Biology-based management in metastatic bone tumors

2008 Fiscal Year Final Research Report

• Project/Area Number: 18390412
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Mie University
• Principal Investigator: UCHIDA Atsumasa Mie University, 大学院・医学系研究科, 教授 (40176681)
• Co-Investigator(Kenkyū-buntansha): KUSUZAKI Katsuyu 三重大学, 医学部・附属病院, 診療等従事者 (30177993) ; MATSUMINE Akihiko 三重大学, 医学部・附属病院, 講師 (00335118) ; AKEDA Koji 三重大学, 医学部・附属病院, 助教 (20422826)
• Project Period (FY): 2006 – 2008
• Keywords: 転移性骨腫瘍 / 温熱療法 / 光線力学療法 / 磁性体 / アクリジンオレンジ

Research Abstract

四肢や骨盤部および肩甲帯に発生する転移性骨腫瘍に対して低侵襲で有効性の高い治療法の開発は進行期の癌患者のQOLを高めるのに重要である。そのため、磁性体温熱療法およびアクリジン光線力学療法の有効性を検討した。その結果、腫瘍局所制御の効果は長期間維持されていた。患者の活動性はADL評価で著しい向上がみられた。治療後の副作用を全く認めない点に置いて放射線治療群より有用と考えられた。

Research Products

• [Journal Article] A new therapeutic modality involvingacridine orange excitation by photonenergy used during reduction surgeryfor rhabdomyosarcomas (2008)
  • Author(s): Matsubara T, Kusuzaki K, Matsumine A, Murata H, Satonaka H, Shintani K, Nakamura T, Hosoi H, Iehara T, Sugimoto T, Uchida A
  • Journal Title: Oncol Rep 21 Pages: 89-94
• [Journal Article] Differentiation betweenneurofibromas and malignantperipheral nerve sheath tumors inneurofibromatosis 1 evaluated by MRIa (2008)
  • Author(s): Matsumine A, Kusuzaki K, Nakamura T, Nakazora S, Niimi R, Matsubara T, Uchida K, Murata T, Kudawara I, UedaT, Naka N, Araki N, Maeda M, Uchida A
  • Journal Title: J Cancer Res Clin Oncol (Epub aheadof print)
• [Journal Article] Usefulness of limb salvage surgery forbone and soft tissue sarcomas of thedistal lower leg (2008)
  • Author(s): Niimi R, Matsumine A, Kusuzaki K,Kuratsu S, Araki N, Aoki Y, Ueda T,Kudawara I, Myoui A, Ieguchi M,Hashimoto N, Yoshikawa H, Uchida A
  • Journal Title: J Cancer Res ClinOncolc 134 Pages: 1087-95
• [Journal Article] Flash wave light strongly enhanced thecytocidal effect of photodynamictherapy with acridine orange on amouse osteosarcoma cell line (2007)
  • Author(s): Satonaka H, Kusuzaki K, Matsubara T,Shintani K, Wakabayashi T, Nakamura T,Matsumine A, Uchida A
  • Journal Title: Anticancer Res 27 Pages: 3339-44
• [Journal Article] Novel hyperthermia for metastaticbone tumors with magnetic materials bygenerating an alternatingelectromagnetic field (2007)
  • Author(s): Matsumine A, Kusuzaki K, Matsubara T, Shintani K, Satonaka H, Wakabayashi T, Miyazaki S, Morita K, Takegami K,Uchida A
  • Journal Title: Clin ExpMetastasis 24 Pages: 191-200
• [Journal Article] Expression of hypoxia-induciblefactor (HIF)-1alpha as a biomarker ofoutcome in soft-tissue sarcomas (2006)
  • Author(s): Shintani K, Matsumine A, Kusuzaki K,Matsubara T, Satonaka H, WakabayashiT, Hoki Y, Uchida A
  • Journal Title: Virchows Arch 449 Pages: 673-81
• [Journal Article] Calcium phosphate cement in musculoskeletal tumor surgery (2006)
  • Author(s): Matsumine A, Kusuzaki K, Matsubara T, Okamura A, Okuyama N, Myyazaki S, Shintani K, Uchida A
  • Journal Title: J Surg Oncol 93 Pages: 212-220
• [Journal Article] Low-dose methotrexate inhibits lungmetastasis and lengthens survival inrat osteosarcomae (2006)
  • Author(s): Tomoda R, Seto M, Hioki Y, Sonoda J,Matsumine A, Kusuzaki K, Uchida A
  • Journal Title: Clin Exp Metastasis 22 Pages: 559-564
• [Journal Article] Acridine orange used for photodynamic therapy accumulates in malignant musculoskeletal tumors depending on pHgradient (2006)
  • Author(s): Matsubara T, Kusuzaki K, MatsumineA, Shintani K, Satonaka H, Uchida A
  • Journal Title: Anticancer Res 26 Pages: 187-194
• [Journal Article] Lung radiofrequency ablation inpatients with pulmonary metastasesfrom musculoskeletal sarcomas : Aninitial experience
  • Author(s): Nakamura T, Matsumine A, Yamakado K, Nakazora S, Kusuzaki K, Matsubara T,Takaki H, Nakatsuka A, Takeda K , Abo D, Shimizu T, Uchida A
  • Journal Title: Cancer (in press)
• [Presentation] A new Limb Salvage Surgery in Cases ofHigh-Grade Soft Tissue Sarcoma usingPhotodynamic Surgery, followed byPhoto- and Radiodynamic Therapy withAcridine Orange (2008)
  • Author(s): Nakamura T, Kusuzaki K, Niimi R,Nakazora S, Matsubara T, Matsumine A,Murata H, Uchida A
  • Organizer: 7th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Year and Date: 20080926-28
• [Presentation] In Vivo Antitumor Effect Of Photodynamic Therapy With AcridineOrange Using Flash Wave Light On MouseOsteosarcoma (2008)
  • Author(s): Satonaka H, Kusuzaki K, Matsubara T,Shintani K, Wakabayashi T, NakamuraT, Matsumine A, Uchida A
  • Organizer: 7th Asia Pacific Musculoskeletal Tumor Society Meeting
  • Year and Date: 20080926-28
• [Presentation] Limb Salvage Surgery for Bone And SoftTissue of The Distal Lower Leg7th (2008)
  • Author(s): Niimi R, Matsumine A, Kusuzaki K,Nakamura T, Nakazora S, Kuratsu N.Araki Y, Aoki T, Ueda T, Kudawara I, Myoui A, Ieguchi M, Hashimoto N ,Yoshikawa H , Uchida A
  • Organizer: 7th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Year and Date: 20080926-28
• [Presentation] Novel Hyperthermia for MetastaticBone Tumors with Magnetic Materials (2008)
  • Author(s): Matsumine A, Kusuzaki K, Nakamura T,Niimi R, Nakazora S, Matsubara T,Satonaka H, Uchida A
  • Organizer: 7th. Asia Pacific MusculoskeletalTumor Society Meeting
  • Year and Date: 20080926-28
• [Presentation] Total Femoral Replacement afterResection of Malignant Musculoskeletal Tumors (2008)
  • Author(s): Nakazora S, Matsumine A, Nakamura T,Niimi R, Kusuzaki K, Uchida A
  • Organizer: 7th. Asia Pacific MusculoskeletalTumor Society Meeting
  • Year and Date: 20080926-28
• [Presentation] Transfection of Naked NF kappa B DecoyOligodeoxynucleotide SuppressesPulmonary Metastasis by MurineOsteosarcoma in theAlginate-encapsulated Tumor Spheroid Model (2008)
  • Author(s): Nishimura A, Akeda A, Matsubara T,Kusuzaki K, Matsumine A, Kasai K,Gemba T, Uchida A
  • Organizer: 54th Annual Meeting of the OrthopaedicResearch Society
  • Year and Date: 20080302-05
• [Presentation] Injection of Naked DecoyOligodeoxynucleotide against Nuclear Factorkappa B into a MurineOsteosarcoma in a SpontaneousPulmonary Metastasis Mode (2008)
  • Author(s): Matsubara T, Akeda K, Nishimura A,Kusuzaki K, Matsumine A, Shintani K,Satonaka H, Kasai Y, Gemba T, Uchida A
  • Organizer: 54th Annual Meeting of the OrthopaedicResearch Society
  • Year and Date: 20080302-05
• [Presentation] Novel hyperthermia for metastasisbone tumors with magnetic materials bygenerating an alternatingelectromagnetic field 14th (2007)
  • Author(s): Matsumine A, Kusuzaki K, Matsubara T, Morita K, Takegami K, Uchida A
  • Organizer: International Symposium on Limb Salvage
  • Year and Date: 20070911-14
• [Presentation] Calcium Phosphate Cement InMusculoskeletal Tumor Surgery (2006)
  • Author(s): Matsumine A, Kusuzaki K, Matsubara T, Okamura A, Okuyama N, Miyazaki S, Shintani K, Uchida A
  • Organizer: 58th Annual International Congress of the Egyptian Orthopaedic Association
  • Place of Presentation: Cairo
  • Year and Date: 20061200
• [Presentation] Prevention of bone metastasis by thethrombin inhibitor (2006)
  • Author(s): Asanuma K, Yoshikawa T, WakabayashiH, Hayashi T, Matsumine A, KusuzakiK, Suzuki K, Uchida A
  • Organizer: 52th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Chicago
  • Year and Date: 20060300