2008 Fiscal Year Final Research Report
Elucidation and reguration of the periodontal disease progression mechanism based on new inflammation adjustments(ANA and HMGB-1)
Project/Area Number |
18390561
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Periodontal dentistry
|
Research Institution | Tokyo Medical and Dental University (2007-2008) Kagoshima University (2006) |
Principal Investigator |
IZUMI Yuichi Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (60159803)
|
Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Ikuro 鹿児島大学, 医歯(薬)学総合研究科, 教授 (20082282)
MACHIGASHIRA Miho 鹿児島大学, 医学部・歯学部附属病院, 講師 (80253897)
NAKAMURA Toshiaki 鹿児島大学, 医歯(薬)学総合研究科, 助教 (60381183)
KOBAYASHI Hiroaki 東京医科歯科大学, 大学院・医歯学総合研科, 助教 (50396967)
|
Project Period (FY) |
2006 – 2008
|
Keywords | 歯周病 / HMGB-1 / アナンダマイド / 炎症 |
Research Abstract |
歯周炎の疾患進行における、新規炎症メディエーターであるアナンダマイド(ANA)とHigh Mobility Group Box-1(HMGB-1)に関する研究を行った。ANAは神経性物質であり、神経末端から放出される。このANAは歯周炎局所で発現が亢進しており、歯周炎疾患進行において神経機構が関与している可能性が示唆された。HMGB-1は核内では転写因子として働き、細胞外では起炎性物質として働く。HMGB-1の歯周組織での発現が認められ、疾患進行に関与している可能性が示唆された。
|
-
-
[Journal Article] Periodontal status and Prevotella intermedia antibody in acute coronary syndrome2008
Author(s)
Soejima H., Oe Y.,Nakayama, H., Matsuo K., Fukunaga T., Sugamura K., Kawano H., Sugiyama S., Shinohara M., Izumi Y., Ogawa H.
-
Journal Title
Int J Cardiol, 2008,doi 10, 1016(/j.ijcard)
Pages: 057
-
-
-
-
-
[Journal Article] Injectable growth/differentiation factor-5/recombinant human collagen composite induces endochondral ossification via sox9 expression and angiogenesis in murine calvariae2008
Author(s)
Kadomatsu, H., Matsuyama, T., Yoshimoto, T., Negishi, Y., Sekiya, H., Yamamoto, M. Izumi, Y.,
-
Journal Title
J. Periodontal Res 43
Pages: 483-489
-
-
[Journal Article] Tumor necrosisi factor-alpha stimulates gingival epithelial cells to release high mobility-group box 12008
Author(s)
Morimoto, Y., Kawahara, K-I., Tancharoen, S., Kikuchi, K., Matsuyama, T., Hashiguchi, T., Izumi, Y., Maruyama, I.
-
Journal Title
J Periodontal Res. 43
Pages: 76-83
-
-
[Journal Article] Comparison of injectable calcium phosphate bone cement grafting and open flap debridement in periodontal intrabony defects A randomized clinical trial2008
Author(s)
Shirakata, Y., Setoguchi, T., Machigashira, M., Matsuyama, T., Furuichi, Y., Hasegawa, K., Nakamura, T. and Izumi, Y.
-
Journal Title
J. Periodontol. 79
Pages: 25-32
-
-
-
-
-
-
-
[Journal Article] Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments2007
Author(s)
M. Ibi, A. Ishisaki, M. Yamamoto, A. Wada, T. Kozakai, A. Nakashima, J. Iida, S. Takao, Y. Izumi, A. Yokoyama, M. Tamura,
-
Journal Title
Arch Oral Biol 52
Pages: 1002-1008
-
[Journal Article] Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese2007
Author(s)
Gunji, T., Onouchi, Y., Nagasawa, T., Katagiri, S., Watanabe, H., Kobayashi, H., Arakawa, S., Noguchi, K., Hata, A., Izumi, Y., Ishikawa, I.
-
Journal Title
Biophys. Res. Commun 364
Pages: 7-13
-
[Journal Article] Favorable periodontal healing of 1-wall infrabony defects after application of calcium phosphate cement wall alone or in combination with enamel matrix derivative : A pilot study with canine mandibles2007
Author(s)
Shirakata, Y., Yoshimoto, T., Goto, H., Yonamine, Y., Kadomatsu, H., Miyamoto, M., Nakamura, T., Hayashi, C. and Izumi, Y.
-
Journal Title
J. Periodontol 78
Pages: 889-898
-
-
[Journal Article] B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease2006
Author(s)
Toshihisa Kawai, Takashi Matsuyama, Yoshitaka Hosokawa, Seicho Makihira, Makoto Seki, Nadeem Y. Karimbux, Reginaldo B. Goncalves, Paloma Valverde, Serge Dibart, Yi-Ping Li, Leticia A. Miranda, Cory W.O. Ernst, Yuichi Izumi, Martin A. Taubman
-
Journal Title
Am J Pathol 169
Pages: 987-998
-
[Journal Article] Gene Transfer to Corneal Epithelium and Keratocytes Mediated by Ultrasound with Microbubbles2006
Author(s)
Shozo Sonoda, Katsuro Tachibana, Eisuke Uchino, Akiko Okubo, Matsuo Yamamoto, Kenji Sakoda, Toshio Hisatomi, Koh-Hei Sonoda, Yoichi Negishi, Yuichi Izumi, Sonshin Takao, Taiji Sakamoto
-
Journal Title
Invest Ophthalmol Vis Sci 47
Pages: 558-564
-
-
-
-
-
-
[Journal Article] Periodontal tissue regeneration using fibroblast growth factor-2
Author(s)
Kitamura M., Nakashima K., Kowashi Y., Fujii T., Shimauchi H., Sasano T., Furuuchi T., Fukuda M., Noguchi T., Shibutani T., Iwayama Y., Takashiba S., Kurihara H., Ninomiya M., Kido J., Nagata T., Hamachi T., Maeda K., Hara Y., Izumi Y., Hirofuji T., Imai E., Omae M., Watanuki M., Murakami S.
-
Journal Title
Randomized controlled phase II clinical trial PLos ONE 3(7)
Pages: e2611(Doi10.1371/j.pone.0002611)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-