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2008 Fiscal Year Final Research Report

Elucidation of the mechanism of enhancement of ectopic bone formation in osteopetrotic mice.

Research Project

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Project/Area Number 18390558
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

MIYAZAWA Hiroo  Matsumoto Dental University, 大学院歯学独立研究科, 教授 (90147637)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Midori  松本歯科大学, 歯学部, 講師 (90278177)
NAKAMURA Hiroshi  松本歯科大学, 総合歯科医学研究所, 講師 (00278178)
NAKAMURA Hiroaki  松本歯科大学, 歯学部, 教授 (50227930)
KOIDE Masanori  松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
UDAGAWA Nobuyuki  松本歯科大学, 歯学部, 教授 (70245801)
Project Period (FY) 2006 – 2008
Keywords歯の萌出不全マウス / 異所性骨形成 / 大理石骨病マウス / 破骨細胞 / 骨形成 / 歯の萌出不全
Research Abstract

破骨細胞の分化障害が認められるop/opマウスにおいては,BMP誘導性の異所性骨形成の著明な亢進を示している。また,これらの異所性骨には形態学的異常が観察されたことより,骨形成の際に出現する破骨細胞が正常な骨の形態形成に重要な役割を果たしていることが示され、破骨細胞の存在の重要性がさらに深まった。

  • Research Products

    (10 results)

All 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009

    • Author(s)
      Mizoguchi T, Muto A, Udagawa N et al.
    • Journal Title

      J Cell Biol 184

      Pages: 541-554

    • Peer Reviewed
  • [Journal Article] Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.2009

    • Author(s)
      Koide M, Kinugawa S, Udagawa N et al.
    • Journal Title

      J Bone Miner Res in press

  • [Journal Article] Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.2009

    • Author(s)
      Narita N, Kobayashi Y, Udagawa N et al.
    • Journal Title

      Nano Lett 9

      Pages: 1406-1413

    • Peer Reviewed
  • [Journal Article] MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.2008

    • Author(s)
      Yamashita T, Kobayashi Y, Udagawa N et al.
    • Journal Title

      Biochem Biophys Res Commun 365

      Pages: 252-257

    • Peer Reviewed
  • [Journal Article] Effects of heat treatment of hydroxyapatite on osteoblast differentiation.2008

    • Author(s)
      Asami A, Nakamura M, Nakamura H, Udagawa N, Miyazawa H et al.
    • Journal Title

      J Hard Tissue Biol 17

      Pages: 37-46

    • Peer Reviewed
  • [Journal Article] Synthesis and structure-activity relationships of 16-ene-22-thia-1α, 25-dihydroxy-26,27-dimethyl-19-norvitamin D_3 analogs having side chains of different sizes.2008

    • Author(s)
      Takaku H, Miyamoto Y, Udagawa N et al.
    • Journal Title

      Bioorg Med Chem 16

      Pages: 1796-1815

    • Peer Reviewed
  • [Journal Article] The murine glucagon-like peptide-1 receptor is essential for control of bone resorption.2008

    • Author(s)
      Yamada C, Yamada Y, Udagawa N et al.
    • Journal Title

      Endocrinology 149

      Pages: 574-579

    • Peer Reviewed
  • [Journal Article] Signal transduction of lipopolysaccharide- induced osteoclast differentiation.2007

    • Author(s)
      Udagawa N, Sato N et al.
    • Journal Title

      Periodontology 2000 43

      Pages: 56-64

    • Peer Reviewed
  • [Presentation] Regulation of RANK ligand production and its signaling in osteoclast formation.2008

    • Author(s)
      Udagawa N
    • Organizer
      13^<th>International Congress of Endocrinology
    • Place of Presentation
      Rio de Janeiro
    • Year and Date
      2008-11-09
  • [Book] Principles of Bone Biology2009

    • Author(s)
      Takahashi N, Udagawa N et al.
    • Publisher
      Third Edition in press

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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