2009 Fiscal Year Final Research Report
Control of invasion and metastasis of oral cancer via clarification of the epithelial-mesenchymal transition
| Project/Area Number |
18390541
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAMATA Nobuyuki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (70242211)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHIKAWA Koichiro 広島大学, 大学院・医歯薬学総合研究科, 助教 (80363084)
ONO Shigehiro 広島大学, 大学院・医歯薬学総合研究科, 助教 (70379882)
SHIGEISHI Hideo 広島大学, 大学院・医歯薬学総合研究科, 助教 (90397943)
TAKI Masayuki 広島大学, 病院, 助教 (00403551)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 口腔癌 / 浸潤転移 / 上皮間葉移行 / 発現遺伝子 / 転写因子 / Snail / p63 |
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| Research Abstract |
Epithelial-Mesenchymal Transition (EMT) is a phenomenon that epithelial cells lose their polarity and change into mesenshymal cells possessing active migration. In this study, we aimed to clarify the molecular mechanism of acquisition of highly invasive phenotype through EMT in oral cancer. We identified the genes being regulated accompanied with EMT using micro-array analysis and analyzed the functions of these gene products and the regulatory mechanisms of gene expression. We found that p63 was one of the target gene of EMT and had the important function in invasion of squamous cell carcinoma.
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Research Products
(51 results)
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[Journal Article] Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease.2009
Author(s)
Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K
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Journal Title
American Journal of Pathology 175(5)
Pages: 2235-2248
Peer Reviewed
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