Transformation of nasopharyngeal tissue by EBV reactivation and gene expression

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18390456
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa University
• Principal Investigator: YOSHIZAKI Tomokazu Kanazawa University, 医学系, 教授 (70262582)
• Project Period (FY): 2006 – 2009
• Keywords: Epstein-Barr / ウイルス / 上咽頭癌 / エピジェネティクス / がん化

Research Abstract

EB ウイルス複製サイクル活性化により誘導される潜伏感染遺伝子を同定し、正常上皮がん化が誘導されるかどうかを検討する

Research Products

• [Journal Article] Treatment of locally recurrent Epstein-Barrvirus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir (2008)
  • Author(s): Yoshizaki T(他7名,1番目)
  • Journal Title: J Med Virol 80 Pages: 879-882
• [Journal Article] Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma (2007)
  • Author(s): Horikawa T, Yoshizaki T(他5名, 4番目).
  • Journal Title: Cancer Res 67 Pages: 1970-1978
  • Peer Reviewed
• [Journal Article] MUC1 induced by Epstein-Barr Virus Latent Membrane Protein 1 Causes Dissociation of Cell-Matrix Interaction and Cellular Invasiveness via STAT Signaling (2007)
  • Author(s): Kondo S, Yoshizaki T(他7名, 2番目)
  • Journal Title: J Virol 81 Pages: 1554-1562
  • Peer Reviewed
• [Journal Article] Intra-arterial chemotherapy less intensive than RADPLAT with concurrent radiotherapy for resectable advanced head and neck squamous cell carcinoma: a prospective study (2007)
  • Author(s): Yoshizaki T(他9名,1番目)
  • Journal Title: Ann Otol Rhinol Laryngol 116 Pages: 754-761
• [Journal Article] EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolylydroxylases 1 and 3 in nasopharyngeal epithelial cells (2006)
  • Author(s): Kondo S, Yoshizaki T(他6名, 3番目)
  • Journal Title: Cancer Res 66 Pages: 9870-9877
• [Presentation] EB ウイルスRNA・EBERs 発現と感染細胞形質転換能 (2008)
  • Author(s): 吉崎智一
  • Organizer: 日本耳鼻咽喉科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-16