• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2007 Fiscal Year Final Research Report Summary

Study on the role of lysophosphatidic acid in the seminal fluids and its related molecules in the development of prostate cancer

Research Project

Project/Area Number 18390438
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKagawa University

Principal Investigator

KAKEHI Yoshiyuki  Kagawa University, Faculty of Medicine, Professor (20214273)

Co-Investigator(Kenkyū-buntansha) WU Xiuxian  Kagawa University, Faculty of Medicine, Associate (10346645)
TAOKA Rikiya  Kagawa University, Faculty of Medidne, Associate (10403784)
INUI Mashashi  Kagawa University, Faculty of Medicine, Assistant Professor (40314918)
Project Period (FY) 2006 – 2007
KeywordsLysophosohatidic acid (LPA) / Prostate cancer / Benign prostate hyperplasia / Autotaxin / Acylglycerol kinase / Lipid mediator
Research Abstract

This study was carried out to elucidate the role of lysophosphatidic acid (LPA) and LPA-relating molecules in the development and progression of prostate cancer. Prostate tissue samples were surgically obtained from 10 patients with localized prostate cancer and 7 patients with invasive bladder cancer. Cancer cells, high grade intraepithelial neoplasia (HGPIN), benign hyperplastic glands, normal glands, and their corresponding stromal cells were isolated by laser capture microdissection. Normal glands and its corresponding stroma from the prostate of bladder cancer patients were referred as a control. mRNA levels of three LPA receptors, LPA1, LPA2, LPA3, two LPA-synthetic enzymes, autotaxin (ATX), acylglycerol kinase (AGK), and a LPA-degradation enzyme, prostatic acid phosphatase (PAP), were quantitatively assessed. Gene expression levels were also evaluated in human prostate cancer LNCaP, PC-3, and DU-145 cells.LPA1 mRNA level was significantly decreased in HGPIN and cancer epithelia as compared to the benign glands. LPA3 mRNA level was elevated in cancer epithelia as compared to control benign glands. LPA3, AGK, and PAP gene expressions were predominant in LNCaP cells while LPA1 and ATX gene expressions were predominant in PC-3 and Du-145 cells. In BPH, elevated expression of AGK in stroma and PAP in epithelia was simultaneously found. LPA stimuli via LPA3 may play a pivotal role in the development of prostate cancer. Switching of predominant type of LPA receptors (LPA3 to LPA1) may be involved in the progression and/or androgen independence.

  • Research Products

    (8 results)

All 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Complication rates of ultrasound-guided prostate biopsy:a nation-wide survey in Japan2008

    • Author(s)
      Kakehi Y, ほか
    • Journal Title

      International Journal of Urology 15

      Pages: 319-321

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Prospective evaluation of selection criteria for active surveillance in Japanese patients with stage T1cN0M0 prostate cancer2008

    • Author(s)
      Kakehi Y, ほか
    • Journal Title

      Japanese Journal of Clinical Oncology 38

      Pages: 122-128

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Complication rates of ultrasound-guided prostate biopsy : a nation-wide survey in Japan2008

    • Author(s)
      Kakehi, Y, et. al.
    • Journal Title

      International Journal of Urology 15

      Pages: 319-321

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prospective evaluation of selection criteria for active surveillance in Japanese patients with stage T1cN0M0 prostate cancer2008

    • Author(s)
      Kakehi, Y, et. al.
    • Journal Title

      Japanese Journal of Clinical Oncology 38

      Pages: 122-128

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Health related quality of life in Japanese men with localized prostate cancer treated with current multiple modalities assessed by a newly developed Japanese version of the Expanded Prostate Cancer Index Composite2007

    • Author(s)
      Kakehi Y, ほか
    • Journal Title

      Journal of Urology 177

      Pages: 1856-1861

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Health related quality of life in Japanese men with localized prostate cancer treated with current multiple modalities assessed by a newly developed Japanese version of the Expanded Prostate Cancer Index Composite2007

    • Author(s)
      Kakehi, Y, et. al.
    • Journal Title

      Journal of Urology 177

      Pages: 1856-1861

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Autotaxin Immunohistochemical Expression Is Closely Linked to the Histopathologic Pattern in Prostate Cancer.2007

    • Author(s)
      ノウ モハメド、呉 秀賢、乾 政志、筧 善行, ほか
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Autotaxin Immunohistochemical Expression Is Closely Linked to the Histopathologic Pattern in Prostate Cancer2007

    • Author(s)
      Nouh, Mohammed, Xiuxian, Wu, Masashi, Inui, kakehi, Y
    • Organizer
      The 95th Annual Meeting of the Japanese Urological Association
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2010-02-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi