibial tunnels created with the transtibial tunnel technique for anatomic double-bundle anterior cruciate ligament reconstruction2007

    • Author(s)
      Kondo E, Yasuda K, Ichiyama H, Azuma C, Tohyama H.
    • Journal Title

      Arthroscopy 23(8)

      Pages: 869-76

    • Peer Reviewed
  • [Journal Article] In vivo effects of partial electrothermal shrinkage on mechanical properties of the anterior cruciate ligament in rabbits2007

    • Author(s)
      Kondo E, Yasuda K, Tohyama H.
    • Journal Title

      Clin Biomech (Bristol, Avon) 22(9)

      Pages: 1037-44

    • Peer Reviewed
  • [Journal Article] The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1beta are different from those of normal tendon fibroblasts2007

    • Author(s)
      Tohyama H, Yasuda K, Uchida H, Nishihira J.
    • Journal Title

      J Bone Joint Surg Br. 89(9)

      Pages: 1261-7

    • Peer Reviewed
  • [Journal Article] Effects of Local Administration of Vascular Endothelial Growth Factor on Properties of the in Situ Frozen-Thawed Anterior Cruciate Ligament in Rabbits2006

    • Author(s)
      Ju YJ, Tohyama H, Kondo E, Yoshikawa T, Muneta T, Shinomiya K, Yasuda K.
    • Journal Title

      Am J Sports Med. 6:34(1)

      Pages: 84-91

    • Peer Reviewed
  • [Journal Article] Stabilizing effects of ankle bracing under a combination of inversion and axial compression loading2006

    • Author(s)
      Tohyama H, Yasuda K, Beynnon BD, Renstrom PA.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 14(4)

      Pages: 373-8

    • Peer Reviewed
  • [Journal Article] Clinical evaluation of anatomic double-bundle anterior cruciate ligament reconstruction procedure using hamstring tendon grafts comparisons among 3 different procedures2006

    • Author(s)
      Yasuda K, Kondo E, Ichiyama H, Tanabe Y, Tohyama H.
    • Journal Title

      Arthroscopy 22(3)

      Pages: 240-51

    • Peer Reviewed
  • [Journal Article] Effects of administration of transforming growth factor (TGF)-beta1 and anti-TGF-beta1 antibody on the mechanical properties of the stress-shielded patellar tendon2006

    • Author(s)
      Katsura T, Tohyama H, Kondo E, Kitamura N, Yasuda K.
    • Journal Title

      J Biomech 39(14)

      Pages: 2566-72

    • Peer Reviewed
  • [Journal Article] Expression of vascular endothelial growth factor and angiogenesis in patellar tendon grafts in the early phase after anterior cruciate ligament reconstruction2006

    • Author(s)
      Yoshikawa T, Tohyama H, Enomoto H, Matsumoto H, Toyama Y, Yasuda K.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 14(9)

      Pages: 804-10

    • Peer Reviewed
  • [Journal Article] Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep2006

    • Author(s)
      Yoshikawa T, Tohyama H, Katsura T, Kotani Y, Matsumoto H, Toyama Y, Yasuda K
    • Journal Title

      Am J Sports Med 34(12)

      Pages: 1918-25

    • Peer Reviewed
  • [Journal Article] Is the increase in type III collagen of the patellar tendon graft after ligament reconstruction really caused by "ligamentization" of the graft?2006

    • Author(s)
      Tohyama H, Uchida H, Yasuda K.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 14(12)

      Pages: 1270-7

    • Peer Reviewed
  • [Journal Article] Transgenic mice overexpressing macrophage migration inhibitory factor (MIF) exhibit high-turnover osteoporosis2006

    • Author(s)
      Onodera S, Sasaki S, Ohshima S, Amizuka N, Li M, Udagawa N, Irie K, Nishihira J, Koyama Y, Shiraishi A, Tohyama H, Yasuda K.
    • Journal Title

      Bone Miner Res 21(6)

      Pages: 876-85

    • Peer Reviewed
  • [Journal Article] The effect of intraosseous graft length on tendon-bone healing in anterior cruciate ligament reconstruction using flexor tendon2006

    • Author(s)
      Yamazaki S, Yasuda K, Tomita F, Minami A, Tohyama H.
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc 14(11)

      Pages: 1086-93

    • Peer Reviewed
  • [Presentation] The relationship between open and closed kinetic chain strength of the lower limb and jumping performance in the anterior cruciate ligament deficient Subjects2008

    • Author(s)
      Tohyama H, Ikoma K, Ueda M, Yuri M, Chiba T, Urayama R, Hori K, Yasuda K.
    • Organizer
      the XVII Congress of International Society of Electrophysiology and Kinesiology (ISEK)
    • Place of Presentation
      Niagara Falls, Ontario, Canada
    • Year and Date
      2008-06-19
  • [Presentation] Synovium-derived fibroblast transplantation possibly deteriorates mechanical properties of the regenerated tissue in the patellar tendon after the harvest of its central one-third portion2008

    • Author(s)
      Tohyama H, Okamoto S, Hayashi K, Yasuda K.
    • Organizer
      International Symposium on Ligaments & Tendons VIII
    • Place of Presentation
      Stanford University, CA, U.S,A
    • Year and Date
      2008-03-01
  • [Presentation] The implantation of autologous synovial tissue-derived fibroblasts after TGF-beta stimulation Inhibits mechanical and ultrastructural deterioration of the ACL after the in situ freeze-thaw treatment2007

    • Author(s)
      Tohyama H., Okuizumi T., Kondo E., Nakamura H., Yasuda K.
    • Organizer
      The 6th biennial congress of International Society of Arthroscopy, Knee, and Orthopaedic Sports Medicine
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2007-05-29
  • [Presentation] The effect of cytokine inactivation on stress-deprived patellar tendons tendons2007

    • Author(s)
      Tohyama H., Kondo E. , Miyatake S., Katsura T., Yasuda K.
    • Organizer
      the 7th International Symposium on Ligaments & Tendons
    • Place of Presentation
      La Jolla, Carifornia, U.S.A
    • Year and Date
      2007-02-10
  • [Book] 後十字靱帯二重束再建術(安田和則編 : OS NOW Instruction No.8 スポーツによる膝・足関節靱帯損傷の治療)2008

    • Author(s)
      遠山晴一, 安田和則
    • Total Pages
      94-99
    • Publisher
      メジカルビュー, 東京
  • [Book] 靱帯・腱(岩谷 力ほか編 : 運動器リハビリテーションクルズス)2008

    • Author(s)
      遠山晴一, 安田和則
    • Total Pages
      16-19
    • Publisher
      南江堂, 東京
  • [Book] 力とモーメント, 関節にかかる負荷(越智隆弘編 : 最新整形外科大系 運動器の生物学と生体力学)2008

    • Author(s)
      遠山晴一, 安田和則
    • Total Pages
      202-207
    • Publisher
      中山書店, 東京
  • [Book] Growth Factors and Other New Methods for Graft Healing Enhancement(Chadwick Prodromos, Charles Brown, Freddie Fu, edt. : THE ANTERIOR CRUCIATE LIGAMENT : RECONSTRUCTION AND BASIC SCIENCE)2007

    • Author(s)
      Tohyama H., Yasuda K.
    • Publisher
      WB Saunders Co
  • [Book] ジャンパー膝(山口 撤、北原光夫、福井次矢編 : 今日の治療指針2007)2007

    • Author(s)
      遠山晴一
    • Total Pages
      767-768
    • Publisher
      医学書院, 東京
  • [Book] 半月板切除(越智隆弘編 : 最新整形外科大系 膝関節・大腿)2006

    • Author(s)
      遠山晴一, 安田和則
    • Total Pages
      327-331
    • Publisher
      中山書店, 東京
  • [Book] 治癒促進のための前十字靱帯再建膝への成長因子の応用(宗田 大編 : 実践すぐに役立つ膝靱帯損傷 診断・治療マニュアル)2006

    • Author(s)
      遠山晴一, 安田和則
    • Total Pages
      36-43
    • Publisher
      全日本病院出版, 東京
  • [Book] 膝関節の診察(守屋秀繁, 糸満盛憲, 内田淳正, 荻野利彦, 黒坂昌弘, 戸山芳昭編 : 整形外科診療実践ガイド)2006

    • Author(s)
      遠山晴一, 安田和則
    • Total Pages
      47-51
    • Publisher
      文光堂, 東京

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Published: 2010-06-10   Modified: 2016-04-21  

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